Oxaliplatin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Oxaliplatin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.148046
MT2A metallothionein 2A 0.145335
LOC112694756 uncharaterized LOC112694756 0.131992
RPL35A ribosomal protein L35a 0.093087
GRAMD1B GRAM domain containing 1B 0.0926317
ACTG1 actin gamma 1 0.0903958
RPS3 ribosomal protein S3 0.0877207
RPL37A ribosomal protein L37a 0.0812685
TPT1 tumor protein, translationally-controlled 1 0.0791484
KRT18 keratin 18, type I 0.0789576
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0785256
THSD4 thrombospondin, type I, domain containing 4 0.0775391
ENO1 enolase 1, (alpha) 0.0772751
LDHA lactate dehydrogenase A 0.0771917
SEC61G Sec61 gamma subunit 0.0766201
B2M beta-2-microglobulin 0.0764443
RPLP1 ribosomal protein, large, P1 0.0741786
MYH9 myosin, heavy chain 9, non-muscle 0.0722264
CEMIP cell migration inducing protein, hyaluronan binding 0.0721156
RNF213 ring finger protein 213 0.071043
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.069167
FTL ferritin, light polypeptide 0.0688283
PTMA prothymosin, alpha 0.0685784
HSPA8 heat shock 70kDa protein 8 0.0672818
INTS6 integrator complex subunit 6 0.0654186
PKM pyruvate kinase, muscle 0.0652324
RPL31 ribosomal protein L31 0.0642695
SRRM2 serine/arginine repetitive matrix 2 0.0641976
RPS25 ribosomal protein S25 0.0637741
MCL1 myeloid cell leukemia 1 0.062104
RPL37 ribosomal protein L37 0.0620443
PLEC plectin 0.0620313
ASPH aspartate beta-hydroxylase 0.0617457
RPL11 ribosomal protein L11 0.059578
RPS6 ribosomal protein S6 0.0578119
EGR1 early growth response 1 0.0564123
STC1 stanniocalcin 1 0.0558123
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0556308
CST3 cystatin C 0.0553297
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0542569
RPS27 ribosomal protein S27 0.0531665
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0513853
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0508601
RPS17 ribosomal protein S17 0.0507223
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.050713
HLA-B major histocompatibility complex, class I, B 0.0492975
FTH1 ferritin, heavy polypeptide 1 0.0492633
EEF2 eukaryotic translation elongation factor 2 0.0483853
SMAD3 SMAD family member 3 0.0483688
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0483056
TNIP1 TNFAIP3 interacting protein 1 0.0479206
RPL19 ribosomal protein L19 0.0459397
RPS8 ribosomal protein S8 0.045774
IFI6 interferon, alpha-inducible protein 6 0.0452868
HOMER1 homer scaffolding protein 1 0.0444547
RPL23 ribosomal protein L23 0.0441587
RPS12 ribosomal protein S12 0.0440382
ANKRD11 ankyrin repeat domain 11 0.0439438
KRT8 keratin 8, type II 0.0437774
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0437071
RPS19 ribosomal protein S19 0.0433683
RPS27A ribosomal protein S27a 0.0431578
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0429986
S100P S100 calcium binding protein P 0.0429895
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0391788
AREG amphiregulin 0.0388417
IGFBP3 insulin-like growth factor binding protein 3 0.0384657
RPS24 ribosomal protein S24 0.0381551
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0377528
RPLP2 ribosomal protein, large, P2 0.0375723
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0368278
RPL36 ribosomal protein L36 0.0368006
RPL7 ribosomal protein L7 0.0363546
NTSR1 neurotensin receptor 1 (high affinity) 0.0363316
CIB1 calcium and integrin binding 1 (calmyrin) 0.0353901
RPL34 ribosomal protein L34 0.0353015
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0348524
RPL3 ribosomal protein L3 0.0348072
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.034703
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0345307
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.034368
SLTM SAFB-like, transcription modulator 0.0342148
MAP7 microtubule-associated protein 7 0.0342003
RPL9 ribosomal protein L9 0.0341805
RPS14 ribosomal protein S14 0.0338544
RPS29 ribosomal protein S29 0.0336726
RACK1 receptor for activated C kinase 1 0.0334264
SP100 SP100 nuclear antigen 0.0329856
ZSWIM6 zinc finger, SWIM-type containing 6 0.0329039
RPL12 ribosomal protein L12 0.0326791
PDE4D phosphodiesterase 4D, cAMP-specific 0.0326286
SON SON DNA binding protein 0.0324512
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0321033
RPLP0 ribosomal protein, large, P0 0.0320928
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0317667
AKAP12 A kinase (PRKA) anchor protein 12 0.0316574
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0310434
APLP2 amyloid beta (A4) precursor-like protein 2 0.0309883
RPS13 ribosomal protein S13 0.0309541
BCAR3 breast cancer anti-estrogen resistance 3 0.0308492

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.26761
TMEM165 transmembrane protein 165 -0.0604662
NAMPT nicotinamide phosphoribosyltransferase -0.0590362
BRWD1 bromodomain and WD repeat domain containing 1 -0.0486649
