Oxaliplatin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.480552
MYH9 myosin, heavy chain 9, non-muscle 0.221359
HLA-B major histocompatibility complex, class I, B 0.209514
IGFBP3 insulin-like growth factor binding protein 3 0.203338
B2M beta-2-microglobulin 0.116884
TGFBI transforming growth factor, beta-induced, 68kDa 0.114744
MT2A metallothionein 2A 0.105141
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0789644
LOC112694756 uncharaterized LOC112694756 0.0784522
EEF2 eukaryotic translation elongation factor 2 0.0737766
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0722992
HLA-A major histocompatibility complex, class I, A 0.0681357
TNIP1 TNFAIP3 interacting protein 1 0.067625
COL5A1 collagen, type V, alpha 1 0.0630766
TMSB10 thymosin beta 10 0.0630107
CD44 CD44 molecule (Indian blood group) 0.0594179
MACF1 microtubule-actin crosslinking factor 1 0.0592517
HLA-C major histocompatibility complex, class I, C 0.0577138
SDC4 syndecan 4 0.057009
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0549931
VEGFA vascular endothelial growth factor A 0.0546688
FLNA filamin A, alpha 0.0527735
STC1 stanniocalcin 1 0.0523851
FTH1 ferritin, heavy polypeptide 1 0.0519409
SRRM2 serine/arginine repetitive matrix 2 0.0506039
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0502216
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0497304
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0496946
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0494605
CALR calreticulin 0.0494436
NDRG1 N-myc downstream regulated 1 0.0473995
EXT1 exostosin glycosyltransferase 1 0.0462104
KYNU kynureninase 0.0449138
PLEC plectin 0.0400301
COL7A1 collagen, type VII, alpha 1 0.0397715
ECE1 endothelin converting enzyme 1 0.0384461
SMAD3 SMAD family member 3 0.0383519
MSN moesin 0.0382907
PDLIM5 PDZ and LIM domain 5 0.0378524
NRXN3 neurexin 3 0.037485
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0353461
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0349393
LDHA lactate dehydrogenase A 0.0347683
HSPA8 heat shock 70kDa protein 8 0.0335724
MPRIP myosin phosphatase Rho interacting protein 0.0329427
AHNAK AHNAK nucleoprotein 0.0327049
INTS6 integrator complex subunit 6 0.0322442
ASPH aspartate beta-hydroxylase 0.0321706
MKI67 marker of proliferation Ki-67 0.0312665
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0307487
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0302711
RPL31 ribosomal protein L31 0.0296269
NCOR2 nuclear receptor corepressor 2 0.0292088
LGALS1 lectin, galactoside-binding, soluble, 1 0.0287342
PLAUR plasminogen activator, urokinase receptor 0.0286965
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0280858
IGFBP7 insulin-like growth factor binding protein 7 0.0279057
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0278359
PTMA prothymosin, alpha 0.0277364
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0273181
NUMA1 nuclear mitotic apparatus protein 1 0.0272385
SHB Src homology 2 domain containing adaptor protein B 0.0271817
RPL37 ribosomal protein L37 0.0268922
BBS9 Bardet-Biedl syndrome 9 0.0266921
ITGAV integrin, alpha V 0.0259999
GOLGB1 golgin B1 0.0258669
BHLHE40 basic helix-loop-helix family, member e40 0.025764
APP amyloid beta (A4) precursor protein 0.0255232
RRM2 ribonucleotide reductase M2 0.0253438
BSG basigin (Ok blood group) 0.0249109
SOD2 superoxide dismutase 2, mitochondrial 0.0248811
NONO non-POU domain containing, octamer-binding 0.024715
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0243096
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0242193
ENO1 enolase 1, (alpha) 0.024094
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0240722
RPLP1 ribosomal protein, large, P1 0.0239141
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0238855
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0238183
CPNE1 copine I 0.0237658
APLP2 amyloid beta (A4) precursor-like protein 2 0.0236826
NIBAN2 niban apoptosis regulator 2 0.0236609
ATXN1 ataxin 1 0.023618
SND1 staphylococcal nuclease and tudor domain containing 1 0.0236003
ZSWIM6 zinc finger, SWIM-type containing 6 0.0235943
CDK6 cyclin-dependent kinase 6 0.0235867
RPL3 ribosomal protein L3 0.0231088
TIMP1 TIMP metallopeptidase inhibitor 1 0.0230748
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0229797
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.0227002
ALK anaplastic lymphoma receptor tyrosine kinase 0.0226813
RPL11 ribosomal protein L11 0.0226271
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0223608
ACTN4 actinin, alpha 4 0.0222832
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0220136
RPL37A ribosomal protein L37a 0.0218344
C1S complement component 1, s subcomponent 0.0216546
TLN1 talin 1 0.0216246
GSE1 Gse1 coiled-coil protein 0.0214369
RPL23 ribosomal protein L23 0.0213809

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113072
NAMPT nicotinamide phosphoribosyltransferase -0.107252
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0918797
