Oxaliplatin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.133368
CADM2 cell adhesion molecule 2 0.127552
COL5A2 collagen, type V, alpha 2 0.116102
PCLO piccolo presynaptic cytomatrix protein 0.112187
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.10267
EEF2 eukaryotic translation elongation factor 2 0.0906388
TENM3 teneurin transmembrane protein 3 0.0875069
NONO non-POU domain containing, octamer-binding 0.0816082
DST dystonin 0.0784002
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0705452
MYH9 myosin, heavy chain 9, non-muscle 0.0674744
DOCK5 dedicator of cytokinesis 5 0.0598767
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0597012
SRRM2 serine/arginine repetitive matrix 2 0.0577658
RBMS3 RNA binding motif, single stranded interacting protein 3 0.051277
PBX3 pre-B-cell leukemia homeobox 3 0.0489889
FOXP2 forkhead box P2 0.0468469
ARID1A AT rich interactive domain 1A (SWI-like) 0.0461479
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0416645
PCDH7 protocadherin 7 0.0412475
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0408863
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0398293
EEF1G eukaryotic translation elongation factor 1 gamma 0.0393669
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0384935
ADGRV1 adhesion G protein-coupled receptor V1 0.0377662
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0373894
ZNF608 zinc finger protein 608 0.0373886
RPL3 ribosomal protein L3 0.036678
PCDH9 protocadherin 9 0.0359805
DLX2 distal-less homeobox 2 0.0351957
GREB1L growth regulation by estrogen in breast cancer-like 0.0329374
MAML2 mastermind-like 2 (Drosophila) 0.0325487
OSBPL10 oxysterol binding protein-like 10 0.0318972
BRD2 bromodomain containing 2 0.0313821
TMSB4X thymosin beta 4, X-linked 0.0312688
KMT2D lysine (K)-specific methyltransferase 2D 0.0311229
SOX5 SRY (sex determining region Y)-box 5 0.0309981
LOC112694756 uncharaterized LOC112694756 0.0308695
ACTN4 actinin, alpha 4 0.0301144
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0299423
CEP250 centrosomal protein 250kDa 0.029289
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0292012
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0290237
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0284817
LDHA lactate dehydrogenase A 0.0282963
SERTAD2 SERTA domain containing 2 0.028172
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0278894
TRIO trio Rho guanine nucleotide exchange factor 0.0278236
PRPF8 pre-mRNA processing factor 8 0.0275654
SON SON DNA binding protein 0.0270431
PDLIM5 PDZ and LIM domain 5 0.0267107
CDH19 cadherin 19, type 2 0.0262728
NCOR2 nuclear receptor corepressor 2 0.0256248
CCNYL1 cyclin Y-like 1 0.0251156
FAT1 FAT atypical cadherin 1 0.0247809
PDE4D phosphodiesterase 4D, cAMP-specific 0.0246787
PRRC2C proline-rich coiled-coil 2C 0.0245922
CLIC4 chloride intracellular channel 4 0.0245675
TPM3 tropomyosin 3 0.0243038
PLEC plectin 0.0240578
NALF1 NALCN channel auxiliary factor 1 0.0238038
RBM5 RNA binding motif protein 5 0.0237718
CPNE1 copine I 0.0235653
BRD4 bromodomain containing 4 0.0234376
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.023423
DIDO1 death inducer-obliterator 1 0.0233947
SET SET nuclear proto-oncogene 0.0232965
PDGFC platelet derived growth factor C 0.0232644
SMC1A structural maintenance of chromosomes 1A 0.0231923
GIGYF2 GRB10 interacting GYF protein 2 0.0231045
VWA8 von Willebrand factor A domain containing 8 0.023038
HYOU1 hypoxia up-regulated 1 0.0228541
MACROD2 MACRO domain containing 2 0.02285
EXOC4 exocyst complex component 4 0.0225529
HMGA2 high mobility group AT-hook 2 0.0223259
FUS FUS RNA binding protein 0.022222
MPRIP myosin phosphatase Rho interacting protein 0.0220879
RPL37 ribosomal protein L37 0.0220615
FLNA filamin A, alpha 0.0219607
NFE2L1 nuclear factor, erythroid 2-like 1 0.0217369
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0217067
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0215144
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0214689
EIF4H eukaryotic translation initiation factor 4H 0.0214497
TRAPPC9 trafficking protein particle complex 9 0.0213689
SPTBN1 spectrin, beta, non-erythrocytic 1 0.021228
ASXL2 additional sex combs like transcriptional regulator 2 0.0211193
YBX1 Y box binding protein 1 0.0211165
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0208727
VEGFA vascular endothelial growth factor A 0.0208284
BHLHE40 basic helix-loop-helix family, member e40 0.0207311
RPL7 ribosomal protein L7 0.0207271
PPL periplakin 0.020643
SAMD4A sterile alpha motif domain containing 4A 0.0205988
SKIL SKI-like proto-oncogene 0.0204701
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0204138
PCM1 pericentriolar material 1 0.0204049
FXR1 fragile X mental retardation, autosomal homolog 1 0.0203127
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.020209
APLP2 amyloid beta (A4) precursor-like protein 2 0.0201197

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.256165
