P4HB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description prolyl 4-hydroxylase, beta polypeptide|This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5034)
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Genes

282 genes differentially expressed following the P4HB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFI complement factor I 2.12555
TRIM62 tripartite motif containing 62 2.12555
IDI2 isopentenyl-diphosphate delta isomerase 2 2.12555
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.12555
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.12555
CALHM2 calcium homeostasis modulator 2 2.12555
EPX eosinophil peroxidase 2.12555
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.12555
CHAD chondroadherin 2.12555
PLA1A phospholipase A1 member A 2.12555
CYS1 cystin 1 2.12555
BTK Bruton agammaglobulinemia tyrosine kinase 2.12555
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.12555
C11ORF42 chromosome 11 open reading frame 42 2.12555
DMRT1 doublesex and mab-3 related transcription factor 1 2.12555
SPON2 spondin 2, extracellular matrix protein 2.12555
BAIAP3 BAI1-associated protein 3 2.12555
ARHGAP40 Rho GTPase activating protein 40 2.12555
CNGB1 cyclic nucleotide gated channel beta 1 2.12555
TTC22 tetratricopeptide repeat domain 22 2.12555
MT2A metallothionein 2A 2.12555
KRT3 keratin 3, type II 2.12555
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.12555
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.09887
SIX3 SIX homeobox 3 2.09887
SIX2 SIX homeobox 2 2.09887
GPR52 G protein-coupled receptor 52 2.09887
GIP gastric inhibitory polypeptide 2.09887
SCGN secretagogin, EF-hand calcium binding protein 2.09887
ZNF492 zinc finger protein 492 2.09887
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.09887
CST11 cystatin 11 2.09887
HLF hepatic leukemia factor 2.09887
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.09887
FOLR1 folate receptor 1 (adult) 2.09887
NPPC natriuretic peptide C 2.09887
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.09887
SFTPD surfactant protein D 2.09887
SDF2 stromal cell-derived factor 2 2.09887
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.09887
ZNF324B zinc finger protein 324B 2.09887
DCP1B decapping mRNA 1B 2.09887
CPB2 carboxypeptidase B2 (plasma) 2.09887
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 2.09887
GMNC geminin coiled-coil domain containing 2.09887
LARP6 La ribonucleoprotein domain family, member 6 2.09887
SPRR1B small proline-rich protein 1B 2.09887
CIITA class II, major histocompatibility complex, transactivator 2.09887
TNNT3 troponin T type 3 (skeletal, fast) 2.09887
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.09887
ABHD16B abhydrolase domain containing 16B 2.09887
GRXCR2 glutaredoxin, cysteine rich 2 2.09887
CLEC19A C-type lectin domain family 19, member A 2.09887
C8ORF48 chromosome 8 open reading frame 48 2.09887
SLC25A45 solute carrier family 25, member 45 2.09887
HBA1 hemoglobin, alpha 1 2.09887
LRG1 leucine-rich alpha-2-glycoprotein 1 2.09887
CRYGA crystallin, gamma A 2.09887
SPMIP8 sperm microtubule inner protein 8 2.09887
C9ORF43 chromosome 9 open reading frame 43 2.09887
PDF peptide deformylase (mitochondrial) 2.09887
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.09887
MYZAP myocardial zonula adherens protein 2.09887
BBLN bublin coiled coil protein 2.09887
BHLHE41 basic helix-loop-helix family, member e41 2.09887
LEKR1 leucine, glutamate and lysine rich 1 2.09887
KL klotho 2.09887
NDP Norrie disease (pseudoglioma) 2.09887
ZAR1 zygote arrest 1 2.09887
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.09887
ZNF593OS ZNF593 opposite strand 2.09887
RHEX regulator of hemoglobinization and erythroid cell expansion 2.09887
LY6L lymphocyte antigen 6 family member L 2.09887
GLYATL1B glycine-N-acyltransferase like 1B 2.09887
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.09887
JAML junction adhesion molecule like 2.09887
PHB1 prohibitin 1 2.09887
MMUT methylmalonyl-CoA mutase 2.09887
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.09887
LTB lymphotoxin beta (TNF superfamily, member 3) 2.09887
CFAP52 cilia and flagella associated protein 52 2.09887
LRP1B low density lipoprotein receptor-related protein 1B 2.09887
CHRD chordin 2.09887
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.09887
MAGEB3 melanoma antigen family B3 2.09887
MBD1 methyl-CpG binding domain protein 1 2.09887
TLE6 transducin-like enhancer of split 6 2.09887
RAB44 RAB44, member RAS oncogene family 2.09887
