P31FUJ Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Acute Myeloid Leukemia cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-000770
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Genes

332 gene knockdowns changing fitness of P31FUJ relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
PTPN6 protein tyrosine phosphatase, non-receptor type 6 20.7405
SPAST spastin 15.241
ULK3 unc-51 like kinase 3 12.8564
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 12.2255
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 12.0663
ZMYM6 zinc finger, MYM-type 6 10.2784
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 10.1482
ING4 inhibitor of growth family, member 4 10.0711
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 8.84732
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 8.01063
AFF2 AF4/FMR2 family, member 2 8.00433
CENPB centromere protein B, 80kDa 7.88314
PPIG peptidylprolyl isomerase G (cyclophilin G) 7.85416
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 7.76788
GFI1 growth factor independent 1 transcription repressor 7.56349
EXOC6 exocyst complex component 6 6.84767
TERF2IP telomeric repeat binding factor 2, interacting protein 6.69555
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 6.65741
FIZ1 FLT3-interacting zinc finger 1 6.24275
MYDGF myeloid-derived growth factor 6.19807
STMN1 stathmin 1 6.10915
TPCN1 two pore segment channel 1 6.08548
CLEC4G C-type lectin domain family 4, member G 6.07645
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 5.77205
SPI1 Spi-1 proto-oncogene 5.76151
C1QTNF9 C1q and tumor necrosis factor related protein 9 5.72016
LMO2 LIM domain only 2 (rhombotin-like 1) 5.67336
ERCC6 excision repair cross-complementation group 6 5.53885
GJC3 gap junction protein, gamma 3, 30.2kDa 5.4127
UFSP2 UFM1-specific peptidase 2 5.2776
IPMK inositol polyphosphate multikinase 5.25045
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 5.17662
PICALM phosphatidylinositol binding clathrin assembly protein 5.14482
GOLGA7 golgin A7 5.1434
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 5.14088
IFNA6 interferon, alpha 6 4.94335
EXO1 exonuclease 1 4.88445
STEAP3 STEAP family member 3, metalloreductase 4.85255
ABHD17B abhydrolase domain containing 17B 4.83075
MED13L mediator complex subunit 13-like 4.80053
VAC14 Vac14 homolog (S. cerevisiae) 4.74656
CPA5 carboxypeptidase A5 4.72713
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 4.71491
PROZ protein Z, vitamin K-dependent plasma glycoprotein 4.65112
CXCR5 chemokine (C-X-C motif) receptor 5 4.6036
KCTD5 potassium channel tetramerization domain containing 5 4.5343
OR2A25 olfactory receptor, family 2, subfamily A, member 25 4.51339
FLI1 Fli-1 proto-oncogene, ETS transcription factor 4.44886
BCL2 B-cell CLL/lymphoma 2 4.43165
KRTAP4-4 keratin associated protein 4-4 4.41086
FBXO7 F-box protein 7 4.31336
TRIM25 tripartite motif containing 25 4.26253
RCE1 Ras converting CAAX endopeptidase 1 4.26154
UBQLN1 ubiquilin 1 4.25212
ALAS1 5'-aminolevulinate synthase 1 4.24928
EGLN2 egl-9 family hypoxia-inducible factor 2 4.19318
UROS uroporphyrinogen III synthase 4.1311
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 4.12972
E2F8 E2F transcription factor 8 4.1055
ALG12 ALG12, alpha-1,6-mannosyltransferase 4.09491
WSB1 WD repeat and SOCS box containing 1 4.09184
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 4.07316
RAP2A RAP2A, member of RAS oncogene family 4.06325
GNG5 guanine nucleotide binding protein (G protein), gamma 5 4.05321
ALG3 ALG3, alpha-1,3- mannosyltransferase 4.02458
C5ORF30 chromosome 5 open reading frame 30 4.02092
TMC1 transmembrane channel-like 1 4.00067
EIF2A eukaryotic translation initiation factor 2A, 65kDa 3.98953
ECPAS Ecm29 proteasome adaptor and scaffold 3.9262
OR7D4 olfactory receptor, family 7, subfamily D, member 4 3.85862
CCL3L3 chemokine (C-C motif) ligand 3-like 3 3.85773
CCDC106 coiled-coil domain containing 106 3.85563
TPK1 thiamin pyrophosphokinase 1 3.83253
CTBP1 C-terminal binding protein 1 3.81268
NGLY1 N-glycanase 1 3.79304
OR10K2 olfactory receptor, family 10, subfamily K, member 2 3.74306
EXOC3L2 exocyst complex component 3-like 2 3.72689
