Oxaliplatin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaliplatin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaliplatin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.168373
HLA-B major histocompatibility complex, class I, B 0.149026
ASPH aspartate beta-hydroxylase 0.149017
FN1 fibronectin 1 0.11463
FTH1 ferritin, heavy polypeptide 1 0.106122
FTL ferritin, light polypeptide 0.098369
SFTPA2 surfactant protein A2 0.0982273
MYH9 myosin, heavy chain 9, non-muscle 0.0874522
NTN4 netrin 4 0.0841573
SQSTM1 sequestosome 1 0.0823843
SEPTIN9 septin 9 0.0777407
B2M beta-2-microglobulin 0.0771869
VEGFA vascular endothelial growth factor A 0.0747637
VCL vinculin 0.0731462
LOC112694756 uncharaterized LOC112694756 0.069533
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0675491
PLEC plectin 0.0639358
HIPK2 homeodomain interacting protein kinase 2 0.0622272
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0596889
SMAD3 SMAD family member 3 0.0592152
TMSB4X thymosin beta 4, X-linked 0.0587202
RPL35A ribosomal protein L35a 0.057182
HLA-A major histocompatibility complex, class I, A 0.0539777
RPL37 ribosomal protein L37 0.0528158
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0527676
PALLD palladin, cytoskeletal associated protein 0.051872
SRRM2 serine/arginine repetitive matrix 2 0.0483848
MLPH melanophilin 0.0481987
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0477385
RNF213 ring finger protein 213 0.0475449
CLIP2 CAP-GLY domain containing linker protein 2 0.0474838
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0454079
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0446977
NRP1 neuropilin 1 0.0444301
FHL2 four and a half LIM domains 2 0.044221
IFI27 interferon, alpha-inducible protein 27 0.0439315
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0429197
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0427447
LTBP1 latent transforming growth factor beta binding protein 1 0.0423755
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.042242
MT2A metallothionein 2A 0.0420796
PELO pelota homolog (Drosophila) 0.0411537
TMEM156 transmembrane protein 156 0.0410546
NPAS2 neuronal PAS domain protein 2 0.0403142
KSR1 kinase suppressor of ras 1 0.0394915
EGR1 early growth response 1 0.0386889
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0386221
OSMR oncostatin M receptor 0.038411
HSPA8 heat shock 70kDa protein 8 0.0383328
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0382237
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0379027
PDLIM5 PDZ and LIM domain 5 0.0378654
AHNAK2 AHNAK nucleoprotein 2 0.0367079
MAP1B microtubule-associated protein 1B 0.0363857
WWTR1 WW domain containing transcription regulator 1 0.0361764
SHB Src homology 2 domain containing adaptor protein B 0.0361689
RPS27 ribosomal protein S27 0.0358206
FLNA filamin A, alpha 0.0349635
NXN nucleoredoxin 0.0348576
ACTG1 actin gamma 1 0.0346624
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0338491
HLA-C major histocompatibility complex, class I, C 0.0335197
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0329699
IFI6 interferon, alpha-inducible protein 6 0.0326329
NUMA1 nuclear mitotic apparatus protein 1 0.0326002
WDR1 WD repeat domain 1 0.0325988
DST dystonin 0.0323123
STC2 stanniocalcin 2 0.0321391
YBX3 Y box binding protein 3 0.0321256
LMNA lamin A/C 0.0320765
LOC102724023 ES1 protein homolog, mitochondrial 0.03183
SDC2 syndecan 2 0.0296942
SVIL supervillin 0.0294803
MPRIP myosin phosphatase Rho interacting protein 0.0292431
RPH3AL rabphilin 3A-like (without C2 domains) 0.0292423
EIF1 eukaryotic translation initiation factor 1 0.0288729
UBASH3B ubiquitin associated and SH3 domain containing B 0.0286645
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0283099
JAG1 jagged 1 0.028264
TMSB10 thymosin beta 10 0.0275681
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0270804
NFE2L1 nuclear factor, erythroid 2-like 1 0.0269398
BSG basigin (Ok blood group) 0.0268488
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.026483
RPLP0 ribosomal protein, large, P0 0.0261672
NCOR2 nuclear receptor corepressor 2 0.0259827
TPT1 tumor protein, translationally-controlled 1 0.0256006
RPS6 ribosomal protein S6 0.0254785
SH3KBP1 SH3-domain kinase binding protein 1 0.0252466
ADAR adenosine deaminase, RNA-specific 0.0251586
ETV1 ets variant 1 0.0251042
ECE1 endothelin converting enzyme 1 0.025086
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0249762
GUK1 guanylate kinase 1 0.0246718
AGO2 argonaute RISC catalytic component 2 0.0245456
RPL11 ribosomal protein L11 0.0243462
BCL3 B-cell CLL/lymphoma 3 0.0241851
TPI1 triosephosphate isomerase 1 0.0241749
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0240492
UBE2H ubiquitin-conjugating enzyme E2H 0.023982

decreased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.136223
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116493
