Ouabain (Octahydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.045096
PTMA prothymosin, alpha 0.0428674
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0418934
WAC WW domain containing adaptor with coiled-coil 0.0375402
TFRC transferrin receptor 0.0310848
PUM2 pumilio RNA-binding family member 2 0.0301924
WDR43 WD repeat domain 43 0.0278439
SQSTM1 sequestosome 1 0.0240945
HILPDA hypoxia inducible lipid droplet-associated 0.0208643
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0207905
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0204412
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0195225
TSC22D2 TSC22 domain family, member 2 0.0191637
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0181784
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0177665
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0176748
RNF145 ring finger protein 145 0.0176508
ANKRD10 ankyrin repeat domain 10 0.0169952
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0168704
NUP58 nucleoporin 58 0.0168251
PUM1 pumilio RNA-binding family member 1 0.0167773
CHD1 chromodomain helicase DNA binding protein 1 0.0165013
IER3 immediate early response 3 0.016299
NUP153 nucleoporin 153kDa 0.0156618
EWSR1 EWS RNA-binding protein 1 0.0156184
DIAPH1 diaphanous-related formin 1 0.0153314
KDM6A lysine (K)-specific demethylase 6A 0.0150725
AREG amphiregulin 0.0147614
USP36 ubiquitin specific peptidase 36 0.0146537
RLF rearranged L-myc fusion 0.0144326
RBM39 RNA binding motif protein 39 0.0143051
PDLIM5 PDZ and LIM domain 5 0.0142979
BIRC3 baculoviral IAP repeat containing 3 0.0142704
NOP58 NOP58 ribonucleoprotein 0.0136401
CCNL1 cyclin L1 0.0133355
KMT2E lysine (K)-specific methyltransferase 2E 0.0132298
GPBP1 GC-rich promoter binding protein 1 0.0131983
SIRT1 sirtuin 1 0.0129968
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0128674
BRD2 bromodomain containing 2 0.0124808
GADD45B growth arrest and DNA-damage-inducible, beta 0.0124677
PRPF4B pre-mRNA processing factor 4B 0.0124369
TCERG1 transcription elongation regulator 1 0.0121209
INSIG1 insulin induced gene 1 0.0118327
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0116571
XPO1 exportin 1 0.0114967
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0114427
RSRC2 arginine/serine-rich coiled-coil 2 0.0113302
EREG epiregulin 0.0112139
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0111112
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0110992
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0109702
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0108652
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0108236
USP3 ubiquitin specific peptidase 3 0.0107585
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0107563
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0107349
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0106162
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0105934
EGR1 early growth response 1 0.0105172
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0105081
SLMAP sarcolemma associated protein 0.0103949
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0103025
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0102686
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0101623
OTUD4 OTU deubiquitinase 4 0.0100647
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0100471
ANXA1 annexin A1 0.0100313
INO80 INO80 complex subunit 0.00998555
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00997884
RAB10 RAB10, member RAS oncogene family 0.00965599
PARD3 par-3 family cell polarity regulator 0.00965486
ECT2 epithelial cell transforming 2 0.00962081
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.00947831
H1-4 H1.4 linker histone, cluster member 0.00942311
SENP6 SUMO1/sentrin specific peptidase 6 0.00938942
UBA2 ubiquitin-like modifier activating enzyme 2 0.0092978
BIRC2 baculoviral IAP repeat containing 2 0.00929657
MARCHF6 membrane associated ring-CH-type finger 6 0.00929063
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00924781
PRRC2C proline-rich coiled-coil 2C 0.00921361
EIF3E eukaryotic translation initiation factor 3, subunit E 0.00920608
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.00917868
SETD2 SET domain containing 2 0.00916396
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.00913767
FUBP1 far upstream element (FUSE) binding protein 1 0.00912
FMNL2 formin-like 2 0.00901811
ZC3H11A zinc finger CCCH-type containing 11A 0.00898186
ZNF207 zinc finger protein 207 0.00894287
MED13 mediator complex subunit 13 0.0088753
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.00885211
NFXL1 nuclear transcription factor, X-box binding-like 1 0.00880763
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.00871635
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.00868516
LRPPRC leucine-rich pentatricopeptide repeat containing 0.00866787
EIF4E eukaryotic translation initiation factor 4E 0.00861867