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 3.71981
NLRP7 NLR family, pyrin domain containing 7 3.66092
INAFM1 InaF-motif containing 1 3.66036
ZMYM3 zinc finger, MYM-type 3 3.64304
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 3.64271
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 3.62528
WASHC2C WASH complex subunit 2C 3.56691
IFNA21 interferon, alpha 21 3.55868
UBE2T ubiquitin-conjugating enzyme E2T 3.52596
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 3.50027
ICMT isoprenylcysteine carboxyl methyltransferase 3.48721
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 3.48375
TMCO3 transmembrane and coiled-coil domains 3 3.48203
RBM26 RNA binding motif protein 26 3.46709
NFE2L1 nuclear factor, erythroid 2-like 1 3.43338
ZNF613 zinc finger protein 613 3.43324
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 3.42532
OR2M7 olfactory receptor, family 2, subfamily M, member 7 3.42248
TMEM139 transmembrane protein 139 3.41418
KRTAP10-11 keratin associated protein 10-11 3.3783
C16ORF54 chromosome 16 open reading frame 54 3.37713
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 3.37644
KRTAP19-3 keratin associated protein 19-3 3.35516
ALAD aminolevulinate dehydratase 3.34286
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 3.3353
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 3.30657
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 3.29464
VDAC2 voltage-dependent anion channel 2 3.28327
FIG4 FIG4 phosphoinositide 5-phosphatase 3.28017
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 3.26255
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.24725
BIN2 bridging integrator 2 3.22395
ALG9 ALG9, alpha-1,2-mannosyltransferase 3.22085
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 3.21698
CLEC18B C-type lectin domain family 18, member B 3.19034
EMB embigin 3.1883
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 3.18402
BTN3A1 butyrophilin, subfamily 3, member A1 3.15164
C4ORF3 chromosome 4 open reading frame 3 3.11125
PIEZO1 piezo-type mechanosensitive ion channel component 1 3.09367
BRD9 bromodomain containing 9 3.07095
AKT1 v-akt murine thymoma viral oncogene homolog 1 3.0687
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 3.06844
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 3.06438
KRTAP9-8 keratin associated protein 9-8 3.04704
PQLC3 PQ loop repeat containing 3 3.0355
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.02417
TTLL11 tubulin tyrosine ligase-like family member 11 3.01881
MYB v-myb avian myeloblastosis viral oncogene homolog 3.01704
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.01003
TMEM64 transmembrane protein 64 2.98451
ADGRB2 adhesion G protein-coupled receptor B2 2.97757
STK17A serine/threonine kinase 17a 2.97083
C20ORF96 chromosome 20 open reading frame 96 2.96031
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 2.94022
TPPP tubulin polymerization promoting protein 2.93819
PF4 platelet factor 4 2.93234
ERCC8 excision repair cross-complementation group 8 2.92532
HMBS hydroxymethylbilane synthase 2.91818
PSPH phosphoserine phosphatase 2.91494
CPNE7 copine VII 2.9004
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.88646
TRIT1 tRNA isopentenyltransferase 1 2.8797
KRTAP4-8 keratin associated protein 4-8 2.8738
CCND2 cyclin D2 2.86996
GTF2I general transcription factor IIi 2.86558
SP1 Sp1 transcription factor 2.86256
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.85526
TTC5 tetratricopeptide repeat domain 5 2.83964
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2.83527
CRYGC crystallin, gamma C 2.83009
ZNF222 zinc finger protein 222 2.82644
ODR4 odr-4 GPCR localization factor homolog 2.81653
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.80354
AK2 adenylate kinase 2 2.80326
LCN10 lipocalin 10 2.79795
NYNRIN NYN domain and retroviral integrase containing 2.78953
TMUB1 transmembrane and ubiquitin-like domain containing 1 2.77986
SH2D5 SH2 domain containing 5 2.77531
ETAA1 Ewing tumor-associated antigen 1 2.77365
MNMIP1 manchette microtubule inner protein 1 2.76144
TP53BP1 tumor protein p53 binding protein 1 2.76057
GALP galanin-like peptide 2.75205
AFTPH aftiphilin 2.75138
CPOX coproporphyrinogen oxidase 2.73198
