Ouabain (Octahydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CENPF centromere protein F, 350/400kDa 0.0555248
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.055027
ELOVL5 ELOVL fatty acid elongase 5 0.0491738
EZR ezrin 0.0460389
MKI67 marker of proliferation Ki-67 0.0455082
BRD2 bromodomain containing 2 0.0420166
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.041902
ANXA1 annexin A1 0.0388221
GOLGA4 golgin A4 0.0387517
DIAPH3 diaphanous-related formin 3 0.0382473
SMC4 structural maintenance of chromosomes 4 0.0372547
CRY1 cryptochrome circadian clock 1 0.0355832
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0345011
ECT2 epithelial cell transforming 2 0.0340815
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.032511
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0323192
SGMS2 sphingomyelin synthase 2 0.0282022
ANLN anillin, actin binding protein 0.0270703
MED13 mediator complex subunit 13 0.0266722
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0252011
SFPQ splicing factor proline/glutamine-rich 0.0245066
SON SON DNA binding protein 0.0244944
RAB7A RAB7A, member RAS oncogene family 0.024481
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0240175
TMF1 TATA element modulatory factor 1 0.0231071
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0224643
SRRM2 serine/arginine repetitive matrix 2 0.0224119
NIPBL Nipped-B homolog (Drosophila) 0.0212441
NUP58 nucleoporin 58 0.0211083
ARL5B ADP-ribosylation factor-like 5B 0.020671
UBA6 ubiquitin-like modifier activating enzyme 6 0.0205567
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0200217
DIAPH1 diaphanous-related formin 1 0.0196286
BRD4 bromodomain containing 4 0.0196182
COPA coatomer protein complex, subunit alpha 0.0191645
RFC3 replication factor C (activator 1) 3, 38kDa 0.0188005
RPL3 ribosomal protein L3 0.0182977
TPX2 TPX2, microtubule-associated 0.0182237
RCOR1 REST corepressor 1 0.0182132
LATS2 large tumor suppressor kinase 2 0.0180898
ZFAND3 zinc finger, AN1-type domain 3 0.0180327
CKAP2 cytoskeleton associated protein 2 0.0179663
INO80 INO80 complex subunit 0.0179576
FNDC3B fibronectin type III domain containing 3B 0.017892
RBM25 RNA binding motif protein 25 0.0178251
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0176484
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0175767
FNIP1 folliculin interacting protein 1 0.0173842
RTN4 reticulon 4 0.017362
SEC31A SEC31 homolog A (S. cerevisiae) 0.0173397
ARF4 ADP-ribosylation factor 4 0.0172163
NOCT nocturnin 0.0171869
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0171346
BCLAF1 BCL2-associated transcription factor 1 0.0170992
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0170337
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0166355
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0166253
DSCAM Down syndrome cell adhesion molecule 0.0165151
YAP1 Yes-associated protein 1 0.0163242
PLK2 polo-like kinase 2 0.0162769
KMT2E lysine (K)-specific methyltransferase 2E 0.0161814
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0159944
NAV2 neuron navigator 2 0.0159468
BLZF1 basic leucine zipper nuclear factor 1 0.0159262
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0158862
TBC1D15 TBC1 domain family, member 15 0.015866
NUP153 nucleoporin 153kDa 0.0158424
QKI QKI, KH domain containing, RNA binding 0.015816
ANKHD1 ankyrin repeat and KH domain containing 1 0.0156373
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0154736
MYOF myoferlin 0.0154186
RLF rearranged L-myc fusion 0.015398
GLS2 glutaminase 2 (liver, mitochondrial) 0.0153643
SUCO SUN domain containing ossification factor 0.0153351
GATAD2B GATA zinc finger domain containing 2B 0.0152722
ATAD2 ATPase family, AAA domain containing 2 0.0152128
LOC102724023 ES1 protein homolog, mitochondrial 0.0149749
CCNH cyclin H 0.0145965
CAMTA1 calmodulin binding transcription activator 1 0.0145622
PCBP2 poly(rC) binding protein 2 0.0144866
HSPH1 heat shock 105kDa/110kDa protein 1 0.0144844
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0144628
ZC3H11A zinc finger CCCH-type containing 11A 0.01424
JUN jun proto-oncogene 0.0138796
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0138396
APLP2 amyloid beta (A4) precursor-like protein 2 0.0138094
CENPE centromere protein E, 312kDa 0.0137312
ZBTB11 zinc finger and BTB domain containing 11 0.0136705
FAT1 FAT atypical cadherin 1 0.0136273
SRP54 signal recognition particle 54kDa 0.0135475
AFF4 AF4/FMR2 family, member 4 0.0135002
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.013494
ERRFI1 ERBB receptor feedback inhibitor 1 0.0134654
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0133969
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0133756
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.013153
KDM6B lysine (K)-specific demethylase 6B 0.0131319
NUP98 nucleoporin 98kDa 0.0131193
