P3H1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description prolyl 3-hydroxylase 1|This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 64175)
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Genes

319 genes differentially expressed following the P3H1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RAB44 RAB44, member RAS oncogene family 3.45626
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.45626
SPINK6 serine peptidase inhibitor, Kazal type 6 3.45626
FGL2 fibrinogen-like 2 3.45626
RAX retina and anterior neural fold homeobox 3.45626
PCDHB8 protocadherin beta 8 3.45626
PCDHB9 protocadherin beta 9 3.45626
SLC35G5 solute carrier family 35, member G5 3.45626
CASP5 caspase 5, apoptosis-related cysteine peptidase 3.45626
CCNB3 cyclin B3 3.45626
TBX18 T-box 18 3.45626
SLC46A2 solute carrier family 46, member 2 3.45626
KNG1 kininogen 1 3.45626
ATP13A5 ATPase type 13A5 3.45626
RGS9BP regulator of G protein signaling 9 binding protein 3.45626
USH1G Usher syndrome 1G (autosomal recessive) 3.45626
TMPRSS11F transmembrane protease, serine 11F 3.45626
CD274 CD274 molecule 3.45626
SELPLG selectin P ligand 3.45626
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.45626
CARD18 caspase recruitment domain family, member 18 3.45626
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.45626
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.45626
SIRPB2 signal-regulatory protein beta 2 3.45626
UMOD uromodulin 3.45626
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.45626
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.45626
C1ORF141 chromosome 1 open reading frame 141 3.45626
LRRC10B leucine rich repeat containing 10B 3.45626
CPB2 carboxypeptidase B2 (plasma) 3.45626
NEUROG3 neurogenin 3 3.45626
DRGX dorsal root ganglia homeobox 3.45626
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.45626
NPIPA8 nuclear pore complex interacting protein family, member A8 3.45626
GNRHR gonadotropin-releasing hormone receptor 3.45626
TPSD1 tryptase delta 1 3.45626
BIRC3 baculoviral IAP repeat containing 3 3.45626
LRRC52 leucine rich repeat containing 52 3.45626
PDE7B phosphodiesterase 7B 3.45626
C6ORF58 chromosome 6 open reading frame 58 3.45626
ASB10 ankyrin repeat and SOCS box containing 10 3.45626
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.45626
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.45626
SSTR5 somatostatin receptor 5 3.45626
C19ORF67 chromosome 19 open reading frame 67 3.45626
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.45626
MEA1 male-enhanced antigen 1 3.45626
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 3.45626
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.45626
ALDOB aldolase B, fructose-bisphosphate 3.45626
AVPR1B arginine vasopressin receptor 1B 3.45626
PROP1 PROP paired-like homeobox 1 3.45626
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.45626
PNLIPRP3 pancreatic lipase-related protein 3 3.45626
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.45626
RD3 retinal degeneration 3 3.45626
C20ORF202 chromosome 20 open reading frame 202 3.45626
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 3.45626
LOC124905976 uncharacterized LOC124905976 3.45626
ERVW-1 endogenous retrovirus group W, member 1 3.45626
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 3.45626
DRC5 dynein regulatory complex subunit 5 3.45626
WASL-DT WASL divergent transcript 3.45626
CD8B2 CD8b2 molecule 3.45626
H4C12 H4 clustered histone 12 3.45626
MYMK myomaker, myoblast fusion factor 3.45626
DNAAF6 dynein axonemal assembly factor 6 3.45626
ODAPH odontogenesis associated phosphoprotein 3.45626
CCDC190 coiled-coil domain containing 190 3.45626
ANGPTL8 angiopoietin like 8 3.45626
SQOR sulfide quinone oxidoreductase 3.45626
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.45626
TRIM31 tripartite motif containing 31 3.45626