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.72449
BRPF1 bromodomain and PHD finger containing, 1 2.71618
MED23 mediator complex subunit 23 2.7135
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.70602
MEIS1 Meis homeobox 1 2.69892
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 2.67194
MAP2K2 mitogen-activated protein kinase kinase 2 2.67107
GAMT guanidinoacetate N-methyltransferase 2.66975
LDB1 LIM domain binding 1 2.65877
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 2.64091
USP12 ubiquitin specific peptidase 12 2.64019
KNSTRN kinetochore-localized astrin/SPAG5 binding protein 2.63441
ANGPTL4 angiopoietin-like 4 2.63389
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.62367
FLYWCH2 FLYWCH family member 2 2.62007
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.61865
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2.61071
PIMREG PICALM interacting mitotic regulator 2.60838
TICAM2 toll-like receptor adaptor molecule 2 2.60654
CBFB core-binding factor, beta subunit 2.6048
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 2.59037
MICOS13 mitochondrial contact site and cristae organizing system subunit 13 2.5886
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.55535
RARA retinoic acid receptor, alpha 2.54638
IFRD1 interferon-related developmental regulator 1 2.54062
FAAP24 FA core complex associated protein 24 2.53302
MSS51 MSS51 mitochondrial translational activator 2.52546
FANCI Fanconi anemia, complementation group I 2.52486
SOBP sine oculis binding protein homolog (Drosophila) 2.5228
OR2T29 olfactory receptor, family 2, subfamily T, member 29 2.52107
SYT5 synaptotagmin V 2.51757
FCHO1 FCH domain only 1 2.51746
HCRTR1 hypocretin (orexin) receptor 1 2.51125
ZFP36L2 ZFP36 ring finger protein-like 2 2.50926
PUS3 pseudouridylate synthase 3 2.50099
FAM205A family with sequence similarity 205, member A 2.49862
PLAC8 placenta-specific 8 2.48531
GCLC glutamate-cysteine ligase, catalytic subunit 2.48478
NXPH4 neurexophilin 4 2.4805
RAD50 RAD50 homolog (S. cerevisiae) 2.46807
MED16 mediator complex subunit 16 2.46381
SPDYE4 speedy/RINGO cell cycle regulator family member E4 2.45994
ARL8B ADP-ribosylation factor-like 8B 2.4575
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 2.45441
STOX1 storkhead box 1 2.43476
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.42215
ZBTB12 zinc finger and BTB domain containing 12 2.40734
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.40683
IRF8 interferon regulatory factor 8 2.39993
TFF1 trefoil factor 1 2.39851
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 2.3909
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.38872
RCOR1 REST corepressor 1 2.38852
UBE3C ubiquitin protein ligase E3C 2.38821
MMP19 matrix metallopeptidase 19 2.38206
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 2.37438
CYS1 cystin 1 2.35968
DOT1L DOT1-like histone H3K79 methyltransferase 2.353
IRF2BP2 interferon regulatory factor 2 binding protein 2 2.35297
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.35214
LCE3D late cornified envelope 3D 2.3519
OR52E2 olfactory receptor, family 52, subfamily E, member 2 2.34573
ZEB2 zinc finger E-box binding homeobox 2 2.33556
PPCS phosphopantothenoylcysteine synthetase 2.33071
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 2.32351
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.31399
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2.31028
PRAMEF20 PRAME family member 20 2.30708
CPB2 carboxypeptidase B2 (plasma) 2.30541
CSRNP1 cysteine-serine-rich nuclear protein 1 2.30538
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 2.30278
FH fumarate hydratase 2.30218
ITPK1 inositol-tetrakisphosphate 1-kinase 2.29452
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 2.29438
RNF186 ring finger protein 186 2.29234
CCND3 cyclin D3 2.29107
ZNF551 zinc finger protein 551 2.28861
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 2.28307
OR10H5 olfactory receptor, family 10, subfamily H, member 5 2.28011
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.27298
WFDC10B WAP four-disulfide core domain 10B 2.27001
UBXN1 UBX domain protein 1 2.26798
EPHA2 EPH receptor A2 2.26557
