Oxaliplatin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.214547
LMO7 LIM domain 7 0.185471
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.146253
RNF213 ring finger protein 213 0.126841
AKAP13 A kinase (PRKA) anchor protein 13 0.111991
SPTBN1 spectrin, beta, non-erythrocytic 1 0.108279
B2M beta-2-microglobulin 0.107567
MYH9 myosin, heavy chain 9, non-muscle 0.0988972
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0976975
LCN2 lipocalin 2 0.0951715
C6ORF132 chromosome 6 open reading frame 132 0.09005
EXT1 exostosin glycosyltransferase 1 0.0873921
SHB Src homology 2 domain containing adaptor protein B 0.0859301
SRRM2 serine/arginine repetitive matrix 2 0.0852193
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0849205
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0819869
HLA-B major histocompatibility complex, class I, B 0.0781584
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0754274
BCL2L1 BCL2-like 1 0.0687761
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0648201
ARGLU1 arginine and glutamate rich 1 0.0640312
LOC112694756 uncharaterized LOC112694756 0.0623462
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0599936
MYO5B myosin VB 0.056046
FAT1 FAT atypical cadherin 1 0.0560075
MLPH melanophilin 0.0553287
EEF2 eukaryotic translation elongation factor 2 0.0548107
RUNX1 runt-related transcription factor 1 0.0543211
MPRIP myosin phosphatase Rho interacting protein 0.053442
EPHB2 EPH receptor B2 0.0528539
ETV6 ets variant 6 0.0526389
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0508833
APP amyloid beta (A4) precursor protein 0.0498529
ASPH aspartate beta-hydroxylase 0.0486803
YAP1 Yes-associated protein 1 0.048629
DST dystonin 0.0482278
MACF1 microtubule-actin crosslinking factor 1 0.0476989
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0464295
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0463784
MSI2 musashi RNA-binding protein 2 0.0462165
IFNGR1 interferon gamma receptor 1 0.0461839
MAP7 microtubule-associated protein 7 0.0457887
HKDC1 hexokinase domain containing 1 0.0457177
KRT8 keratin 8, type II 0.0454139
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0453604
CTBP2 C-terminal binding protein 2 0.044938
ADAR adenosine deaminase, RNA-specific 0.044874
NIBAN2 niban apoptosis regulator 2 0.0444861
ABHD2 abhydrolase domain containing 2 0.0438849
ARHGAP5 Rho GTPase activating protein 5 0.0431829
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0430542
MYO10 myosin X 0.0420228
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0400891
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0398143
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0395481
KYNU kynureninase 0.0391535
DIAPH1 diaphanous-related formin 1 0.0390469
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0386724
NONO non-POU domain containing, octamer-binding 0.0383732
ACTG1 actin gamma 1 0.038048
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0379895
APOL1 apolipoprotein L, 1 0.0376939
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0374784
ACTN4 actinin, alpha 4 0.036925
NCOR2 nuclear receptor corepressor 2 0.0367979
PDZD8 PDZ domain containing 8 0.0358225
ATP11A ATPase, class VI, type 11A 0.0356251
STK24 serine/threonine kinase 24 0.0351832
APOL2 apolipoprotein L, 2 0.0350659
MACC1 metastasis associated in colon cancer 1 0.0346663
SEPTIN9 septin 9 0.0345527
HLA-A major histocompatibility complex, class I, A 0.0341422
PADI1 peptidyl arginine deiminase, type I 0.0336837
DSPP dentin sialophosphoprotein 0.0336782
CTNND1 catenin (cadherin-associated protein), delta 1 0.0334926
DUSP16 dual specificity phosphatase 16 0.0326851
TXNRD1 thioredoxin reductase 1 0.0324424
KRT18 keratin 18, type I 0.0324037
CEMIP cell migration inducing protein, hyaluronan binding 0.0322735
HLA-C major histocompatibility complex, class I, C 0.0322267
TJP1 tight junction protein 1 0.0319841
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0318367
GCLC glutamate-cysteine ligase, catalytic subunit 0.0317759
MYO1E myosin IE 0.0314873
TRERF1 transcriptional regulating factor 1 0.0314441
TSC22D1 TSC22 domain family, member 1 0.0308045
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0307653
SLK STE20-like kinase 0.0303518
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0299325
SOX9 SRY (sex determining region Y)-box 9 0.0298152
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0297799
SFTPA2 surfactant protein A2 0.0297737
LPP LIM domain containing preferred translocation partner in lipoma 0.0297042
CALR calreticulin 0.0296658
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.0294706
SH3PXD2A SH3 and PX domains 2A 0.0294468
VEGFA vascular endothelial growth factor A 0.0294422
LDHA lactate dehydrogenase A 0.0294401
DNM2 dynamin 2 0.0292047
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0292017

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.106385
TPT1 tumor protein, translationally-controlled 1 -0.0843283
INTS6 integrator complex subunit 6 -0.0815458