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.45626
CXCL16 chemokine (C-X-C motif) ligand 16 3.45626
ULBP1 UL16 binding protein 1 3.45626
CD79A CD79a molecule, immunoglobulin-associated alpha 3.45626
ACTA1 actin, alpha 1, skeletal muscle 3.45626
AMBP alpha-1-microglobulin/bikunin precursor 3.45626
PCDHB11 protocadherin beta 11 3.45626
PTPRH protein tyrosine phosphatase, receptor type, H 3.45626
GGT5 gamma-glutamyltransferase 5 3.45626
RHOXF2 Rhox homeobox family, member 2 3.45626
C12ORF54 chromosome 12 open reading frame 54 3.45626
INSRR insulin receptor-related receptor 3.45626
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.45626
GATA3 GATA binding protein 3 3.45626
GATA4 GATA binding protein 4 3.45626
CSAG3 CSAG family, member 3 3.45626
DYNAP dynactin associated protein 3.45626
TMEM119 transmembrane protein 119 3.45626
TAS1R3 taste receptor, type 1, member 3 3.45626
IL7R interleukin 7 receptor 3.45626
GTSF1 gametocyte specific factor 1 3.45626
CCR3 chemokine (C-C motif) receptor 3 3.45626
FOXD1 forkhead box D1 3.45626
GOLGA6D golgin A6 family, member D 3.45626
CATIP ciliogenesis associated TTC17 interacting protein 3.45626
PRSS56 protease, serine, 56 3.45626
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.45626
CALML6 calmodulin-like 6 3.45626
TBC1D21 TBC1 domain family, member 21 3.45626
TF transferrin 3.45626
ALOX15B arachidonate 15-lipoxygenase, type B 3.45626
NT5C1B 5'-nucleotidase, cytosolic IB 3.45626
SUN3 Sad1 and UNC84 domain containing 3 3.45626
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.45626
PRTN3 proteinase 3 3.45626
FITM1 fat storage-inducing transmembrane protein 1 3.45626
DAPL1 death associated protein-like 1 3.45626
RNF222 ring finger protein 222 3.45626
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.45626
SOSTDC1 sclerostin domain containing 1 3.45626
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.45626
ZNF474 zinc finger protein 474 3.45626
KRT15 keratin 15, type I 3.45626
HRCT1 histidine rich carboxyl terminus 1 3.45626
C16ORF78 chromosome 16 open reading frame 78 3.45626
NOX1 NADPH oxidase 1 3.45626
NANOGNB NANOG neighbor homeobox 3.45626
ARG1 arginase 1 3.45626
S100Z S100 calcium binding protein Z 3.45626
CLRN2 clarin 2 3.45626
AQP7 aquaporin 7 3.45626
EHF ets homologous factor 3.45626
CPA3 carboxypeptidase A3 (mast cell) 3.45626
CDH19 cadherin 19, type 2 3.45626
EMP1 epithelial membrane protein 1 3.45626
ODF1 outer dense fiber of sperm tails 1 3.45626
FOXE3 forkhead box E3 3.45626
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 3.45626
IL21R interleukin 21 receptor 3.45626
VWA3B von Willebrand factor A domain containing 3B 3.45626
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.45626
LHX2 LIM homeobox 2 3.45626
PCDHGA12 protocadherin gamma subfamily A, 12 3.45626
PCDHAC2 protocadherin alpha subfamily C, 2 3.45626
R3HDML R3H domain containing-like 3.45626
HRG histidine-rich glycoprotein 3.45626
EN1 engrailed homeobox 1 3.45626
PRSS27 protease, serine 27 3.45626
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.45626
LRRN4 leucine rich repeat neuronal 4 3.45626
GOLGA8N golgin A8 family, member N 3.45626
FGF4 fibroblast growth factor 4 3.45626
ERAP2 endoplasmic reticulum aminopeptidase 2 3.45626
EMCN endomucin 3.45626
HMX3 H6 family homeobox 3 3.45626
EVPL envoplakin 3.45626
SPACA3 sperm acrosome associated 3 3.45626
BCL2A1 BCL2-related protein A1 3.45626
AMPD1 adenosine monophosphate deaminase 1 3.45626
LGALS14 lectin, galactoside-binding, soluble, 14 3.45626
IFNK interferon, kappa 3.45626
IFITM10 interferon induced transmembrane protein 10 3.45626
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.45626
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.45626
GCGR glucagon receptor 3.45626
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.45626
NEUROD4 neuronal differentiation 4 3.45626
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.45626
