Ouabain (Octahydrate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.172277
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0907011
SPAG9 sperm associated antigen 9 0.0875332
ZFAND3 zinc finger, AN1-type domain 3 0.0784282
MYH9 myosin, heavy chain 9, non-muscle 0.0774311
USP9X ubiquitin specific peptidase 9, X-linked 0.0718501
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0707006
TRIO trio Rho guanine nucleotide exchange factor 0.0684114
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0652109
NAV2 neuron navigator 2 0.065188
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0626288
CXCL8 chemokine (C-X-C motif) ligand 8 0.0594084
CD44 CD44 molecule (Indian blood group) 0.0585554
CRY1 cryptochrome circadian clock 1 0.0561938
ICAM1 intercellular adhesion molecule 1 0.0552496
ATP13A3 ATPase type 13A3 0.0506645
CADM1 cell adhesion molecule 1 0.0504524
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0496223
OGA O-GlcNAcase 0.04918
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0479222
NAMPT nicotinamide phosphoribosyltransferase 0.0452754
RBM39 RNA binding motif protein 39 0.0452192
TNIP1 TNFAIP3 interacting protein 1 0.0451219
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0446333
ALCAM activated leukocyte cell adhesion molecule 0.0440538
JMJD1C jumonji domain containing 1C 0.0438755
SDC4 syndecan 4 0.0435858
ERBIN erbb2 interacting protein 0.0429084
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0424307
THBS1 thrombospondin 1 0.0421295
LAMP2 lysosomal-associated membrane protein 2 0.0409651
FAT1 FAT atypical cadherin 1 0.0405375
UGCG UDP-glucose ceramide glucosyltransferase 0.0401386
BIRC3 baculoviral IAP repeat containing 3 0.0397514
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0397509
EPS8 epidermal growth factor receptor pathway substrate 8 0.0392362
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0391768
QKI QKI, KH domain containing, RNA binding 0.0391389
AHR aryl hydrocarbon receptor 0.0389154
CYLD cylindromatosis (turban tumor syndrome) 0.0383823
GLS2 glutaminase 2 (liver, mitochondrial) 0.038314
KDM6A lysine (K)-specific demethylase 6A 0.0381055
FNIP1 folliculin interacting protein 1 0.0373332
NAP1L1 nucleosome assembly protein 1-like 1 0.0357152
IPO7 importin 7 0.0355342
RB1CC1 RB1-inducible coiled-coil 1 0.0353855
CCNL1 cyclin L1 0.0353836
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0351407
UVRAG UV radiation resistance associated 0.0335972
SNX9 sorting nexin 9 0.0335771
CCBE1 collagen and calcium binding EGF domains 1 0.0324217
NRXN3 neurexin 3 0.03092
EEF2 eukaryotic translation elongation factor 2 0.0307118
WTAP Wilms tumor 1 associated protein 0.0306448
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0293216
CHD1 chromodomain helicase DNA binding protein 1 0.0291176
MCTP1 multiple C2 domains, transmembrane 1 0.0287068
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0284483
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0282141
CUL3 cullin 3 0.0279384
WAC WW domain containing adaptor with coiled-coil 0.0278339
DSCAM Down syndrome cell adhesion molecule 0.0277645
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0276778
ARL5B ADP-ribosylation factor-like 5B 0.0276728
PPP4R4 protein phosphatase 4, regulatory subunit 4 0.0276294
IGF2R insulin-like growth factor 2 receptor 0.0272173
AFDN afadin, adherens junction formation factor 0.0269159
PUM2 pumilio RNA-binding family member 2 0.0267542
ANKHD1 ankyrin repeat and KH domain containing 1 0.0266725
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0265703
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0261555
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261136
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0258441
FN1 fibronectin 1 0.0257942
SFTPA2 surfactant protein A2 0.0254089
PAWR PRKC, apoptosis, WT1, regulator 0.0253543
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0253364
IARS1 isoleucyl-tRNA synthetase 1 0.025289
LCORL ligand dependent nuclear receptor corepressor-like 0.0251973
MED13 mediator complex subunit 13 0.0251585
AFF4 AF4/FMR2 family, member 4 0.0251508
PTK2 protein tyrosine kinase 2 0.0249515
SCAF8 SR-related CTD-associated factor 8 0.0248698
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0246808
ADAM17 ADAM metallopeptidase domain 17 0.0246622
WDR43 WD repeat domain 43 0.0245516
TJP2 tight junction protein 2 0.024267
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.024205
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0240227
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0237604
USP12 ubiquitin specific peptidase 12 0.0237371
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0235613
NUP153 nucleoporin 153kDa 0.0235131
ELL2 elongation factor, RNA polymerase II, 2 0.0234536
GPHN gephyrin 0.0229429
OSBPL8 oxysterol binding protein-like 8 0.0229301