EIF3B eukaryotic translation initiation factor 3, subunit B 0.00857478
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0085076
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.00849922
HDAC3 histone deacetylase 3 0.00849226

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.0619388
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0565285
RAD51B RAD51 paralog B -0.0521304
EGFR epidermal growth factor receptor -0.0516614
CD36 CD36 molecule (thrombospondin receptor) -0.0507907
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.049639
ATXN1 ataxin 1 -0.0492694
TMSB10 thymosin beta 10 -0.0467194
LAMC2 laminin, gamma 2 -0.0440473
UBC ubiquitin C -0.0428672
ACTG1 actin gamma 1 -0.0428337
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0408073
AHNAK AHNAK nucleoprotein -0.0400859
EEF2 eukaryotic translation elongation factor 2 -0.0384355
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.036532
LMO7 LIM domain 7 -0.0362887
NDRG1 N-myc downstream regulated 1 -0.0361682
FERMT1 fermitin family member 1 -0.0359661
LAMB3 laminin, beta 3 -0.0354117
PLAUR plasminogen activator, urokinase receptor -0.0334206
CCSER1 coiled-coil serine-rich protein 1 -0.0318534
FHIT fragile histidine triad -0.0291058
RPS27A ribosomal protein S27a -0.0290697
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0280594
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0276966
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0274487
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0271654
ITPKC inositol-trisphosphate 3-kinase C -0.0269161
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0264884
RPL23 ribosomal protein L23 -0.0256449
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.025278
CD9 CD9 molecule -0.0247666
MACF1 microtubule-actin crosslinking factor 1 -0.0244966
EZR ezrin -0.0242671
EXOC4 exocyst complex component 4 -0.0242023
SMYD3 SET and MYND domain containing 3 -0.0237945
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0236816
PHF14 PHD finger protein 14 -0.0228774
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0224899
FHL2 four and a half LIM domains 2 -0.0218292
DSPP dentin sialophosphoprotein -0.0216553
ACTN4 actinin, alpha 4 -0.020945
PATJ PATJ crumbs cell polarity complex component -0.020721
RPS24 ribosomal protein S24 -0.019981
AKAP12 A kinase (PRKA) anchor protein 12 -0.0199228
DOCK5 dedicator of cytokinesis 5 -0.0195079
SEPTIN9 septin 9 -0.0191965
ANXA11 annexin A11 -0.0190232
PCBP2 poly(rC) binding protein 2 -0.0187928
NAV2 neuron navigator 2 -0.0183341
PDE4B phosphodiesterase 4B, cAMP-specific -0.0179268
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0179019
EMP1 epithelial membrane protein 1 -0.0178791
VCL vinculin -0.0175827
NTSR1 neurotensin receptor 1 (high affinity) -0.0175743
RNF43 ring finger protein 43 -0.0175069
CANX calnexin -0.017326
PRELID2 PRELI domain containing 2 -0.0170872
RPS3 ribosomal protein S3 -0.0169524
TPM4 tropomyosin 4 -0.0167314
BCL2L1 BCL2-like 1 -0.0166997
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0166213
TBC1D22A TBC1 domain family, member 22A -0.0165126
NCEH1 neutral cholesterol ester hydrolase 1 -0.016474
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.016297
S100A10 S100 calcium binding protein A10 -0.0162962
MTAP methylthioadenosine phosphorylase -0.0162672
NIBAN2 niban apoptosis regulator 2 -0.016099
FLOT1 flotillin 1 -0.0159489
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0155042
RPS4X ribosomal protein S4, X-linked -0.015409
EHBP1 EH domain binding protein 1 -0.0152519
ENO1 enolase 1, (alpha) -0.0151763
CDCP1 CUB domain containing protein 1 -0.015143
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0150772
TBC1D5 TBC1 domain family, member 5 -0.0150323
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0150319
TPT1 tumor protein, translationally-controlled 1 -0.0146877
PERP PERP, TP53 apoptosis effector -0.0146794
EEF1G eukaryotic translation elongation factor 1 gamma -0.0146145
HMGA1 high mobility group AT-hook 1 -0.014575
ITGA6 integrin, alpha 6 -0.0145371
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.014529
LOC112694756 uncharaterized LOC112694756 -0.014433
KRT8 keratin 8, type II -0.0144117
AKAP9 A kinase (PRKA) anchor protein 9 -0.0143952
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0142972
MYH9 myosin, heavy chain 9, non-muscle -0.0141668
RPLP1 ribosomal protein, large, P1 -0.0140257
LPP LIM domain containing preferred translocation partner in lipoma -0.0139725
EXOC6B exocyst complex component 6B -0.0139359
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0137781
KDM4C lysine (K)-specific demethylase 4C -0.013765
DST dystonin -0.013671
VMP1 vacuole membrane protein 1 -0.013671
LAMA4 laminin, alpha 4 -0.0136092
SKAP1 src kinase associated phosphoprotein 1 -0.0135845
ZBTB20 zinc finger and BTB domain containing 20 -0.0135243
BMP4 bone morphogenetic protein 4 -0.0134858
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0134748