Oxaprozin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaprozin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.114346
NAMPT nicotinamide phosphoribosyltransferase 0.0699445
FAM13A family with sequence similarity 13, member A 0.0451669
SPAG9 sperm associated antigen 9 0.0448691
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0392258
NGLY1 N-glycanase 1 0.0384176
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0351136
RICTOR RPTOR independent companion of MTOR, complex 2 0.035068
ADAM17 ADAM metallopeptidase domain 17 0.031087
SOD2 superoxide dismutase 2, mitochondrial 0.0302975
ELL2 elongation factor, RNA polymerase II, 2 0.0291888
PGK1 phosphoglycerate kinase 1 0.0290748
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0279675
KMT2E lysine (K)-specific methyltransferase 2E 0.0261714
ARRDC3 arrestin domain containing 3 0.0255543
UVRAG UV radiation resistance associated 0.0249954
TPD52 tumor protein D52 0.0248541
GSK3B glycogen synthase kinase 3 beta 0.024614
TOP1 topoisomerase (DNA) I 0.0244589
OGA O-GlcNAcase 0.0243228
UBA6 ubiquitin-like modifier activating enzyme 6 0.0241473
HELZ helicase with zinc finger 0.0234041
ATP13A3 ATPase type 13A3 0.0223527
RNF145 ring finger protein 145 0.0221519
USP9X ubiquitin specific peptidase 9, X-linked 0.0218649
ZC3H11A zinc finger CCCH-type containing 11A 0.0216698
PUM2 pumilio RNA-binding family member 2 0.0210425
KCMF1 potassium channel modulatory factor 1 0.0208521
CAMTA1 calmodulin binding transcription activator 1 0.0203551
TMEM165 transmembrane protein 165 0.0202603
ERRFI1 ERBB receptor feedback inhibitor 1 0.0200975
TXNRD1 thioredoxin reductase 1 0.0199458
TSC22D2 TSC22 domain family, member 2 0.0198141
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0197672
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0195199
KDM6A lysine (K)-specific demethylase 6A 0.0192708
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0191437
NUP58 nucleoporin 58 0.0191333
RNMT RNA (guanine-7-) methyltransferase 0.0191301
WDR45B WD repeat domain 45B 0.018838
MATR3 matrin 3 0.0183678
PRRC2C proline-rich coiled-coil 2C 0.0181104
LMO7 LIM domain 7 0.0179074
ECT2 epithelial cell transforming 2 0.0178198
BRWD1 bromodomain and WD repeat domain containing 1 0.0174958
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0173641
MXI1 MAX interactor 1, dimerization protein 0.0173533
STRN3 striatin, calmodulin binding protein 3 0.0171922
NPTN neuroplastin 0.0170478
ANKRD10 ankyrin repeat domain 10 0.0169662
NCKAP1 NCK-associated protein 1 0.0168621
PCBP2 poly(rC) binding protein 2 0.016777
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0166054
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0165619
ZFC3H1 zinc finger, C3H1-type containing 0.016418
USP3 ubiquitin specific peptidase 3 0.0160145
BRWD3 bromodomain and WD repeat domain containing 3 0.0156967
ANO6 anoctamin 6 0.0155668
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0154677
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0152897
SLMAP sarcolemma associated protein 0.0152738
MKI67 marker of proliferation Ki-67 0.0150853
SEPTIN2 septin 2 0.0148714
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0148296
RAP1B RAP1B, member of RAS oncogene family 0.0146533
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0146019
SUCO SUN domain containing ossification factor 0.0145939
CYLD cylindromatosis (turban tumor syndrome) 0.0142944
KDM2A lysine (K)-specific demethylase 2A 0.0142054
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0140932
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0140072
RLF rearranged L-myc fusion 0.0139294
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0137128
CSNK1A1 casein kinase 1, alpha 1 0.0136602
TFG TRK-fused gene 0.0136151
ARL8B ADP-ribosylation factor-like 8B 0.0136057
VEZT vezatin, adherens junctions transmembrane protein 0.0136011
INSIG2 insulin induced gene 2 0.0134641
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0134632
MARF1 meiosis regulator and mRNA stability factor 1 0.0133647
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0133559
LAMC2 laminin, gamma 2 0.0133427
HOOK2 hook microtubule-tethering protein 2 0.0133157
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0132747
RUNX1 runt-related transcription factor 1 0.0132411
DSCAM Down syndrome cell adhesion molecule 0.0132339
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0132217
WAC WW domain containing adaptor with coiled-coil 0.0131744
RAB6A RAB6A, member RAS oncogene family 0.0130604
YEATS2 YEATS domain containing 2 0.0130387
ANXA5 annexin A5 0.0129883
TENT2 terminal nucleotidyltransferase 2 0.0129382
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0127675
H1-0 H1.0 linker histone 0.0127288
PDE8A phosphodiesterase 8A 0.0127213
KDM3A lysine (K)-specific demethylase 3A 0.0123506
TM9SF2 transmembrane 9 superfamily member 2 0.0122846