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0692104
ZMYND8 zinc finger, MYND-type containing 8 -0.0681929
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0671423
SQSTM1 sequestosome 1 -0.0666946
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0629082
XAF1 XIAP associated factor 1 -0.0608925
PLSCR2 phospholipid scramblase 2 -0.0547075
GMDS GDP-mannose 4,6-dehydratase -0.0545712
PHF3 PHD finger protein 3 -0.052223
PLSCR1 phospholipid scramblase 1 -0.0511226
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0508319
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0485698
ZBTB20 zinc finger and BTB domain containing 20 -0.0478137
NDRG1 N-myc downstream regulated 1 -0.0460594
H1-0 H1.0 linker histone -0.0444847
TXNIP thioredoxin interacting protein -0.0441853
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0436981
BTBD9 BTB (POZ) domain containing 9 -0.0415558
MBD5 methyl-CpG binding domain protein 5 -0.0415075
PATJ PATJ crumbs cell polarity complex component -0.0408665
AHI1 Abelson helper integration site 1 -0.040828
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0397197
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0382825
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0377228
SSH2 slingshot protein phosphatase 2 -0.0376405
SP100 SP100 nuclear antigen -0.0369927
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0369251
MBNL2 muscleblind-like splicing regulator 2 -0.0365505
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0363081
MAML2 mastermind-like 2 (Drosophila) -0.0349458
RIGI RNA sensor RIG-I -0.0344185
MUC20 mucin 20, cell surface associated -0.0336364
ZMYM2 zinc finger, MYM-type 2 -0.0331949
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0328182
FBXO39 F-box protein 39 -0.0327822
PRKCA protein kinase C, alpha -0.0323005
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0320927
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -0.0313917
CCDC146 coiled-coil domain containing 146 -0.0309701
LCORL ligand dependent nuclear receptor corepressor-like -0.0307185
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0306402
SPDYA speedy/RINGO cell cycle regulator family member A -0.030329
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0289861
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0280565
IRF1 interferon regulatory factor 1 -0.0277474
POF1B premature ovarian failure, 1B -0.0276725
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0275695
DIAPH3 diaphanous-related formin 3 -0.0273675
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0271235
NCOA7 nuclear receptor coactivator 7 -0.0270394
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.026056
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0256006
RAD51B RAD51 paralog B -0.0249596
STS steroid sulfatase (microsomal), isozyme S -0.0248742
SDCBP2 syndecan binding protein (syntenin) 2 -0.0248295
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0246116
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0244943
TFRC transferrin receptor -0.0244926
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0243684
TAS2R14 taste receptor, type 2, member 14 -0.024128
EGR1 early growth response 1 -0.0239885
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0239679
PRELID2 PRELI domain containing 2 -0.0237616
AHNAK AHNAK nucleoprotein -0.0237251
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0236447
SBF2 SET binding factor 2 -0.0236337
GOLGB1 golgin B1 -0.0235785
ADIPOR2 adiponectin receptor 2 -0.0232372
SEC31A SEC31 homolog A (S. cerevisiae) -0.0231326
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0231315
LYZ lysozyme -0.0229254
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0229052
BABAM2 BRISC and BRCA1 A complex member 2 -0.0228988
WSB1 WD repeat and SOCS box containing 1 -0.0228669
UGDH UDP-glucose 6-dehydrogenase -0.0227882
EZR ezrin -0.0220599
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0217435
RAB1A RAB1A, member RAS oncogene family -0.021663
WNT2B wingless-type MMTV integration site family, member 2B -0.0216473
ARHGAP26 Rho GTPase activating protein 26 -0.0215836
RTN3 reticulon 3 -0.0214436
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0208257
CATSPERB catsper channel auxiliary subunit beta -0.0207354
KDM4C lysine (K)-specific demethylase 4C -0.0206734
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0204509
NABP1 nucleic acid binding protein 1 -0.0201804
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0197238
DYNC2I1 dynein 2 intermediate chain 1 -0.0195533
RFC3 replication factor C (activator 1) 3, 38kDa -0.0194602
SCAPER S-phase cyclin A-associated protein in the ER -0.0194408
ITPKC inositol-trisphosphate 3-kinase C -0.0192773
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0190533
PLCH1 phospholipase C, eta 1 -0.019018
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0190161
NBEAL1 neurobeachin-like 1 -0.0189978
KIF16B kinesin family member 16B -0.01853
STK39 serine threonine kinase 39 -0.0184844