MNX1 motor neuron and pancreas homeobox 1 3.45626
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.45626
PCDHB14 protocadherin beta 14 3.38425
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 3.38425
CD160 CD160 molecule 3.37128
RAB23 RAB23, member RAS oncogene family 3.29193
CCDC170 coiled-coil domain containing 170 3.12263
SPMIP10 sperm microtubule inner protein 10 3.02949
COA6 cytochrome c oxidase assembly factor 6 3.02058
GTF2IRD2B GTF2I repeat domain containing 2B 2.94909
ARL14EP ADP-ribosylation factor-like 14 effector protein 2.92699
LRRC56 leucine rich repeat containing 56 2.92452
FAM216A family with sequence similarity 216, member A 2.9238
MYB v-myb avian myeloblastosis viral oncogene homolog 2.81322
SLC22A17 solute carrier family 22, member 17 2.78612
THAP12 THAP domain containing 12 2.70162
SIRT7 sirtuin 7 2.60116
PKN1 protein kinase N1 2.53524
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 2.50401
KCNIP2 Kv channel interacting protein 2 2.50184
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.45479
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.45479
BTC betacellulin 2.45479
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.42974
MTMR4 myotubularin related protein 4 2.42076
CLEC2D C-type lectin domain family 2, member D 2.40473
ZNF324B zinc finger protein 324B 2.38847
LIME1 Lck interacting transmembrane adaptor 1 2.38847
FKBP9 FK506 binding protein 9, 63 kDa 2.38847
TBX15 T-box 15 2.38847
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.38847
DISP2 dispatched homolog 2 (Drosophila) 2.38847
LRRC55 leucine rich repeat containing 55 2.38847
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.38847
GJA4 gap junction protein, alpha 4, 37kDa 2.38847
SP140 SP140 nuclear body protein 2.38847
CCAR1 cell division cycle and apoptosis regulator 1 2.38847
LCN10 lipocalin 10 2.38847
VTCN1 V-set domain containing T cell activation inhibitor 1 2.34916
SLC25A38 solute carrier family 25, member 38 2.33057
GOLGA8R golgin A8 family, member R 2.3295
MINAR2 membrane integral NOTCH2 associated receptor 2 2.30746
TMEM179B transmembrane protein 179B 2.26681
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 2.21917
DERL2 derlin 2 2.21145
C2ORF68 chromosome 2 open reading frame 68 2.17517
TST thiosulfate sulfurtransferase (rhodanese) 2.1702
MRPL51 mitochondrial ribosomal protein L51 2.16674
GLB1 galactosidase, beta 1 2.16062
RDH10 retinol dehydrogenase 10 (all-trans) 2.15256
TRIM9 tripartite motif containing 9 2.1226
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.10527
ZNRF3 zinc and ring finger 3 2.10246
DENND4B DENN/MADD domain containing 4B 2.09702
PLAA phospholipase A2-activating protein 2.07626
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.07289
CEP57 centrosomal protein 57kDa 2.06588
LIAS lipoic acid synthetase 2.05821
CEP104 centrosomal protein 104kDa 2.05426
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.05426
LAGE3 L antigen family, member 3 2.05426
LRRC14 leucine rich repeat containing 14 2.03678
PRELID2 PRELI domain containing 2 2.03185
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.03185
RIC8A RIC8 guanine nucleotide exchange factor A 2.03154
ERLEC1 endoplasmic reticulum lectin 1 2.03109
C15ORF40 chromosome 15 open reading frame 40 2.02925
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.01789
ARHGAP29 Rho GTPase activating protein 29 2.01584
RIPOR2 RHO family interacting cell polarization regulator 2 2.01477
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 2.01458

decreased expression

Symbol Name Standardized Value
TRIM50 tripartite motif containing 50 -3.45626
RANBP3L RAN binding protein 3-like -3.45626
PRB1 proline-rich protein BstNI subfamily 1 -3.45626
GPR52 G protein-coupled receptor 52 -3.45626
CX3CL1 chemokine (C-X3-C motif) ligand 1 -3.45626
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.45626
PON3 paraoxonase 3 -3.45626
