Oxaprozin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaprozin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.123425
CDH13 cadherin 13 0.110886
VIM vimentin 0.0975164
COL6A3 collagen, type VI, alpha 3 0.094561
ERRFI1 ERBB receptor feedback inhibitor 1 0.0929275
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0896553
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0884303
CXCL8 chemokine (C-X-C motif) ligand 8 0.0846411
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0828309
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0780644
LOX lysyl oxidase 0.068617
SPAG9 sperm associated antigen 9 0.0667529
AKAP9 A kinase (PRKA) anchor protein 9 0.0666905
STC1 stanniocalcin 1 0.0665347
RAB1A RAB1A, member RAS oncogene family 0.0635172
FAM13A family with sequence similarity 13, member A 0.0630797
NRXN3 neurexin 3 0.0602004
COL1A2 collagen, type I, alpha 2 0.0579893
RPS16 ribosomal protein S16 0.0567216
WASF2 WAS protein family, member 2 0.0544399
EFNA5 ephrin-A5 0.0534188
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0530046
WSB1 WD repeat and SOCS box containing 1 0.0520256
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.050132
HELZ helicase with zinc finger 0.0493438
F3 coagulation factor III (thromboplastin, tissue factor) 0.0487518
TM4SF1 transmembrane 4 L six family member 1 0.046216
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0454139
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0445815
COL6A2 collagen, type VI, alpha 2 0.0445623
COG5 component of oligomeric golgi complex 5 0.0438005
NPEPPS aminopeptidase puromycin sensitive 0.0434216
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0425985
ATP13A3 ATPase type 13A3 0.0424407
ASPH aspartate beta-hydroxylase 0.0424272
NCOR1 nuclear receptor corepressor 1 0.0421038
RPL37A ribosomal protein L37a 0.0418454
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0412261
PGK1 phosphoglycerate kinase 1 0.0411222
BACE2 beta-site APP-cleaving enzyme 2 0.0411035
LOXL2 lysyl oxidase-like 2 0.041097
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0410255
EIF1 eukaryotic translation initiation factor 1 0.0401076
AHNAK AHNAK nucleoprotein 0.0393549
COL7A1 collagen, type VII, alpha 1 0.0392958
IL6 interleukin 6 0.0385696
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0381974
SAMD4A sterile alpha motif domain containing 4A 0.0377882
IGFBP3 insulin-like growth factor binding protein 3 0.0374822
COL5A1 collagen, type V, alpha 1 0.0372432
RPL5 ribosomal protein L5 0.0370345
LMAN1 lectin, mannose-binding, 1 0.0368889
CD2AP CD2-associated protein 0.036608
TGFBI transforming growth factor, beta-induced, 68kDa 0.035902
TFPI2 tissue factor pathway inhibitor 2 0.0357965
ADM adrenomedullin 0.0357689
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0350815
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.035036
PRSS23 protease, serine, 23 0.0345472
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0336125
TIMP3 TIMP metallopeptidase inhibitor 3 0.0335472
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0332366
WDR43 WD repeat domain 43 0.0331042
RBM39 RNA binding motif protein 39 0.0329426
PYGL phosphorylase, glycogen, liver 0.0325459
MORC3 MORC family CW-type zinc finger 3 0.0325261
CAPN2 calpain 2, (m/II) large subunit 0.0325142
ABLIM3 actin binding LIM protein family, member 3 0.0324506
FBL fibrillarin 0.0324444
KDM4C lysine (K)-specific demethylase 4C 0.0319066
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0318046
RND3 Rho family GTPase 3 0.031546
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0313885
LAMB3 laminin, beta 3 0.0313223
AKAP12 A kinase (PRKA) anchor protein 12 0.0312742
KDM2A lysine (K)-specific demethylase 2A 0.0309293
RAP1B RAP1B, member of RAS oncogene family 0.0305299
UBE2H ubiquitin-conjugating enzyme E2H 0.030418
FBXW11 F-box and WD repeat domain containing 11 0.0303038
CLINT1 clathrin interactor 1 0.0302132
MMP12 matrix metallopeptidase 12 0.0301773
IST1 increased sodium tolerance 1 homolog (yeast) 0.0297132
WDFY2 WD repeat and FYVE domain containing 2 0.0295305
TMEM41B transmembrane protein 41B 0.0294658
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.029464
PRRC2C proline-rich coiled-coil 2C 0.0294614
KCTD9 potassium channel tetramerization domain containing 9 0.0291047
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0290538
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0289832
CA12 carbonic anhydrase XII 0.0289095
VMP1 vacuole membrane protein 1 0.0288246
SEC23A Sec23 homolog A (S. cerevisiae) 0.0286995
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0286911
EXOC4 exocyst complex component 4 0.0285642
TSC22D2 TSC22 domain family, member 2 0.0282993
ENO1 enolase 1, (alpha) 0.0282415
FBXO11 F-box protein 11 0.0279342
NAP1L1 nucleosome assembly protein 1-like 1 0.0279279
RPL36 ribosomal protein L36 0.0278647
SCAMP1 secretory carrier membrane protein 1 0.0278326

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155216
MT2A metallothionein 2A -0.137293
B2M beta-2-microglobulin -0.0732062