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.159589
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.106497
COL3A1 collagen, type III, alpha 1 -0.10444
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0888154
PGAP1 post-GPI attachment to proteins 1 -0.0865063
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0789414
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0745352
ANKRD33B ankyrin repeat domain 33B -0.0726309
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0722488
SPAG9 sperm associated antigen 9 -0.069136
NRG1 neuregulin 1 -0.0650956
PLPP1 phospholipid phosphatase 1 -0.0633537
WSB1 WD repeat and SOCS box containing 1 -0.0597256
KDM3A lysine (K)-specific demethylase 3A -0.059354
MDK midkine (neurite growth-promoting factor 2) -0.0580907
GPC3 glypican 3 -0.0571042
PDIA3 protein disulfide isomerase family A, member 3 -0.0565022
MRPS30 mitochondrial ribosomal protein S30 -0.0564438
STRN3 striatin, calmodulin binding protein 3 -0.056026
MAP4 microtubule-associated protein 4 -0.0559202
CHD1 chromodomain helicase DNA binding protein 1 -0.055141
CAMTA1 calmodulin binding transcription activator 1 -0.0545786
VIM vimentin -0.0544304
TUT4 terminal uridylyl transferase 4 -0.0535801
GNAS GNAS complex locus -0.0535144
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0513057
FNDC3B fibronectin type III domain containing 3B -0.050208
ADGRL2 adhesion G protein-coupled receptor L2 -0.0498315
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0491776
NIPBL Nipped-B homolog (Drosophila) -0.0486423
KMT2C lysine (K)-specific methyltransferase 2C -0.0483625
SRP54 signal recognition particle 54kDa -0.0480888
PHIP pleckstrin homology domain interacting protein -0.0476153
TSC22D2 TSC22 domain family, member 2 -0.0450499
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0449812
MARCHF6 membrane associated ring-CH-type finger 6 -0.0447455
SNX6 sorting nexin 6 -0.0447433
ZNF292 zinc finger protein 292 -0.0434323
THOC2 THO complex 2 -0.0431201
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0431028
NEBL nebulette -0.0428607
ZNF217 zinc finger protein 217 -0.0417085
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0411767
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0410854
AHNAK AHNAK nucleoprotein -0.0398697
JMJD1C jumonji domain containing 1C -0.0394391
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0392713
NOP58 NOP58 ribonucleoprotein -0.0384765
PTK2 protein tyrosine kinase 2 -0.037969
URI1 URI1, prefoldin-like chaperone -0.0379523
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0378853
BIRC6 baculoviral IAP repeat containing 6 -0.037815
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0373824
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0372642
UPP1 uridine phosphorylase 1 -0.0370694
SOX2 SRY (sex determining region Y)-box 2 -0.036753
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0362873
SRP72 signal recognition particle 72kDa -0.0360804
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0360505
PRELID2 PRELI domain containing 2 -0.0358674
RAB1A RAB1A, member RAS oncogene family -0.0356337
ANXA2 annexin A2 -0.0355178
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0349335
CDK13 cyclin-dependent kinase 13 -0.0348032
RPS16 ribosomal protein S16 -0.0346783
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0342379
RPS8 ribosomal protein S8 -0.0340767
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0340077
USP53 ubiquitin specific peptidase 53 -0.033479
TAS2R14 taste receptor, type 2, member 14 -0.0334525
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0332555
SEC31A SEC31 homolog A (S. cerevisiae) -0.0332378
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0329598
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0328319
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0327653
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0327276
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0326691
CD2AP CD2-associated protein -0.0326152
VGLL3 vestigial-like family member 3 -0.0323851
MRPS6 mitochondrial ribosomal protein S6 -0.0322729
EMP1 epithelial membrane protein 1 -0.032089
FBXO11 F-box protein 11 -0.0313626
CEP350 centrosomal protein 350kDa -0.0312445
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0311089
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.031047
TMEM87A transmembrane protein 87A -0.0309838
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0306705
CXADR coxsackie virus and adenovirus receptor -0.0306703
GOLGA4 golgin A4 -0.0305515
RCOR1 REST corepressor 1 -0.030462
ARL13B ADP-ribosylation factor-like 13B -0.029686
TENM2 teneurin transmembrane protein 2 -0.0295517
ZFR zinc finger RNA binding protein -0.0294934
KDM2A lysine (K)-specific demethylase 2A -0.0293527
TRA2A transformer 2 alpha homolog (Drosophila) -0.0293102
TTC28 tetratricopeptide repeat domain 28 -0.0291329
RAD21 RAD21 homolog (S. pombe) -0.0288419
ZMYM2 zinc finger, MYM-type 2 -0.0287805
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.028748