P38A Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase 14|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1432)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase P38A from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MPG N-methylpurine-DNA glycosylase
FAM65A family with sequence similarity 65, member A
MICALL1 MICAL-like 1
TBX18 T-box 18
SOX15 SRY (sex determining region Y)-box 15
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
MYRF myelin regulatory factor
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
N4BP3 NEDD4 binding protein 3
CHAMP1 chromosome alignment maintaining phosphoprotein 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
C19ORF26 chromosome 19 open reading frame 26
TTN titin
ARHGAP30 Rho GTPase activating protein 30
IL2RB interleukin 2 receptor, beta
SPEG SPEG complex locus
ANKRD11 ankyrin repeat domain 11
GSG2 germ cell associated 2 (haspin)
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
TSC22D4 TSC22 domain family, member 4
HAUS6 HAUS augmin-like complex, subunit 6
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
KMT2B lysine (K)-specific methyltransferase 2B
MACF1 microtubule-actin crosslinking factor 1
KMT2D lysine (K)-specific methyltransferase 2D
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
STRN4 striatin, calmodulin binding protein 4
HJURP Holliday junction recognition protein
SHROOM3 shroom family member 3
CC2D1A coiled-coil and C2 domain containing 1A
CEP170B centrosomal protein 170B
PRRC2A proline-rich coiled-coil 2A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
PARVB parvin, beta
PARVA parvin, alpha
SFPQ splicing factor proline/glutamine-rich
ORC1 origin recognition complex, subunit 1
SLC12A9 solute carrier family 12, member 9
RELL1 RELT-like 1
BBC3 BCL2 binding component 3
GBE1 glucan (1,4-alpha-), branching enzyme 1
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
INO80B INO80 complex subunit B
COL1A1 collagen, type I, alpha 1
ARHGAP4 Rho GTPase activating protein 4
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
BRSK1 BR serine/threonine kinase 1
FLJ22184
TGIF1 TGFB-induced factor homeobox 1
COL14A1 collagen, type XIV, alpha 1
ZNF219 zinc finger protein 219
CTTNBP2NL CTTNBP2 N-terminal like
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PCNXL3 pecanex-like 3 (Drosophila)
CNKSR1 connector enhancer of kinase suppressor of Ras 1
SRCAP Snf2-related CREBBP activator protein
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
AHDC1 AT hook, DNA binding motif, containing 1
ZC3H13 zinc finger CCCH-type containing 13
GTSE1 G-2 and S-phase expressed 1
DRD4 dopamine receptor D4
PHF2 PHD finger protein 2
BCOR BCL6 corepressor
NOTCH3 notch 3
BCL2L11 BCL2-like 11 (apoptosis facilitator)
MTX1 metaxin 1
SCRIB scribbled planar cell polarity protein
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
NDE1 nudE neurodevelopment protein 1
DOCK5 dedicator of cytokinesis 5
SLC4A2 solute carrier family 4 (anion exchanger), member 2
ZNF276 zinc finger protein 276
MAP7 microtubule-associated protein 7
TRERF1 transcriptional regulating factor 1
CUEDC1 CUE domain containing 1
NELFA negative elongation factor complex member A
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
SHKBP1 SH3KBP1 binding protein 1
PPP4R2 protein phosphatase 4, regulatory subunit 2
DEAF1 DEAF1 transcription factor
CCDC86 coiled-coil domain containing 86
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
KANSL1 KAT8 regulatory NSL complex subunit 1
RASIP1 Ras interacting protein 1
DMWD dystrophia myotonica, WD repeat containing
COL12A1 collagen, type XII, alpha 1
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae)
SRRM2 serine/arginine repetitive matrix 2
ARHGAP22 Rho GTPase activating protein 22
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
RAI1 retinoic acid induced 1
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
BAG3 BCL2-associated athanogene 3
MMP1 matrix metallopeptidase 1
TNRC18 trinucleotide repeat containing 18
ITPKB inositol-trisphosphate 3-kinase B
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6
FAM110D family with sequence similarity 110, member D