Oxaprozin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Oxaprozin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0610664
EFNA5 ephrin-A5 0.05122
GDA guanine deaminase 0.030998
LIMCH1 LIM and calponin homology domains 1 0.0279187
RTN4 reticulon 4 0.0270733
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0258229
MFF mitochondrial fission factor 0.0239332
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0238174
AVL9 AVL9 homolog (S. cerevisiase) 0.0208073
NPAS2 neuronal PAS domain protein 2 0.0197437
ESYT2 extended synaptotagmin-like protein 2 0.0189201
NEK7 NIMA-related kinase 7 0.0187845
PTEN phosphatase and tensin homolog 0.0180801
CARD16 caspase recruitment domain family, member 16 0.0171839
ENAH enabled homolog (Drosophila) 0.0166608
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0160181
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0156941
TM4SF1 transmembrane 4 L six family member 1 0.0153774
NGLY1 N-glycanase 1 0.0148926
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0148831
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0146387
SAMD4A sterile alpha motif domain containing 4A 0.0145558
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.014275
USP34 ubiquitin specific peptidase 34 0.0141628
ARHGAP29 Rho GTPase activating protein 29 0.0137013
ANKRD28 ankyrin repeat domain 28 0.0132949
BMERB1 bMERB domain containing 1 0.0129523
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.012896
THOC2 THO complex 2 0.0127119
PYGL phosphorylase, glycogen, liver 0.0125883
FNIP1 folliculin interacting protein 1 0.0125233
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0123548
ANKRD17 ankyrin repeat domain 17 0.0121763
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.012084
CEP170 centrosomal protein 170kDa 0.012059
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0118511
SKAP2 src kinase associated phosphoprotein 2 0.0118488
STC1 stanniocalcin 1 0.0117191
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 0.0117043
ATP13A3 ATPase type 13A3 0.0115624
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0115379
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0115361
ITPRID2 ITPR interacting domain containing 2 0.0114962
AGFG1 ArfGAP with FG repeats 1 0.0113429
GSK3B glycogen synthase kinase 3 beta 0.0113073
BIRC6 baculoviral IAP repeat containing 6 0.0112133
CDCP1 CUB domain containing protein 1 0.0110772
SEPTIN10 septin 10 0.0109932
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0109282
NBEAL1 neurobeachin-like 1 0.0107898
ARHGAP5 Rho GTPase activating protein 5 0.0105921
FBXL5 F-box and leucine-rich repeat protein 5 0.0102186
MCL1 myeloid cell leukemia 1 0.0101608
NIPBL Nipped-B homolog (Drosophila) 0.00995556
ATXN2 ataxin 2 0.00974011
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.00973205
CD109 CD109 molecule 0.00963784
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.00959973
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.00951132
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0093918
TFPI2 tissue factor pathway inhibitor 2 0.00935985
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.00931306
ZNF292 zinc finger protein 292 0.00928041
MAP2K4 mitogen-activated protein kinase kinase 4 0.00913975
UBXN4 UBX domain protein 4 0.00907513
WDFY2 WD repeat and FYVE domain containing 2 0.00907232
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0090492
COL4A6 collagen, type IV, alpha 6 0.00904284
ITGAV integrin, alpha V 0.00899606
CREB1 cAMP responsive element binding protein 1 0.00894165
GOLGA4 golgin A4 0.00893416
STARD4 StAR-related lipid transfer (START) domain containing 4 0.00892736
NCEH1 neutral cholesterol ester hydrolase 1 0.00891896
NKTR natural killer cell triggering receptor 0.00871942
KDM7A lysine (K)-specific demethylase 7A 0.00870764
DISP1 dispatched homolog 1 (Drosophila) 0.00870054
NMT2 N-myristoyltransferase 2 0.0086976
USP53 ubiquitin specific peptidase 53 0.00867597
CHD1L chromodomain helicase DNA binding protein 1-like 0.00863176
ZNF652 zinc finger protein 652 0.00860635
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00844021
ACBD6 acyl-CoA binding domain containing 6 0.0084231
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.00838949
MON2 MON2 homolog (S. cerevisiae) 0.00833638
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.00833621
ERRFI1 ERBB receptor feedback inhibitor 1 0.00830962
PLCB4 phospholipase C, beta 4 0.00823285
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.00814459
TPD52 tumor protein D52 0.00813534
ATAD2B ATPase family, AAA domain containing 2B 0.00810087
WDR26 WD repeat domain 26 0.00802281
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.00800625
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00797801
RUNX1 runt-related transcription factor 1 0.00794089
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00792311
ZC3H12C zinc finger CCCH-type containing 12C 0.00792142
