Oxaprozin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Oxaprozin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.114023
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0812871
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0760257
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0738249
ZFAND3 zinc finger, AN1-type domain 3 0.0670187
TRIO trio Rho guanine nucleotide exchange factor 0.0554258
TSC22D2 TSC22 domain family, member 2 0.0549047
PUM1 pumilio RNA-binding family member 1 0.0536195
STRN3 striatin, calmodulin binding protein 3 0.0531629
SPAG9 sperm associated antigen 9 0.0529958
DST dystonin 0.0469318
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0468019
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0437837
CSDE1 cold shock domain containing E1, RNA-binding 0.0433893
ARID4B AT rich interactive domain 4B (RBP1-like) 0.041945
TRA2A transformer 2 alpha homolog (Drosophila) 0.0417764
PCBP2 poly(rC) binding protein 2 0.0417055
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0413419
WSB1 WD repeat and SOCS box containing 1 0.0406189
TLK2 tousled-like kinase 2 0.0405286
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0396713
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0388569
MEMO1 mediator of cell motility 1 0.0383957
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.0383418
CDC73 cell division cycle 73 0.0380434
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0372909
NCKAP1 NCK-associated protein 1 0.0368971
PTMA prothymosin, alpha 0.0361262
WAC WW domain containing adaptor with coiled-coil 0.0358744
JMJD1C jumonji domain containing 1C 0.0357859
PGAP1 post-GPI attachment to proteins 1 0.0355815
TMSB4X thymosin beta 4, X-linked 0.0354409
GARS1 glycyl-tRNA synthetase 1 0.0352811
MKI67 marker of proliferation Ki-67 0.0348775
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0341392
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0333624
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0331485
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0325152
KMT2E lysine (K)-specific methyltransferase 2E 0.0324461
ANKRD33B ankyrin repeat domain 33B 0.0320354
CTBP2 C-terminal binding protein 2 0.0317333
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0316588
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0315221
FNDC3B fibronectin type III domain containing 3B 0.03058
ATG5 autophagy related 5 0.0303524
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0300731
CENPF centromere protein F, 350/400kDa 0.0297343
TPX2 TPX2, microtubule-associated 0.0297315
ENAH enabled homolog (Drosophila) 0.0292765
SCAF4 SR-related CTD-associated factor 4 0.0290202
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0290066
HMGB2 high mobility group box 2 0.0288776
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0288764
RHEB Ras homolog enriched in brain 0.0287746
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0286584
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0286539
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0284829
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0282815
PDS5B PDS5 cohesin associated factor B 0.0281565
RAD21 RAD21 homolog (S. pombe) 0.0280971
GRB2 growth factor receptor-bound protein 2 0.0277722
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0275312
ADAM9 ADAM metallopeptidase domain 9 0.027437
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0273305
NAP1L1 nucleosome assembly protein 1-like 1 0.0272312
ANXA2 annexin A2 0.0268287
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0267352
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0266953
SMC4 structural maintenance of chromosomes 4 0.0266253
PRRC1 proline-rich coiled-coil 1 0.026576
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.026084
SRRM1 serine/arginine repetitive matrix 1 0.0258825
NOP58 NOP58 ribonucleoprotein 0.0258136
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.025682
KIF5B kinesin family member 5B 0.0255061
VIM vimentin 0.0254494
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0252265
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0251647
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0246261
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.024479
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0244433
RLF rearranged L-myc fusion 0.0243399
RIOK3 RIO kinase 3 0.024246
TBC1D12 TBC1 domain family, member 12 0.0240043
PDIA3 protein disulfide isomerase family A, member 3 0.0239391
SLMAP sarcolemma associated protein 0.023861
MARCHF6 membrane associated ring-CH-type finger 6 0.0238288
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0238177
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0237903
DSCAM Down syndrome cell adhesion molecule 0.0234937
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.023467
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0234272
FUBP1 far upstream element (FUSE) binding protein 1 0.023209
SET SET nuclear proto-oncogene 0.0232075
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0230657
KMT2C lysine (K)-specific methyltransferase 2C 0.0230546