CXCL8 chemokine (C-X-C motif) ligand 8 -0.107809
NAMPT nicotinamide phosphoribosyltransferase -0.104497
EFNA5 ephrin-A5 -0.101041
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0847052
NRG1 neuregulin 1 -0.0828931
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0817799
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0801434
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0768565
CANX calnexin -0.0751473
UBC ubiquitin C -0.0663271
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0658631
CADM1 cell adhesion molecule 1 -0.0656936
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.062933
ZNF292 zinc finger protein 292 -0.0602803
TAS2R14 taste receptor, type 2, member 14 -0.0567154
MRPS6 mitochondrial ribosomal protein S6 -0.0559698
FNDC3B fibronectin type III domain containing 3B -0.053872
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0521496
SUCO SUN domain containing ossification factor -0.0501162
RPS27A ribosomal protein S27a -0.0499872
MBD5 methyl-CpG binding domain protein 5 -0.049933
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0474188
LCORL ligand dependent nuclear receptor corepressor-like -0.046172
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0447711
BIRC6 baculoviral IAP repeat containing 6 -0.0446347
NEK7 NIMA-related kinase 7 -0.0435876
NAP1L1 nucleosome assembly protein 1-like 1 -0.0418922
PTMA prothymosin, alpha -0.0409496
CD109 CD109 molecule -0.0385929
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0375215
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.036933
SPDYA speedy/RINGO cell cycle regulator family member A -0.0362856
HELZ helicase with zinc finger -0.036221
CALU calumenin -0.0356228
RAB1A RAB1A, member RAS oncogene family -0.0340382
FAM13A family with sequence similarity 13, member A -0.0338637
YME1L1 YME1-like 1 ATPase -0.0335392
TRIO trio Rho guanine nucleotide exchange factor -0.0334402
OGA O-GlcNAcase -0.0329632
ITGA1 integrin, alpha 1 -0.0326899
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0324627
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0322636
SPAG9 sperm associated antigen 9 -0.0320758
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0320503
TMEM165 transmembrane protein 165 -0.031515
TMEM263 transmembrane protein 263 -0.0313802
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0298548
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0293167
TM9SF3 transmembrane 9 superfamily member 3 -0.0292743
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0289825
OSBPL8 oxysterol binding protein-like 8 -0.0289691
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0289249
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.028673
PDE4D phosphodiesterase 4D, cAMP-specific -0.0285765
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.028384
TFG TRK-fused gene -0.0282802
AEBP2 AE binding protein 2 -0.0280352
SOD2 superoxide dismutase 2, mitochondrial -0.0274342
RSF1 remodeling and spacing factor 1 -0.0271058
FLNB filamin B, beta -0.0267515
PUM2 pumilio RNA-binding family member 2 -0.0264885
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0264212
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0261775
RBM39 RNA binding motif protein 39 -0.0258891
ANKRD12 ankyrin repeat domain 12 -0.0258845
GNAS GNAS complex locus -0.0257319
RYBP RING1 and YY1 binding protein -0.0256573
RAD51B RAD51 paralog B -0.0251301
RBM25 RNA binding motif protein 25 -0.0251169
TXNIP thioredoxin interacting protein -0.0249586
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0246893
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0246561
ZMYND8 zinc finger, MYND-type containing 8 -0.0245452
TM4SF1 transmembrane 4 L six family member 1 -0.0243612
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0243352
QKI QKI, KH domain containing, RNA binding -0.0242532
GOLGA4 golgin A4 -0.0242418
GPC6 glypican 6 -0.0239395
DNM1L dynamin 1-like -0.0238938
MARCHF6 membrane associated ring-CH-type finger 6 -0.0238264
PDIA3 protein disulfide isomerase family A, member 3 -0.0236694
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0235483
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0234857
LRRC23 leucine rich repeat containing 23 -0.0234685
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0232511
CDC73 cell division cycle 73 -0.0232432
PCBP2 poly(rC) binding protein 2 -0.02294
FMNL2 formin-like 2 -0.0226312
COG5 component of oligomeric golgi complex 5 -0.0225616
SNX14 sorting nexin 14 -0.0224115
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0223364
RIC1 RAB6A GEF complex partner 1 -0.0222146
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0221437
OSBPL3 oxysterol binding protein-like 3 -0.0221288
BRWD1 bromodomain and WD repeat domain containing 1 -0.0220353
MAPK8 mitogen-activated protein kinase 8 -0.0220014
HDLBP high density lipoprotein binding protein -0.0219403
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0219174