Oxaliplatin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.131466
MYH9 myosin, heavy chain 9, non-muscle 0.0823683
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0667871
EEF2 eukaryotic translation elongation factor 2 0.0666495
TGM2 transglutaminase 2 0.0636401
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.061776
VEGFA vascular endothelial growth factor A 0.0524452
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0517965
FAM20C family with sequence similarity 20, member C 0.0500473
CEP250 centrosomal protein 250kDa 0.0446351
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0438363
TNIP1 TNFAIP3 interacting protein 1 0.043233
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0412243
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0410771
PLEC plectin 0.0403394
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0401676
COL7A1 collagen, type VII, alpha 1 0.0385029
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0353144
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0350625
CNOT12 CCR4-NOT transcription complex subunit 12 0.0332259
HLA-B major histocompatibility complex, class I, B 0.0318014
KSR1 kinase suppressor of ras 1 0.031695
PFKP phosphofructokinase, platelet 0.0311718
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0309738
NTN4 netrin 4 0.0308566
RPL3 ribosomal protein L3 0.0297525
PCBP2 poly(rC) binding protein 2 0.0295111
MT2A metallothionein 2A 0.0290898
ANGPTL4 angiopoietin-like 4 0.0289432
SRRM2 serine/arginine repetitive matrix 2 0.0286195
AKAP12 A kinase (PRKA) anchor protein 12 0.0277817
MYO10 myosin X 0.0272748
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0271597
NUMA1 nuclear mitotic apparatus protein 1 0.0265146
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0263539
NAV2 neuron navigator 2 0.0262427
YBX3 Y box binding protein 3 0.0260295
SEPTIN9 septin 9 0.0259611
CPNE1 copine I 0.0252682
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.0250147
HSPA8 heat shock 70kDa protein 8 0.0247648
BHLHE40 basic helix-loop-helix family, member e40 0.0246712
LOC112694756 uncharaterized LOC112694756 0.0246653
APLP2 amyloid beta (A4) precursor-like protein 2 0.0239682
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0239505
ECE1 endothelin converting enzyme 1 0.0237123
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.023707
HLA-C major histocompatibility complex, class I, C 0.0234756
STK38L serine/threonine kinase 38 like 0.0233025
SHB Src homology 2 domain containing adaptor protein B 0.0230696
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0226433
ZNF469 zinc finger protein 469 0.0222354
MSN moesin 0.0217193
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0213311
DSCAM Down syndrome cell adhesion molecule 0.0210689
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0204839
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0202115
FLNA filamin A, alpha 0.0199336
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0198368
WWTR1 WW domain containing transcription regulator 1 0.0196152
RNF213 ring finger protein 213 0.0194266
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0194165
SIK3 SIK family kinase 3 0.0193383
BCL3 B-cell CLL/lymphoma 3 0.0191225
SFTPA2 surfactant protein A2 0.0187629
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0186672
INTS1 integrator complex subunit 1 0.0183668
NONO non-POU domain containing, octamer-binding 0.0182193
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0181194
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0180941
CTNND1 catenin (cadherin-associated protein), delta 1 0.018056
EIF4H eukaryotic translation initiation factor 4H 0.0179976
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0176911
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0176821
MEIS1 Meis homeobox 1 0.0176771
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0174207
APP amyloid beta (A4) precursor protein 0.0173997
EZR ezrin 0.0172459
IL1R1 interleukin 1 receptor, type I 0.0170361
OPTN optineurin 0.0170122
NFE2L1 nuclear factor, erythroid 2-like 1 0.0169354
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0166832
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0164328
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0164109
NCOR2 nuclear receptor corepressor 2 0.0162105
EHBP1L1 EH domain binding protein 1-like 1 0.0161644
LOXL2 lysyl oxidase-like 2 0.0159276
AMPD3 adenosine monophosphate deaminase 3 0.0158762
B2M beta-2-microglobulin 0.0158115
BRD2 bromodomain containing 2 0.0156125
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0156044
STX1A syntaxin 1A (brain) 0.0155924
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0155373
IFI44L interferon-induced protein 44-like 0.0154394
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 0.0152634
KIAA1217 KIAA1217 0.0150854
TRIO trio Rho guanine nucleotide exchange factor 0.0150147
NIBAN2 niban apoptosis regulator 2 0.0147777
MX1 MX dynamin-like GTPase 1 0.0147776
