Oxaliplatin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.165749
PLEC plectin 0.151629
MSN moesin 0.0941086
PODXL podocalyxin-like 0.0940783
SMAD3 SMAD family member 3 0.0837186
MACF1 microtubule-actin crosslinking factor 1 0.074306
MYOF myoferlin 0.0705861
BCL2L1 BCL2-like 1 0.0694545
LOC112694756 uncharaterized LOC112694756 0.0668049
DOCK5 dedicator of cytokinesis 5 0.0641292
MKI67 marker of proliferation Ki-67 0.0636413
APLP2 amyloid beta (A4) precursor-like protein 2 0.0634237
TGM2 transglutaminase 2 0.0629677
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0587391
DST dystonin 0.0579114
B2M beta-2-microglobulin 0.0577984
MPRIP myosin phosphatase Rho interacting protein 0.0566405
CPNE1 copine I 0.0564242
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0547295
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0545166
SRRM2 serine/arginine repetitive matrix 2 0.0545053
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0535392
EEF2 eukaryotic translation elongation factor 2 0.0533642
FOXP1 forkhead box P1 0.0529489
CD44 CD44 molecule (Indian blood group) 0.0509165
BCAR3 breast cancer anti-estrogen resistance 3 0.0506356
NONO non-POU domain containing, octamer-binding 0.0491174
AMOTL1 angiomotin like 1 0.0488607
MBNL1 muscleblind-like splicing regulator 1 0.0479074
TMSB4X thymosin beta 4, X-linked 0.0469069
FLNA filamin A, alpha 0.0464207
LAMA5 laminin, alpha 5 0.0459468
SOX13 SRY (sex determining region Y)-box 13 0.0458447
RPL37 ribosomal protein L37 0.045584
AOPEP aminopeptidase O (putative) 0.0455442
HLA-B major histocompatibility complex, class I, B 0.0443908
NUMA1 nuclear mitotic apparatus protein 1 0.044088
PLXNA2 plexin A2 0.0439455
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.043415
YBX1 Y box binding protein 1 0.0428529
SH3PXD2A SH3 and PX domains 2A 0.0419402
CMIP c-Maf inducing protein 0.0417011
PTK2 protein tyrosine kinase 2 0.0410963
ACTN1 actinin, alpha 1 0.0407279
RPL3 ribosomal protein L3 0.0401814
FLNB filamin B, beta 0.0400178
NCOR2 nuclear receptor corepressor 2 0.0395548
JAG1 jagged 1 0.0395474
BLCAP bladder cancer associated protein 0.0381285
KRT8 keratin 8, type II 0.0378606
ASPH aspartate beta-hydroxylase 0.0378032
TPM3 tropomyosin 3 0.0376668
HSPG2 heparan sulfate proteoglycan 2 0.0373589
RPL11 ribosomal protein L11 0.036461
HLA-C major histocompatibility complex, class I, C 0.0363021
FOXO1 forkhead box O1 0.0361264
PKM pyruvate kinase, muscle 0.0354213
APP amyloid beta (A4) precursor protein 0.0350626
CEP250 centrosomal protein 250kDa 0.0350455
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0347513
NRG1 neuregulin 1 0.0342882
HSPA8 heat shock 70kDa protein 8 0.0341188
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0339587
ACTN4 actinin, alpha 4 0.0338014
LDHA lactate dehydrogenase A 0.0336818
CENPF centromere protein F, 350/400kDa 0.0335714
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0335423
TNS4 tensin 4 0.0334644
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0333414
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.032747
MT2A metallothionein 2A 0.0326054
SULF2 sulfatase 2 0.032587
CD59 CD59 molecule, complement regulatory protein 0.0325668
ITGB4 integrin, beta 4 0.0324682
PRELID3B PRELI domain containing 3B 0.0324419
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0322094
ITGA6 integrin, alpha 6 0.0319962
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0318862
ZMIZ1 zinc finger, MIZ-type containing 1 0.0318143
SLTM SAFB-like, transcription modulator 0.0316516
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0313269
TXNRD1 thioredoxin reductase 1 0.0312741
KRT6A keratin 6A, type II 0.0312609
DUSP4 dual specificity phosphatase 4 0.0307798
KRT14 keratin 14, type I 0.030642
SMC1A structural maintenance of chromosomes 1A 0.0305567
SEPTIN9 septin 9 0.0304927
ARHGAP23 Rho GTPase activating protein 23 0.0304774
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0302595
ADAR adenosine deaminase, RNA-specific 0.0302264
KIAA0040 KIAA0040 0.0300985
POTEF POTE ankyrin domain family, member F 0.0300863
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0295552
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0292327
EEF1G eukaryotic translation elongation factor 1 gamma 0.0290624
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0290017
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0289148
ARGLU1 arginine and glutamate rich 1 0.0288213
SVIL supervillin 0.0287351
PICALM phosphatidylinositol binding clathrin assembly protein 0.028518

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.266518
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.185191
MTSS1 metastasis suppressor 1 -0.117112
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113319
