P3H3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description prolyl 3-hydroxylase 3|The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013] (NCBI Entrez Gene Database, 10536)
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Genes

290 genes differentially expressed following the P3H3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CRLF1 cytokine receptor-like factor 1 2.40424
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.40424
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.40424
ZACN zinc activated ligand-gated ion channel 2.40424
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.40424
FGF21 fibroblast growth factor 21 2.40424
ZNF503 zinc finger protein 503 2.40424
FBXL8 F-box and leucine-rich repeat protein 8 2.40424
LIPH lipase, member H 2.40424
OR8A1 olfactory receptor, family 8, subfamily A, member 1 2.40424
FAM187B family with sequence similarity 187, member B 2.40424
TMPRSS11A transmembrane protease, serine 11A 2.40424
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.40424
WDR38 WD repeat domain 38 2.40424
PCDHB14 protocadherin beta 14 2.40424
PCDHA7 protocadherin alpha 7 2.40424
PCDHA2 protocadherin alpha 2 2.40424
ERAS ES cell expressed Ras 2.40424
DPF3 D4, zinc and double PHD fingers, family 3 2.40424
ZNF99 zinc finger protein 99 2.40424
NDRG1 N-myc downstream regulated 1 2.40424
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 2.40424
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.40424
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.40424
TRIM77 tripartite motif containing 77 2.40424
TNS4 tensin 4 2.40424
LCN15 lipocalin 15 2.40424
UBA7 ubiquitin-like modifier activating enzyme 7 2.40424
OCM2 oncomodulin 2 2.40424
NOA1 nitric oxide associated 1 2.40424
TMEM82 transmembrane protein 82 2.40424
TMEM121 transmembrane protein 121 2.40424
LRRC61 leucine rich repeat containing 61 2.40424
ZNF234 zinc finger protein 234 2.40424
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.40424
FNDC7 fibronectin type III domain containing 7 2.40424
AKR1C2 aldo-keto reductase family 1, member C2 2.40424
ZFP57 ZFP57 zinc finger protein 2.40424
CELA3B chymotrypsin-like elastase family, member 3B 2.40424
FOXA2 forkhead box A2 2.40424
TM4SF1 transmembrane 4 L six family member 1 2.40424
TMEM151A transmembrane protein 151A 2.40424
PAX6 paired box 6 2.40424
SLC15A5 solute carrier family 15, member 5 2.40424
TCHHL1 trichohyalin-like 1 2.40424
BRICD5 BRICHOS domain containing 5 2.40424
DRC11L dynein regulatory complex subunit 11 like 2.40424
H3-5 H3.5 histone 2.40424
HAO2 hydroxyacid oxidase 2 (long chain) 2.40424
GBP2 guanylate binding protein 2, interferon-inducible 2.40424
C2ORF72 chromosome 2 open reading frame 72 2.40424
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.40424
MYH1 myosin, heavy chain 1, skeletal muscle, adult 2.40424
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.40424
CXCL13 chemokine (C-X-C motif) ligand 13 2.40424
HTRA4 HtrA serine peptidase 4 2.40424
FAM237B family with sequence similarity 237 member B 2.40424
PMIS2 PMIS2 transmembrane protein 2.40424
PIERCE2 piercer of microtubule wall 2 2.40424
CIMAP2 ciliary microtubule associated protein 2 2.40424
EPCIP exosomal polycystin 1 interacting protein 2.40424
CFAP96 cilia and flagella associated protein 96 2.40424
LOC124906010 uncharacterized LOC124906010 2.40424
ZNF593OS ZNF593 opposite strand 2.40424
H3-7 H3.7 histone (putative) 2.40424
TERB1 telomere repeat binding bouquet formation protein 1 2.40424
GARIN1A golgi associated RAB2 interactor 1A 2.40424
RTL5 retrotransposon Gag like 5 2.40424
TMEM126A transmembrane protein 126A 2.40424
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.40424
S100G S100 calcium binding protein G 2.40424
NPFF neuropeptide FF-amide peptide precursor 2.40424
CFAP45 cilia and flagella associated protein 45 2.40424
DNASE2B deoxyribonuclease II beta 2.40424
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.40424
CXCL16 chemokine (C-X-C motif) ligand 16 2.40424
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.40424
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.40424
BBS5 Bardet-Biedl syndrome 5 2.40424
CNTFR ciliary neurotrophic factor receptor 2.40424
UTS2 urotensin 2 2.40424
ABHD15 abhydrolase domain containing 15 2.40424
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.40424
TMPRSS6 transmembrane protease, serine 6 2.40424
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.40424
C4ORF50 chromosome 4 open reading frame 50 2.40424
LRRN4CL LRRN4 C-terminal like 2.40424
CSF1 colony stimulating factor 1 (macrophage) 2.40424
PRG4 proteoglycan 4 2.40424
NPIPB8 nuclear pore complex interacting protein family, member B8 2.40424
GPR132 G protein-coupled receptor 132 2.40424
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.40424
