| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2819993 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in P005091 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ARSB | arylsulfatase B | 1.47 |
| HBA1 | hemoglobin, alpha 1 | 1.04 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.87 |
| WNK2 | WNK lysine deficient protein kinase 2 | 0.79 |
| CENPJ | centromere protein J | 0.73 |
| IFRD1 | interferon-related developmental regulator 1 | 0.7 |
| HAL | histidine ammonia-lyase | 0.69 |
| CLU | clusterin | 0.69 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.66 |
| TRIB1 | tribbles pseudokinase 1 | 0.66 |
| FLNC | filamin C, gamma | 0.65 |
| SMTN | smoothelin | 0.64 |
| HMOX1 | heme oxygenase 1 | 0.64 |
| TMEM246 | transmembrane protein 246 | 0.64 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.64 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | 0.62 |
| SESN2 | sestrin 2 | 0.62 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.62 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | 0.6 |
| FN1 | fibronectin 1 | 0.6 |
| PLEKHA8 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 | 0.59 |
| KBTBD2 | kelch repeat and BTB (POZ) domain containing 2 | 0.59 |
| ZFP1 | ZFP1 zinc finger protein | 0.59 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.59 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 0.59 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | 0.58 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.58 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.57 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.57 |
| DUSP14 | dual specificity phosphatase 14 | 0.56 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.56 |
| TAOK2 | TAO kinase 2 | 0.56 |
| APOBEC3D | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | 0.55 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 0.53 |
| KIF20A | kinesin family member 20A | 0.53 |
| HSPA1A | heat shock 70kDa protein 1A | 0.53 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 0.53 |
| HSBP1 | heat shock factor binding protein 1 | 0.52 |
| F2 | coagulation factor II (thrombin) | 0.52 |
| INCENP | inner centromere protein antigens 135/155kDa | 0.51 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 0.51 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.5 |
| KCTD13 | potassium channel tetramerization domain containing 13 | 0.49 |
| CCN2 | cellular communication network factor 2 | 0.49 |
| JUN | jun proto-oncogene | 0.48 |
| CENPE | centromere protein E, 312kDa | 0.48 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.48 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 0.48 |
| VWA5A | von Willebrand factor A domain containing 5A | 0.47 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 0.47 |
| KLK6 | kallikrein-related peptidase 6 | 0.47 |
| PLD6 | phospholipase D family, member 6 | 0.47 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | 0.47 |
| CCN1 | cellular communication network factor 1 | 0.47 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | 0.46 |
| MFSD5 | major facilitator superfamily domain containing 5 | 0.46 |
| AMOTL1 | angiomotin like 1 | 0.46 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 0.46 |
| IL27RA | interleukin 27 receptor, alpha | 0.45 |
| TIFA | TRAF-interacting protein with forkhead-associated domain | 0.45 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.45 |
| CDCA3 | cell division cycle associated 3 | 0.45 |
| DEAF1 | DEAF1 transcription factor | 0.44 |
| AURKA | aurora kinase A | 0.44 |
| APOE | apolipoprotein E | 0.44 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.44 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.44 |
| BAG3 | BCL2-associated athanogene 3 | 0.44 |
| KLHL15 | kelch-like family member 15 | 0.43 |
| LAMC2 | laminin, gamma 2 | 0.43 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.43 |
| PHETA1 | PH domain containing endocytic trafficking adaptor 1 | 0.42 |
| ARL14EP | ADP-ribosylation factor-like 14 effector protein | 0.41 |
| SELENOK | selenoprotein K | 0.4 |
| TTC13 | tetratricopeptide repeat domain 13 | 0.4 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | 0.4 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 0.4 |
| CCNB1 | cyclin B1 | 0.4 |
| SRXN1 | sulfiredoxin 1 | 0.39 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.39 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | 0.39 |
| RNF7 | ring finger protein 7 | 0.39 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.39 |
| NPNT | nephronectin | 0.39 |
| CD63 | CD63 molecule | 0.39 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.39 |
| SIX5 | SIX homeobox 5 | 0.38 |
| MANEA | mannosidase, endo-alpha | 0.38 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.37 |
| SGO2 | shugoshin 2 | 0.37 |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 0.37 |
| QTRT1 | queuine tRNA-ribosyltransferase 1 | 0.37 |
| VIM | vimentin | 0.37 |
| ZNF518A | zinc finger protein 518A | 0.37 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.37 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.37 |
| AURKB | aurora kinase B | 0.37 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.36 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.36 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | 0.36 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFAND3 | zinc finger, AN1-type domain 3 | -1.08 |