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0144119

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.253134
FN1 fibronectin 1 -0.211068
PDE4D phosphodiesterase 4D, cAMP-specific -0.176515
CXCL8 chemokine (C-X-C motif) ligand 8 -0.166795
VIM vimentin -0.165324
LOX lysyl oxidase -0.140327
SDK1 sidekick cell adhesion molecule 1 -0.0995531
CDH13 cadherin 13 -0.0967633
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0959565
TFPI2 tissue factor pathway inhibitor 2 -0.094445
DPYD dihydropyrimidine dehydrogenase -0.0884687
MEF2A myocyte enhancer factor 2A -0.0852936
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0831914
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0785845
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0760637
TMSB10 thymosin beta 10 -0.0745053
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0736154
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.073106
USP34 ubiquitin specific peptidase 34 -0.0715782
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.067848
RAB1A RAB1A, member RAS oncogene family -0.0668694
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0655779
TAS2R14 taste receptor, type 2, member 14 -0.0654573
MTSS1 metastasis suppressor 1 -0.0643135
NRG1 neuregulin 1 -0.0641285
PSD3 pleckstrin and Sec7 domain containing 3 -0.0636603
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0617161
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0612062
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0608342
STC1 stanniocalcin 1 -0.0602006
RAI14 retinoic acid induced 14 -0.0596554
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0587782
LMAN1 lectin, mannose-binding, 1 -0.0573423
PTMA prothymosin, alpha -0.0571977
DLG1 discs, large homolog 1 (Drosophila) -0.0558686
GOLGA4 golgin A4 -0.0549099
KDM2A lysine (K)-specific demethylase 2A -0.054554
NAMPT nicotinamide phosphoribosyltransferase -0.053259
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0528601
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0526379
GPC6 glypican 6 -0.050432
HMGA2 high mobility group AT-hook 2 -0.0500351
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0477337
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0470734
CDCP1 CUB domain containing protein 1 -0.0455494
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.045419
S100A6 S100 calcium binding protein A6 -0.0449149
OXR1 oxidation resistance 1 -0.0448253
ZMYND8 zinc finger, MYND-type containing 8 -0.0435136
IER3 immediate early response 3 -0.0425989
CANX calnexin -0.0425883
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0424442
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0423861
ENO1 enolase 1, (alpha) -0.0422172
BTG1 B-cell translocation gene 1, anti-proliferative -0.040509
TMEM165 transmembrane protein 165 -0.0403452
SEC31A SEC31 homolog A (S. cerevisiae) -0.0402868
TM4SF1 transmembrane 4 L six family member 1 -0.0398567
MSRB3 methionine sulfoxide reductase B3 -0.0397456
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0382097
RIOK3 RIO kinase 3 -0.0382073
EFNA5 ephrin-A5 -0.037904
GNAS GNAS complex locus -0.0376811
HMGA1 high mobility group AT-hook 1 -0.0376316
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0370724
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0369001
PDIA3 protein disulfide isomerase family A, member 3 -0.0364831
MAP4 microtubule-associated protein 4 -0.0336889
CDK14 cyclin-dependent kinase 14 -0.0333698
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0333637
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0329392
OSMR oncostatin M receptor -0.0319293
MAML3 mastermind-like 3 (Drosophila) -0.0316431
NBEAL1 neurobeachin-like 1 -0.0311313
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0309461
CLMP CXADR-like membrane protein -0.0300686
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0298746
JMJD1C jumonji domain containing 1C -0.0298095
ZFP36L1 ZFP36 ring finger protein-like 1 -0.029761
DIAPH2 diaphanous-related formin 2 -0.0296325
MECOM MDS1 and EVI1 complex locus -0.0295196
GREB1L growth regulation by estrogen in breast cancer-like -0.0294104
PLIN2 perilipin 2 -0.0292118
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0291764
ZNF292 zinc finger protein 292 -0.0290438
FBN1 fibrillin 1 -0.0290289
TTC3 tetratricopeptide repeat domain 3 -0.0290119
TMEM263 transmembrane protein 263 -0.0288572
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0288354
PGK1 phosphoglycerate kinase 1 -0.0286079
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0285317
CA12 carbonic anhydrase XII -0.028384
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0283648
S100A10 S100 calcium binding protein A10 -0.0276647
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0276509
DENND4A DENN/MADD domain containing 4A -0.0275203
NF1 neurofibromin 1 -0.0274367
CUX1 cut-like homeobox 1 -0.0274183
RPL34 ribosomal protein L34 -0.0274017
SYT1 synaptotagmin I -0.0271729