P4HA1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description prolyl 4-hydroxylase, alpha polypeptide I|This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5033)
Similar Terms
Downloads & Tools

Genes

347 genes differentially expressed following the P4HA1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NDNF neuron-derived neurotrophic factor 2.81449
IL1R1 interleukin 1 receptor, type I 2.81449
POMC proopiomelanocortin 2.81449
PCDHB9 protocadherin beta 9 2.81449
MMD2 monocyte to macrophage differentiation-associated 2 2.81449
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.81449
ACP3 acid phosphatase 3 2.81449
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.81449
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.81449
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.81449
CSMD3 CUB and Sushi multiple domains 3 2.81449
NELL1 NEL-like 1 (chicken) 2.81449
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 2.81449
TBX10 T-box 10 2.81449
PCDHB15 protocadherin beta 15 2.81449
EBF4 early B-cell factor 4 2.81449
CD52 CD52 molecule 2.81449
UPK1A uroplakin 1A 2.81449
HIPK4 homeodomain interacting protein kinase 4 2.81449
GBX1 gastrulation brain homeobox 1 2.81449
LIN37 lin-37 DREAM MuvB core complex component 2.81449
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.81449
IRF8 interferon regulatory factor 8 2.81449
AKR1D1 aldo-keto reductase family 1, member D1 2.73074
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.73074
NHLRC4 NHL repeat containing 4 2.73074
SCRT1 scratch family zinc finger 1 2.73074
TMEM19 transmembrane protein 19 2.73074
ACTL10 actin-like 10 2.73074
ITK IL2-inducible T-cell kinase 2.73074
PCDHB14 protocadherin beta 14 2.73074
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.73074
FOXD1 forkhead box D1 2.73074
FAM43B family with sequence similarity 43, member B 2.73074
TMIE transmembrane inner ear 2.73074
CFHR2 complement factor H-related 2 2.73074
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.73074
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.73074
PBOV1 prostate and breast cancer overexpressed 1 2.73074
TCAF2 TRPM8 channel-associated factor 2 2.73074
C9ORF152 chromosome 9 open reading frame 152 2.73074
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.73074
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.73074
NPIPA2 nuclear pore complex interacting protein family, member A2 2.73074
HBM hemoglobin, mu 2.73074
CARD16 caspase recruitment domain family, member 16 2.73074
OSR2 odd-skipped related transciption factor 2 2.73074
CST11 cystatin 11 2.73074
NPPC natriuretic peptide C 2.73074
SLC46A2 solute carrier family 46, member 2 2.73074
LRRTM1 leucine rich repeat transmembrane neuronal 1 2.73074
IGFL2 IGF-like family member 2 2.73074
TMEM176B transmembrane protein 176B 2.73074
KRT20 keratin 20, type I 2.73074
PCDHGB3 protocadherin gamma subfamily B, 3 2.73074
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.73074
MYO1G myosin IG 2.73074
LOC124906892 uncharacterized LOC124906892 2.73074
DEFB131B defensin beta 131B 2.73074
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.73074
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.73074
SMIM41 small integral membrane protein 41 2.73074
ALPG alkaline phosphatase, germ cell 2.73074
ANGPTL8 angiopoietin like 8 2.73074
H3-5 H3.5 histone 2.73074
VSIR V-set immunoregulatory receptor 2.73074
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.73074
ITPRID1 ITPR interacting domain containing 1 2.73074
FNDC11 fibronectin type III domain containing 11 2.73074
CATSPERT catsper channel auxiliary subunit tau 2.73074
SPMIP10 sperm microtubule inner protein 10 2.73074
TEX53 testis expressed 53 2.73074
ANKRD42-DT ANKRD42 divergent transcript 2.73074
NOTCH2NLB notch 2 N-terminal like B 2.73074
CTXND1 cortexin domain containing 1 2.73074
SMIM35 small integral membrane protein 35 2.73074
LHFPL7 LHFPL tetraspan subfamily member 7 2.73074
PEAK3 PEAK family member 3 2.73074
ZAR1 zygote arrest 1 2.73074
CLDN14 claudin 14 2.73074
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.73074
SASH3 SAM and SH3 domain containing 3 2.73074
PGLYRP2 peptidoglycan recognition protein 2 2.73074
CCR1 chemokine (C-C motif) receptor 1 2.73074