| GBA2 | glucosidase, beta (bile acid) 2 | -1.04 |
| ZGRF1 | zinc finger, GRF-type containing 1 | -1.02 |
| GGT7 | gamma-glutamyltransferase 7 | -1.01 |
| ANKRD12 | ankyrin repeat domain 12 | -1.0 |
| LRP11 | low density lipoprotein receptor-related protein 11 | -0.91 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | -0.84 |
| MT2A | metallothionein 2A | -0.78 |
| IFT52 | intraflagellar transport 52 | -0.76 |
| SETMAR | SET domain and mariner transposase fusion gene | -0.75 |
| ZFP64 | ZFP64 zinc finger protein | -0.72 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | -0.69 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.69 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.63 |
| ZNF749 | zinc finger protein 749 | -0.62 |
| REPIN1 | replication initiator 1 | -0.62 |
| GLRX5 | glutaredoxin 5 | -0.61 |
| ACTBL2 | actin, beta-like 2 | -0.61 |
| ZNF584 | zinc finger protein 584 | -0.6 |
| WRB | tryptophan rich basic protein | -0.6 |
| IRX4 | iroquois homeobox 4 | -0.56 |
| PLEC | plectin | -0.56 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.55 |
| PRMT2 | protein arginine methyltransferase 2 | -0.55 |
| FAM161A | family with sequence similarity 161, member A | -0.54 |
| KLF13 | Kruppel-like factor 13 | -0.54 |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | -0.54 |
| PIGO | phosphatidylinositol glycan anchor biosynthesis, class O | -0.54 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.53 |
| PIAS3 | protein inhibitor of activated STAT, 3 | -0.53 |
| BID | BH3 interacting domain death agonist | -0.52 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.52 |
| CNPY2 | canopy FGF signaling regulator 2 | -0.51 |
| KLHL22 | kelch-like family member 22 | -0.49 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 | -0.48 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 | -0.48 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | -0.48 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | -0.47 |
| GOLGA4 | golgin A4 | -0.46 |
| KIF26A | kinesin family member 26A | -0.46 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | -0.46 |
| LMO4 | LIM domain only 4 | -0.46 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | -0.45 |
| S100A5 | S100 calcium binding protein A5 | -0.44 |
| PEX5 | peroxisomal biogenesis factor 5 | -0.44 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.44 |
| BAD | BCL2-associated agonist of cell death | -0.43 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | -0.42 |
| WDSUB1 | WD repeat, sterile alpha motif and U-box domain containing 1 | -0.42 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | -0.42 |
| ZNF12 | zinc finger protein 12 | -0.42 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -0.41 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | -0.41 |
| WASHC3 | WASH complex subunit 3 | -0.4 |
| SUMF2 | sulfatase modifying factor 2 | -0.4 |
| JDP2 | Jun dimerization protein 2 | -0.4 |
| CENPH | centromere protein H | -0.4 |
| ANKRD16 | ankyrin repeat domain 16 | -0.39 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -0.39 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.39 |
| DIXDC1 | DIX domain containing 1 | -0.39 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | -0.39 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | -0.38 |
| TXNDC12 | thioredoxin domain containing 12 (endoplasmic reticulum) | -0.38 |
| USP30 | ubiquitin specific peptidase 30 | -0.38 |
| CHCHD6 | coiled-coil-helix-coiled-coil-helix domain containing 6 | -0.37 |
| KLHL9 | kelch-like family member 9 | -0.37 |
| SPRTN | SprT-like N-terminal domain | -0.37 |
| ZNF397 | zinc finger protein 397 | -0.37 |
| ENO1 | enolase 1, (alpha) | -0.37 |
| GM2A | GM2 ganglioside activator | -0.37 |
| TMEM9 | transmembrane protein 9 | -0.37 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -0.36 |
| ZNF280B | zinc finger protein 280B | -0.36 |
| ELOVL1 | ELOVL fatty acid elongase 1 | -0.36 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -0.36 |
| DUSP7 | dual specificity phosphatase 7 | -0.36 |
| OBSL1 | obscurin-like 1 | -0.36 |
| TMEM106B | transmembrane protein 106B | -0.36 |
| COX19 | COX19 cytochrome c oxidase assembly factor | -0.36 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.36 |
| KIAA0753 | KIAA0753 | -0.36 |
| C12ORF73 | chromosome 12 open reading frame 73 | -0.36 |
| MACC1 | metastasis associated in colon cancer 1 | -0.36 |
| MRPL34 | mitochondrial ribosomal protein L34 | -0.36 |
| S100A2 | S100 calcium binding protein A2 | -0.35 |
| CCDC9B | coiled-coil domain containing 9B | -0.35 |
| CAMLG | calcium modulating ligand | -0.35 |
| MAF1 | MAF1 homolog (S. cerevisiae) | -0.35 |
| TRAPPC2 | trafficking protein particle complex 2 | -0.35 |
| PRDM4 | PR domain containing 4 | -0.35 |
| KLHL2 | kelch-like family member 2 | -0.35 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | -0.34 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.34 |
| ACY1 | aminoacylase 1 | -0.34 |
| SNRNP35 | small nuclear ribonucleoprotein 35kDa (U11/U12) | -0.34 |
| COX20 | COX20 cytochrome c oxidase assembly factor | -0.33 |
| DTNBP1 | dystrobrevin binding protein 1 | -0.33 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.33 |
| ANO10 | anoctamin 10 | -0.33 |
