Oxaliplatin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.166049
EXT1 exostosin glycosyltransferase 1 0.127297
TLE4 transducin-like enhancer of split 4 0.124557
FMN1 formin 1 0.120435
MYH9 myosin, heavy chain 9, non-muscle 0.0931094
RNF213 ring finger protein 213 0.0919067
TRIO trio Rho guanine nucleotide exchange factor 0.0916846
ACTG1 actin gamma 1 0.0884613
THSD4 thrombospondin, type I, domain containing 4 0.0794457
LSAMP limbic system-associated membrane protein 0.0758717
EEF2 eukaryotic translation elongation factor 2 0.0758417
TPM1 tropomyosin 1 (alpha) 0.0738179
ZSWIM6 zinc finger, SWIM-type containing 6 0.0707831
SLIT2 slit homolog 2 (Drosophila) 0.0701627
DST dystonin 0.0678492
PRKCA protein kinase C, alpha 0.062383
PDE4D phosphodiesterase 4D, cAMP-specific 0.0617758
RIGI RNA sensor RIG-I 0.0611055
NPAS2 neuronal PAS domain protein 2 0.060097
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0528242
LPP LIM domain containing preferred translocation partner in lipoma 0.04938
ATXN1 ataxin 1 0.0488251
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0478592
SRRM2 serine/arginine repetitive matrix 2 0.047283
HOMER1 homer scaffolding protein 1 0.0469853
ACTN1 actinin, alpha 1 0.0469166
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0466377
TPST1 tyrosylprotein sulfotransferase 1 0.0459779
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0451259
TENM4 teneurin transmembrane protein 4 0.0447592
RPL23 ribosomal protein L23 0.0446523
PLPP1 phospholipid phosphatase 1 0.0439936
PTPRE protein tyrosine phosphatase, receptor type, E 0.0438891
HSPA8 heat shock 70kDa protein 8 0.0438638
EGR1 early growth response 1 0.0437097
PDE10A phosphodiesterase 10A 0.0433027
PDLIM5 PDZ and LIM domain 5 0.0431597
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0423047
TRIB2 tribbles pseudokinase 2 0.0416725
NUMA1 nuclear mitotic apparatus protein 1 0.0416265
ANTXR1 anthrax toxin receptor 1 0.0411999
MRTFA myocardin related transcription factor A 0.040907
APP amyloid beta (A4) precursor protein 0.0407532
BCAS3 breast carcinoma amplified sequence 3 0.0403312
PTPRK protein tyrosine phosphatase, receptor type, K 0.0403186
SIK2 salt-inducible kinase 2 0.0396133
GREM2 gremlin 2, DAN family BMP antagonist 0.0393828
BPTF bromodomain PHD finger transcription factor 0.0393191
EIF1 eukaryotic translation initiation factor 1 0.0392206
MSI2 musashi RNA-binding protein 2 0.0390694
LPIN1 lipin 1 0.0388118
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0386011
INTS6 integrator complex subunit 6 0.0379729
STK38L serine/threonine kinase 38 like 0.037949
ITPRID2 ITPR interacting domain containing 2 0.0376404
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0374458
LOC112694756 uncharaterized LOC112694756 0.0374161
FERMT2 fermitin family member 2 0.0373761
CENPF centromere protein F, 350/400kDa 0.0370689
SMAD3 SMAD family member 3 0.0370413
SEPTIN9 septin 9 0.0367482
NALF1 NALCN channel auxiliary factor 1 0.0362516
FHL2 four and a half LIM domains 2 0.0353922
SYT1 synaptotagmin I 0.0351666
NONO non-POU domain containing, octamer-binding 0.0350272
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0347678
DGKH diacylglycerol kinase, eta 0.0345465
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0339849
RET ret proto-oncogene 0.0331562
IGF1R insulin-like growth factor 1 receptor 0.0331279
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0329476
RPL19 ribosomal protein L19 0.032147
B2M beta-2-microglobulin 0.0320646
ACTN4 actinin, alpha 4 0.0319762
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0318796
TPT1 tumor protein, translationally-controlled 1 0.0315553
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0315474
MYO1E myosin IE 0.0315405
MX2 MX dynamin-like GTPase 2 0.0314674
CTNND1 catenin (cadherin-associated protein), delta 1 0.0311584
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0310983
BICD1 bicaudal D homolog 1 (Drosophila) 0.0310905
IRS1 insulin receptor substrate 1 0.0310697
PSD3 pleckstrin and Sec7 domain containing 3 0.0309099
AUTS2 autism susceptibility candidate 2 0.0307395
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0304983
GLCCI1 glucocorticoid induced 1 0.0302476
ZMIZ1 zinc finger, MIZ-type containing 1 0.0301624
MACF1 microtubule-actin crosslinking factor 1 0.0298768
RPL7A ribosomal protein L7a 0.0298176
AHNAK AHNAK nucleoprotein 0.0297008
PRRC2C proline-rich coiled-coil 2C 0.0296896
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.029638
FAM107B family with sequence similarity 107, member B 0.0293938
THBS1 thrombospondin 1 0.0293085
RPS27 ribosomal protein S27 0.029252
NCOR2 nuclear receptor corepressor 2 0.0290307
ENAH enabled homolog (Drosophila) 0.0288178
RPL35A ribosomal protein L35a 0.0287673
WDR1 WD repeat domain 1 0.0286611

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.20762
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0930385
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0648539