CHRM1 cholinergic receptor, muscarinic 1 2.40424
KLHL1 kelch-like family member 1 2.40424
NANOGNB NANOG neighbor homeobox 2.40424
PCP2 Purkinje cell protein 2 2.40424
CDHR5 cadherin-related family member 5 2.40424
CDHR3 cadherin-related family member 3 2.40424
PRM1 protamine 1 2.40424
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.40424
PLET1 placenta expressed transcript 1 2.40424
ADGRA1 adhesion G protein-coupled receptor A1 2.40424
HCRT hypocretin (orexin) neuropeptide precursor 2.40424
SOWAHA sosondowah ankyrin repeat domain family member A 2.40424
NUTM2G NUT family member 2G 2.40424
C9ORF57 chromosome 9 open reading frame 57 2.40424
CSPG4 chondroitin sulfate proteoglycan 4 2.40424
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.40424
DYTN dystrotelin 2.40424
SPTBN5 spectrin, beta, non-erythrocytic 5 2.40424
TMEM132E transmembrane protein 132E 2.40424
LCN1 lipocalin 1 2.40424
CLEC4G C-type lectin domain family 4, member G 2.40424
MCCD1 mitochondrial coiled-coil domain 1 2.40424
LMOD3 leiomodin 3 (fetal) 2.40424
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.40424
VAV1 vav 1 guanine nucleotide exchange factor 2.40424
LGALS16 lectin, galactoside-binding, soluble, 16 2.40424
SLC25A35 solute carrier family 25, member 35 2.40424
EFCAB12 EF-hand calcium binding domain 12 2.40424
MSMP microseminoprotein, prostate associated 2.40424
IGIP IgA-inducing protein 2.40424
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.40424
ZNF750 zinc finger protein 750 2.40424
ARL13A ADP-ribosylation factor-like 13A 2.40424
CLYBL citrate lyase beta like 2.40424
MYF5 myogenic factor 5 2.40424
KLK15 kallikrein-related peptidase 15 2.40424
TEX12 testis expressed 12 2.40424
RELN reelin 2.40424
C8B complement component 8, beta polypeptide 2.40424
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.40424
SPEF1 sperm flagellar 1 2.40424
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.40424
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 2.40424
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.40424
IL18R1 interleukin 18 receptor 1 2.40424
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.40424
IGFL2 IGF-like family member 2 2.40424
STEAP4 STEAP family member 4 2.40424
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 2.40424
LEP leptin 2.40424
TLN2 talin 2 2.40424
IL23R interleukin 23 receptor 2.40424
HES2 hes family bHLH transcription factor 2 2.40424
PRDM1 PR domain containing 1, with ZNF domain 2.40424
VCX variable charge, X-linked 2.40424
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.40424
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.40424
GRP gastrin-releasing peptide 2.40424
GYS2 glycogen synthase 2 (liver) 2.40424
LDHC lactate dehydrogenase C 2.40424
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.40424
PRR29 proline rich 29 2.40424
TMEM184A transmembrane protein 184A 2.40424
GALP galanin-like peptide 2.40424
CLCNKA chloride channel, voltage-sensitive Ka 2.40424
FXYD3 FXYD domain containing ion transport regulator 3 2.40424
A1CF APOBEC1 complementation factor 2.40424
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.40424
MEIG1 meiosis/spermiogenesis associated 1 2.40424
PRAP1 proline-rich acidic protein 1 2.40424
CHRDL2 chordin-like 2 2.40424
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.40424
CEP128 centrosomal protein 128kDa 2.39867
FAS Fas cell surface death receptor 2.39111
KIAA2013 KIAA2013 2.36027
DISP3 dispatched RND transporter family member 3 2.34222
ELL2 elongation factor, RNA polymerase II, 2 2.31855
GPR180 G protein-coupled receptor 180 2.31613
SPRYD3 SPRY domain containing 3 2.29793
IL11 interleukin 11 2.29793
CREB1 cAMP responsive element binding protein 1 2.2882
EXOC3 exocyst complex component 3 2.25684
IER2 immediate early response 2 2.25684
PKD1 polycystic kidney disease 1 (autosomal dominant) 2.25672
HPN hepsin 2.25542
CSK c-src tyrosine kinase 2.21637
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 2.21064
CEP76 centrosomal protein 76kDa 2.1853
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 2.1853
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.1853
BCL2 B-cell CLL/lymphoma 2 2.1853
FBXO9 F-box protein 9 2.1853
IQSEC1 IQ motif and Sec7 domain 1 2.16786
SLC38A2 solute carrier family 38, member 2 2.16351
FAM117A family with sequence similarity 117, member A 2.16351
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.14993
MCPH1 microcephalin 1 2.12798
PKD2 polycystic kidney disease 2 (autosomal dominant) 2.12798
SH3BP1 SH3-domain binding protein 1 2.12798
NME7 NME/NM23 family member 7 2.11735
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 2.10865
FAM193B family with sequence similarity 193, member B 2.08024
GOLPH3L golgi phosphoprotein 3-like 2.05379