HLA-B major histocompatibility complex, class I, B -0.0707154
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0678512
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0564616
H3-3B H3.3 histone B -0.0532311
RAD51B RAD51 paralog B -0.0530148
MAP1B microtubule-associated protein 1B -0.0506757
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0506291
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0493728
KMT2E lysine (K)-specific methyltransferase 2E -0.048889
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0485037
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0476609
SMYD3 SET and MYND domain containing 3 -0.0459505
CLIC4 chloride intracellular channel 4 -0.0446524
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0434461
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0425681
IGFBP7 insulin-like growth factor binding protein 7 -0.0424409
AFF4 AF4/FMR2 family, member 4 -0.0418204
PRELID2 PRELI domain containing 2 -0.0417521
HOOK2 hook microtubule-tethering protein 2 -0.0416248
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.041271
MEF2A myocyte enhancer factor 2A -0.0410768
ZBTB20 zinc finger and BTB domain containing 20 -0.0409432
NBAS neuroblastoma amplified sequence -0.0409157
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.040531
RSF1 remodeling and spacing factor 1 -0.0401154
THRAP3 thyroid hormone receptor associated protein 3 -0.039826
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0398218
ANKRD17 ankyrin repeat domain 17 -0.0391435
NALF1 NALCN channel auxiliary factor 1 -0.038949
EXT1 exostosin glycosyltransferase 1 -0.0386703
EXOC6B exocyst complex component 6B -0.0383569
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.038065
MBNL1 muscleblind-like splicing regulator 1 -0.0379441
EGR1 early growth response 1 -0.0378256
NCOR2 nuclear receptor corepressor 2 -0.0375839
MAML2 mastermind-like 2 (Drosophila) -0.0373691
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.037273
SEPTIN7 septin 7 -0.037262
MKI67 marker of proliferation Ki-67 -0.0367524
CALD1 caldesmon 1 -0.0365394
WDPCP WD repeat containing planar cell polarity effector -0.0363435
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.036283
TXNIP thioredoxin interacting protein -0.0362383
PHF21A PHD finger protein 21A -0.0358915
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0357439
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0355693
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0354472
RNF24 ring finger protein 24 -0.0346705
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -0.0345393
RBM6 RNA binding motif protein 6 -0.034226
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0337481
ANLN anillin, actin binding protein -0.0334757
ARRDC3 arrestin domain containing 3 -0.0334177
VEGFA vascular endothelial growth factor A -0.0331801
CD44 CD44 molecule (Indian blood group) -0.0324198
CCNI cyclin I -0.0322229
BCAR3 breast cancer anti-estrogen resistance 3 -0.0321273
RPL11 ribosomal protein L11 -0.0321207
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0320801
TRIP12 thyroid hormone receptor interactor 12 -0.0318132
TENT4A terminal nucleotidyltransferase 4A -0.0310153
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0306826
ANKHD1 ankyrin repeat and KH domain containing 1 -0.030058
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0299221
FNBP1 formin binding protein 1 -0.029816
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0297998
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0296492
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0296397
RPL19 ribosomal protein L19 -0.0295968
METTL15 methyltransferase like 15 -0.0295166
HMGB1 high mobility group box 1 -0.0293943
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0293686
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0292147
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0290528
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0290208
SNX29 sorting nexin 29 -0.0289085
MIER1 mesoderm induction early response 1, transcriptional regulator -0.028852
ZNF292 zinc finger protein 292 -0.0287685
FN1 fibronectin 1 -0.0287684
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0287666
RPL26 ribosomal protein L26 -0.0287584
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0287541
TNPO1 transportin 1 -0.0285218
SDK1 sidekick cell adhesion molecule 1 -0.0285204
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0283327
GOLIM4 golgi integral membrane protein 4 -0.0281524
SMAD3 SMAD family member 3 -0.0276636
LCORL ligand dependent nuclear receptor corepressor-like -0.0275735
MAML3 mastermind-like 3 (Drosophila) -0.0275518
YTHDC1 YTH domain containing 1 -0.0272406
PTN pleiotrophin -0.0272031
MED13 mediator complex subunit 13 -0.0270024
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0269492
LGALS1 lectin, galactoside-binding, soluble, 1 -0.026932
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.026809
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0267613
OSBPL3 oxysterol binding protein-like 3 -0.026736