Oxaliplatin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.148276
GRAMD1B GRAM domain containing 1B 0.14167
ACTG1 actin gamma 1 0.119338
EEF2 eukaryotic translation elongation factor 2 0.107546
AKAP12 A kinase (PRKA) anchor protein 12 0.0864502
THSD4 thrombospondin, type I, domain containing 4 0.08311
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0778888
SMOC1 SPARC related modular calcium binding 1 0.0753974
IGFBP3 insulin-like growth factor binding protein 3 0.0740026
HLA-A major histocompatibility complex, class I, A 0.0735555
HLA-B major histocompatibility complex, class I, B 0.0727545
CMIP c-Maf inducing protein 0.0701675
MYH9 myosin, heavy chain 9, non-muscle 0.0701183
TMSB10 thymosin beta 10 0.0676656
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0622269
RPL3 ribosomal protein L3 0.0599699
LDHA lactate dehydrogenase A 0.0558073
HSPA8 heat shock 70kDa protein 8 0.0555149
SVIL supervillin 0.0555068
BRD2 bromodomain containing 2 0.0554138
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0542985
SAMD4A sterile alpha motif domain containing 4A 0.0536177
RPL37 ribosomal protein L37 0.0518351
HDAC9 histone deacetylase 9 0.0503164
KYNU kynureninase 0.0502086
DOCK5 dedicator of cytokinesis 5 0.049799
SRRM2 serine/arginine repetitive matrix 2 0.0494753
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0492864
CCL5 chemokine (C-C motif) ligand 5 0.0470018
VIM vimentin 0.0461347
DOCK4 dedicator of cytokinesis 4 0.0449711
LOC112694756 uncharaterized LOC112694756 0.0438305
DST dystonin 0.0435284
PDE4D phosphodiesterase 4D, cAMP-specific 0.042471
ACTN1 actinin, alpha 1 0.0421275
RPS27 ribosomal protein S27 0.0413885
RPL31 ribosomal protein L31 0.0408175
RPL13A ribosomal protein L13a 0.0400734
FAM107B family with sequence similarity 107, member B 0.0390656
HLA-C major histocompatibility complex, class I, C 0.0387848
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0378165
EEF1G eukaryotic translation elongation factor 1 gamma 0.0371937
RPL35A ribosomal protein L35a 0.0370035
MAML3 mastermind-like 3 (Drosophila) 0.0369256
MCL1 myeloid cell leukemia 1 0.0367884
FLNA filamin A, alpha 0.0367218
PLEC plectin 0.0363216
RPS17 ribosomal protein S17 0.0354918
RPL37A ribosomal protein L37a 0.0353039
ANGPTL4 angiopoietin-like 4 0.0352952
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0347314
TNIP1 TNFAIP3 interacting protein 1 0.0336831
EGR1 early growth response 1 0.033417
MACF1 microtubule-actin crosslinking factor 1 0.0329498
ASPH aspartate beta-hydroxylase 0.0315113
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0306177
UTRN utrophin 0.0302278
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0299253
GLIS3 GLIS family zinc finger 3 0.0297359
PM20D1 peptidase M20 domain containing 1 0.029206
SON SON DNA binding protein 0.0291023
INTS6 integrator complex subunit 6 0.0290341
NONO non-POU domain containing, octamer-binding 0.0289973
ATXN1 ataxin 1 0.0281123
TPM3 tropomyosin 3 0.0279497
APLP2 amyloid beta (A4) precursor-like protein 2 0.0279137
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0278843
RPL23 ribosomal protein L23 0.0276989
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0273545
RPTOR regulatory associated protein of MTOR, complex 1 0.0273081
RNF213 ring finger protein 213 0.0272318
STC1 stanniocalcin 1 0.027188
ZFHX3 zinc finger homeobox 3 0.0269063
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0268763
RCC1 regulator of chromosome condensation 1 0.0263594
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0258559
IGF1R insulin-like growth factor 1 receptor 0.0258382
RPL11 ribosomal protein L11 0.0257997
EGFR epidermal growth factor receptor 0.0257342
NNMT nicotinamide N-methyltransferase 0.0257069
RPS13 ribosomal protein S13 0.0255191
FTH1 ferritin, heavy polypeptide 1 0.0254483
MSN moesin 0.0251469
RAD51B RAD51 paralog B 0.0249475
CTSL cathepsin L 0.0248562
ARHGAP26 Rho GTPase activating protein 26 0.0248406
PTPRG protein tyrosine phosphatase, receptor type, G 0.0248295
UBASH3B ubiquitin associated and SH3 domain containing B 0.0247705
NUMA1 nuclear mitotic apparatus protein 1 0.0246153
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0243063
SLC38A2 solute carrier family 38, member 2 0.024119
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0239535
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0238685
TRAPPC9 trafficking protein particle complex 9 0.0234875
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0234253
B2M beta-2-microglobulin 0.0232682
BASP1 brain abundant, membrane attached signal protein 1 0.023183
MPRIP myosin phosphatase Rho interacting protein 0.0228429
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0227853
RACK1 receptor for activated C kinase 1 0.0227791

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.34636
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.169666
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.153903
