Oxaprozin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaprozin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 0.0913875
TXNIP thioredoxin interacting protein 0.0729443
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0701498
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0551268
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0516352
N4BP2L2 NEDD4 binding protein 2-like 2 0.0482738
UBC ubiquitin C 0.0445293
B2M beta-2-microglobulin 0.0432761
PGK1 phosphoglycerate kinase 1 0.0413319
DSCAM Down syndrome cell adhesion molecule 0.0409928
LIMA1 LIM domain and actin binding 1 0.0387043
RNF149 ring finger protein 149 0.0386198
CLTC clathrin, heavy chain (Hc) 0.0375634
KIF16B kinesin family member 16B 0.0373895
CANX calnexin 0.0371549
LYZ lysozyme 0.036829
WDR45B WD repeat domain 45B 0.0366951
ACBD3 acyl-CoA binding domain containing 3 0.0358291
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0351591
IGFBP3 insulin-like growth factor binding protein 3 0.0350567
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0340465
UGCG UDP-glucose ceramide glucosyltransferase 0.0338207
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0331729
FTH1 ferritin, heavy polypeptide 1 0.0327467
ESYT2 extended synaptotagmin-like protein 2 0.032118
MEF2A myocyte enhancer factor 2A 0.0305808
SEC31A SEC31 homolog A (S. cerevisiae) 0.0304712
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0304366
ERBIN erbb2 interacting protein 0.0300927
NDRG1 N-myc downstream regulated 1 0.0294954
PCBP2 poly(rC) binding protein 2 0.0287636
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0286747
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0284597
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0282946
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0279524
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0272938
NIPSNAP2 nipsnap homolog 2 0.02722
YY1 YY1 transcription factor 0.0269613
NPEPPS aminopeptidase puromycin sensitive 0.0264848
SMIM14 small integral membrane protein 14 0.026364
TM9SF3 transmembrane 9 superfamily member 3 0.0263151
ERRFI1 ERBB receptor feedback inhibitor 1 0.0262699
CEP350 centrosomal protein 350kDa 0.0258558
RPS6 ribosomal protein S6 0.0254465
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0250727
CDHR2 cadherin-related family member 2 0.0250199
SCAF11 SR-related CTD-associated factor 11 0.025017
HLA-B major histocompatibility complex, class I, B 0.0247408
COPA coatomer protein complex, subunit alpha 0.0242243
ZMYM2 zinc finger, MYM-type 2 0.0240339
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0240278
EIF1 eukaryotic translation initiation factor 1 0.0236684
IFNGR1 interferon gamma receptor 1 0.0234959
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0231929
LDHA lactate dehydrogenase A 0.0227223
TMEM51 transmembrane protein 51 0.0226744
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0223015
ARHGAP5 Rho GTPase activating protein 5 0.0219413
EPCAM epithelial cell adhesion molecule 0.0219096
PTGR1 prostaglandin reductase 1 0.0218365
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.02162
SCFD1 sec1 family domain containing 1 0.0215574
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0214706
THOC2 THO complex 2 0.0214611
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0214428
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0213486
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0213076
GRAMD2B GRAM domain containing 2B 0.020611
ZNF652 zinc finger protein 652 0.0203972
ANXA11 annexin A11 0.0201563
APOL1 apolipoprotein L, 1 0.0200466
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0199507
TSC22D1 TSC22 domain family, member 1 0.0198999
PTBP3 polypyrimidine tract binding protein 3 0.019872
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0196958
UFM1 ubiquitin-fold modifier 1 0.0196384
RPS12 ribosomal protein S12 0.0193556
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0193133
EPS8 epidermal growth factor receptor pathway substrate 8 0.0193088
RPLP0 ribosomal protein, large, P0 0.0191867
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0190093
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0189332
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0189171
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0188328
TAOK3 TAO kinase 3 0.0187866
CDCP1 CUB domain containing protein 1 0.0186155
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0185401
ZNF148 zinc finger protein 148 0.0185385
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0183167
GRB2 growth factor receptor-bound protein 2 0.0182745
DIAPH1 diaphanous-related formin 1 0.0182577
DSTN destrin (actin depolymerizing factor) 0.0182238
PLAUR plasminogen activator, urokinase receptor 0.0182171
HLA-E major histocompatibility complex, class I, E 0.0181634
SYTL3 synaptotagmin-like 3 0.0181023
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0180824
ZNF609 zinc finger protein 609 0.0180666
DNM2 dynamin 2 0.0178844
MON2 MON2 homolog (S. cerevisiae) 0.0177703
PNRC1 proline-rich nuclear receptor coactivator 1 0.017727

