Ouabain (Octahydrate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in SW1417 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.108491
PABPC1 poly(A) binding protein, cytoplasmic 1 0.101091
TXNIP thioredoxin interacting protein 0.0996447
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0815054
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0663683
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0632465
CCNL1 cyclin L1 0.060387
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.060153
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0582727
LOC102724023 ES1 protein homolog, mitochondrial 0.057678
B2M beta-2-microglobulin 0.0575605
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0572359
OSBPL8 oxysterol binding protein-like 8 0.0537489
JMJD1C jumonji domain containing 1C 0.0525841
CST3 cystatin C 0.052018
JUN jun proto-oncogene 0.0512147
SPAG9 sperm associated antigen 9 0.0486103
CRY1 cryptochrome circadian clock 1 0.0472071
OGA O-GlcNAcase 0.0471446
ZFAND3 zinc finger, AN1-type domain 3 0.0453011
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.044552
TFRC transferrin receptor 0.0442339
IFRD1 interferon-related developmental regulator 1 0.0431109
APLP2 amyloid beta (A4) precursor-like protein 2 0.042418
SIK3 SIK family kinase 3 0.0405317
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0378639
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0368739
RAB7A RAB7A, member RAS oncogene family 0.0363482
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.0354742
XPO1 exportin 1 0.0352962
TOP1 topoisomerase (DNA) I 0.0350303
TMSB10 thymosin beta 10 0.0344336
BRD2 bromodomain containing 2 0.0343205
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0336864
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0333901
RBM5 RNA binding motif protein 5 0.0331688
KDM2A lysine (K)-specific demethylase 2A 0.03261
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0322119
KDM6A lysine (K)-specific demethylase 6A 0.0317647
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0316837
YTHDC1 YTH domain containing 1 0.0316808
SPPL3 signal peptide peptidase like 3 0.0314602
PCBP2 poly(rC) binding protein 2 0.0310514
NPTN neuroplastin 0.0304794
ARHGAP26 Rho GTPase activating protein 26 0.0301764
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0294132
POU2F1 POU class 2 homeobox 1 0.0288874
ANKRD12 ankyrin repeat domain 12 0.0287348
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0283453
WAC WW domain containing adaptor with coiled-coil 0.0283085
ATOSA atos homolog A 0.0282916
PRRC2C proline-rich coiled-coil 2C 0.0281975
ZFP36 ZFP36 ring finger protein 0.0281856
MEMO1 mediator of cell motility 1 0.0280338
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0279196
FNBP1L formin binding protein 1-like 0.0277916
NCKAP1 NCK-associated protein 1 0.0277545
FTL ferritin, light polypeptide 0.0275733
RLF rearranged L-myc fusion 0.027422
PEAK1 pseudopodium-enriched atypical kinase 1 0.0270844
GNAS GNAS complex locus 0.0263828
RICTOR RPTOR independent companion of MTOR, complex 2 0.0260608
SQSTM1 sequestosome 1 0.0260041
TRA2A transformer 2 alpha homolog (Drosophila) 0.0258285
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.025765
TRA2B transformer 2 beta homolog (Drosophila) 0.0255772
LCORL ligand dependent nuclear receptor corepressor-like 0.02553
FOSL1 FOS-like antigen 1 0.0254843
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0251747
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0251515
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0251481
MXD1 MAX dimerization protein 1 0.025013
CLDN4 claudin 4 0.0246225
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0245223
PUM2 pumilio RNA-binding family member 2 0.0242597
RPS19 ribosomal protein S19 0.0241716
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0239145
ATP11B ATPase, class VI, type 11B 0.0238205
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0237246
FXR1 fragile X mental retardation, autosomal homolog 1 0.0236103
OSBPL9 oxysterol binding protein-like 9 0.02354
RSRC2 arginine/serine-rich coiled-coil 2 0.0229768
ITSN2 intersectin 2 0.0228025
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0226933
ESYT2 extended synaptotagmin-like protein 2 0.0226378
ARRDC3 arrestin domain containing 3 0.0225566
BAIAP2L1 BAI1-associated protein 2-like 1 0.0225467
LEMD3 LEM domain containing 3 0.0224532
RNASE3 ribonuclease, RNase A family, 3 0.0224245
CHD1 chromodomain helicase DNA binding protein 1 0.022238
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.022132
CREBRF CREB3 regulatory factor 0.0220918
ACER3 alkaline ceramidase 3 0.0220777
TAOK3 TAO kinase 3 0.0219013
RPL35A ribosomal protein L35a 0.0216956
VGF VGF nerve growth factor inducible 0.0216906
NXF1 nuclear RNA export factor 1 0.021489
SFPQ splicing factor proline/glutamine-rich 0.0213522
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0213304
RPLP2 ribosomal protein, large, P2 0.0212867