ACTL8 actin-like 8 2.09887
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.09887
ULBP3 UL16 binding protein 3 2.09887
TACSTD2 tumor-associated calcium signal transducer 2 2.09887
LRRC70 leucine rich repeat containing 70 2.09887
VCX3B variable charge, X-linked 3B 2.09887
PGA5 pepsinogen 5, group I (pepsinogen A) 2.09887
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.09887
LRRC3C leucine rich repeat containing 3C 2.09887
SAA4 serum amyloid A4, constitutive 2.09887
PLB1 phospholipase B1 2.09887
FAM186A family with sequence similarity 186, member A 2.09887
ZAN zonadhesin (gene/pseudogene) 2.09887
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 2.09887
EDN3 endothelin 3 2.09887
MBP myelin basic protein 2.09887
CLEC4D C-type lectin domain family 4, member D 2.09887
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.09887
PCDHGA4 protocadherin gamma subfamily A, 4 2.09887
MUCL1 mucin-like 1 2.09887
KISS1 KiSS-1 metastasis-suppressor 2.09887
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.09887
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.09887
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.09887
DCAF7 DDB1 and CUL4 associated factor 7 2.09887
PRM1 protamine 1 2.09887
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 2.09887
EFCAB3 EF-hand calcium binding domain 3 2.09887
DQX1 DEAQ box RNA-dependent ATPase 1 2.09887
ACTC1 actin, alpha, cardiac muscle 1 2.09887
NOX1 NADPH oxidase 1 2.09887
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.09887
CDHR5 cadherin-related family member 5 2.09887
EMX2 empty spiracles homeobox 2 2.09887
BSPH1 binder of sperm protein homolog 1 2.09887
AMH anti-Mullerian hormone 2.09887
ELP5 elongator acetyltransferase complex subunit 5 2.09887
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.09887
ESPNL espin-like 2.09887
CCNA1 cyclin A1 2.09887
MEPE matrix extracellular phosphoglycoprotein 2.09887
CNR1 cannabinoid receptor 1 (brain) 2.09887
LRRC24 leucine rich repeat containing 24 2.09887
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.09887
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.09887
CAPSL calcyphosine-like 2.09887
RGS1 regulator of G-protein signaling 1 2.09887
ANKRD53 ankyrin repeat domain 53 2.09887
PTHLH parathyroid hormone-like hormone 2.09887
INTS12 integrator complex subunit 12 2.09887
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.09887
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.09887
IP6K2 inositol hexakisphosphate kinase 2 2.09887
GPR62 G protein-coupled receptor 62 2.09887
FSD1L fibronectin type III and SPRY domain containing 1-like 2.09887
MSMB microseminoprotein, beta- 2.09887
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.09887
IRX1 iroquois homeobox 1 2.09887
NRGN neurogranin (protein kinase C substrate, RC3) 2.09887
ZNF619 zinc finger protein 619 2.09887
NLRP6 NLR family, pyrin domain containing 6 2.09887
KCTD4 potassium channel tetramerization domain containing 4 2.09887
TAS2R43 taste receptor, type 2, member 43 2.09887
MAGED4B melanoma antigen family D4B 2.09887
TMPRSS13 transmembrane protease, serine 13 2.09887
LKAAEAR1 LKAAEAR motif containing 1 2.09887
WFDC11 WAP four-disulfide core domain 11 2.09887
TSHZ1 teashirt zinc finger homeobox 1 2.09887
RTP1 receptor (chemosensory) transporter protein 1 2.09887
HES2 hes family bHLH transcription factor 2 2.09887
FGF8 fibroblast growth factor 8 (androgen-induced) 2.09887
PCDHGA11 protocadherin gamma subfamily A, 11 2.09887
IL23R interleukin 23 receptor 2.09887
SNAI2 snail family zinc finger 2 2.09887
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.09887
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 2.09887
HSPB1 heat shock 27kDa protein 1 2.09887
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.09887
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.09887
TBPL2 TATA box binding protein like 2 2.09887
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.09887
NTSR2 neurotensin receptor 2 2.09887
PCDHGB2 protocadherin gamma subfamily B, 2 2.09887
CCL25 chemokine (C-C motif) ligand 25 2.09887
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.09887
ECM1 extracellular matrix protein 1 2.09887
C9ORF50 chromosome 9 open reading frame 50 2.09887
PRRX1 paired related homeobox 1 2.09887
SCN3A sodium channel, voltage gated, type III alpha subunit 2.09887
ERICH3 glutamate-rich 3 2.09887
MMEL1 membrane metallo-endopeptidase-like 1 2.09887
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.0924