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0121241
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0121198
KDM5B lysine (K)-specific demethylase 5B 0.0120572

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.132059
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13084
TMSB10 thymosin beta 10 -0.0559823
MT2A metallothionein 2A -0.0468491
THSD4 thrombospondin, type I, domain containing 4 -0.040518
EGR1 early growth response 1 -0.0342989
INTS6 integrator complex subunit 6 -0.0314713
S100A10 S100 calcium binding protein A10 -0.0307486
RPLP1 ribosomal protein, large, P1 -0.0297518
ACTG1 actin gamma 1 -0.0294
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0271576
RPL35A ribosomal protein L35a -0.0260534
CST3 cystatin C -0.0250024
FTH1 ferritin, heavy polypeptide 1 -0.0243611
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0240585
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0237184
ASPH aspartate beta-hydroxylase -0.0234462
RPS25 ribosomal protein S25 -0.0233651
RNF213 ring finger protein 213 -0.021882
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0218226
MCL1 myeloid cell leukemia 1 -0.0213143
RPL37A ribosomal protein L37a -0.0208657
EFNA5 ephrin-A5 -0.020854
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0199425
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0195116
RPS8 ribosomal protein S8 -0.019014
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0188788
TPT1 tumor protein, translationally-controlled 1 -0.018819
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0184881
EXT1 exostosin glycosyltransferase 1 -0.0184494
RPS6 ribosomal protein S6 -0.0182215
RAD51B RAD51 paralog B -0.0181194
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0180667
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0176738
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0173144
RPL34 ribosomal protein L34 -0.0173062
RPL31 ribosomal protein L31 -0.0170611
FTL ferritin, light polypeptide -0.0168696
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0167764
RPS23 ribosomal protein S23 -0.0164258
IFI6 interferon, alpha-inducible protein 6 -0.0162442
NABP1 nucleic acid binding protein 1 -0.0162249
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0158053
RPL11 ribosomal protein L11 -0.0156539
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0151271
SCEL sciellin -0.0149746
RPS12 ribosomal protein S12 -0.014891
RPS29 ribosomal protein S29 -0.014714
CCSER1 coiled-coil serine-rich protein 1 -0.0146375
GRAMD1B GRAM domain containing 1B -0.0146094
S100P S100 calcium binding protein P -0.0145876
FOXP1 forkhead box P1 -0.0145735
CCND1 cyclin D1 -0.0144376
KRT7 keratin 7, type II -0.0143174
RPL23 ribosomal protein L23 -0.0142229
RPS27A ribosomal protein S27a -0.0140602
RPLP2 ribosomal protein, large, P2 -0.0139368
TNS3 tensin 3 -0.0138674
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0138262
SP100 SP100 nuclear antigen -0.0137458
SEC61G Sec61 gamma subunit -0.0136443
HLA-B major histocompatibility complex, class I, B -0.0135396
RPL19 ribosomal protein L19 -0.0134859
SLC38A2 solute carrier family 38, member 2 -0.0133845
IGFBP3 insulin-like growth factor binding protein 3 -0.0133548
RPS3 ribosomal protein S3 -0.0132405
RPS27 ribosomal protein S27 -0.0131917
CUX1 cut-like homeobox 1 -0.0131197
RPS24 ribosomal protein S24 -0.0130841
OSMR oncostatin M receptor -0.0129651
CMIP c-Maf inducing protein -0.0129545
CAV1 caveolin 1, caveolae protein, 22kDa -0.0124696
AREG amphiregulin -0.0124425
LPP LIM domain containing preferred translocation partner in lipoma -0.0119214
RIMS2 regulating synaptic membrane exocytosis 2 -0.0118905
S100A11 S100 calcium binding protein A11 -0.011814
RPS13 ribosomal protein S13 -0.0117499
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.011747
PDE4D phosphodiesterase 4D, cAMP-specific -0.0117215
ZBTB20 zinc finger and BTB domain containing 20 -0.0116578
SMYD3 SET and MYND domain containing 3 -0.0115331
RPS17 ribosomal protein S17 -0.0115173
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.011387
LOC112694756 uncharaterized LOC112694756 -0.0113729
VCL vinculin -0.011365
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0112507
RPL37 ribosomal protein L37 -0.0112133
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0111966
HMGA1 high mobility group AT-hook 1 -0.0110037
RPL30 ribosomal protein L30 -0.0108729
PDLIM5 PDZ and LIM domain 5 -0.0107742
RPS14 ribosomal protein S14 -0.0107626
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0107265
PTPRM protein tyrosine phosphatase, receptor type, M -0.0106514
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0106399
RPL36 ribosomal protein L36 -0.0104995
NTSR1 neurotensin receptor 1 (high affinity) -0.0104922
CEMIP cell migration inducing protein, hyaluronan binding -0.0104568
RPS16 ribosomal protein S16 -0.0103233
BPTF bromodomain PHD finger transcription factor -0.0103068