Oxaprozin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oxaprozin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oxaprozin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.0636112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0628501
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.05992
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0549615
NAMPT nicotinamide phosphoribosyltransferase 0.0506546
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0449015
RNF145 ring finger protein 145 0.044428
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0418724
SUCO SUN domain containing ossification factor 0.0362905
HELZ helicase with zinc finger 0.0329323
CD109 CD109 molecule 0.0326638
OGA O-GlcNAcase 0.0315001
CANX calnexin 0.0314568
WDR45B WD repeat domain 45B 0.0310911
WAC WW domain containing adaptor with coiled-coil 0.0308833
SPAG9 sperm associated antigen 9 0.0298624
PTMA prothymosin, alpha 0.0298156
RLF rearranged L-myc fusion 0.0292712
NEK7 NIMA-related kinase 7 0.0285199
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0281615
KDM3A lysine (K)-specific demethylase 3A 0.0280781
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0276095
RICTOR RPTOR independent companion of MTOR, complex 2 0.0273663
LCORL ligand dependent nuclear receptor corepressor-like 0.0273388
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0271876
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0269878
NUP58 nucleoporin 58 0.0264646
FAM13A family with sequence similarity 13, member A 0.0263048
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0262754
PRRC2C proline-rich coiled-coil 2C 0.0257354
EPS8 epidermal growth factor receptor pathway substrate 8 0.0254182
GOLGA4 golgin A4 0.0253927
HILPDA hypoxia inducible lipid droplet-associated 0.0253807
UBA6 ubiquitin-like modifier activating enzyme 6 0.0246041
MARCHF6 membrane associated ring-CH-type finger 6 0.0245207
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0245025
ZNF292 zinc finger protein 292 0.024335
SEC23A Sec23 homolog A (S. cerevisiae) 0.0239458
COPA coatomer protein complex, subunit alpha 0.0238352
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0232719
CDC73 cell division cycle 73 0.0231628
SOD2 superoxide dismutase 2, mitochondrial 0.0226054
GPBP1 GC-rich promoter binding protein 1 0.0222486
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0221781
NOP58 NOP58 ribonucleoprotein 0.0220954
RAB1A RAB1A, member RAS oncogene family 0.0218448
NAP1L1 nucleosome assembly protein 1-like 1 0.0215232
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0211706
TFG TRK-fused gene 0.0210929
BIRC6 baculoviral IAP repeat containing 6 0.0209205
ELL2 elongation factor, RNA polymerase II, 2 0.0201132
KMT2E lysine (K)-specific methyltransferase 2E 0.0200399
USP3 ubiquitin specific peptidase 3 0.0200066
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0199177
QKI QKI, KH domain containing, RNA binding 0.0198623
RBM39 RNA binding motif protein 39 0.0197098
RAD21 RAD21 homolog (S. pombe) 0.0196419
TENT2 terminal nucleotidyltransferase 2 0.0195384
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0193057
RAB8B RAB8B, member RAS oncogene family 0.0192732
KMT2C lysine (K)-specific methyltransferase 2C 0.0191082
NPEPPS aminopeptidase puromycin sensitive 0.0190061
TRA2A transformer 2 alpha homolog (Drosophila) 0.0183376
FXR1 fragile X mental retardation, autosomal homolog 1 0.0182598
PUM2 pumilio RNA-binding family member 2 0.0182131
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0181094
TPR translocated promoter region, nuclear basket protein 0.0180851
UGCG UDP-glucose ceramide glucosyltransferase 0.0179635
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0178414
XPO1 exportin 1 0.0178056
GARS1 glycyl-tRNA synthetase 1 0.0176761
DDIT4 DNA-damage-inducible transcript 4 0.0170726
BHLHE40 basic helix-loop-helix family, member e40 0.0168605
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0168409
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0168062
ADAM17 ADAM metallopeptidase domain 17 0.0168009
CLINT1 clathrin interactor 1 0.0167237
ERRFI1 ERBB receptor feedback inhibitor 1 0.0166322
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.01648
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0164592
AFDN afadin, adherens junction formation factor 0.0164451
ACBD3 acyl-CoA binding domain containing 3 0.0163588
SRP54 signal recognition particle 54kDa 0.0161708
MATR3 matrin 3 0.0160429
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0160386
ESYT2 extended synaptotagmin-like protein 2 0.0156115
WDR43 WD repeat domain 43 0.0156027
MTF2 metal response element binding transcription factor 2 0.0155963
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0155957
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0155247
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0154609
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0154604
KDM5B lysine (K)-specific demethylase 5B 0.0154457
RAD23B RAD23 homolog B (S. cerevisiae) 0.0154325
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0154113
