Oxaprozin_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaprozin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.0634338
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0579347
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0506044
ASPH aspartate beta-hydroxylase 0.0503254
FAM13A family with sequence similarity 13, member A 0.0450313
FXR1 fragile X mental retardation, autosomal homolog 1 0.0404732
RNF145 ring finger protein 145 0.0398898
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0392048
FNDC3B fibronectin type III domain containing 3B 0.0362334
GRB10 growth factor receptor-bound protein 10 0.0353133
ADAM9 ADAM metallopeptidase domain 9 0.035181
UBA6 ubiquitin-like modifier activating enzyme 6 0.0342167
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0339995
PCBP2 poly(rC) binding protein 2 0.0332802
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0327107
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0323904
NAMPT nicotinamide phosphoribosyltransferase 0.0316388
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.030789
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0303343
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0297904
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0296529
ZNF292 zinc finger protein 292 0.0283069
KMT2E lysine (K)-specific methyltransferase 2E 0.0276773
TFG TRK-fused gene 0.0270116
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0257766
PGK1 phosphoglycerate kinase 1 0.0257732
GARS1 glycyl-tRNA synthetase 1 0.0257484
MARCHF6 membrane associated ring-CH-type finger 6 0.0254438
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0252334
CCNL1 cyclin L1 0.0250425
CDC73 cell division cycle 73 0.0241624
DSTN destrin (actin depolymerizing factor) 0.0232699
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0231187
MXD1 MAX dimerization protein 1 0.0230863
NUP58 nucleoporin 58 0.0230021
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0228348
PUM1 pumilio RNA-binding family member 1 0.0228273
GPBP1 GC-rich promoter binding protein 1 0.0224373
COPA coatomer protein complex, subunit alpha 0.0220847
BHLHE40 basic helix-loop-helix family, member e40 0.0215887
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0215092
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0213881
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0212389
PAPOLA poly(A) polymerase alpha 0.0212237
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0211978
QKI QKI, KH domain containing, RNA binding 0.0208803
HMGB2 high mobility group box 2 0.0205874
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.020583
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0204534
SSBP2 single-stranded DNA binding protein 2 0.0199482
PLAU plasminogen activator, urokinase 0.0199014
PTK2 protein tyrosine kinase 2 0.019694
NPEPPS aminopeptidase puromycin sensitive 0.0196196
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0193545
ATP13A3 ATPase type 13A3 0.01889
USP3 ubiquitin specific peptidase 3 0.0187722
SPAG9 sperm associated antigen 9 0.0185784
MATR3 matrin 3 0.0182589
LDHA lactate dehydrogenase A 0.0182063
NCKAP1 NCK-associated protein 1 0.0180736
PRRC1 proline-rich coiled-coil 1 0.0179966
WAC WW domain containing adaptor with coiled-coil 0.0178567
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0176449
RLF rearranged L-myc fusion 0.017453
KDM5B lysine (K)-specific demethylase 5B 0.0167741
MYO6 myosin VI 0.0167075
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0166502
AZIN1 antizyme inhibitor 1 0.0166225
RYBP RING1 and YY1 binding protein 0.0164919
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0164828
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0164719
APLP2 amyloid beta (A4) precursor-like protein 2 0.0163436
MSMO1 methylsterol monooxygenase 1 0.0163298
SEC23A Sec23 homolog A (S. cerevisiae) 0.0159847
ANXA5 annexin A5 0.0156255
RAD21 RAD21 homolog (S. pombe) 0.0155962
MBNL1 muscleblind-like splicing regulator 1 0.0153706
MTMR3 myotubularin related protein 3 0.0152819
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0149031
TPM3 tropomyosin 3 0.0148087
MSN moesin 0.014801
CD109 CD109 molecule 0.0147886
KDM6A lysine (K)-specific demethylase 6A 0.0147591
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0144637
RHEB Ras homolog enriched in brain 0.0143891
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0141674
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0140491
DDIT4 DNA-damage-inducible transcript 4 0.0140381
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0137155
PDLIM5 PDZ and LIM domain 5 0.013638
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0135875
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0135042
GRID1 glutamate receptor, ionotropic, delta 1 0.0134093
KDM3A lysine (K)-specific demethylase 3A 0.0132733