WDR43 WD repeat domain 43 0.0230401
RNF145 ring finger protein 145 0.0227661
MATR3 matrin 3 0.0225152
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0224976

decreased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 -0.124719
CDH10 cadherin 10, type 2 (T2-cadherin) -0.101051
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0940194
PCDH9 protocadherin 9 -0.0799655
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0754223
GPC3 glypican 3 -0.0714791
PCLO piccolo presynaptic cytomatrix protein -0.06344
COL11A1 collagen, type XI, alpha 1 -0.0587816
TRPS1 trichorhinophalangeal syndrome I -0.0541642
SMYD3 SET and MYND domain containing 3 -0.0524665
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0511951
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0504159
TENM3 teneurin transmembrane protein 3 -0.0488782
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0474221
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0447598
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.042954
SLIT2 slit homolog 2 (Drosophila) -0.0422415
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0419808
CDH19 cadherin 19, type 2 -0.0404586
TMSB10 thymosin beta 10 -0.0391079
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0383471
ADGRV1 adhesion G protein-coupled receptor V1 -0.0368744
ARHGAP15 Rho GTPase activating protein 15 -0.0347385
RPS8 ribosomal protein S8 -0.0344766
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0339132
RPL35A ribosomal protein L35a -0.0330407
PCDH7 protocadherin 7 -0.0325784
RPLP1 ribosomal protein, large, P1 -0.0323847
MBD5 methyl-CpG binding domain protein 5 -0.0319621
CDK13 cyclin-dependent kinase 13 -0.0309597
TAS2R14 taste receptor, type 2, member 14 -0.0305948
FTL ferritin, light polypeptide -0.0303086
TPT1 tumor protein, translationally-controlled 1 -0.0302824
PDE4D phosphodiesterase 4D, cAMP-specific -0.0302225
RPL19 ribosomal protein L19 -0.0299501
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0294545
TRIM2 tripartite motif containing 2 -0.0288287
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0286865
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0285218
FOXP2 forkhead box P2 -0.0284077
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0283968
RAD51B RAD51 paralog B -0.0281429
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0267369
GNAS GNAS complex locus -0.0262162
COG5 component of oligomeric golgi complex 5 -0.0260011
RPL37A ribosomal protein L37a -0.0257944
RASAL2 RAS protein activator like 2 -0.0257409
RPL26 ribosomal protein L26 -0.0256813
KIAA1328 KIAA1328 -0.0253572
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0252886
HDAC9 histone deacetylase 9 -0.025264
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0252621
AHNAK AHNAK nucleoprotein -0.0250151
MRPS30 mitochondrial ribosomal protein S30 -0.0245288
SHROOM3 shroom family member 3 -0.0244868
CCDC91 coiled-coil domain containing 91 -0.0243322
TOX thymocyte selection-associated high mobility group box -0.0243261
ZC3H12B zinc finger CCCH-type containing 12B -0.0242357
RPL9 ribosomal protein L9 -0.0239707
COL5A2 collagen, type V, alpha 2 -0.0237769
DENND5B DENN/MADD domain containing 5B -0.0235711
PBX3 pre-B-cell leukemia homeobox 3 -0.0231877
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0230687
EIF1 eukaryotic translation initiation factor 1 -0.0230464
THBS1 thrombospondin 1 -0.0230307
LRRC4C leucine rich repeat containing 4C -0.0229941
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0229796
ADGRL3 adhesion G protein-coupled receptor L3 -0.022938
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0228534
ZBTB20 zinc finger and BTB domain containing 20 -0.0226057
FTH1 ferritin, heavy polypeptide 1 -0.0222656
ATXN1 ataxin 1 -0.0221674
FBXO17 F-box protein 17 -0.021775
HMCN1 hemicentin 1 -0.0215306
SSH2 slingshot protein phosphatase 2 -0.0214696
RPL31 ribosomal protein L31 -0.0213846
RPS27A ribosomal protein S27a -0.0212186
ENO1 enolase 1, (alpha) -0.0207965
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0206289
NCAM2 neural cell adhesion molecule 2 -0.0206106
NHSL1 NHS-like 1 -0.0205132
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0203285
MED12L mediator complex subunit 12-like -0.0203197
HSPB1 heat shock 27kDa protein 1 -0.0201361
KDM4B lysine (K)-specific demethylase 4B -0.0199232
FAM177A1 family with sequence similarity 177, member A1 -0.0197144
PLCB4 phospholipase C, beta 4 -0.0194342
GOLIM4 golgi integral membrane protein 4 -0.019389
GREB1L growth regulation by estrogen in breast cancer-like -0.0192081
FBXL2 F-box and leucine-rich repeat protein 2 -0.0191532
NACA nascent polypeptide-associated complex alpha subunit -0.0190917
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0190796
PARD3B par-3 family cell polarity regulator beta -0.019016
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0189998
MEIS2 Meis homeobox 2 -0.0188491
ISG15 ISG15 ubiquitin-like modifier -0.0183003
MPG N-methylpurine-DNA glycosylase -0.0181675
PEG10 paternally expressed 10 -0.0181504
RPS4X ribosomal protein S4, X-linked -0.0180727
RPL23 ribosomal protein L23 -0.0180213