TMEM179 transmembrane protein 179 2.73074
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.73074
INSRR insulin receptor-related receptor 2.73074
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.73074
ZAN zonadhesin (gene/pseudogene) 2.73074
REC114 REC114 meiotic recombination protein 2.73074
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.73074
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.73074
RHCG Rh family, C glycoprotein 2.73074
STX11 syntaxin 11 2.73074
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.73074
LMNTD1 lamin tail domain containing 1 2.73074
C10ORF53 chromosome 10 open reading frame 53 2.73074
MYL10 myosin, light chain 10, regulatory 2.73074
GATA2 GATA binding protein 2 2.73074
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.73074
LTF lactotransferrin 2.73074
TPTE transmembrane phosphatase with tensin homology 2.73074
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.73074
MMP3 matrix metallopeptidase 3 2.73074
ZBED6 zinc finger, BED-type containing 6 2.73074
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.73074
SYTL4 synaptotagmin-like 4 2.73074
SCML4 sex comb on midleg-like 4 (Drosophila) 2.73074
TGM4 transglutaminase 4 2.73074
TGM6 transglutaminase 6 2.73074
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.73074
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.73074
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.73074
TMEM88 transmembrane protein 88 2.73074
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.73074
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.73074
MAMLD1 mastermind-like domain containing 1 2.73074
ASCL3 achaete-scute family bHLH transcription factor 3 2.73074
NOP56 NOP56 ribonucleoprotein 2.73074
SLITRK1 SLIT and NTRK-like family, member 1 2.73074
PIH1D2 PIH1 domain containing 2 2.73074
ZNF474 zinc finger protein 474 2.73074
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.73074
HSPB2 heat shock 27kDa protein 2 2.73074
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.73074
PRSS51 protease, serine, 51 2.73074
KRT3 keratin 3, type II 2.73074
EBF2 early B-cell factor 2 2.73074
CD177 CD177 molecule 2.73074
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.73074
RSAD2 radical S-adenosyl methionine domain containing 2 2.73074
NOG noggin 2.73074
AOC3 amine oxidase, copper containing 3 2.73074
EDN2 endothelin 2 2.73074
CST9 cystatin 9 (testatin) 2.73074
FADS6 fatty acid desaturase 6 2.73074
NRGN neurogranin (protein kinase C substrate, RC3) 2.73074
LKAAEAR1 LKAAEAR motif containing 1 2.73074
ZNF804B zinc finger protein 804B 2.73074
TCEA3 transcription elongation factor A (SII), 3 2.73074
PRPH2 peripherin 2 (retinal degeneration, slow) 2.73074
CTSH cathepsin H 2.73074
MOG myelin oligodendrocyte glycoprotein 2.73074
EFCC1 EF-hand and coiled-coil domain containing 1 2.73074
TSPAN16 tetraspanin 16 2.73074
IL18R1 interleukin 18 receptor 1 2.73074
OIT3 oncoprotein induced transcript 3 2.73074
GPR157 G protein-coupled receptor 157 2.73074
POU4F1 POU class 4 homeobox 1 2.73074
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.73074
PCDHAC1 protocadherin alpha subfamily C, 1 2.73074
HPGDS hematopoietic prostaglandin D synthase 2.73074
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.73074
C10ORF105 chromosome 10 open reading frame 105 2.73074
TH tyrosine hydroxylase 2.73074
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.73074
PITX3 paired-like homeodomain 3 2.73074
DMTN dematin actin binding protein 2.73074
PCDHGA3 protocadherin gamma subfamily A, 3 2.73074
BAHCC1 BAH domain and coiled-coil containing 1 2.73074
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.73074
VWA7 von Willebrand factor A domain containing 7 2.73074
GJC2 gap junction protein, gamma 2, 47kDa 2.73074
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.73074
KISS1 KiSS-1 metastasis-suppressor 2.73074
PARM1 prostate androgen-regulated mucin-like protein 1 2.64062
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.61067
GSTO1 glutathione S-transferase omega 1 2.59015
OLFM2 olfactomedin 2 2.5602
RIMS4 regulating synaptic membrane exocytosis 4 2.5602
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.5596
SAPCD1 suppressor APC domain containing 1 2.5596
PLCB4 phospholipase C, beta 4 2.55504