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0723985
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0703646
TM4SF1 transmembrane 4 L six family member 1 -0.0696866
TFPI2 tissue factor pathway inhibitor 2 -0.0626993
RBM39 RNA binding motif protein 39 -0.0587699
RBM25 RNA binding motif protein 25 -0.0527716
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0522011
USP3 ubiquitin specific peptidase 3 -0.0497531
S100A10 S100 calcium binding protein A10 -0.0495301
ZNF292 zinc finger protein 292 -0.0495232
PDIA3 protein disulfide isomerase family A, member 3 -0.0485594
NOP58 NOP58 ribonucleoprotein -0.0470416
NAMPT nicotinamide phosphoribosyltransferase -0.0469785
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0464545
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0460037
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0427538
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0410857
TFG TRK-fused gene -0.0401771
ZFAND3 zinc finger, AN1-type domain 3 -0.0387806
RTN4 reticulon 4 -0.0379304
DEK DEK proto-oncogene -0.0376985
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.037125
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0369173
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0365136
RAB1A RAB1A, member RAS oncogene family -0.0364897
TRA2A transformer 2 alpha homolog (Drosophila) -0.0364435
VEZT vezatin, adherens junctions transmembrane protein -0.0363536
FNBP1L formin binding protein 1-like -0.035948
TPD52 tumor protein D52 -0.0341117
YME1L1 YME1-like 1 ATPase -0.0335275
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0332556
MARCHF6 membrane associated ring-CH-type finger 6 -0.0326913
MIS18BP1 MIS18 binding protein 1 -0.0324693
HMGB1 high mobility group box 1 -0.0322808
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0319996
TMEM123 transmembrane protein 123 -0.0316821
PUM2 pumilio RNA-binding family member 2 -0.0309561
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0307515
WAC WW domain containing adaptor with coiled-coil -0.0307313
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0294016
ECT2 epithelial cell transforming 2 -0.0292958
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0289746
PDIA6 protein disulfide isomerase family A, member 6 -0.0285168
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0285067
RPS15 ribosomal protein S15 -0.0279965
ZNF207 zinc finger protein 207 -0.0277162
HMGA1 high mobility group AT-hook 1 -0.0276033
RPL8 ribosomal protein L8 -0.0275927
KMT2E lysine (K)-specific methyltransferase 2E -0.0274696
NPEPPS aminopeptidase puromycin sensitive -0.0271897
SRGN serglycin -0.0267733
NUP58 nucleoporin 58 -0.0265615
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0264995
NEK7 NIMA-related kinase 7 -0.0264954
NAP1L1 nucleosome assembly protein 1-like 1 -0.0264947
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0264875
TLK1 tousled-like kinase 1 -0.0260096
TMEM87A transmembrane protein 87A -0.0255806
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0254647
TCEA1 transcription elongation factor A (SII), 1 -0.0253545
PTMA prothymosin, alpha -0.0250162
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0245992
GNAS GNAS complex locus -0.024478
ADAM9 ADAM metallopeptidase domain 9 -0.0244439
DENND4A DENN/MADD domain containing 4A -0.0243946
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0241045
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0240885
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.02383
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0236151
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0233515
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0232864
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0231036
NEMF nuclear export mediator factor -0.0230552
PFN1 profilin 1 -0.0230547
PNISR PNN-interacting serine/arginine-rich protein -0.0229723
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.022752
PRRC1 proline-rich coiled-coil 1 -0.022721
CHN1 chimerin 1 -0.0226451
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0226139
MATR3 matrin 3 -0.0226101
LMAN1 lectin, mannose-binding, 1 -0.0225048
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0225029
ADAM17 ADAM metallopeptidase domain 17 -0.0224836
GARS1 glycyl-tRNA synthetase 1 -0.0223059
GOLGA4 golgin A4 -0.0222922
SEPTIN7 septin 7 -0.0219852
FOXJ3 forkhead box J3 -0.0219594
CDC73 cell division cycle 73 -0.021932
OSBPL9 oxysterol binding protein-like 9 -0.0219297
ZFR zinc finger RNA binding protein -0.0217932
POU2F1 POU class 2 homeobox 1 -0.0217112
FTL ferritin, light polypeptide -0.0217068
MAPK8 mitogen-activated protein kinase 8 -0.0216024
ADGRG6 adhesion G protein-coupled receptor G6 -0.0215411
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0214207
PARD3 par-3 family cell polarity regulator -0.0213825
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0212596