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.059451
GPC5 glypican 5 -0.048953
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0417369
COL1A1 collagen, type I, alpha 1 -0.0411146
COL3A1 collagen, type III, alpha 1 -0.0408896
NAMPT nicotinamide phosphoribosyltransferase -0.033855
SEC31A SEC31 homolog A (S. cerevisiae) -0.0313083
FNDC3B fibronectin type III domain containing 3B -0.0299675
MBD5 methyl-CpG binding domain protein 5 -0.0283116
MEF2A myocyte enhancer factor 2A -0.028036
NPEPPS aminopeptidase puromycin sensitive -0.0274324
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0266151
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0263973
DSCAM Down syndrome cell adhesion molecule -0.0259909
KMT2E lysine (K)-specific methyltransferase 2E -0.023292
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0230184
PCNX1 pecanex 1 -0.0223005
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0222238
WDR45B WD repeat domain 45B -0.0222226
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0217405
GOLGA4 golgin A4 -0.0207738
COPA coatomer protein complex, subunit alpha -0.0199354
ZNF292 zinc finger protein 292 -0.0197268
PTMA prothymosin, alpha -0.0193414
OGA O-GlcNAcase -0.0191845
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0191501
WDR43 WD repeat domain 43 -0.0187952
DTNA dystrobrevin, alpha -0.0184304
PNISR PNN-interacting serine/arginine-rich protein -0.0182285
HMGA1 high mobility group AT-hook 1 -0.0166174
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0165677
ERRFI1 ERBB receptor feedback inhibitor 1 -0.016321
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0162386
RTN4 reticulon 4 -0.0160441
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.01604
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0159998
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0158496
MATR3 matrin 3 -0.0158022
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0157714
ZFR zinc finger RNA binding protein -0.0155277
BIRC6 baculoviral IAP repeat containing 6 -0.0154863
TCERG1 transcription elongation regulator 1 -0.0154746
AKAP12 A kinase (PRKA) anchor protein 12 -0.0154679
ACBD3 acyl-CoA binding domain containing 3 -0.0154036
SEC24D SEC24 family member D -0.0153539
SKIC3 SKI3 subunit of superkiller complex -0.0153097
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0152743
ARF4 ADP-ribosylation factor 4 -0.0150447
SEC63 SEC63 homolog (S. cerevisiae) -0.0149552
MXI1 MAX interactor 1, dimerization protein -0.0148914
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0148434
FUBP3 far upstream element (FUSE) binding protein 3 -0.0148403
ANKRD12 ankyrin repeat domain 12 -0.0146568
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0145034
RHOBTB3 Rho-related BTB domain containing 3 -0.0143867
SETD5 SET domain containing 5 -0.0143866
SREBF2 sterol regulatory element binding transcription factor 2 -0.0143777
CCND1 cyclin D1 -0.0140927
RAI14 retinoic acid induced 14 -0.0140745
MON2 MON2 homolog (S. cerevisiae) -0.013945
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0138676
SLMAP sarcolemma associated protein -0.0138551
ACACA acetyl-CoA carboxylase alpha -0.0138493
LRP1B low density lipoprotein receptor-related protein 1B -0.0138001
USP34 ubiquitin specific peptidase 34 -0.0137532
LCORL ligand dependent nuclear receptor corepressor-like -0.0136949
LMAN1 lectin, mannose-binding, 1 -0.013662
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0136352
SOS1 son of sevenless homolog 1 (Drosophila) -0.0135584
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0135173
ZNF207 zinc finger protein 207 -0.0133931
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0133635
DPH6 diphthamine biosynthesis 6 -0.0133422
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0133275
GNAS GNAS complex locus -0.0133265
KIAA1958 KIAA1958 -0.0133191
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0132849
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -0.0132222
USP3 ubiquitin specific peptidase 3 -0.0131653
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0131632
RNMT RNA (guanine-7-) methyltransferase -0.0130737
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0130737
TM9SF3 transmembrane 9 superfamily member 3 -0.0129379
SEC24B SEC24 family member B -0.0129106
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.012848
ZC3H15 zinc finger CCCH-type containing 15 -0.012815
RSF1 remodeling and spacing factor 1 -0.0127935
RBM26 RNA binding motif protein 26 -0.012712
KDM3A lysine (K)-specific demethylase 3A -0.012706
IGFBP4 insulin-like growth factor binding protein 4 -0.0126945
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0125987
TENT5A terminal nucleotidyltransferase 5A -0.0125797
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0124175
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0124088
TFG TRK-fused gene -0.0124051
PIBF1 progesterone immunomodulatory binding factor 1 -0.0123706
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0123652