Oxaprozin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaprozin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.115888
TXNRD1 thioredoxin reductase 1 0.102242
GRAMD1B GRAM domain containing 1B 0.0782185
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0767991
AKAP12 A kinase (PRKA) anchor protein 12 0.0741895
WDR43 WD repeat domain 43 0.0734472
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0672267
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0650735
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0639684
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0590814
TPD52 tumor protein D52 0.053506
RBM39 RNA binding motif protein 39 0.0531343
ZFAND3 zinc finger, AN1-type domain 3 0.0501786
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.049758
USP3 ubiquitin specific peptidase 3 0.0484877
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0480858
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0477306
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0470173
TM4SF1 transmembrane 4 L six family member 1 0.0455273
RTN4 reticulon 4 0.0441632
ERBIN erbb2 interacting protein 0.0438514
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.042954
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0416637
CHN1 chimerin 1 0.0415712
YME1L1 YME1-like 1 ATPase 0.0411346
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0406808
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0402232
PAWR PRKC, apoptosis, WT1, regulator 0.0400553
RBM25 RNA binding motif protein 25 0.0396611
YBX3 Y box binding protein 3 0.0387025
VMP1 vacuole membrane protein 1 0.0384323
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0382575
ERRFI1 ERBB receptor feedback inhibitor 1 0.0380828
TPM3 tropomyosin 3 0.0378153
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0377494
FAM168A family with sequence similarity 168, member A 0.037677
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0374324
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0373057
PTK2 protein tyrosine kinase 2 0.0369634
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0369165
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0368117
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0365781
UGCG UDP-glucose ceramide glucosyltransferase 0.0365315
NAMPT nicotinamide phosphoribosyltransferase 0.0364194
RICTOR RPTOR independent companion of MTOR, complex 2 0.0363227
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0358313
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0355253
PFDN2 prefoldin subunit 2 0.0354827
NOP58 NOP58 ribonucleoprotein 0.0353928
TPX2 TPX2, microtubule-associated 0.0352792
MEMO1 mediator of cell motility 1 0.0351007
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0345944
ECT2 epithelial cell transforming 2 0.0340279
PDIA6 protein disulfide isomerase family A, member 6 0.0338941
RASAL2 RAS protein activator like 2 0.0338772
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0337399
PITPNB phosphatidylinositol transfer protein, beta 0.0331587
RHEB Ras homolog enriched in brain 0.0331154
MORF4L1 mortality factor 4 like 1 0.0330456
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0326558
INO80 INO80 complex subunit 0.0326099
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0322906
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0320174
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.031832
NUP58 nucleoporin 58 0.0315964
FMNL2 formin-like 2 0.0315326
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0311861
AFTPH aftiphilin 0.0311203
MATR3 matrin 3 0.0309849
RHOA ras homolog family member A 0.0309395
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0309181
RAD21 RAD21 homolog (S. pombe) 0.0307253
CYRIB CYFIP related Rac1 interactor B 0.0300487
PLS3 plastin 3 0.0299761
ANKRD28 ankyrin repeat domain 28 0.0298853
KLF6 Kruppel-like factor 6 0.02896
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0288741
NCEH1 neutral cholesterol ester hydrolase 1 0.0286352
FGB fibrinogen beta chain 0.0285155
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0284533
MARCHF6 membrane associated ring-CH-type finger 6 0.028391
RBM8A RNA binding motif protein 8A 0.0282551
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0282486
MTF2 metal response element binding transcription factor 2 0.0281971
CASC3 cancer susceptibility candidate 3 0.0275555
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0272542
BCLAF1 BCL2-associated transcription factor 1 0.0270302
NOL10 nucleolar protein 10 0.0266977
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0265238
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0264276
ABI1 abl-interactor 1 0.0263855
ILF2 interleukin enhancer binding factor 2 0.0261129
PUM1 pumilio RNA-binding family member 1 0.0260909
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.026082
GTPBP4 GTP binding protein 4 0.0257548
SLC38A1 solute carrier family 38, member 1 0.0257011
MRTFA myocardin related transcription factor A 0.02555