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0154106
SEPTIN7 septin 7 0.0153599
YME1L1 YME1-like 1 ATPase 0.0152496
BZW1 basic leucine zipper and W2 domains 1 0.0152153
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0151873

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.13904
FN1 fibronectin 1 -0.0930493
HMGA2 high mobility group AT-hook 2 -0.0906128
ASPH aspartate beta-hydroxylase -0.050166
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0480028
GLIS3 GLIS family zinc finger 3 -0.0461983
EXT1 exostosin glycosyltransferase 1 -0.0427785
IFI27 interferon, alpha-inducible protein 27 -0.042488
TMEM156 transmembrane protein 156 -0.0376233
ITGA1 integrin, alpha 1 -0.0374648
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0374317
SYT1 synaptotagmin I -0.0350137
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0339292
EFNA5 ephrin-A5 -0.0309616
ZBTB20 zinc finger and BTB domain containing 20 -0.0291511
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0287155
PDE4D phosphodiesterase 4D, cAMP-specific -0.0280371
MAP1B microtubule-associated protein 1B -0.028023
NRP1 neuropilin 1 -0.0276171
VCL vinculin -0.025607
NTN4 netrin 4 -0.0249656
OSMR oncostatin M receptor -0.0245315
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0244959
KLHL5 kelch-like family member 5 -0.0240808
SOX4 SRY (sex determining region Y)-box 4 -0.0235991
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0233787
MBD5 methyl-CpG binding domain protein 5 -0.0232699
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0232535
HIPK2 homeodomain interacting protein kinase 2 -0.0228035
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0226769
HLA-B major histocompatibility complex, class I, B -0.0224368
POTEF POTE ankyrin domain family, member F -0.0223592
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0219555
RNF213 ring finger protein 213 -0.0216074
AEBP2 AE binding protein 2 -0.0215206
LRMDA leucine rich melanocyte differentiation associated -0.0214287
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0213492
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0212741
ETV1 ets variant 1 -0.0200583
MAML2 mastermind-like 2 (Drosophila) -0.0197619
FTL ferritin, light polypeptide -0.0196955
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0192744
IFI16 interferon, gamma-inducible protein 16 -0.0190276
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0182308
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0182242
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0178264
FOXP1 forkhead box P1 -0.017321
HMGA1 high mobility group AT-hook 1 -0.0168624
MT2A metallothionein 2A -0.016336
IFI6 interferon, alpha-inducible protein 6 -0.01627
DNAH5 dynein, axonemal, heavy chain 5 -0.0158655
RAD51B RAD51 paralog B -0.0158375
FTH1 ferritin, heavy polypeptide 1 -0.0157151
ACTG1 actin gamma 1 -0.015409
RANBP17 RAN binding protein 17 -0.0151584
IFI44L interferon-induced protein 44-like -0.0147783
BICD1 bicaudal D homolog 1 (Drosophila) -0.0147625
S100A6 S100 calcium binding protein A6 -0.0145102
TSC22D1 TSC22 domain family, member 1 -0.0145102
SQSTM1 sequestosome 1 -0.0145093
EGR1 early growth response 1 -0.0144766
TMSB10 thymosin beta 10 -0.0144749
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.014398
RAI14 retinoic acid induced 14 -0.0143762
TAS2R14 taste receptor, type 2, member 14 -0.0142758
DOCK5 dedicator of cytokinesis 5 -0.0142275
EXOC4 exocyst complex component 4 -0.0139413
LIMCH1 LIM and calponin homology domains 1 -0.013921
TNS3 tensin 3 -0.0138348
SMYD3 SET and MYND domain containing 3 -0.0138246
FRY furry homolog (Drosophila) -0.0137173
RASAL2 RAS protein activator like 2 -0.0137031
ENO2 enolase 2 (gamma, neuronal) -0.0135959
SSH1 slingshot protein phosphatase 1 -0.0135843
VEGFA vascular endothelial growth factor A -0.0133348
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0132899
SEPTIN9 septin 9 -0.0130448
SOX5 SRY (sex determining region Y)-box 5 -0.0127958
MX2 MX dynamin-like GTPase 2 -0.0126509
NAV1 neuron navigator 1 -0.0126289
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0126018
BPTF bromodomain PHD finger transcription factor -0.0124828
TSHZ2 teashirt zinc finger homeobox 2 -0.0124708
NALF1 NALCN channel auxiliary factor 1 -0.0124534
CCDC91 coiled-coil domain containing 91 -0.0123915
ZMYND8 zinc finger, MYND-type containing 8 -0.0120499
SLC35F3 solute carrier family 35, member F3 -0.0119011
PRH1 proline-rich protein HaeIII subfamily 1 -0.0116085
NBEA neurobeachin -0.0115547
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0115435
BABAM2 BRISC and BRCA1 A complex member 2 -0.0115061
EGFR epidermal growth factor receptor -0.0114998
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0114344
TTC28 tetratricopeptide repeat domain 28 -0.0109901
LOC102724023 ES1 protein homolog, mitochondrial -0.0109523
TENM4 teneurin transmembrane protein 4 -0.0109281
STC2 stanniocalcin 2 -0.0108726
ATXN1 ataxin 1 -0.0108561
NPC1 Niemann-Pick disease, type C1 -0.010809
CCSER1 coiled-coil serine-rich protein 1 -0.0107413