NUSAP1 nucleolar and spindle associated protein 1 0.013018
RSRC2 arginine/serine-rich coiled-coil 2 0.0129102

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146458
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.124965
PDE4D phosphodiesterase 4D, cAMP-specific -0.118206
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.111688
VCL vinculin -0.111013
FLNB filamin B, beta -0.109949
AHNAK AHNAK nucleoprotein -0.108291
EGFR epidermal growth factor receptor -0.103746
FOXP1 forkhead box P1 -0.0833234
TMSB4X thymosin beta 4, X-linked -0.0821023
PKM pyruvate kinase, muscle -0.0796837
PTMA prothymosin, alpha -0.0781672
ADAM10 ADAM metallopeptidase domain 10 -0.0777985
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0769235
SMYD3 SET and MYND domain containing 3 -0.076839
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0723165
NBEA neurobeachin -0.0697237
EFNA5 ephrin-A5 -0.0662534
PRELID2 PRELI domain containing 2 -0.0654787
ZBTB20 zinc finger and BTB domain containing 20 -0.0642538
TPT1 tumor protein, translationally-controlled 1 -0.0627341
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0584578
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0544727
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0542256
PYGB phosphorylase, glycogen; brain -0.0536877
NPAS2 neuronal PAS domain protein 2 -0.0534169
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.052501
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0520739
S100A6 S100 calcium binding protein A6 -0.0515556
ANK2 ankyrin 2, neuronal -0.0511277
PDGFC platelet derived growth factor C -0.0500222
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0500167
GLI2 GLI family zinc finger 2 -0.0491249
TJP1 tight junction protein 1 -0.0485336
PGK1 phosphoglycerate kinase 1 -0.0482526
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0481743
ZEB1 zinc finger E-box binding homeobox 1 -0.0469772
PDE4B phosphodiesterase 4B, cAMP-specific -0.0468954
ZMYND8 zinc finger, MYND-type containing 8 -0.045416
SSBP2 single-stranded DNA binding protein 2 -0.0452566
TMEM65 transmembrane protein 65 -0.0451835
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0434672
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0410134
LOC112694756 uncharaterized LOC112694756 -0.0408898
RPL35A ribosomal protein L35a -0.0408742
NFIA nuclear factor I/A -0.0398649
FHIT fragile histidine triad -0.0386332
TBC1D5 TBC1 domain family, member 5 -0.0375078
HDAC9 histone deacetylase 9 -0.0374741
ACTG1 actin gamma 1 -0.036656
RPS19 ribosomal protein S19 -0.0364048
DLG1 discs, large homolog 1 (Drosophila) -0.0363383
TRERF1 transcriptional regulating factor 1 -0.0362861
METTL15 methyltransferase like 15 -0.0355005
GLI3 GLI family zinc finger 3 -0.034539
RPL11 ribosomal protein L11 -0.0342363
RPL26 ribosomal protein L26 -0.0341548
DIAPH2 diaphanous-related formin 2 -0.0339311
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.033879
DOCK3 dedicator of cytokinesis 3 -0.0336517
CCND1 cyclin D1 -0.0332885
MYO5C myosin VC -0.0332079
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0320377
BABAM2 BRISC and BRCA1 A complex member 2 -0.0310862
RPLP1 ribosomal protein, large, P1 -0.0308263
RPLP0 ribosomal protein, large, P0 -0.0307697
TBC1D22A TBC1 domain family, member 22A -0.0307248
MACROD2 MACRO domain containing 2 -0.0304556
HDLBP high density lipoprotein binding protein -0.0295663
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0295057
RPL34 ribosomal protein L34 -0.0294977
RPL12 ribosomal protein L12 -0.029353
RPS23 ribosomal protein S23 -0.0293497
EXOC6B exocyst complex component 6B -0.0290054
CAMKMT calmodulin-lysine N-methyltransferase -0.0287972
RAD51B RAD51 paralog B -0.0285588
RPL19 ribosomal protein L19 -0.0279458
ZNF217 zinc finger protein 217 -0.027745
PHF3 PHD finger protein 3 -0.0272897
RPL13A ribosomal protein L13a -0.0272399
LPP LIM domain containing preferred translocation partner in lipoma -0.0271843
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0270494
PTPRG protein tyrosine phosphatase, receptor type, G -0.026981
RPL31 ribosomal protein L31 -0.0269548
ARL15 ADP-ribosylation factor-like 15 -0.0268239
GARS1 glycyl-tRNA synthetase 1 -0.0267833
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0266547
KLF3 Kruppel-like factor 3 (basic) -0.0265893
ARL4C ADP-ribosylation factor-like 4C -0.0265189
RPS24 ribosomal protein S24 -0.0264455
RPS8 ribosomal protein S8 -0.0262901
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0260065
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0259395
EXT1 exostosin glycosyltransferase 1 -0.0258616
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0258187
PIWIL1 piwi-like RNA-mediated gene silencing 1 -0.0256334
OSMR oncostatin M receptor -0.025559
RPL9 ribosomal protein L9 -0.0255044
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0254998
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0254785