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0132358
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0132052
TOP1 topoisomerase (DNA) I 0.0131941
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0131756
SRRM1 serine/arginine repetitive matrix 1 0.0131656
ZBTB10 zinc finger and BTB domain containing 10 0.0130897

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182181
FTL ferritin, light polypeptide -0.118932
ACTG1 actin gamma 1 -0.110421
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.108774
TMSB10 thymosin beta 10 -0.0948473
RPL35A ribosomal protein L35a -0.0725304
RPLP1 ribosomal protein, large, P1 -0.0693594
NDRG1 N-myc downstream regulated 1 -0.0692495
TPT1 tumor protein, translationally-controlled 1 -0.0677519
RPLP2 ribosomal protein, large, P2 -0.0563959
RPL34 ribosomal protein L34 -0.0557587
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0509832
RPS23 ribosomal protein S23 -0.0502228
SAMD4A sterile alpha motif domain containing 4A -0.0479386
EFNA5 ephrin-A5 -0.0471269
LAMB3 laminin, beta 3 -0.0461945
RPS19 ribosomal protein S19 -0.0449852
IFI27 interferon, alpha-inducible protein 27 -0.0448942
EXT1 exostosin glycosyltransferase 1 -0.0431594
MT2A metallothionein 2A -0.0428953
RPL23 ribosomal protein L23 -0.0412645
RPS29 ribosomal protein S29 -0.0397454
EIF1 eukaryotic translation initiation factor 1 -0.0384649
RPL8 ribosomal protein L8 -0.0380831
RPS8 ribosomal protein S8 -0.0378802
S100A10 S100 calcium binding protein A10 -0.037691
RPL9 ribosomal protein L9 -0.0361889
HLA-B major histocompatibility complex, class I, B -0.035407
RPS13 ribosomal protein S13 -0.0351229
ISG15 ISG15 ubiquitin-like modifier -0.0339676
FBXO32 F-box protein 32 -0.0322804
IFI6 interferon, alpha-inducible protein 6 -0.0319547
FN1 fibronectin 1 -0.0318923
RPL19 ribosomal protein L19 -0.0311393
RPL32 ribosomal protein L32 -0.0298702
FTH1 ferritin, heavy polypeptide 1 -0.0295574
RPS6 ribosomal protein S6 -0.0291224
S100A9 S100 calcium binding protein A9 -0.0290762
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0270526
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0268058
PTMA prothymosin, alpha -0.0267166
RPS21 ribosomal protein S21 -0.0266342
RPL37 ribosomal protein L37 -0.0261936
SDC4 syndecan 4 -0.0259319
RPS27 ribosomal protein S27 -0.025814
RPL12 ribosomal protein L12 -0.025607
IFITM3 interferon induced transmembrane protein 3 -0.0256028
S100A6 S100 calcium binding protein A6 -0.0253277
RPL31 ribosomal protein L31 -0.0249743
CTNND1 catenin (cadherin-associated protein), delta 1 -0.024603
ARHGAP5 Rho GTPase activating protein 5 -0.0234814
RPL37A ribosomal protein L37a -0.0234441
RPL30 ribosomal protein L30 -0.0231968
SOX4 SRY (sex determining region Y)-box 4 -0.0230087
IFITM1 interferon induced transmembrane protein 1 -0.0227087
RPL11 ribosomal protein L11 -0.0226908
HLA-A major histocompatibility complex, class I, A -0.0226284
RPS27A ribosomal protein S27a -0.0223401
TXNIP thioredoxin interacting protein -0.0222681
NAV2 neuron navigator 2 -0.0220014
RPL36 ribosomal protein L36 -0.0219232
MYO1E myosin IE -0.0214002
RPS15 ribosomal protein S15 -0.0209604
RPS25 ribosomal protein S25 -0.020937
RPL28 ribosomal protein L28 -0.0209096
ERBIN erbb2 interacting protein -0.0207598
RACK1 receptor for activated C kinase 1 -0.0205206
SMAD3 SMAD family member 3 -0.0202303
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0201886
RPL35 ribosomal protein L35 -0.0201382
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0200374
RPL36A ribosomal protein L36a -0.019953
TUBB4B tubulin, beta 4B class IVb -0.0199018
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0198305
RPS17 ribosomal protein S17 -0.019797
CSTB cystatin B (stefin B) -0.0197047
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0195744
PLSCR1 phospholipid scramblase 1 -0.0194363
ZBTB20 zinc finger and BTB domain containing 20 -0.0192879
RPL27 ribosomal protein L27 -0.0192336
IFI16 interferon, gamma-inducible protein 16 -0.0192095
ATXN1 ataxin 1 -0.0191271
RPS24 ribosomal protein S24 -0.0190371
EGFR epidermal growth factor receptor -0.0189151
RPL38 ribosomal protein L38 -0.0187657
LPP LIM domain containing preferred translocation partner in lipoma -0.0187626
RPS14 ribosomal protein S14 -0.0185627
RPS10 ribosomal protein S10 -0.0184876
RPS16 ribosomal protein S16 -0.0183358
RPS11 ribosomal protein S11 -0.0183065
RRBP1 ribosome binding protein 1 -0.0182611
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0182312
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0182093
VGLL3 vestigial-like family member 3 -0.0181985
RPS3 ribosomal protein S3 -0.018026
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0180017
CDCP1 CUB domain containing protein 1 -0.0174727
RPL26 ribosomal protein L26 -0.0174131
LIMCH1 LIM and calponin homology domains 1 -0.0173648
TMEM165 transmembrane protein 165 -0.0173381