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0545246
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0518562
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0513599
RAI14 retinoic acid induced 14 -0.0487656
CDH13 cadherin 13 -0.0479201
RTN4 reticulon 4 -0.0433343
LOX lysyl oxidase -0.0410355
ZMYND8 zinc finger, MYND-type containing 8 -0.0401008
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0366369
AKAP9 A kinase (PRKA) anchor protein 9 -0.0365586
EGFR epidermal growth factor receptor -0.0354696
GOLGA4 golgin A4 -0.0347799
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0344271
INHBA inhibin, beta A -0.0342715
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.034074
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.033396
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0333097
WSB1 WD repeat and SOCS box containing 1 -0.033283
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0316123
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0311172
TENT5A terminal nucleotidyltransferase 5A -0.0307999
ATP13A3 ATPase type 13A3 -0.0305321
GARS1 glycyl-tRNA synthetase 1 -0.0300649
USP34 ubiquitin specific peptidase 34 -0.0299629
PSD3 pleckstrin and Sec7 domain containing 3 -0.0292739
RBM39 RNA binding motif protein 39 -0.028429
KMT2E lysine (K)-specific methyltransferase 2E -0.0283716
MEF2A myocyte enhancer factor 2A -0.0277591
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0276805
KDM5B lysine (K)-specific demethylase 5B -0.0264333
COPB1 coatomer protein complex, subunit beta 1 -0.0261171
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0258665
BIRC6 baculoviral IAP repeat containing 6 -0.0255914
SEC24D SEC24 family member D -0.0252762
TMEM165 transmembrane protein 165 -0.0252372
GCC2 GRIP and coiled-coil domain containing 2 -0.0250608
NIPBL Nipped-B homolog (Drosophila) -0.0249162
IARS1 isoleucyl-tRNA synthetase 1 -0.0248844
ELL2 elongation factor, RNA polymerase II, 2 -0.0246343
MAP4 microtubule-associated protein 4 -0.024413
OSMR oncostatin M receptor -0.0237189
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0235636
AK1 adenylate kinase 1 -0.0234163
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0234127
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0233888
DPYD dihydropyrimidine dehydrogenase -0.0232885
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.022546
PDIA3 protein disulfide isomerase family A, member 3 -0.0225361
FMNL2 formin-like 2 -0.022473
RINT1 RAD50 interactor 1 -0.0224156
TM4SF1 transmembrane 4 L six family member 1 -0.0223431
ARF4 ADP-ribosylation factor 4 -0.021965
ZNF292 zinc finger protein 292 -0.0218622
TMEM41B transmembrane protein 41B -0.0217174
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0215636
FNIP1 folliculin interacting protein 1 -0.0214497
TMEM263 transmembrane protein 263 -0.0214353
LMAN1 lectin, mannose-binding, 1 -0.0214025
CDK13 cyclin-dependent kinase 13 -0.0212931
MXI1 MAX interactor 1, dimerization protein -0.0211045
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0209118
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0208127
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0206764
FAM13A family with sequence similarity 13, member A -0.0205122
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0198768
USP3 ubiquitin specific peptidase 3 -0.0197518
EPAS1 endothelial PAS domain protein 1 -0.0195182
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0191892
JARID2 jumonji, AT rich interactive domain 2 -0.0191612
NOP58 NOP58 ribonucleoprotein -0.0191257
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0190057
KAZN kazrin, periplakin interacting protein -0.0189382
AAK1 AP2 associated kinase 1 -0.0188923
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0188188
MMP12 matrix metallopeptidase 12 -0.018772
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0187306
NBAS neuroblastoma amplified sequence -0.0186425
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0185387
ESYT2 extended synaptotagmin-like protein 2 -0.0185018
PDE4D phosphodiesterase 4D, cAMP-specific -0.0185013
TFPI2 tissue factor pathway inhibitor 2 -0.0182928
RLF rearranged L-myc fusion -0.0182844
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0182557
PRRC1 proline-rich coiled-coil 1 -0.0180816
CDC27 cell division cycle 27 -0.0178201
MX2 MX dynamin-like GTPase 2 -0.0178023
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0176621
MON2 MON2 homolog (S. cerevisiae) -0.0176422
RBM25 RNA binding motif protein 25 -0.0175684
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0175508
CADM1 cell adhesion molecule 1 -0.0173834
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0173633
TM9SF3 transmembrane 9 superfamily member 3 -0.0172777
ARHGAP12 Rho GTPase activating protein 12 -0.0170728
FRMD4A FERM domain containing 4A -0.0169417
KCTD9 potassium channel tetramerization domain containing 9 -0.0169071
ZBTB35 zinc finger and BTB domain containing 35 -0.0167188