Oxaliplatin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.130261
DST dystonin 0.123569
TPT1 tumor protein, translationally-controlled 1 0.116296
PDE10A phosphodiesterase 10A 0.113115
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.102178
RPS6 ribosomal protein S6 0.10099
RPL35A ribosomal protein L35a 0.100861
RPL31 ribosomal protein L31 0.0978122
PM20D1 peptidase M20 domain containing 1 0.0945999
RPLP1 ribosomal protein, large, P1 0.0832432
FTL ferritin, light polypeptide 0.0828809
RPS19 ribosomal protein S19 0.0809141
RPL37A ribosomal protein L37a 0.0788702
TBXT T-box transcription factor T 0.0754132
P3H2 prolyl 3-hydroxylase 2 0.0752633
RPL37 ribosomal protein L37 0.0722535
EEF2 eukaryotic translation elongation factor 2 0.0720828
RPL11 ribosomal protein L11 0.0689248
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.066323
GRAMD1B GRAM domain containing 1B 0.0656215
COL5A2 collagen, type V, alpha 2 0.0646262
RPL19 ribosomal protein L19 0.0642934
PRKN parkin RBR E3 ubiquitin protein ligase 0.0638648
TMSB10 thymosin beta 10 0.0631146
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0629029
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0627456
RPL9 ribosomal protein L9 0.0624221
CDH13 cadherin 13 0.061118
HLA-B major histocompatibility complex, class I, B 0.0607951
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0604714
RPLP0 ribosomal protein, large, P0 0.0595068
RPS27 ribosomal protein S27 0.058792
NALF1 NALCN channel auxiliary factor 1 0.0584939
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0583643
LOC112694756 uncharaterized LOC112694756 0.0574381
PSD3 pleckstrin and Sec7 domain containing 3 0.0571227
SMOC1 SPARC related modular calcium binding 1 0.0557574
RPL7A ribosomal protein L7a 0.0555942
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0538631
NONO non-POU domain containing, octamer-binding 0.0533739
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0531965
HLA-A major histocompatibility complex, class I, A 0.0522658
RPL13A ribosomal protein L13a 0.0520844
B2M beta-2-microglobulin 0.0520386
RPL36A ribosomal protein L36a 0.0519049
RPL23 ribosomal protein L23 0.0517577
MAML3 mastermind-like 3 (Drosophila) 0.0517176
RPS8 ribosomal protein S8 0.0513086
RPL26 ribosomal protein L26 0.0505716
RPS17 ribosomal protein S17 0.0505395
ANTXR1 anthrax toxin receptor 1 0.0501301
ACTG1 actin gamma 1 0.0487014
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0482357
COL8A1 collagen, type VIII, alpha 1 0.0481187
CTSL cathepsin L 0.0478525
RPL36 ribosomal protein L36 0.0478208
RPLP2 ribosomal protein, large, P2 0.0471663
VIM vimentin 0.0467606
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0466519
RPS3 ribosomal protein S3 0.0463119
RACK1 receptor for activated C kinase 1 0.0458239
CTIF CBP80/20-dependent translation initiation factor 0.0456433
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0449112
PTPRM protein tyrosine phosphatase, receptor type, M 0.0447768
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0447073
KYNU kynureninase 0.0437516
RPL38 ribosomal protein L38 0.0436787
RPS13 ribosomal protein S13 0.0436743
RAB3B RAB3B, member RAS oncogene family 0.0431391
RPS25 ribosomal protein S25 0.0425555
RPS4X ribosomal protein S4, X-linked 0.0425059
RPS24 ribosomal protein S24 0.0418956
RPL35 ribosomal protein L35 0.0416179
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0412947
PDE7B phosphodiesterase 7B 0.0409434
RPL3 ribosomal protein L3 0.0400909
HSPA8 heat shock 70kDa protein 8 0.0391002
RPS14 ribosomal protein S14 0.0390933
MAP7 microtubule-associated protein 7 0.0386744
SH3KBP1 SH3-domain kinase binding protein 1 0.0385917
RPL27 ribosomal protein L27 0.0385332
RPH3AL rabphilin 3A-like (without C2 domains) 0.0384917
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0379549
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0366195
YBX3 Y box binding protein 3 0.0362303
SMYD3 SET and MYND domain containing 3 0.035824
MYH9 myosin, heavy chain 9, non-muscle 0.0354239
RPS21 ribosomal protein S21 0.0350743
DOCK4 dedicator of cytokinesis 4 0.0347195
EEF1G eukaryotic translation elongation factor 1 gamma 0.0346724
PDLIM5 PDZ and LIM domain 5 0.0343209
RPS12 ribosomal protein S12 0.0340771
MT2A metallothionein 2A 0.0340284
SRRM2 serine/arginine repetitive matrix 2 0.0339463
RPL12 ribosomal protein L12 0.0336716
IGF1R insulin-like growth factor 1 receptor 0.0328545
LSAMP limbic system-associated membrane protein 0.031941
NCOR2 nuclear receptor corepressor 2 0.0313041
RPL34 ribosomal protein L34 0.0310873
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0304766

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17419
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148076
NAMPT nicotinamide phosphoribosyltransferase -0.116464
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0824484