TMEM123 transmembrane protein 123 0.0254991
ADAM9 ADAM metallopeptidase domain 9 0.0254845
QKI QKI, KH domain containing, RNA binding 0.0252621

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.243804
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.143567
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0985693
PDE4D phosphodiesterase 4D, cAMP-specific -0.0888051
RPL23 ribosomal protein L23 -0.0707661
RAD51B RAD51 paralog B -0.059706
RPLP1 ribosomal protein, large, P1 -0.0462817
FTL ferritin, light polypeptide -0.0453715
SMOC1 SPARC related modular calcium binding 1 -0.0427652
KYNU kynureninase -0.0414672
TMSB10 thymosin beta 10 -0.0405225
RPS8 ribosomal protein S8 -0.0385809
NNMT nicotinamide N-methyltransferase -0.0373323
CXCL8 chemokine (C-X-C motif) ligand 8 -0.035189
WWOX WW domain containing oxidoreductase -0.0351781
RPS19 ribosomal protein S19 -0.0333449
RPL31 ribosomal protein L31 -0.0330024
VIM vimentin -0.0323944
FTH1 ferritin, heavy polypeptide 1 -0.0321432
EIF1 eukaryotic translation initiation factor 1 -0.0319532
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0319185
RPS25 ribosomal protein S25 -0.0315007
HLA-B major histocompatibility complex, class I, B -0.03141
RPL9 ribosomal protein L9 -0.0301595
EXOC6B exocyst complex component 6B -0.0291308
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.029106
RPL19 ribosomal protein L19 -0.029097
INTS6 integrator complex subunit 6 -0.0288906
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0287327
SAMD4A sterile alpha motif domain containing 4A -0.0283848
SOD2 superoxide dismutase 2, mitochondrial -0.0281467
C15ORF48 chromosome 15 open reading frame 48 -0.0271961
BIRC3 baculoviral IAP repeat containing 3 -0.0270354
TPT1 tumor protein, translationally-controlled 1 -0.0267041
ATXN1 ataxin 1 -0.0266025
RPL35A ribosomal protein L35a -0.0265985
GOLGB1 golgin B1 -0.0261639
PM20D1 peptidase M20 domain containing 1 -0.0258856
PCNX4 pecanex 4 -0.0252128
RPS20 ribosomal protein S20 -0.0246843
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0245771
ALCAM activated leukocyte cell adhesion molecule -0.0243154
PARD3B par-3 family cell polarity regulator beta -0.0237819
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0232464
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0231429
LRMDA leucine rich melanocyte differentiation associated -0.0228556
AKAP9 A kinase (PRKA) anchor protein 9 -0.022568
BICC1 BicC family RNA binding protein 1 -0.0222074
CCDC88A coiled-coil domain containing 88A -0.0213237
HMGA2 high mobility group AT-hook 2 -0.0212516
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0209912
S100A10 S100 calcium binding protein A10 -0.0205736
NF1 neurofibromin 1 -0.0202482
ASPH aspartate beta-hydroxylase -0.0199785
BCAS3 breast carcinoma amplified sequence 3 -0.0198463
RPS17 ribosomal protein S17 -0.0198358
RPL28 ribosomal protein L28 -0.019824
MORF4L2 mortality factor 4 like 2 -0.0198144
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0197101
RACK1 receptor for activated C kinase 1 -0.0194433
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0192398
LDHA lactate dehydrogenase A -0.0192116
GLIS3 GLIS family zinc finger 3 -0.0190134
PATJ PATJ crumbs cell polarity complex component -0.0189621
CCL5 chemokine (C-C motif) ligand 5 -0.0189007
CCL2 chemokine (C-C motif) ligand 2 -0.0186368
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0186353
RPL34 ribosomal protein L34 -0.0182545
SPDYA speedy/RINGO cell cycle regulator family member A -0.0182301
RPL37A ribosomal protein L37a -0.0181327
ANKRD12 ankyrin repeat domain 12 -0.0181031
NEBL nebulette -0.0180208
NHSL1 NHS-like 1 -0.0178407
MBD5 methyl-CpG binding domain protein 5 -0.0178324
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0178293
TAS2R14 taste receptor, type 2, member 14 -0.017749
EFNA5 ephrin-A5 -0.0177471
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0176731
TRAPPC9 trafficking protein particle complex 9 -0.0176453
KANSL1L KAT8 regulatory NSL complex subunit 1-like -0.017268
EHBP1 EH domain binding protein 1 -0.0172491
RPL36 ribosomal protein L36 -0.017148
TRIP11 thyroid hormone receptor interactor 11 -0.0170994
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0170314
RPL36AL ribosomal protein L36a-like -0.0166381
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0166225
USP34 ubiquitin specific peptidase 34 -0.016482
FAM177A1 family with sequence similarity 177, member A1 -0.0164383
SNX14 sorting nexin 14 -0.0160805
LOC102724023 ES1 protein homolog, mitochondrial -0.0159615
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0158878
CDK13 cyclin-dependent kinase 13 -0.0157136
ACTN1 actinin, alpha 1 -0.015649
STK17A serine/threonine kinase 17a -0.0156276
UBB ubiquitin B -0.0155544
EGFR epidermal growth factor receptor -0.0155316
RPL37 ribosomal protein L37 -0.0153936
TPM1 tropomyosin 1 (alpha) -0.0153914
PTPRM protein tyrosine phosphatase, receptor type, M -0.0153099
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.015003