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0942739
ABI3BP ABI family, member 3 (NESH) binding protein -0.0928396
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0751812
ALCAM activated leukocyte cell adhesion molecule -0.0726993
NDRG1 N-myc downstream regulated 1 -0.0653247
RAI14 retinoic acid induced 14 -0.0609557
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0534554
STC1 stanniocalcin 1 -0.0528675
MEF2A myocyte enhancer factor 2A -0.0515574
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.046392
S100A10 S100 calcium binding protein A10 -0.0452948
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0437852
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0418896
PSD3 pleckstrin and Sec7 domain containing 3 -0.0404048
NAMPT nicotinamide phosphoribosyltransferase -0.039436
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0377627
CLU clusterin -0.0357799
PALLD palladin, cytoskeletal associated protein -0.0355663
PTMA prothymosin, alpha -0.0349032
SQLE squalene epoxidase -0.0342362
EMP1 epithelial membrane protein 1 -0.0337006
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0334756
GNAS GNAS complex locus -0.0320347
SLC35F3 solute carrier family 35, member F3 -0.031738
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.031711
KIAA1217 KIAA1217 -0.0313422
HM13 histocompatibility (minor) 13 -0.0313
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0311795
SEC31A SEC31 homolog A (S. cerevisiae) -0.0307377
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0305289
LDLR low density lipoprotein receptor -0.0299651
RBM39 RNA binding motif protein 39 -0.0298072
PDGFB platelet-derived growth factor beta polypeptide -0.0291279
WASF2 WAS protein family, member 2 -0.0291127
ITCH itchy E3 ubiquitin protein ligase -0.0290731
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0286881
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0286499
ZMYND8 zinc finger, MYND-type containing 8 -0.0270089
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.02668
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0266581
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0263588
TMEM165 transmembrane protein 165 -0.0261343
COPB1 coatomer protein complex, subunit beta 1 -0.0256956
TM4SF1 transmembrane 4 L six family member 1 -0.0256896
GARS1 glycyl-tRNA synthetase 1 -0.0256332
H1-0 H1.0 linker histone -0.025546
RAB1A RAB1A, member RAS oncogene family -0.0254118
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.025369
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0244909
SAMD9 sterile alpha motif domain containing 9 -0.024284
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0242112
OXR1 oxidation resistance 1 -0.0241547
SULF1 sulfatase 1 -0.0240307
THBD thrombomodulin -0.0236109
TMEM263 transmembrane protein 263 -0.0235974
KDM3A lysine (K)-specific demethylase 3A -0.0232947
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0229542
AHNAK AHNAK nucleoprotein -0.0228029
ARF1 ADP-ribosylation factor 1 -0.02277
JMJD1C jumonji domain containing 1C -0.0225204
CDK13 cyclin-dependent kinase 13 -0.0224755
KLF6 Kruppel-like factor 6 -0.0223951
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0223921
CALU calumenin -0.0223151
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0222794
KDM5B lysine (K)-specific demethylase 5B -0.0219579
PPARG peroxisome proliferator-activated receptor gamma -0.0219306
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0218131
NAV2 neuron navigator 2 -0.0216751
OSBP oxysterol binding protein -0.021617
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0216091
TMEM123 transmembrane protein 123 -0.0215442
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.021417
CLDN1 claudin 1 -0.0213227
TRAM1 translocation associated membrane protein 1 -0.021192
FN1 fibronectin 1 -0.021144
BZW1 basic leucine zipper and W2 domains 1 -0.0208345
GOLGA4 golgin A4 -0.0207971
RPL34 ribosomal protein L34 -0.0207561
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0207163
RCOR1 REST corepressor 1 -0.0205985
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0205564
LMAN1 lectin, mannose-binding, 1 -0.0204898
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.020371
RTN4 reticulon 4 -0.0201832
FNDC3A fibronectin type III domain containing 3A -0.0201604
FBXO11 F-box protein 11 -0.0201408
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0198274
CUL4B cullin 4B -0.0196653
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0194115
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0191988
WDFY2 WD repeat and FYVE domain containing 2 -0.0191348
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0190883
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0189946
ZMYM2 zinc finger, MYM-type 2 -0.0189871
IARS1 isoleucyl-tRNA synthetase 1 -0.0188969