decreased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.178166
INTS6 integrator complex subunit 6 -0.159956
LMO7 LIM domain 7 -0.103048
SQSTM1 sequestosome 1 -0.0988263
GMDS GDP-mannose 4,6-dehydratase -0.0949876
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0940131
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0930243
RNF213 ring finger protein 213 -0.0899593
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.085959
SP100 SP100 nuclear antigen -0.0850969
VCL vinculin -0.0813476
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0810448
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0792693
RIGI RNA sensor RIG-I -0.0726236
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0694357
ANXA2 annexin A2 -0.0689567
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0656611
ARHGAP26 Rho GTPase activating protein 26 -0.064498
LCN2 lipocalin 2 -0.0571768
EPHB2 EPH receptor B2 -0.0564212
EPSTI1 epithelial stromal interaction 1 (breast) -0.0562935
NKD1 naked cuticle homolog 1 (Drosophila) -0.0535813
RUNX1 runt-related transcription factor 1 -0.0535729
IGF1R insulin-like growth factor 1 receptor -0.0517669
PLSCR2 phospholipid scramblase 2 -0.0517214
EFNB2 ephrin-B2 -0.0508123
ANKRD10 ankyrin repeat domain 10 -0.0506734
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0498177
MYO1E myosin IE -0.0476732
PLSCR1 phospholipid scramblase 1 -0.0448083
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.043986
RABGAP1L RAB GTPase activating protein 1-like -0.0432972
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0410327
ATP11A ATPase, class VI, type 11A -0.0409141
LPP LIM domain containing preferred translocation partner in lipoma -0.040648
CATSPERB catsper channel auxiliary subunit beta -0.0405835
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0400671
XAF1 XIAP associated factor 1 -0.0396723
MSI2 musashi RNA-binding protein 2 -0.0393493
SERINC5 serine incorporator 5 -0.0370726
MECOM MDS1 and EVI1 complex locus -0.037057
TRIO trio Rho guanine nucleotide exchange factor -0.0368713
RNF43 ring finger protein 43 -0.0368134
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.036375
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0360382
EXT1 exostosin glycosyltransferase 1 -0.0359171
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0342081
MX2 MX dynamin-like GTPase 2 -0.0341413
GCLC glutamate-cysteine ligase, catalytic subunit -0.0341025
IRF1 interferon regulatory factor 1 -0.0327918
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0325204
NCKAP5 NCK-associated protein 5 -0.0324595
SHB Src homology 2 domain containing adaptor protein B -0.0322191
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0322036
MAP7 microtubule-associated protein 7 -0.0322027
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0315162
SMAD3 SMAD family member 3 -0.0310311
NRIP1 nuclear receptor interacting protein 1 -0.0306948
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0306929
NCALD neurocalcin delta -0.0304277
SYT1 synaptotagmin I -0.0303525
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0301677
HDAC4 histone deacetylase 4 -0.0298669
BTBD9 BTB (POZ) domain containing 9 -0.0296606
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0295437
NABP1 nucleic acid binding protein 1 -0.0294255
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0292399
USP15 ubiquitin specific peptidase 15 -0.0291549
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0289787
PRKCA protein kinase C, alpha -0.0289153
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0285732
WWOX WW domain containing oxidoreductase -0.0285516
EGR1 early growth response 1 -0.0283371
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0280988
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0278139
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0276476
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0275414
TSHZ2 teashirt zinc finger homeobox 2 -0.0275353
FBXO39 F-box protein 39 -0.0272802
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0268856
SPATA13 spermatogenesis associated 13 -0.0264843
MX1 MX dynamin-like GTPase 1 -0.0264238
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0262739
EZR ezrin -0.0260571
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.0259977
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0258026
MYH9 myosin, heavy chain 9, non-muscle -0.0257699
RPL23 ribosomal protein L23 -0.0255799
POF1B premature ovarian failure, 1B -0.0253983
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0252214
LAMB3 laminin, beta 3 -0.0250347
NPSR1 neuropeptide S receptor 1 -0.0246629
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -0.0246542
RFC3 replication factor C (activator 1) 3, 38kDa -0.0243547
IFI6 interferon, alpha-inducible protein 6 -0.023908
IRS2 insulin receptor substrate 2 -0.023628
CENPP centromere protein P -0.0236246
ARL15 ADP-ribosylation factor-like 15 -0.0235475
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0233887
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0227198