HES7 hes family bHLH transcription factor 7 -3.45626
EPHX4 epoxide hydrolase 4 -3.45626
FNDC7 fibronectin type III domain containing 7 -3.45626
C11ORF87 chromosome 11 open reading frame 87 -3.45626
PSORS1C1 psoriasis susceptibility 1 candidate 1 -3.45626
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -3.45626
FAM216B family with sequence similarity 216, member B -3.45626
VWC2L von Willebrand factor C domain containing protein 2-like -3.45626
ATOH7 atonal homolog 7 (Drosophila) -3.45626
FAM209A family with sequence similarity 209, member A -3.45626
FAM209B family with sequence similarity 209, member B -3.45626
IL18R1 interleukin 18 receptor 1 -3.45626
CFAP299 cilia and flagella associated protein 299 -3.45626
KLB klotho beta -3.45626
SYT15 synaptotagmin XV -3.45626
TSPAN19 tetraspanin 19 -3.45626
KLHL10 kelch-like family member 10 -3.45626
MYOT myotilin -3.45626
TMEM238L transmembrane protein 238 like -3.45626
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -3.45626
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -3.45626
ULBP3 UL16 binding protein 3 -3.45626
GDA guanine deaminase -3.45626
CLASP2 cytoplasmic linker associated protein 2 -3.33989
TMEM106C transmembrane protein 106C -3.12263
PCDH19 protocadherin 19 -2.90254
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -2.83398
TCEA2 transcription elongation factor A (SII), 2 -2.83398
ZBTB7C zinc finger and BTB domain containing 7C -2.75879
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.74338
MSRB3 methionine sulfoxide reductase B3 -2.6707
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.65901
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B -2.64077
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 -2.59129
RAB24 RAB24, member RAS oncogene family -2.59129
RSL24D1 ribosomal L24 domain containing 1 -2.57793
RPH3A rabphilin 3A -2.49542
CEL carboxyl ester lipase -2.49542
CORT cortistatin -2.49542
DAPK1 death-associated protein kinase 1 -2.44659
IFT27 intraflagellar transport 27 -2.43926
P3H1 prolyl 3-hydroxylase 1 -2.43857
IPO13 importin 13 -2.4262
PNP purine nucleoside phosphorylase -2.41576
SNRPC small nuclear ribonucleoprotein polypeptide C -2.40994
TIGD6 tigger transposable element derived 6 -2.38847
PCDHA9 protocadherin alpha 9 -2.38847
CRYGS crystallin, gamma S -2.38847
BBS5 Bardet-Biedl syndrome 5 -2.38847
NXPH1 neurexophilin 1 -2.38025
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.3753
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.37427
CES3 carboxylesterase 3 -2.36087
SAMD4B sterile alpha motif domain containing 4B -2.33358
ARID5A AT rich interactive domain 5A (MRF1-like) -2.33057
SDS serine dehydratase -2.33057
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.33057
CEND1 cell cycle exit and neuronal differentiation 1 -2.33057
ING2 inhibitor of growth family, member 2 -2.30506
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.30331
KCNK5 potassium channel, two pore domain subfamily K, member 5 -2.2766
FCGBP Fc fragment of IgG binding protein -2.27288
ATCAY ataxia, cerebellar, Cayman type -2.26525
CUL9 cullin 9 -2.1766
ARRDC1 arrestin domain containing 1 -2.16125
C1QBP complement component 1, q subcomponent binding protein -2.137
LSAMP limbic system-associated membrane protein -2.10246
IQCK IQ motif containing K -2.09702
FBXO46 F-box protein 46 -2.03154
NDN necdin, melanoma antigen (MAGE) family member -2.03033
FBXO24 F-box protein 24 -2.01698
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.01698
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -2.01698
LNPK lunapark, ER junction formation factor -2.01689
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.01477
CDH24 cadherin 24, type 2 -2.01477
KIAA1549 KIAA1549 -2.01458
CHRM2 cholinergic receptor, muscarinic 2 -2.01215
MRPS26 mitochondrial ribosomal protein S26 -2.01215
PPP1R21 protein phosphatase 1, regulatory subunit 21 -2.00524