| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Oxaprozin perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Oxaprozin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.125736 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.113721 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0878166 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0739651 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0573109 |
| INSIG2 | insulin induced gene 2 | 0.0534685 |
| CPE | carboxypeptidase E | 0.0481534 |
| TF | transferrin | 0.0452835 |
| NDRG1 | N-myc downstream regulated 1 | 0.0451858 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0419737 |
| RPL37A | ribosomal protein L37a | 0.0413789 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.040649 |
| AHSG | alpha-2-HS-glycoprotein | 0.0402721 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0390962 |
| RPS6 | ribosomal protein S6 | 0.0384395 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.038121 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0371165 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0368025 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0356914 |
| DTNA | dystrobrevin, alpha | 0.0354212 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0352371 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0337709 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0332891 |
| PCBP2 | poly(rC) binding protein 2 | 0.0323121 |
| VEGFA | vascular endothelial growth factor A | 0.0310524 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0296431 |
| APOA1 | apolipoprotein A-I | 0.0278703 |
| RPL31 | ribosomal protein L31 | 0.0277932 |
| APOE | apolipoprotein E | 0.0273181 |
| PDE8A | phosphodiesterase 8A | 0.0269267 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0268553 |
| FTL | ferritin, light polypeptide | 0.0264654 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0263459 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0259719 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0256127 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0254718 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0249139 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0244711 |
| FAM13A | family with sequence similarity 13, member A | 0.0243707 |
| PLIN2 | perilipin 2 | 0.0242589 |
| MYO6 | myosin VI | 0.0241829 |
| ENO1 | enolase 1, (alpha) | 0.0233408 |
| RYBP | RING1 and YY1 binding protein | 0.0231333 |
| RPL5 | ribosomal protein L5 | 0.022911 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0228906 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0226039 |
| RPS3 | ribosomal protein S3 | 0.0223673 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0222281 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0222052 |
| HELZ | helicase with zinc finger | 0.0222024 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0216118 |
| WDR45B | WD repeat domain 45B | 0.0213481 |
| FMNL2 | formin-like 2 | 0.0212995 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0209104 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0206402 |
| LDHA | lactate dehydrogenase A | 0.0206226 |
| RPS29 | ribosomal protein S29 | 0.0202289 |
| RPL11 | ribosomal protein L11 | 0.0201982 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0199935 |
| RNF145 | ring finger protein 145 | 0.0197992 |
| RPS13 | ribosomal protein S13 | 0.0197195 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0197146 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0193579 |
| KIF1B | kinesin family member 1B | 0.0192495 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0191501 |
| GDF15 | growth differentiation factor 15 | 0.018981 |
| NGLY1 | N-glycanase 1 | 0.0187906 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0186271 |
| SPAG9 | sperm associated antigen 9 | 0.0181011 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.017962 |
| ZNF292 | zinc finger protein 292 | 0.0179263 |
| RPL7A | ribosomal protein L7a | 0.0179141 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0177791 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0177395 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0177345 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.016875 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0166946 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0161975 |
| QKI | QKI, KH domain containing, RNA binding | 0.0158103 |
| FBXO42 | F-box protein 42 | 0.0157074 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0157059 |
| CRY1 | cryptochrome circadian clock 1 | 0.0156875 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0156222 |
| SRP54 | signal recognition particle 54kDa | 0.0156108 |
| SETD5 | SET domain containing 5 | 0.0155322 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0154458 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0154256 |
| GOLGA4 | golgin A4 | 0.0154113 |
| EFNA1 | ephrin-A1 | 0.0154042 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0153789 |
| B2M | beta-2-microglobulin | 0.0152718 |
| USP47 | ubiquitin specific peptidase 47 | 0.0149694 |
| RPS8 | ribosomal protein S8 | 0.0149684 |
| RPS12 | ribosomal protein S12 | 0.0149541 |
| FAM162A | family with sequence similarity 162, member A | 0.0148209 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0145668 |
| AFDN | afadin, adherens junction formation factor | 0.0144761 |
| DSCAM | Down syndrome cell adhesion molecule | 0.014452 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0144124 |
| OPTN | optineurin | 0.014398 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.143523 |
| EHBP1 | EH domain binding protein 1 | -0.123102 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.106958 |
| GPC6 | glypican 6 | -0.0878708 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0849445 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.08108 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0766627 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0745843 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.071844 |
| APOB | apolipoprotein B | -0.0716798 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0710855 |
| FRMD5 | FERM domain containing 5 | -0.0627945 |
| GPC3 | glypican 3 | -0.0626666 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.062357 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0584064 |
| VCL | vinculin | -0.0582895 |
| SLC38A2 | solute carrier family 38, member 2 | -0.054299 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0540658 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0539392 |
| RNF213 | ring finger protein 213 | -0.0494795 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0487614 |
| PEG3 | paternally expressed 3 | -0.0470316 |
| ITGAV | integrin, alpha V | -0.0469111 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0464845 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0457345 |
| DSPP | dentin sialophosphoprotein | -0.0429991 |
| ATXN1 | ataxin 1 | -0.0417596 |
| DST | dystonin | -0.0409093 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0402619 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0396978 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0380491 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.037936 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0374153 |
| PTCHD4 | patched domain containing 4 | -0.036867 |
| RIGI | RNA sensor RIG-I | -0.035877 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0352685 |
| CNKSR3 | CNKSR family member 3 | -0.0350396 |
| FAT1 | FAT atypical cadherin 1 | -0.034553 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0341878 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0338177 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.033763 |
| SVIL | supervillin | -0.0322671 |
| EGR1 | early growth response 1 | -0.0315744 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0311711 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0309942 |
| OSMR | oncostatin M receptor | -0.0298265 |
| RRBP1 | ribosome binding protein 1 | -0.0296747 |
| BCL2L1 | BCL2-like 1 | -0.0295964 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0293567 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0292256 |
| FOXP1 | forkhead box P1 | -0.0290321 |
| ASPH | aspartate beta-hydroxylase | -0.0290078 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0287357 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0286195 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0285345 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0275174 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0273656 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0271358 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0262308 |
| H1-0 | H1.0 linker histone | -0.0259322 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0258145 |
| TMSB10 | thymosin beta 10 | -0.0257091 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0255546 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0254175 |
| NHSL1 | NHS-like 1 | -0.0253273 |
| KIAA1217 | KIAA1217 | -0.0249696 |
| PARD3 | par-3 family cell polarity regulator | -0.0248505 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0247891 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.024741 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0245079 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0244731 |
| KRT23 | keratin 23, type I | -0.0242903 |
| TMEM123 | transmembrane protein 123 | -0.0241417 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0236569 |
| ACTN4 | actinin, alpha 4 | -0.0235079 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0232596 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0232271 |
| FAM107B | family with sequence similarity 107, member B | -0.0231299 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0223745 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0223493 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0222039 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0221683 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0221472 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0221456 |
| LAMA4 | laminin, alpha 4 | -0.0219317 |
| ATP10A | ATPase, class V, type 10A | -0.0218739 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0210795 |
| VCAN | versican | -0.0208437 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.020762 |
| A2M | alpha-2-macroglobulin | -0.0207308 |
| STK39 | serine threonine kinase 39 | -0.0204851 |
| MX2 | MX dynamin-like GTPase 2 | -0.0202403 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.020155 |
| AK1 | adenylate kinase 1 | -0.0201255 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0201255 |
| FERMT1 | fermitin family member 1 | -0.0199892 |
| ITGB5 | integrin, beta 5 | -0.0198612 |
| RUNX1 | runt-related transcription factor 1 | -0.0198126 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0197237 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0194041 |
