Oxaliplatin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.519207
IGFBP3 insulin-like growth factor binding protein 3 0.466233
MYH9 myosin, heavy chain 9, non-muscle 0.162886
CDH13 cadherin 13 0.148119
VEGFA vascular endothelial growth factor A 0.122003
PLEC plectin 0.0994282
EXT1 exostosin glycosyltransferase 1 0.0993112
COL5A1 collagen, type V, alpha 1 0.0948726
EEF2 eukaryotic translation elongation factor 2 0.0946245
NDRG1 N-myc downstream regulated 1 0.0901646
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0807387
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0736214
CALR calreticulin 0.0707176
ASPH aspartate beta-hydroxylase 0.0698079
HLA-B major histocompatibility complex, class I, B 0.0691686
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0606479
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0561521
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0560665
FBN1 fibrillin 1 0.0556692
COL7A1 collagen, type VII, alpha 1 0.0502032
TRIO trio Rho guanine nucleotide exchange factor 0.0477854
MACF1 microtubule-actin crosslinking factor 1 0.0475279
ACTG1 actin gamma 1 0.0463073
ENO1 enolase 1, (alpha) 0.044214
TGFBI transforming growth factor, beta-induced, 68kDa 0.044173
NAV1 neuron navigator 1 0.0431467
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0427159
AHNAK AHNAK nucleoprotein 0.0422216
SQSTM1 sequestosome 1 0.0414895
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0409654
PSD3 pleckstrin and Sec7 domain containing 3 0.0407899
TMSB10 thymosin beta 10 0.0406021
APP amyloid beta (A4) precursor protein 0.0404442
HYOU1 hypoxia up-regulated 1 0.0395901
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0391561
ATXN1 ataxin 1 0.0378308
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0372551
TMSB4X thymosin beta 4, X-linked 0.0350329
COL1A2 collagen, type I, alpha 2 0.0350219
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0346207
LOC112694756 uncharaterized LOC112694756 0.0343266
MYO10 myosin X 0.0342088
RPL35A ribosomal protein L35a 0.03375
NALF1 NALCN channel auxiliary factor 1 0.0336332
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0330887
EGFR epidermal growth factor receptor 0.0326778
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0326768
LDHA lactate dehydrogenase A 0.0322944
SDC2 syndecan 2 0.0322322
FTH1 ferritin, heavy polypeptide 1 0.0316219
DST dystonin 0.0311553
HSPA8 heat shock 70kDa protein 8 0.0310326
COL6A2 collagen, type VI, alpha 2 0.0300453
LPP LIM domain containing preferred translocation partner in lipoma 0.0299067
HDAC9 histone deacetylase 9 0.0297219
FLNA filamin A, alpha 0.0296733
IL6ST interleukin 6 signal transducer 0.0292705
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0284073
PTPRG protein tyrosine phosphatase, receptor type, G 0.0281431
HLA-C major histocompatibility complex, class I, C 0.027878
TNIP1 TNFAIP3 interacting protein 1 0.0278728
RPL3 ribosomal protein L3 0.0276387
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0269904
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0264546
SRRM2 serine/arginine repetitive matrix 2 0.0263053
RND3 Rho family GTPase 3 0.025946
ACTN1 actinin, alpha 1 0.0256259
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.024834
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0247854
RIGI RNA sensor RIG-I 0.0246731
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0245987
HLA-A major histocompatibility complex, class I, A 0.0245921
ANKRD11 ankyrin repeat domain 11 0.0245713
JARID2 jumonji, AT rich interactive domain 2 0.0245127
ADAM12 ADAM metallopeptidase domain 12 0.0239828
NAV2 neuron navigator 2 0.0239237
EPHB1 EPH receptor B1 0.0239033
RUNX1 runt-related transcription factor 1 0.0236963
GOLGB1 golgin B1 0.0235404
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0235104
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0234646
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0234524
VCL vinculin 0.0232139
NFE2L1 nuclear factor, erythroid 2-like 1 0.0231175
CD59 CD59 molecule, complement regulatory protein 0.0230813
FAT1 FAT atypical cadherin 1 0.0229889
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0226883
FBXL7 F-box and leucine-rich repeat protein 7 0.0225713
GLIS3 GLIS family zinc finger 3 0.0224269
NEK10 NIMA-related kinase 10 0.0223532
NCOR2 nuclear receptor corepressor 2 0.0222825
TNS1 tensin 1 0.0217604
RPL23 ribosomal protein L23 0.0217293
ZSWIM6 zinc finger, SWIM-type containing 6 0.0215189
FOXP1 forkhead box P1 0.0213907
TBC1D22A TBC1 domain family, member 22A 0.0212406
AGO2 argonaute RISC catalytic component 2 0.0209168
JAG1 jagged 1 0.0207437
MSN moesin 0.0206311
CMIP c-Maf inducing protein 0.0204244

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175108
ATP13A3 ATPase type 13A3 -0.059978
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0517051
