Oxaprozin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaprozin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.154327
AKAP12 A kinase (PRKA) anchor protein 12 0.117842
TXNRD1 thioredoxin reductase 1 0.0853606
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0770345
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0721778
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0691974
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0642237
COPA coatomer protein complex, subunit alpha 0.060058
CSNK1A1 casein kinase 1, alpha 1 0.055331
ATXN2 ataxin 2 0.054833
TAS2R14 taste receptor, type 2, member 14 0.0537735
ZCCHC7 zinc finger, CCHC domain containing 7 0.0510817
ZNF638 zinc finger protein 638 0.0495665
MACF1 microtubule-actin crosslinking factor 1 0.0489896
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.048412
USP34 ubiquitin specific peptidase 34 0.0477303
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0463758
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0461709
RAD51B RAD51 paralog B 0.0461524
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0447726
TRIO trio Rho guanine nucleotide exchange factor 0.0441549
NF1 neurofibromin 1 0.0437833
OGA O-GlcNAcase 0.0436005
ANO6 anoctamin 6 0.0435057
YBX3 Y box binding protein 3 0.0434299
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0422912
ESYT2 extended synaptotagmin-like protein 2 0.0422711
SAMD4A sterile alpha motif domain containing 4A 0.0421639
RBM39 RNA binding motif protein 39 0.0420572
FAM168A family with sequence similarity 168, member A 0.0407141
FBXO11 F-box protein 11 0.0398831
KDM2A lysine (K)-specific demethylase 2A 0.0398809
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0392536
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0387188
TMEM41B transmembrane protein 41B 0.0372478
GRAMD1B GRAM domain containing 1B 0.0369847
EHBP1 EH domain binding protein 1 0.0369704
NBEAL1 neurobeachin-like 1 0.0363181
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0361087
CAMKMT calmodulin-lysine N-methyltransferase 0.0360088
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0358093
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0357238
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0354996
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0350848
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0346051
THOC2 THO complex 2 0.0343874
CAMTA1 calmodulin binding transcription activator 1 0.0342872
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.034013
CCND2 cyclin D2 0.0340101
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0339826
SNX14 sorting nexin 14 0.0338704
MON2 MON2 homolog (S. cerevisiae) 0.0335737
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0334187
TMEM131 transmembrane protein 131 0.0331755
AKAP9 A kinase (PRKA) anchor protein 9 0.0331313
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.032832
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0328127
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0327576
ETNK1 ethanolamine kinase 1 0.0324786
SRP54 signal recognition particle 54kDa 0.0323554
NIPBL Nipped-B homolog (Drosophila) 0.0323439
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0317711
KDM3A lysine (K)-specific demethylase 3A 0.0316983
RBM25 RNA binding motif protein 25 0.0316036
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0314242
CLIP1 CAP-GLY domain containing linker protein 1 0.031367
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0313321
PPME1 protein phosphatase methylesterase 1 0.0310565
GOLGA4 golgin A4 0.0309791
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0304832
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0304442
ZFC3H1 zinc finger, C3H1-type containing 0.0303918
FLOT1 flotillin 1 0.0302609
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.030127
RSRP1 arginine/serine-rich protein 1 0.0299794
DCAF10 DDB1 and CUL4 associated factor 10 0.0294256
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0291727
ANKRD12 ankyrin repeat domain 12 0.0291285
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0291251
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0290772
DENND1A DENN/MADD domain containing 1A 0.0290245
PFKP phosphofructokinase, platelet 0.0289309
ARHGAP5 Rho GTPase activating protein 5 0.0289063
USP9X ubiquitin specific peptidase 9, X-linked 0.0287833
ATP13A3 ATPase type 13A3 0.0286718
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0285003
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0283323
SEC31A SEC31 homolog A (S. cerevisiae) 0.0282624
SMYD3 SET and MYND domain containing 3 0.0281205
VMP1 vacuole membrane protein 1 0.0280959
PDLIM5 PDZ and LIM domain 5 0.0280452
TRIM33 tripartite motif containing 33 0.0280281
WSB1 WD repeat and SOCS box containing 1 0.0279826
MYO6 myosin VI 0.0278855
CANX calnexin 0.0273727
CTTNBP2NL CTTNBP2 N-terminal like 0.026891
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0267244
