Oxaliplatin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.185048
TMSB4X thymosin beta 4, X-linked 0.157132
PDE4D phosphodiesterase 4D, cAMP-specific 0.128772
PKM pyruvate kinase, muscle 0.115163
EGFR epidermal growth factor receptor 0.0893815
RPL3 ribosomal protein L3 0.0888998
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0793805
EZR ezrin 0.0762332
HDAC9 histone deacetylase 9 0.0753118
SRRM2 serine/arginine repetitive matrix 2 0.0705798
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0705443
LOC112694756 uncharaterized LOC112694756 0.0680686
HSPA8 heat shock 70kDa protein 8 0.0656152
GLI2 GLI family zinc finger 2 0.0643637
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0567219
DUSP4 dual specificity phosphatase 4 0.0559114
MYO5C myosin VC 0.0540743
NCEH1 neutral cholesterol ester hydrolase 1 0.0540488
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0517188
MYH9 myosin, heavy chain 9, non-muscle 0.0493288
ZNF608 zinc finger protein 608 0.0474774
VCL vinculin 0.047448
AMOTL2 angiomotin like 2 0.046445
GSE1 Gse1 coiled-coil protein 0.0453967
EEF1G eukaryotic translation elongation factor 1 gamma 0.0432961
ACTG1 actin gamma 1 0.0428582
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0417876
LOXL3 lysyl oxidase-like 3 0.0416525
PYGB phosphorylase, glycogen; brain 0.0413375
PRPF38B pre-mRNA processing factor 38B 0.041272
NONO non-POU domain containing, octamer-binding 0.0410767
ANXA1 annexin A1 0.0406319
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0355785
ARID1A AT rich interactive domain 1A (SWI-like) 0.035483
TACC2 transforming, acidic coiled-coil containing protein 2 0.0337964
TJP1 tight junction protein 1 0.033235
PTMA prothymosin, alpha 0.032095
PDGFC platelet derived growth factor C 0.0320846
MACROD2 MACRO domain containing 2 0.0309346
NUMA1 nuclear mitotic apparatus protein 1 0.0307323
FBLN2 fibulin 2 0.029282
ZMIZ1 zinc finger, MIZ-type containing 1 0.028989
GLI3 GLI family zinc finger 3 0.028722
JUN jun proto-oncogene 0.0284152
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.0283987
CEP250 centrosomal protein 250kDa 0.028347
TNIP1 TNFAIP3 interacting protein 1 0.0283161
CPNE1 copine I 0.0280471
SFTPA2 surfactant protein A2 0.0277554
RHOA ras homolog family member A 0.0272598
SPTBN1 spectrin, beta, non-erythrocytic 1 0.026827
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0263573
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0263311
PLXNA1 plexin A1 0.0261579
TPM4 tropomyosin 4 0.0258912
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0258786
CREB5 cAMP responsive element binding protein 5 0.0256147
BRD2 bromodomain containing 2 0.0255287
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0253723
MPRIP myosin phosphatase Rho interacting protein 0.0245088
RAB27B RAB27B, member RAS oncogene family 0.024488
B2M beta-2-microglobulin 0.0237264
SMAD6 SMAD family member 6 0.0234952
SPRY2 sprouty homolog 2 (Drosophila) 0.0234947
SQSTM1 sequestosome 1 0.02281
MINK1 misshapen-like kinase 1 0.0226337
AHNAK AHNAK nucleoprotein 0.0225784
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0222515
BRD4 bromodomain containing 4 0.0222042
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0219815
KMT2D lysine (K)-specific methyltransferase 2D 0.0216587
ARGLU1 arginine and glutamate rich 1 0.0216248
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0214438
SOX9 SRY (sex determining region Y)-box 9 0.0213783
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.021196
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.021196
EIF1 eukaryotic translation initiation factor 1 0.0211877
TOB1 transducer of ERBB2, 1 0.0210953
KLF3 Kruppel-like factor 3 (basic) 0.0210206
IRS1 insulin receptor substrate 1 0.0209776
CORO1C coronin, actin binding protein, 1C 0.0208788
PRRC2A proline-rich coiled-coil 2A 0.0208504
PLEC plectin 0.0208395
AHCYL2 adenosylhomocysteinase-like 2 0.0207008
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.020254
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0199715
TPM3 tropomyosin 3 0.0198148
MAVS mitochondrial antiviral signaling protein 0.0196926
PRELID3B PRELI domain containing 3B 0.0195226
TMCO3 transmembrane and coiled-coil domains 3 0.019342
SEPTIN9 septin 9 0.0193033
MLIP muscular LMNA-interacting protein 0.0191201
NCOR2 nuclear receptor corepressor 2 0.0188264
ADAR adenosine deaminase, RNA-specific 0.0187273
CDC25B cell division cycle 25B 0.0186298
LDHA lactate dehydrogenase A 0.0186151
PRDX2 peroxiredoxin 2 0.0186063
YBX3 Y box binding protein 3 0.0185375
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0184543
ARHGAP25 Rho GTPase activating protein 25 0.0184323

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185787
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.18572
CPED1 cadherin-like and PC-esterase domain containing 1 -0.164979
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.128188