TM4SF1 transmembrane 4 L six family member 1 -0.047828
COL1A1 collagen, type I, alpha 1 -0.0428339
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0406172
ZNF292 zinc finger protein 292 -0.0396127
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0356975
POSTN periostin, osteoblast specific factor -0.0332605
KMT2E lysine (K)-specific methyltransferase 2E -0.0317695
SPAG9 sperm associated antigen 9 -0.0305089
LOX lysyl oxidase -0.0302272
ICAM1 intercellular adhesion molecule 1 -0.0279832
NAMPT nicotinamide phosphoribosyltransferase -0.0278176
GOLGA4 golgin A4 -0.0265263
SQLE squalene epoxidase -0.0264278
ELL2 elongation factor, RNA polymerase II, 2 -0.0255902
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0251481
RASA2 RAS p21 protein activator 2 -0.0239143
SBF2 SET binding factor 2 -0.0229363
TFG TRK-fused gene -0.0226103
USP3 ubiquitin specific peptidase 3 -0.0222118
WSB1 WD repeat and SOCS box containing 1 -0.0221021
WASF2 WAS protein family, member 2 -0.0215951
LMAN1 lectin, mannose-binding, 1 -0.0213537
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0201387
ARHGAP29 Rho GTPase activating protein 29 -0.0194017
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0189083
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.018546
DPYSL3 dihydropyrimidinase-like 3 -0.0185206
RLF rearranged L-myc fusion -0.0184778
DLG1 discs, large homolog 1 (Drosophila) -0.0184344
KLF7 Kruppel-like factor 7 (ubiquitous) -0.018184
IER3 immediate early response 3 -0.0180757
CXCL8 chemokine (C-X-C motif) ligand 8 -0.017934
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0172638
SRGN serglycin -0.0171375
FN1 fibronectin 1 -0.0170851
TMEM165 transmembrane protein 165 -0.0169142
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0161571
HMGA1 high mobility group AT-hook 1 -0.0158902
PTMA prothymosin, alpha -0.0157844
NPEPPS aminopeptidase puromycin sensitive -0.0156897
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0156598
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0156561
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0156194
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0156096
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0156023
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0155393
COG5 component of oligomeric golgi complex 5 -0.0155389
SKIC3 SKI3 subunit of superkiller complex -0.0153872
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0153311
RPS2 ribosomal protein S2 -0.0151348
QKI QKI, KH domain containing, RNA binding -0.0150346
DSTN destrin (actin depolymerizing factor) -0.0149578
TRAM1 translocation associated membrane protein 1 -0.014887
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0148821
ANKRD12 ankyrin repeat domain 12 -0.0141847
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0141018
SEC24A SEC24 family member A -0.014035
SEPTIN7 septin 7 -0.0138641
ARRDC3 arrestin domain containing 3 -0.0137855
PRRC1 proline-rich coiled-coil 1 -0.0137461
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0132375
RAB1A RAB1A, member RAS oncogene family -0.013167
SRP54 signal recognition particle 54kDa -0.0131058
FCHSD2 FCH and double SH3 domains 2 -0.0130478
ANTXR2 anthrax toxin receptor 2 -0.0129115
PNISR PNN-interacting serine/arginine-rich protein -0.0128597
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0127621
CCNL1 cyclin L1 -0.0127475
FNBP1L formin binding protein 1-like -0.0125771
RNF145 ring finger protein 145 -0.0123669
NOP58 NOP58 ribonucleoprotein -0.012311
RTN4 reticulon 4 -0.012297
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.01229
TMEM263 transmembrane protein 263 -0.0121983
TAPBP TAP binding protein (tapasin) -0.0120962
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0118037
FOXJ3 forkhead box J3 -0.0116851
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0116562
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0116441
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0116291
COL3A1 collagen, type III, alpha 1 -0.011564
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0115131
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0115115
AGFG1 ArfGAP with FG repeats 1 -0.0114962
RBM39 RNA binding motif protein 39 -0.0112842
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0112527
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0112258
RNF24 ring finger protein 24 -0.0110901
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0110143
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0109309
TMEM123 transmembrane protein 123 -0.0108754
CDC27 cell division cycle 27 -0.0107484
THY1 Thy-1 cell surface antigen -0.0107337
RYK receptor-like tyrosine kinase -0.0107259
SRRM1 serine/arginine repetitive matrix 1 -0.0107097
PTBP2 polypyrimidine tract binding protein 2 -0.0106835
AZIN1 antizyme inhibitor 1 -0.0106186