MTF2 metal response element binding transcription factor 2 0.0266485
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0265888
EIF4B eukaryotic translation initiation factor 4B 0.0265298

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0877827
TFPI2 tissue factor pathway inhibitor 2 -0.0845938
TMSB10 thymosin beta 10 -0.0672647
VIM vimentin -0.0620538
PFN1 profilin 1 -0.0579124
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0521727
SMC4 structural maintenance of chromosomes 4 -0.0462716
RPS6 ribosomal protein S6 -0.0449414
RPL35A ribosomal protein L35a -0.0447202
RPL19 ribosomal protein L19 -0.0427159
RPS8 ribosomal protein S8 -0.0404051
ATP5F1E ATP synthase F1 subunit epsilon -0.0401254
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0398487
RPL12 ribosomal protein L12 -0.0396069
KLF6 Kruppel-like factor 6 -0.0391461
RPL23 ribosomal protein L23 -0.0385549
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.037251
EIF5B eukaryotic translation initiation factor 5B -0.0360986
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0360917
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0357357
RPS19 ribosomal protein S19 -0.0353869
IFI6 interferon, alpha-inducible protein 6 -0.0347153
VDAC1 voltage-dependent anion channel 1 -0.0343151
EGR1 early growth response 1 -0.0328092
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0323744
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0322416
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0321579
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0302796
RPLP1 ribosomal protein, large, P1 -0.0302763
RPL27 ribosomal protein L27 -0.0298713
RPL26 ribosomal protein L26 -0.0293194
RPL9 ribosomal protein L9 -0.0291072
HMGB1 high mobility group box 1 -0.0287073
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0283689
RPL37 ribosomal protein L37 -0.0275459
RPL35 ribosomal protein L35 -0.0271212
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0264908
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0264609
RPS15 ribosomal protein S15 -0.0258533
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0250167
RPS17 ribosomal protein S17 -0.0246241
CELF1 CUGBP, Elav-like family member 1 -0.0245086
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0244687
YBX1 Y box binding protein 1 -0.0243818
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0241108
RPS27 ribosomal protein S27 -0.0240543
RPS10 ribosomal protein S10 -0.0239784
CLSPN claspin -0.0234811
SEPTIN7 septin 7 -0.023341
MT2A metallothionein 2A -0.0232869
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0232272
RPS29 ribosomal protein S29 -0.0227229
MYL12B myosin, light chain 12B, regulatory -0.0224006
TMEM245 transmembrane protein 245 -0.0223826
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.02231
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.02222
ZNFX1 zinc finger, NFX1-type containing 1 -0.0218771
RPS16 ribosomal protein S16 -0.0218763
RPS4X ribosomal protein S4, X-linked -0.0216337
PDIA6 protein disulfide isomerase family A, member 6 -0.0213457
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0212128
SON SON DNA binding protein -0.0210987
RPL28 ribosomal protein L28 -0.0209362
CALR calreticulin -0.020745
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0207286
FOXP1 forkhead box P1 -0.0206962
RPL31 ribosomal protein L31 -0.0204705
H3-3B H3.3 histone B -0.0202647
EEF2 eukaryotic translation elongation factor 2 -0.0202489
POTEF POTE ankyrin domain family, member F -0.0202458
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0199076
PTMS parathymosin -0.0198472
RPL32 ribosomal protein L32 -0.0194171
RPS25 ribosomal protein S25 -0.0192152
RPL18 ribosomal protein L18 -0.0192102
RPL34 ribosomal protein L34 -0.0189233
MAP1B microtubule-associated protein 1B -0.0187592
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.018644
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0186161
FUS FUS RNA binding protein -0.0185705
CCND1 cyclin D1 -0.0185569
TNRC6B trinucleotide repeat containing 6B -0.0185064
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0184644
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0182394
RAD50 RAD50 homolog (S. cerevisiae) -0.018236
RPS21 ribosomal protein S21 -0.0180869
EPAS1 endothelial PAS domain protein 1 -0.0178803
DIAPH3 diaphanous-related formin 3 -0.0178535
EGFR epidermal growth factor receptor -0.0178273
EIF3J eukaryotic translation initiation factor 3, subunit J -0.0177812
RECQL RecQ helicase-like -0.0177693
SENP6 SUMO1/sentrin specific peptidase 6 -0.0177418
TAGLN2 transgelin 2 -0.0177226
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0176226
PMP22 peripheral myelin protein 22 -0.0176132
RTN4 reticulon 4 -0.0175888
WDR70 WD repeat domain 70 -0.0175878
HMGA1 high mobility group AT-hook 1 -0.0175559
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0175234
SCFD1 sec1 family domain containing 1 -0.0174276