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120171
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0942529
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0881168
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.087596
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0839927
GOLGA4 golgin A4 -0.0839547
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0826138
CAMKMT calmodulin-lysine N-methyltransferase -0.0806034
DLG1 discs, large homolog 1 (Drosophila) -0.078995
PDE4B phosphodiesterase 4B, cAMP-specific -0.072604
EVI5 ecotropic viral integration site 5 -0.0720733
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0712357
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0655802
NFIA nuclear factor I/A -0.061242
SBF2 SET binding factor 2 -0.0606114
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0602704
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0597435
WSB1 WD repeat and SOCS box containing 1 -0.0595492
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0552493
NBEA neurobeachin -0.0524559
GPHN gephyrin -0.05173
PNISR PNN-interacting serine/arginine-rich protein -0.0503023
SLC38A2 solute carrier family 38, member 2 -0.047427
BIRC6 baculoviral IAP repeat containing 6 -0.0473315
FNDC3B fibronectin type III domain containing 3B -0.0455205
RBM39 RNA binding motif protein 39 -0.0447592
ZMYM2 zinc finger, MYM-type 2 -0.0440216
FHIT fragile histidine triad -0.0437538
NEBL nebulette -0.0423848
PARD3 par-3 family cell polarity regulator -0.0412412
ECT2 epithelial cell transforming 2 -0.0401548
NF1 neurofibromin 1 -0.0396809
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0393624
TTC3 tetratricopeptide repeat domain 3 -0.0392717
ANKRD12 ankyrin repeat domain 12 -0.0390916
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0389682
SEC31A SEC31 homolog A (S. cerevisiae) -0.0386165
GNAS GNAS complex locus -0.0361639
BRWD1 bromodomain and WD repeat domain containing 1 -0.0358537
NT5C2 5'-nucleotidase, cytosolic II -0.0355415
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0350461
PUM2 pumilio RNA-binding family member 2 -0.0348159
MAP4 microtubule-associated protein 4 -0.0346185
ADAM10 ADAM metallopeptidase domain 10 -0.0346137
GARS1 glycyl-tRNA synthetase 1 -0.0341414
MON2 MON2 homolog (S. cerevisiae) -0.0340672
JMJD1C jumonji domain containing 1C -0.0336877
MSI2 musashi RNA-binding protein 2 -0.0332668
RBM25 RNA binding motif protein 25 -0.033064
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0327116
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0326008
ZNF292 zinc finger protein 292 -0.0320066
TTC28 tetratricopeptide repeat domain 28 -0.0317896
TAS2R14 taste receptor, type 2, member 14 -0.0317832
IARS1 isoleucyl-tRNA synthetase 1 -0.0315836
AHI1 Abelson helper integration site 1 -0.0315787
LPP LIM domain containing preferred translocation partner in lipoma -0.0313031
GLS2 glutaminase 2 (liver, mitochondrial) -0.0311121
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0311042
TUT4 terminal uridylyl transferase 4 -0.0309364
ELOVL5 ELOVL fatty acid elongase 5 -0.0305297
SSBP2 single-stranded DNA binding protein 2 -0.0304018
TMEM263 transmembrane protein 263 -0.0303133
EHBP1 EH domain binding protein 1 -0.0300558
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0295102
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0294572
SMNDC1 survival motor neuron domain containing 1 -0.0293662
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0293008
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0291783
DIAPH3 diaphanous-related formin 3 -0.0291089
DIAPH2 diaphanous-related formin 2 -0.0289961
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0289669
QKI QKI, KH domain containing, RNA binding -0.028931
SETD5 SET domain containing 5 -0.0285138
MBD5 methyl-CpG binding domain protein 5 -0.0281101
NIPBL Nipped-B homolog (Drosophila) -0.0279579
PICALM phosphatidylinositol binding clathrin assembly protein -0.0278476
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0273173
TMEM135 transmembrane protein 135 -0.0268647
LCORL ligand dependent nuclear receptor corepressor-like -0.026851
SEC24D SEC24 family member D -0.0268327
SUCO SUN domain containing ossification factor -0.0268314
KMT2C lysine (K)-specific methyltransferase 2C -0.0268172
HELZ helicase with zinc finger -0.0267272
TPT1 tumor protein, translationally-controlled 1 -0.0266383
PDE10A phosphodiesterase 10A -0.0266279
LMAN1 lectin, mannose-binding, 1 -0.026624
EFNA5 ephrin-A5 -0.0266149
FAF1 Fas (TNFRSF6) associated factor 1 -0.0264284
USP34 ubiquitin specific peptidase 34 -0.0263985
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0263908
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0259587
AKAP9 A kinase (PRKA) anchor protein 9 -0.025898
NAV2 neuron navigator 2 -0.0258969
COG6 component of oligomeric golgi complex 6 -0.0255201
CENPE centromere protein E, 312kDa -0.0250967