TUSC3 tumor suppressor candidate 3 0.0227717
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0227509
APP amyloid beta (A4) precursor protein 0.022728
DENND5A DENN/MADD domain containing 5A 0.0225106

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.124343
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0796421
NDRG1 N-myc downstream regulated 1 -0.0738046
RPS6 ribosomal protein S6 -0.0702658
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0631317
IGFBP3 insulin-like growth factor binding protein 3 -0.0552796
PLIN2 perilipin 2 -0.0489657
MT2A metallothionein 2A -0.0483175
FTL ferritin, light polypeptide -0.0469354
RPS3 ribosomal protein S3 -0.0463835
TMSB10 thymosin beta 10 -0.0442848
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0433567
STC1 stanniocalcin 1 -0.0429313
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0428988
LDHA lactate dehydrogenase A -0.0417667
RPS8 ribosomal protein S8 -0.041106
FRMD4A FERM domain containing 4A -0.0394047
VEGFA vascular endothelial growth factor A -0.0387306
RAI14 retinoic acid induced 14 -0.0385457
HILPDA hypoxia inducible lipid droplet-associated -0.0381286
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0356965
ADM adrenomedullin -0.0351773
IER3 immediate early response 3 -0.0339374
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0337719
RPL35A ribosomal protein L35a -0.0337131
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0334237
PDE10A phosphodiesterase 10A -0.0331744
ZMYND8 zinc finger, MYND-type containing 8 -0.0327839
RPS12 ribosomal protein S12 -0.0325179
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0321068
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0318119
S100A9 S100 calcium binding protein A9 -0.0316836
GDF15 growth differentiation factor 15 -0.0314042
RPL37A ribosomal protein L37a -0.0314012
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0307032
B2M beta-2-microglobulin -0.0304613
RPL23 ribosomal protein L23 -0.0302194
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0301416
RPLP1 ribosomal protein, large, P1 -0.030065
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0283614
RPLP2 ribosomal protein, large, P2 -0.0281461
FRMPD4 FERM and PDZ domain containing 4 -0.0279082
WSB1 WD repeat and SOCS box containing 1 -0.0261969
BASP1 brain abundant, membrane attached signal protein 1 -0.0260514
AKAP12 A kinase (PRKA) anchor protein 12 -0.025744
MMP12 matrix metallopeptidase 12 -0.0256907
DEPP1 DEPP autophagy regulator 1 -0.0255549
PTMA prothymosin, alpha -0.0252292
ENO1 enolase 1, (alpha) -0.0251707
EGFR epidermal growth factor receptor -0.0250876
RPS27A ribosomal protein S27a -0.0249824
RPS13 ribosomal protein S13 -0.0247717
EGR1 early growth response 1 -0.0245412
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0245017
FTH1 ferritin, heavy polypeptide 1 -0.0242113
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0239712
TFPI2 tissue factor pathway inhibitor 2 -0.0235042
LOC112694756 uncharaterized LOC112694756 -0.0232581
RPS19 ribosomal protein S19 -0.0229324
RPS10 ribosomal protein S10 -0.0226153
RPL36 ribosomal protein L36 -0.0219995
RPS14 ribosomal protein S14 -0.0214728
PKM pyruvate kinase, muscle -0.0213175
RNF213 ring finger protein 213 -0.0208911
HMGA2 high mobility group AT-hook 2 -0.0208008
RACK1 receptor for activated C kinase 1 -0.0207634
HLA-B major histocompatibility complex, class I, B -0.0202677
CDCP1 CUB domain containing protein 1 -0.0201828
RPL35 ribosomal protein L35 -0.0201728
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0199856
RPS16 ribosomal protein S16 -0.0198422
RPL26 ribosomal protein L26 -0.0197821
RPS29 ribosomal protein S29 -0.0196171
PHF21A PHD finger protein 21A -0.0195738
LOX lysyl oxidase -0.019407
SNX14 sorting nexin 14 -0.0193711
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0191328
ZHX2 zinc fingers and homeoboxes 2 -0.0189679
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0188727
NGLY1 N-glycanase 1 -0.0184383
RAD51B RAD51 paralog B -0.0183318
RPL13A ribosomal protein L13a -0.0183017
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0182307
HLA-A major histocompatibility complex, class I, A -0.0179367
PFN1 profilin 1 -0.0179312
RPL27A ribosomal protein L27a -0.0178646
BTG1 B-cell translocation gene 1, anti-proliferative -0.0177998
RPS23 ribosomal protein S23 -0.0175798
RPL11 ribosomal protein L11 -0.0175633
TMEM132D transmembrane protein 132D -0.0175594
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0175165
RPL36A ribosomal protein L36a -0.0174187
HDAC8 histone deacetylase 8 -0.0173071
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0172018
AFF3 AF4/FMR2 family, member 3 -0.0169645
FLOT1 flotillin 1 -0.0169485
SMYD3 SET and MYND domain containing 3 -0.0167125
RPL19 ribosomal protein L19 -0.0165689
IFITM3 interferon induced transmembrane protein 3 -0.0165391
RPS24 ribosomal protein S24 -0.0165149