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0745017
TM4SF1 transmembrane 4 L six family member 1 -0.0733283
UBC ubiquitin C -0.072469
EFNA5 ephrin-A5 -0.0631518
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0592033
FN1 fibronectin 1 -0.0564676
RTN4 reticulon 4 -0.0476018
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0437588
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0392032
CANX calnexin -0.0390236
SPAG9 sperm associated antigen 9 -0.0388734
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0380349
BIRC6 baculoviral IAP repeat containing 6 -0.0326318
GOLGA4 golgin A4 -0.0311822
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0306341
PDIA3 protein disulfide isomerase family A, member 3 -0.0302338
OGA O-GlcNAcase -0.0297968
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0296686
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0293374
KMT2C lysine (K)-specific methyltransferase 2C -0.0292436
USP34 ubiquitin specific peptidase 34 -0.0277891
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0277701
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0272369
KMT2E lysine (K)-specific methyltransferase 2E -0.0267125
ZNF292 zinc finger protein 292 -0.026665
JMJD1C jumonji domain containing 1C -0.0262112
PDIA6 protein disulfide isomerase family A, member 6 -0.0258888
MCL1 myeloid cell leukemia 1 -0.0257565
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0257045
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0256685
TFPI2 tissue factor pathway inhibitor 2 -0.0256523
FNDC3B fibronectin type III domain containing 3B -0.0254366
ATP13A3 ATPase type 13A3 -0.0248509
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0247961
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0246965
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0246399
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0239689
ELL2 elongation factor, RNA polymerase II, 2 -0.0238914
SRGN serglycin -0.0235489
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.023043
ZFC3H1 zinc finger, C3H1-type containing -0.0230232
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.023014
ARID4B AT rich interactive domain 4B (RBP1-like) -0.022748
SBF2 SET binding factor 2 -0.0226888
SEC31A SEC31 homolog A (S. cerevisiae) -0.0223532
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0223021
HELZ helicase with zinc finger -0.0221363
PDIA4 protein disulfide isomerase family A, member 4 -0.0218507
NBAS neuroblastoma amplified sequence -0.0215543
LMAN1 lectin, mannose-binding, 1 -0.0214616
RAI1 retinoic acid induced 1 -0.0211762
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0210881
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.02094
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0205498
NF1 neurofibromin 1 -0.0205009
AVL9 AVL9 homolog (S. cerevisiase) -0.0202782
NBEAL1 neurobeachin-like 1 -0.0198992
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0198949
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0198451
COG5 component of oligomeric golgi complex 5 -0.0198427
MON2 MON2 homolog (S. cerevisiae) -0.0195038
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0194203
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0194014
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0193548
WDR45B WD repeat domain 45B -0.0189564
MAP4 microtubule-associated protein 4 -0.0189431
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0188025
RBM39 RNA binding motif protein 39 -0.018725
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0184601
ATAD1 ATPase family, AAA domain containing 1 -0.0184517
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0184296
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0184147
MXI1 MAX interactor 1, dimerization protein -0.0182737
CEP170 centrosomal protein 170kDa -0.0181419
VMP1 vacuole membrane protein 1 -0.0181059
LIMCH1 LIM and calponin homology domains 1 -0.0178332
TXNRD1 thioredoxin reductase 1 -0.0177127
RAB1A RAB1A, member RAS oncogene family -0.0175471
PUM2 pumilio RNA-binding family member 2 -0.0175454
CALU calumenin -0.0175061
BRWD3 bromodomain and WD repeat domain containing 3 -0.0171028
DENND4A DENN/MADD domain containing 4A -0.0170926
USP53 ubiquitin specific peptidase 53 -0.0169248
BMERB1 bMERB domain containing 1 -0.0168629
AGFG1 ArfGAP with FG repeats 1 -0.0166841
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0166794
RUNX1 runt-related transcription factor 1 -0.0166786
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0166767
COPA coatomer protein complex, subunit alpha -0.0166529
TENT5A terminal nucleotidyltransferase 5A -0.0165978
NEK7 NIMA-related kinase 7 -0.0165913
TNPO1 transportin 1 -0.0164859
ANXA5 annexin A5 -0.0164752
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.016391
NUP58 nucleoporin 58 -0.0163529
ANKRD28 ankyrin repeat domain 28 -0.0163001