PAN2 PAN2 poly(A) specific ribonuclease subunit 2.5391
MEPCE methylphosphate capping enzyme 2.53177
PLXNA3 plexin A3 2.51905
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 2.51905
MPL MPL proto-oncogene, thrombopoietin receptor 2.45946
TNS4 tensin 4 2.45946
TBC1D20 TBC1 domain family, member 20 2.43736
CDK14 cyclin-dependent kinase 14 2.43543
MSH5 mutS homolog 5 2.43543
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2.43076
PODNL1 podocan-like 1 2.43076
RASL11A RAS-like, family 11, member A 2.43076
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.43076
TTC6 tetratricopeptide repeat domain 6 2.43076
KCTD15 potassium channel tetramerization domain containing 15 2.40167
AMER2 APC membrane recruitment protein 2 2.34077
TNRC6B trinucleotide repeat containing 6B 2.32401
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 2.32135
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 2.28293
MFSD1 major facilitator superfamily domain containing 1 2.27872
ATOSB atos homolog B 2.26379
DNAI4 dynein axonemal intermediate chain 4 2.26379
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 2.23978
MANEA mannosidase, endo-alpha 2.22535
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.21465
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 2.21465
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 2.2041
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.20384
NOVA2 neuro-oncological ventral antigen 2 2.15911
HIPK1 homeodomain interacting protein kinase 1 2.15765
KIAA0040 KIAA0040 2.14573
TRAF1 TNF receptor-associated factor 1 2.13925
B3GAT2 beta-1,3-glucuronyltransferase 2 2.1374
CTBP1 C-terminal binding protein 1 2.10955
C19ORF33 chromosome 19 open reading frame 33 2.10303
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.09766
SPATA1 spermatogenesis associated 1 2.09584
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 2.09584
SH3RF3 SH3 domain containing ring finger 3 2.08627
TENT5C terminal nucleotidyltransferase 5C 2.08462
JPH3 junctophilin 3 2.07723
RBM39 RNA binding motif protein 39 2.07607
MLEC malectin 2.07455
STAP2 signal transducing adaptor family member 2 2.0708
TMEM9 transmembrane protein 9 2.05615
FAM114A1 family with sequence similarity 114, member A1 2.03949
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.03649
ZNF493 zinc finger protein 493 2.03649
LACTB2 lactamase, beta 2 2.03649
GTPBP10 GTP-binding protein 10 (putative) 2.02565
RIOK2 RIO kinase 2 2.02565
NECAP2 NECAP endocytosis associated 2 2.02565
MDM4 MDM4, p53 regulator 2.02565
PCYT1B phosphate cytidylyltransferase 1, choline, beta 2.01947
OPTN optineurin 2.01947
ZNF563 zinc finger protein 563 2.01947
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.01947
C2ORF69 chromosome 2 open reading frame 69 2.01764
SOX11 SRY (sex determining region Y)-box 11 2.00665
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 2.00452
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.00394
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 2.00094

decreased expression

Symbol Name Standardized Value
LCA5L Leber congenital amaurosis 5-like -2.81449
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -2.81449
TSC22D1 TSC22 domain family, member 1 -2.81449
ADGRL2 adhesion G protein-coupled receptor L2 -2.81449
NUP205 nucleoporin 205kDa -2.73074
CPTP ceramide-1-phosphate transfer protein -2.73074
NOP10 NOP10 ribonucleoprotein -2.73074
REV1 REV1, polymerase (DNA directed) -2.73074
REEP4 receptor accessory protein 4 -2.73074
CLSTN2 calsyntenin 2 -2.73074
ATP5MC2 ATP synthase membrane subunit c locus 2 -2.73074
KIAA1328 KIAA1328 -2.6217
AMZ2 archaelysin family metallopeptidase 2 -2.56619
GGN gametogenetin -2.5602
BOLL boule-like RNA-binding protein -2.5602
CNTN6 contactin 6 -2.5602
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 -2.5602
TMEM86A transmembrane protein 86A -2.5602
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -2.5602
GHRHR growth hormone releasing hormone receptor -2.5602
FER1L6 fer-1-like family member 6 -2.5602
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.5602
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.5602
MUC6 mucin 6, oligomeric mucus/gel-forming -2.5602
RASA4B RAS p21 protein activator 4B -2.5602
