Ozagrel Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5282440
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Genes

199 proteins with high or low expression in Ozagrel relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
RGN regucalcin 2.6
PCLO piccolo presynaptic cytomatrix protein 1.79
PRKD3 protein kinase D3 1.6
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 0.87
ENO1 enolase 1, (alpha) 0.76
PTMA prothymosin, alpha 0.75
PDGFC platelet derived growth factor C 0.67
RWDD1 RWD domain containing 1 0.65
CCNYL1 cyclin Y-like 1 0.6
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.59
PKM pyruvate kinase, muscle 0.59
GVINP1 GTPase, very large interferon inducible pseudogene 1 0.58
PAIP2 poly(A) binding protein interacting protein 2 0.57
KDF1 keratinocyte differentiation factor 1 0.56
MDM1 Mdm1 nuclear protein homolog (mouse) 0.56
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.54
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.53
TTLL4 tubulin tyrosine ligase-like family member 4 0.53
ZNF302 zinc finger protein 302 0.52
KMT2B lysine (K)-specific methyltransferase 2B 0.51
DNAH8 dynein, axonemal, heavy chain 8 0.5
ARL16 ADP-ribosylation factor-like 16 0.5
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 0.49
PMF1 polyamine-modulated factor 1 0.47
RPL3 ribosomal protein L3 0.44
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.44
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.44
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.43
ATG101 autophagy related 101 0.43
RCN2 reticulocalbin 2, EF-hand calcium binding domain 0.43
DES desmin 0.42
TRIP6 thyroid hormone receptor interactor 6 0.42
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.42
TWSG1 twisted gastrulation BMP signaling modulator 1 0.41
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 0.41
FKBP4 FK506 binding protein 4, 59kDa 0.4
SAV1 salvador family WW domain containing protein 1 0.4
PTMS parathymosin 0.39
SIMC1 SUMO-interacting motifs containing 1 0.38
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 0.38
LBR lamin B receptor 0.38
IER2 immediate early response 2 0.37
NLGN2 neuroligin 2 0.37
RPL30 ribosomal protein L30 0.37
ELOC elongin C 0.37
ZNF57 zinc finger protein 57 0.37
PRDM16 PR domain containing 16 0.37
PCNX1 pecanex 1 0.37
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.36
COQ4 coenzyme Q4 0.36
MED7 mediator complex subunit 7 0.35
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.35
FUS FUS RNA binding protein 0.35
NAP1L1 nucleosome assembly protein 1-like 1 0.35
SEH1L SEH1-like (S. cerevisiae) 0.34
ADM adrenomedullin 0.34
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.34
RPS26P11 ribosomal protein S26 pseudogene 11 0.34
ZCCHC24 zinc finger, CCHC domain containing 24 0.34
JPT1 Jupiter microtubule associated homolog 1 0.34
HDAC1 histone deacetylase 1 0.34
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.34
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.34
THAP11 THAP domain containing 11 0.33
FKBP5 FK506 binding protein 5 0.33
DNAAF2 dynein, axonemal, assembly factor 2 0.33
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.33
NFYB nuclear transcription factor Y, beta 0.32
DAP death-associated protein 0.32
IGFBP6 insulin-like growth factor binding protein 6 0.32
ZIC5 Zic family member 5 0.32
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.32
EEF1A1P5 eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 0.32
TPM4 tropomyosin 4 0.32
POMT2 protein-O-mannosyltransferase 2 0.32
NFE2L3 nuclear factor, erythroid 2-like 3 0.31
SPRED2 sprouty-related, EVH1 domain containing 2 0.31
SDF2 stromal cell-derived factor 2 0.31
TJP1 tight junction protein 1 0.31
TCP11L1 t-complex 11, testis-specific-like 1 0.31
YBX3 Y box binding protein 3 0.31
FKBP1A FK506 binding protein 1A, 12kDa 0.31
TRIM7 tripartite motif containing 7 0.31
CNTN1 contactin 1 0.3
NASP nuclear autoantigenic sperm protein (histone-binding) 0.3
IFITM3 interferon induced transmembrane protein 3 0.3
ARRDC1 arrestin domain containing 1 0.3
TSEN15 TSEN15 tRNA splicing endonuclease subunit 0.3
RPL26L1 ribosomal protein L26-like 1 0.3
BCLAF3 BCLAF1 and THRAP3 family member 3 0.29
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 0.29
PTBP1 polypyrimidine tract binding protein 1 0.29
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.29
EIF3H eukaryotic translation initiation factor 3, subunit H 0.29
MAT1A methionine adenosyltransferase I, alpha 0.29
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.28
KANK3 KN motif and ankyrin repeat domains 3 0.28
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.28
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.28