RET ret proto-oncogene 2.05379
RYR3 ryanodine receptor 3 2.03469
SGPL1 sphingosine-1-phosphate lyase 1 2.03094

decreased expression

Symbol Name Standardized Value
C5ORF63 chromosome 5 open reading frame 63 -2.40424
RPL13A ribosomal protein L13a -2.40424
STARD8 StAR-related lipid transfer (START) domain containing 8 -2.40424
DLD dihydrolipoamide dehydrogenase -2.40424
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.40424
SPON2 spondin 2, extracellular matrix protein -2.40424
TMSB10 thymosin beta 10 -2.40424
NACA nascent polypeptide-associated complex alpha subunit -2.40424
RABL3 RAB, member of RAS oncogene family-like 3 -2.40424
PYGB phosphorylase, glycogen; brain -2.40424
CFAP300 cilia and flagella associated protein 300 -2.40424
KLRD1 killer cell lectin-like receptor subfamily D, member 1 -2.40424
ANAPC2 anaphase promoting complex subunit 2 -2.40424
PABPN1 poly(A) binding protein, nuclear 1 -2.40424
KLHL14 kelch-like family member 14 -2.40424
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) -2.35188
C12ORF60 chromosome 12 open reading frame 60 -2.32643
CKS2 CDC28 protein kinase regulatory subunit 2 -2.30814
PJVK pejvakin -2.2982
ZNF311 zinc finger protein 311 -2.27361
AFF3 AF4/FMR2 family, member 3 -2.25684
RPS26 ribosomal protein S26 -2.25684
CA11 carbonic anhydrase XI -2.25684
RPL39 ribosomal protein L39 -2.25684
UQCRB ubiquinol-cytochrome c reductase binding protein -2.25684
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.25542
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit -2.25542
RNF13 ring finger protein 13 -2.20436
CFAP54 cilia and flagella associated 54 -2.1853
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -2.1853
C9ORF78 chromosome 9 open reading frame 78 -2.1853
FGF4 fibroblast growth factor 4 -2.1853
CATSPERQ catsper channel auxiliary subunit theta -2.1853
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.1853
C1ORF74 chromosome 1 open reading frame 74 -2.1853
PAPOLA poly(A) polymerase alpha -2.1853
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -2.1853
PGAM2 phosphoglycerate mutase 2 (muscle) -2.1853
KLHL31 kelch-like family member 31 -2.1853
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 -2.1853
NPNT nephronectin -2.1853
ART3 ADP-ribosyltransferase 3 -2.1853
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 -2.1853
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.1853
SFT2D3 SFT2 domain containing 3 -2.1853
LOC105378220 macrophage receptor MARCO-like -2.1853
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -2.1853
CCDC78 coiled-coil domain containing 78 -2.1853
DRD4 dopamine receptor D4 -2.1853
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -2.1853
CDHR4 cadherin-related family member 4 -2.1853
ERICH6B glutamate-rich 6B -2.1853
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -2.1853
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.1853
ITGA11 integrin, alpha 11 -2.1853
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.1853
TAPBPL TAP binding protein-like -2.1853
PPIF peptidylprolyl isomerase F -2.1853
CTSO cathepsin O -2.1853
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.1853
C6ORF163 chromosome 6 open reading frame 163 -2.1853
TUBA8 tubulin, alpha 8 -2.1853
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.1853
DNAH6 dynein, axonemal, heavy chain 6 -2.1853
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.1853
NLRP1 NLR family, pyrin domain containing 1 -2.1853
IGFBP7 insulin-like growth factor binding protein 7 -2.1853
ETV7 ets variant 7 -2.1853
C5ORF47 chromosome 5 open reading frame 47 -2.1853
CD101 CD101 molecule -2.1853
TTLL10 tubulin tyrosine ligase-like family member 10 -2.1853
PELI2 pellino E3 ubiquitin protein ligase family member 2 -2.1804
SCAF1 SR-related CTD-associated factor 1 -2.18012
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.16786
ZDHHC6 zinc finger, DHHC-type containing 6 -2.16351
NMB neuromedin B -2.15522
PRSS3 protease, serine, 3 -2.14993
CCDC102B coiled-coil domain containing 102B -2.12435
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -2.11311
DPP8 dipeptidyl-peptidase 8 -2.10865
THNSL1 threonine synthase-like 1 (S. cerevisiae) -2.0862
KANSL1L KAT8 regulatory NSL complex subunit 1-like -2.08024
NIPAL3 NIPA-like domain containing 3 -2.07452
UBE2F ubiquitin-conjugating enzyme E2F (putative) -2.04617
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.03724
MRPL44 mitochondrial ribosomal protein L44 -2.03019
POMP proteasome maturation protein -2.02934
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 -2.02521
FAM156A family with sequence similarity 156, member A -2.01564
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -2.01564
TCERG1 transcription elongation regulator 1 -2.01045
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.00126