Ovarian steroidogenesis Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description The ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, the local effects that are essential for normal ovarian physiology are dependent on the endocrine, paracrine, and autocrine actions of E2, P4, and androgens. In most mammals (including humans and mice), ovarian steroidogenesis occurs according to the two-cell/two-gonadotropin theory. This theory describes how granulosa and theca cells work together to make the ovarian steroids. Theca cells respond to LH signaling by increasing the expression of enzymes necessary for the conversion of cholesterol to androgens, such as androstenedione (A) and testosterone (T). Granulosa cells respond to FSH signaling by increasing the expression of enzymes necessary for the conversion of theca-derived androgens into estrogens (E2 and estrone). (Kyoto Encyclopedia of Genes and Genomes, hsa04913)
External Link https://www.kegg.jp/entry/hsa04913
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Genes

51 proteins participating in the Ovarian steroidogenesis pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACOT1 acyl-CoA thioesterase 1
ACOT2 acyl-CoA thioesterase 2
ACOT4 acyl-CoA thioesterase 4
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
AKR1C3 aldo-keto reductase family 1, member C3
AKR1C8 aldo-keto reductase family 1 member C8
ALOX5 arachidonate 5-lipoxygenase
BMP15 bone morphogenetic protein 15
BMP6 bone morphogenetic protein 6
CD163L1 CD163 molecule-like 1
CHGA chromogranin A
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
GNAS GNAS complex locus
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
INS insulin
INSR insulin receptor
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough
LDLR low density lipoprotein receptor
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLA2G4D phospholipase A2, group IVD (cytosolic)
PLA2G4E phospholipase A2, group IVE
PLA2G4F phospholipase A2, group IVF
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SCARB1 scavenger receptor class B, member 1