FAM221A family with sequence similarity 221, member A -2.5602
IFI6 interferon, alpha-inducible protein 6 -2.5602
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -2.5602
FXYD3 FXYD domain containing ion transport regulator 3 -2.5602
HSF5 heat shock transcription factor family member 5 -2.5602
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.5602
TRHR thyrotropin-releasing hormone receptor -2.5602
HPX hemopexin -2.5602
KCTD19 potassium channel tetramerization domain containing 19 -2.5602
DEPP1 DEPP autophagy regulator 1 -2.5602
BEAN1 brain expressed, associated with NEDD4, 1 -2.5602
SYCP1 synaptonemal complex protein 1 -2.5602
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.5602
TNS1-AS1 TNS1 antisense RNA 1 -2.5602
SNAP91 synaptosomal-associated protein, 91kDa -2.5602
FAM163A family with sequence similarity 163, member A -2.5602
AHSG alpha-2-HS-glycoprotein -2.5602
CERS3 ceramide synthase 3 -2.5602
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 -2.5602
PRKN parkin RBR E3 ubiquitin protein ligase -2.54336
UQCRB ubiquinol-cytochrome c reductase binding protein -2.52011
SVOPL SVOP-like -2.51506
BRI3 brain protein I3 -2.50787
ACY1 aminoacylase 1 -2.49118
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 -2.49118
CALD1 caldesmon 1 -2.43543
ZNF415 zinc finger protein 415 -2.43543
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -2.43076
CCDC158 coiled-coil domain containing 158 -2.43076
CDC14B cell division cycle 14B -2.43076
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -2.43076
DMAC2L distal membrane arm assembly component 2 like -2.43076
FHIP2A FHF complex subunit HOOK interacting protein 2A -2.41596
GRTP1 growth hormone regulated TBC protein 1 -2.40677
APEH acylaminoacyl-peptide hydrolase -2.39273
NSFL1C NSFL1 (p97) cofactor (p47) -2.38512
SEC23A Sec23 homolog A (S. cerevisiae) -2.37875
PYCR2 pyrroline-5-carboxylate reductase family, member 2 -2.37093
RELL2 RELT-like 2 -2.37069
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.33375
TMCO1 transmembrane and coiled-coil domains 1 -2.33375
NELFCD negative elongation factor complex member C/D -2.31997
VWA8 von Willebrand factor A domain containing 8 -2.31791
FOXO4 forkhead box O4 -2.26379
CEP43 centrosomal protein 43 -2.26379
NBR1 neighbor of BRCA1 gene 1 -2.26153
UNK unkempt family zinc finger -2.26056
AVIL advillin -2.25712
MYG1 MYG1 exonuclease -2.24177
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.24177
MUC1 mucin 1, cell surface associated -2.23848
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.22535
RHOG ras homolog family member G -2.22535
KIF1B kinesin family member 1B -2.21465
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -2.21465
SLC9D1 solute carrier family 9 member D1 -2.2083
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.17231
C1ORF122 chromosome 1 open reading frame 122 -2.17231
H1-5 H1.5 linker histone, cluster member -2.16906
ZNF736 zinc finger protein 736 -2.15765
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.12624
ANKRD26 ankyrin repeat domain 26 -2.12624
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -2.12516
SSUH2 ssu-2 homolog (C. elegans) -2.1168
A4GALT alpha 1,4-galactosyltransferase -2.1168
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -2.11273
SAXO1 stabilizer of axonemal microtubules 1 -2.09584
ZNF593 zinc finger protein 593 -2.09584
MRPS28 mitochondrial ribosomal protein S28 -2.07723
RTL8A retrotransposon Gag like 8A -2.07455
ZNF551 zinc finger protein 551 -2.0708
GEMIN6 gem (nuclear organelle) associated protein 6 -2.05555
WDR18 WD repeat domain 18 -2.05351
ZNF598 zinc finger protein 598 -2.04718
CHMP4C charged multivesicular body protein 4C -2.04255
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.03649
JMY junction mediating and regulatory protein, p53 cofactor -2.03338
FRAS1 Fraser extracellular matrix complex subunit 1 -2.02565
ADCY9 adenylate cyclase 9 -2.02565
SAT1 spermidine/spermine N1-acetyltransferase 1 -2.01947
SPRY3 sprouty homolog 3 (Drosophila) -2.00452
LPAR6 lysophosphatidic acid receptor 6 -2.00452
GOLGA3 golgin A3 -2.00452
DMKN dermokine -2.00452
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.00452
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) -2.00452
CCDC51 coiled-coil domain containing 51 -2.00094