low expression

Symbol Name Standardized Value
F10 coagulation factor X -0.76
CDC26 cell division cycle 26 -0.75
ZC3H12A zinc finger CCCH-type containing 12A -0.73
DDTL D-dopachrome tautomerase-like -0.71
ZNRD1 zinc ribbon domain containing 1 -0.7
KLHL25 kelch-like family member 25 -0.69
CKS2 CDC28 protein kinase regulatory subunit 2 -0.64
STARD5 StAR-related lipid transfer (START) domain containing 5 -0.56
FAM135B family with sequence similarity 135, member B -0.56
ZNF714 zinc finger protein 714 -0.56
ZNF35 zinc finger protein 35 -0.55
DGKE diacylglycerol kinase, epsilon 64kDa -0.54
PAH phenylalanine hydroxylase -0.54
TAPT1 transmembrane anterior posterior transformation 1 -0.51
FBXO17 F-box protein 17 -0.51
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like -0.51
ZNF587 zinc finger protein 587 -0.5
MCPH1 microcephalin 1 -0.49
GRAMD2B GRAM domain containing 2B -0.48
IFIH1 interferon induced with helicase C domain 1 -0.48
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.47
ZNF808 zinc finger protein 808 -0.46
RPL36A ribosomal protein L36a -0.46
UBE2A ubiquitin-conjugating enzyme E2A -0.45
FAM241B family with sequence similarity 241 member B -0.45
S100A5 S100 calcium binding protein A5 -0.44
ITGA7 integrin, alpha 7 -0.43
CLCN2 chloride channel, voltage-sensitive 2 -0.43
KIF21B kinesin family member 21B -0.43
COL13A1 collagen, type XIII, alpha 1 -0.42
BTN2A1 butyrophilin, subfamily 2, member A1 -0.41
KLK6 kallikrein-related peptidase 6 -0.41
RNASET2 ribonuclease T2 -0.41
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -0.41
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -0.4
OSGIN2 oxidative stress induced growth inhibitor family member 2 -0.4
PTK6 protein tyrosine kinase 6 -0.38
PNPO pyridoxamine 5'-phosphate oxidase -0.38
TMEM184A transmembrane protein 184A -0.38
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 -0.37
BAIAP2 BAI1-associated protein 2 -0.37
TMSB10 thymosin beta 10 -0.36
ZNF564 zinc finger protein 564 -0.36
PDIA4 protein disulfide isomerase family A, member 4 -0.36
E2F8 E2F transcription factor 8 -0.36
ZMYM5 zinc finger, MYM-type 5 -0.36
DOLPP1 dolichyldiphosphatase 1 -0.36
RAB40C RAB40C, member RAS oncogene family -0.35
HBA1 hemoglobin, alpha 1 -0.35
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.35
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.35
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -0.35
ANKRD18B ankyrin repeat domain 18B -0.34
ZNF236 zinc finger protein 236 -0.34
VWA5B2 von Willebrand factor A domain containing 5B2 -0.34
SLC25A30 solute carrier family 25, member 30 -0.34
SVIP small VCP/p97-interacting protein -0.34
SERINC1 serine incorporator 1 -0.34
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -0.33
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.32
SERINC5 serine incorporator 5 -0.32
FBXO46 F-box protein 46 -0.31
RBM18 RNA binding motif protein 18 -0.31
PDGFRL platelet-derived growth factor receptor-like -0.31
SGMS2 sphingomyelin synthase 2 -0.31
HINT3 histidine triad nucleotide binding protein 3 -0.31
EGR1 early growth response 1 -0.31
FBXL15 F-box and leucine-rich repeat protein 15 -0.31
LDHD lactate dehydrogenase D -0.3
RNF13 ring finger protein 13 -0.3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -0.3
GFER growth factor, augmenter of liver regeneration -0.3
ARHGAP23 Rho GTPase activating protein 23 -0.3
ZBTB43 zinc finger and BTB domain containing 43 -0.3
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -0.3
COL14A1 collagen, type XIV, alpha 1 -0.3
CCDC57 coiled-coil domain containing 57 -0.3
NAGS N-acetylglutamate synthase -0.3
GTDC1 glycosyltransferase-like domain containing 1 -0.29
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -0.29
ZBTB47 zinc finger and BTB domain containing 47 -0.29
L1RE1 LINE1 retrotransposable element 1 -0.28
NEBL nebulette -0.28
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 -0.28
UNKL unkempt family zinc finger-like -0.28
PLA2G12A phospholipase A2, group XIIA -0.28
CYBA cytochrome b-245, alpha polypeptide -0.28
CUX2 cut-like homeobox 2 -0.28
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -0.28
GLMP glycosylated lysosomal membrane protein -0.28
NOTCH3 notch 3 -0.27
SRD5A3 steroid 5 alpha-reductase 3 -0.27
IER3IP1 immediate early response 3 interacting protein 1 -0.27
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) -0.27
ZNF22 zinc finger protein 22 -0.27
RAB26 RAB26, member RAS oncogene family -0.27
TMEM147 transmembrane protein 147 -0.27
CALB2 calbindin 2 -0.26
ACP1 acid phosphatase 1, soluble -0.26
CCDC112 coiled-coil domain containing 112 -0.26