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0460578
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0421473
SEC31A SEC31 homolog A (S. cerevisiae) -0.0407061
H1-0 H1.0 linker histone -0.0396299
FAM13A family with sequence similarity 13, member A -0.0394563
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0390295
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0374997
NGLY1 N-glycanase 1 -0.0370188
CAMTA1 calmodulin binding transcription activator 1 -0.0366659
PATJ PATJ crumbs cell polarity complex component -0.0344466
KDM2A lysine (K)-specific demethylase 2A -0.0332843
BIRC6 baculoviral IAP repeat containing 6 -0.0327348
WASF2 WAS protein family, member 2 -0.0320736
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0299867
BRWD3 bromodomain and WD repeat domain containing 3 -0.0285943
SUCO SUN domain containing ossification factor -0.0285151
USP34 ubiquitin specific peptidase 34 -0.0284139
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0283609
TXNRD1 thioredoxin reductase 1 -0.0281997
ZMYM2 zinc finger, MYM-type 2 -0.0279668
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0257381
LRP1B low density lipoprotein receptor-related protein 1B -0.0256883
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.02522
OSMR oncostatin M receptor -0.0248861
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0247455
SPAG9 sperm associated antigen 9 -0.0247309
WDR45B WD repeat domain 45B -0.0246484
JMJD1C jumonji domain containing 1C -0.0243105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0240093
SBF2 SET binding factor 2 -0.0238408
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0238291
SRP54 signal recognition particle 54kDa -0.0238183
MGAT4C MGAT4 family, member C -0.0235556
RASA2 RAS p21 protein activator 2 -0.0235011
AKR1C1 aldo-keto reductase family 1, member C1 -0.023408
MARF1 meiosis regulator and mRNA stability factor 1 -0.0229452
TPD52 tumor protein D52 -0.0227818
STRN3 striatin, calmodulin binding protein 3 -0.0223274
RAB1A RAB1A, member RAS oncogene family -0.0221711
MON2 MON2 homolog (S. cerevisiae) -0.0219933
KMT2E lysine (K)-specific methyltransferase 2E -0.0217493
GSK3B glycogen synthase kinase 3 beta -0.0216842
ADAM17 ADAM metallopeptidase domain 17 -0.0211063
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0209312
CCNL1 cyclin L1 -0.0208885
OGA O-GlcNAcase -0.0208285
ZBTB20 zinc finger and BTB domain containing 20 -0.0206128
GCLC glutamate-cysteine ligase, catalytic subunit -0.0205955
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0203125
FNIP1 folliculin interacting protein 1 -0.0202884
ZC3H11A zinc finger CCCH-type containing 11A -0.0201299
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0200148
PUM2 pumilio RNA-binding family member 2 -0.0200001
ZNF292 zinc finger protein 292 -0.0195853
KDM5B lysine (K)-specific demethylase 5B -0.0194787
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0193136
SEC24A SEC24 family member A -0.019195
UVRAG UV radiation resistance associated -0.0190553
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0189619
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0188203
RAB27B RAB27B, member RAS oncogene family -0.0187637
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0185067
NIPBL Nipped-B homolog (Drosophila) -0.0183057
HELZ helicase with zinc finger -0.0182228
RIN2 Ras and Rab interactor 2 -0.0176227
TFG TRK-fused gene -0.0176134
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.017526
RAP1B RAP1B, member of RAS oncogene family -0.0174434
CCNI cyclin I -0.0173779
ARRDC3 arrestin domain containing 3 -0.017218
ZFC3H1 zinc finger, C3H1-type containing -0.0172008
BLZF1 basic leucine zipper nuclear factor 1 -0.0170281
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0169694
RNF145 ring finger protein 145 -0.0167536
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0167369
KMT2A lysine (K)-specific methyltransferase 2A -0.0166143
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0165519
MXI1 MAX interactor 1, dimerization protein -0.0165189
NEK7 NIMA-related kinase 7 -0.0164926
SEC24D SEC24 family member D -0.0164405
ANO6 anoctamin 6 -0.0162951
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0159866
ZFAND6 zinc finger, AN1-type domain 6 -0.0159457
BBX bobby sox homolog (Drosophila) -0.0159384
ATP13A3 ATPase type 13A3 -0.0159106
FRY furry homolog (Drosophila) -0.015814
ABLIM1 actin binding LIM protein 1 -0.0157012
HDLBP high density lipoprotein binding protein -0.0156637
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0156586
SLMAP sarcolemma associated protein -0.0156147
TENT5A terminal nucleotidyltransferase 5A -0.0155634
ZFR zinc finger RNA binding protein -0.0155627
TAOK1 TAO kinase 1 -0.0153276
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.015285
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0152593
TLK1 tousled-like kinase 1 -0.0152353