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00786777
CD46 CD46 molecule, complement regulatory protein 0.00780524
RLIM ring finger protein, LIM domain interacting 0.00780352
MAP1B microtubule-associated protein 1B 0.00779772

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.298776
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.166085
PDE10A phosphodiesterase 10A -0.10446
TMSB10 thymosin beta 10 -0.101383
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0967732
FN1 fibronectin 1 -0.0955116
NALF1 NALCN channel auxiliary factor 1 -0.0899268
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0806421
COL5A2 collagen, type V, alpha 2 -0.0778481
RPS6 ribosomal protein S6 -0.0727863
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0723674
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0718438
PRKN parkin RBR E3 ubiquitin protein ligase -0.071711
CDH13 cadherin 13 -0.0707837
FTL ferritin, light polypeptide -0.0700756
PM20D1 peptidase M20 domain containing 1 -0.0692158
PTMA prothymosin, alpha -0.0690367
P3H2 prolyl 3-hydroxylase 2 -0.0689837
RPLP1 ribosomal protein, large, P1 -0.0664056
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0600859
PSD3 pleckstrin and Sec7 domain containing 3 -0.0599096
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0575455
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0559228
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0537237
TPT1 tumor protein, translationally-controlled 1 -0.0529886
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0527712
LSAMP limbic system-associated membrane protein -0.0486069
DST dystonin -0.0479712
VIM vimentin -0.0472216
RPL35A ribosomal protein L35a -0.0470599
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0465627
RPL23 ribosomal protein L23 -0.0459827
RPL37A ribosomal protein L37a -0.0454051
RPS12 ribosomal protein S12 -0.0447165
RPS19 ribosomal protein S19 -0.0443543
SMYD3 SET and MYND domain containing 3 -0.0424183
RPS8 ribosomal protein S8 -0.0422641
BASP1 brain abundant, membrane attached signal protein 1 -0.0417895
RPL19 ribosomal protein L19 -0.039946
RPL26 ribosomal protein L26 -0.0396857
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0392713
PTPRM protein tyrosine phosphatase, receptor type, M -0.0381109
ADGRD1 adhesion G protein-coupled receptor D1 -0.0378541
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0363626
RPL12 ribosomal protein L12 -0.036255
ANTXR1 anthrax toxin receptor 1 -0.0349724
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0345988
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0323341
RPL31 ribosomal protein L31 -0.031894
RPS3 ribosomal protein S3 -0.0311864
GNAS GNAS complex locus -0.0311669
KIAA0825 KIAA0825 -0.0307332
RPS25 ribosomal protein S25 -0.0301664
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0301041
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.030026
RPL9 ribosomal protein L9 -0.0296718
RPS27A ribosomal protein S27a -0.0294707
CADM2 cell adhesion molecule 2 -0.0294705
RPS16 ribosomal protein S16 -0.0294626
VCL vinculin -0.0292617
COL8A1 collagen, type VIII, alpha 1 -0.0290903
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.028921
RPL36 ribosomal protein L36 -0.0288294
AGTPBP1 ATP/GTP binding protein 1 -0.0281718
RPL37 ribosomal protein L37 -0.0281303
RPL35 ribosomal protein L35 -0.0280914
RPLP2 ribosomal protein, large, P2 -0.028056
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0274986
RPS4X ribosomal protein S4, X-linked -0.0270976
RPS29 ribosomal protein S29 -0.0269954
SMOC1 SPARC related modular calcium binding 1 -0.0266724
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0265898
PALLD palladin, cytoskeletal associated protein -0.0260885
RPS23 ribosomal protein S23 -0.0260288
S100A10 S100 calcium binding protein A10 -0.0259845
S100A6 S100 calcium binding protein A6 -0.0258665
OASL 2'-5'-oligoadenylate synthetase-like -0.0257634
RPS27 ribosomal protein S27 -0.025757
RPS24 ribosomal protein S24 -0.0256062
RPS14 ribosomal protein S14 -0.0255945
RPL38 ribosomal protein L38 -0.0254847
ASPH aspartate beta-hydroxylase -0.0253836
RPL11 ribosomal protein L11 -0.025109
PCDH15 protocadherin-related 15 -0.02509
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0249161
B2M beta-2-microglobulin -0.0246445
MYOF myoferlin -0.0246285
NCKAP5 NCK-associated protein 5 -0.0241468
NAP1L1 nucleosome assembly protein 1-like 1 -0.0239994
PDE7B phosphodiesterase 7B -0.0239209
RPL34 ribosomal protein L34 -0.023761
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0236689
RPL5 ribosomal protein L5 -0.0236628
RPL13A ribosomal protein L13a -0.0236619
RGS2 regulator of G-protein signaling 2 -0.0235853
EXT1 exostosin glycosyltransferase 1 -0.0234672
MAML3 mastermind-like 3 (Drosophila) -0.0234609
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0233377
ANXA1 annexin A1 -0.0233296
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0227849