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.187813
NCEH1 neutral cholesterol ester hydrolase 1 -0.113723
BCL2L1 BCL2-like 1 -0.0960043
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0929041
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0770254
ACTN4 actinin, alpha 4 -0.0738372
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0702746
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.069818
ANXA2 annexin A2 -0.0689018
NEBL nebulette -0.0616352
MYO1E myosin IE -0.0580263
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0577662
SNX9 sorting nexin 9 -0.0546561
FAM3C family with sequence similarity 3, member C -0.0539052
VCL vinculin -0.0499057
FTH1 ferritin, heavy polypeptide 1 -0.0483545
ETV6 ets variant 6 -0.0477552
PLSCR1 phospholipid scramblase 1 -0.0476923
MYOF myoferlin -0.0476504
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0469985
PTPRK protein tyrosine phosphatase, receptor type, K -0.046929
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0467247
EXOC4 exocyst complex component 4 -0.0463909
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0456853
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0447119
ZNRF3 zinc and ring finger 3 -0.0442613
PTMA prothymosin, alpha -0.0434956
MACC1 metastasis associated in colon cancer 1 -0.0433805
CTBP2 C-terminal binding protein 2 -0.0433679
IARS1 isoleucyl-tRNA synthetase 1 -0.0424947
SMAD2 SMAD family member 2 -0.0418345
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0414165
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0406887
OSBPL10 oxysterol binding protein-like 10 -0.0403088
NKD1 naked cuticle homolog 1 (Drosophila) -0.0395403
GARS1 glycyl-tRNA synthetase 1 -0.0390221
EHBP1 EH domain binding protein 1 -0.0383708
TPT1 tumor protein, translationally-controlled 1 -0.0378226
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0370398
PATJ PATJ crumbs cell polarity complex component -0.0367944
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0363243
ANKRD11 ankyrin repeat domain 11 -0.0361607
NAV2 neuron navigator 2 -0.0360692
PRELID2 PRELI domain containing 2 -0.0357099
HM13 histocompatibility (minor) 13 -0.0352642
FNDC3A fibronectin type III domain containing 3A -0.0350047
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0348786
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0346374
ADAM19 ADAM metallopeptidase domain 19 -0.0342367
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.034207
OXSR1 oxidative stress responsive 1 -0.0335936
KRT20 keratin 20, type I -0.0335873
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0333514
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0331474
AHNAK AHNAK nucleoprotein -0.0330596
SERINC5 serine incorporator 5 -0.0326934
CALU calumenin -0.0326464
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0323937
CADPS Ca++-dependent secretion activator -0.0323438
TGFA transforming growth factor, alpha -0.0321963
NFIA nuclear factor I/A -0.032153
AOPEP aminopeptidase O (putative) -0.0321139
IER3 immediate early response 3 -0.0319766
ZBTB38 zinc finger and BTB domain containing 38 -0.0319224
CDK13 cyclin-dependent kinase 13 -0.0314433
CANX calnexin -0.0314078
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0312623
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.030978
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0308009
TMEM123 transmembrane protein 123 -0.0304956
SVIL supervillin -0.0302604
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0298761
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0298064
ARHGAP42 Rho GTPase activating protein 42 -0.029602
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0292803
TNRC6B trinucleotide repeat containing 6B -0.0289978
RAD21 RAD21 homolog (S. pombe) -0.0287118
HDLBP high density lipoprotein binding protein -0.0286426
PCLO piccolo presynaptic cytomatrix protein -0.0282513
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.028067
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0279673
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0277964
COG5 component of oligomeric golgi complex 5 -0.0275947
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0275045
HDAC4 histone deacetylase 4 -0.0273691
FNDC3B fibronectin type III domain containing 3B -0.026934
CLIP2 CAP-GLY domain containing linker protein 2 -0.0268814
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.02686
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0268473
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0267429
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0264194
SDK1 sidekick cell adhesion molecule 1 -0.0263256
FAT1 FAT atypical cadherin 1 -0.0263081
ANKRD28 ankyrin repeat domain 28 -0.0259069
UBE2H ubiquitin-conjugating enzyme E2H -0.025853
SBF2 SET binding factor 2 -0.025694
KDM7A lysine (K)-specific demethylase 7A -0.0255891
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0255666
CLINT1 clathrin interactor 1 -0.025336
TRIM2 tripartite motif containing 2 -0.0252752