ERCC4 excision repair cross-complementation group 4 2.26367
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.26091
TICAM1 toll-like receptor adaptor molecule 1 2.25689
RFPL2 ret finger protein-like 2 2.24705
FANCA Fanconi anemia, complementation group A 2.24048
GSE1 Gse1 coiled-coil protein 2.24046
SPACA7 sperm acrosome associated 7 2.24019
TDG thymine-DNA glycosylase 2.23751
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.2375
IL17C interleukin 17C 2.23547
DLG3 discs, large homolog 3 (Drosophila) 2.23496
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.23103
KAT6A K(lysine) acetyltransferase 6A 2.22291
FAM86B2 family with sequence similarity 86, member B2 2.21778
PRB2 proline-rich protein BstNI subfamily 2 2.2171
KIF24 kinesin family member 24 2.21427
ANKRD17 ankyrin repeat domain 17 2.21235
RASGRP4 RAS guanyl releasing protein 4 2.21154
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.20614
IL12A interleukin 12A 2.20355
BCL2L11 BCL2-like 11 (apoptosis facilitator) 2.2033
XCL1 chemokine (C motif) ligand 1 2.19731
ANTXRL anthrax toxin receptor-like 2.19235
ZNF98 zinc finger protein 98 2.18812
KRT33A keratin 33A, type I 2.18633
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.18438
ORC2 origin recognition complex, subunit 2 2.17403
DRICH1 aspartate-rich 1 2.16993
CNTNAP3 contactin associated protein-like 3 2.16618
ZNF467 zinc finger protein 467 2.16581
PDE8B phosphodiesterase 8B 2.16446
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2.16089
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.15765
FAHD2B fumarylacetoacetate hydrolase domain containing 2B 2.15686
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.15507
KDM1A lysine (K)-specific demethylase 1A 2.15388
UROC1 urocanate hydratase 1 2.15144
LRRC59 leucine rich repeat containing 59 2.14772
TMEM131 transmembrane protein 131 2.14644
KRTAP10-1 keratin associated protein 10-1 2.13791
PUS7 pseudouridylate synthase 7 (putative) 2.13715
CPA1 carboxypeptidase A1 (pancreatic) 2.13579
OR2T35 olfactory receptor, family 2, subfamily T, member 35 2.13558
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.13409
ZNF417 zinc finger protein 417 2.13079
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 2.13074
SDHAF2 succinate dehydrogenase complex assembly factor 2 2.12835
KAT7 K(lysine) acetyltransferase 7 2.12628
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.12234
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.1222
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 2.11503
MTA2 metastasis associated 1 family, member 2 2.11352
PRPH peripherin 2.11283
ELOVL1 ELOVL fatty acid elongase 1 2.11218
CRAMP1 cramped chromatin regulator homolog 1 2.10962
FCAMR Fc receptor, IgA, IgM, high affinity 2.10904
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.10627
LCE1B late cornified envelope 1B 2.10051
KRTAP10-9 keratin associated protein 10-9 2.09931
LSMEM1 leucine-rich single-pass membrane protein 1 2.09372
MED15 mediator complex subunit 15 2.0915
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.08865
PRAMEF1 PRAME family member 1 2.08399
HCCS holocytochrome c synthase 2.07363
ZNF219 zinc finger protein 219 2.07349
ZDHHC19 zinc finger, DHHC-type containing 19 2.06775
GJD3 gap junction protein, delta 3, 31.9kDa 2.06258
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.06208
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.06201
CEP55 centrosomal protein 55kDa 2.06077
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 2.05411
RC3H1 ring finger and CCCH-type domains 1 2.05376
DCPS decapping enzyme, scavenger 2.05055
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.04539
DHODH dihydroorotate dehydrogenase (quinone) 2.04165
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.04124
FANCL Fanconi anemia, complementation group L 2.04017
YIPF5 Yip1 domain family, member 5 2.03648
SPATA31A7 SPATA31 subfamily A, member 7 2.03605
IFNA17 interferon, alpha 17 2.03264
WDR4 WD repeat domain 4 2.02992
PSKH2 protein serine kinase H2 2.02763
OBI1 ORC ubiquitin ligase 1 2.02275
SNCB synuclein, beta 2.02057
PM20D1 peptidase M20 domain containing 1 2.01548
RIMBP3 RIMS binding protein 3 2.01076
STN1 STN1 subunit of CST complex 2.00327