TMEM263 transmembrane protein 263 2.0924
IGFLR1 IGF-like family receptor 1 2.0924
COL23A1 collagen, type XXIII, alpha 1 2.07178
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 2.06951
RFC1 replication factor C (activator 1) 1, 145kDa 2.05356
OSBPL7 oxysterol binding protein-like 7 2.03212
SLC22A17 solute carrier family 22, member 17 2.03212
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.02122
F10 coagulation factor X 2.02108
FST follistatin 2.02097
DBNL drebrin-like 2.02049

decreased expression

Symbol Name Standardized Value
RBM11 RNA binding motif protein 11 -2.12555
RASL11B RAS-like, family 11, member B -2.12555
JAZF1 JAZF zinc finger 1 -2.12555
TMEM269 transmembrane protein 269 -2.09887
TTC39A tetratricopeptide repeat domain 39A -2.09887
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.09887
EHBP1 EH domain binding protein 1 -2.09887
CCDC141 coiled-coil domain containing 141 -2.09887
KDM6A lysine (K)-specific demethylase 6A -2.09887
ZSCAN20 zinc finger and SCAN domain containing 20 -2.09887
FBXW9 F-box and WD repeat domain containing 9 -2.09887
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) -2.09887
P4HB prolyl 4-hydroxylase, beta polypeptide -2.09887
BOLA3 bolA family member 3 -2.09887
LYPD6 LY6/PLAUR domain containing 6 -2.09887
NRG4 neuregulin 4 -2.09887
ADK adenosine kinase -2.09887
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -2.09887
AFG1L AFG1 like ATPase -2.09887
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -2.09887
PHF14 PHD finger protein 14 -2.09887
ZSWIM1 zinc finger, SWIM-type containing 1 -2.09887
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -2.09887
STAR steroidogenic acute regulatory protein -2.09887
APC2 adenomatosis polyposis coli 2 -2.09887
TRIO trio Rho guanine nucleotide exchange factor -2.09887
JOSD2 Josephin domain containing 2 -2.09887
NFE2L2 nuclear factor, erythroid 2-like 2 -2.09887
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.09887
ZBTB6 zinc finger and BTB domain containing 6 -2.09887
FER fer (fps/fes related) tyrosine kinase -2.09887
QSER1 glutamine and serine rich 1 -2.09887
MOK MOK protein kinase -2.09887
CPXM1 carboxypeptidase X (M14 family), member 1 -2.09887
SVOPL SVOP-like -2.09887
DCTN6 dynactin 6 -2.09887
C12ORF56 chromosome 12 open reading frame 56 -2.09887
CHSY3 chondroitin sulfate synthase 3 -2.09887
XG Xg blood group -2.09887
LYG2 lysozyme G-like 2 -2.09887
ZNF248 zinc finger protein 248 -2.09887
CAMK2G calcium/calmodulin-dependent protein kinase II gamma -2.09887
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.09887
THRB thyroid hormone receptor, beta -2.09887
SLA Src-like-adaptor -2.09887
JPH4 junctophilin 4 -2.09887
ERICH5 glutamate-rich 5 -2.09887
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -2.09887
ANXA13 annexin A13 -2.0924
LRTM3 leucine rich repeat transmembrane protein 3 -2.0924
H3-7 H3.7 histone (putative) -2.0924
EGFLAM EGF-like, fibronectin type III and laminin G domains -2.0924
ERVV-2 endogenous retrovirus group V, member 2 -2.0924
UBXN2B UBX domain protein 2B -2.0924
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -2.0924
ANGPT4 angiopoietin 4 -2.0924
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -2.0924
S100G S100 calcium binding protein G -2.0924
IL4I1 interleukin 4 induced 1 -2.0924
FAM178B family with sequence similarity 178, member B -2.0924
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.0924
DRD3 dopamine receptor D3 -2.0924
RSAD2 radical S-adenosyl methionine domain containing 2 -2.0924
PRSS36 protease, serine, 36 -2.0924
KYNU kynureninase -2.0924
IFI6 interferon, alpha-inducible protein 6 -2.0924
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -2.0924
MMP21 matrix metallopeptidase 21 -2.0924
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -2.0924
CCDC50 coiled-coil domain containing 50 -2.0924
PRSS51 protease, serine, 51 -2.0924
IGFBP7 insulin-like growth factor binding protein 7 -2.0924
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.0924
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.0924
AGMAT agmatine ureohydrolase (agmatinase) -2.0924
TCL1A T-cell leukemia/lymphoma 1A -2.0924
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.0924
C6ORF163 chromosome 6 open reading frame 163 -2.0924
EPHX4 epoxide hydrolase 4 -2.0924
ZBTB42 zinc finger and BTB domain containing 42 -2.0924
SV2C synaptic vesicle glycoprotein 2C -2.0924
SCPEP1 serine carboxypeptidase 1 -2.09218
ANKRD9 ankyrin repeat domain 9 -2.079
ZFYVE9 zinc finger, FYVE domain containing 9 -2.07465
SAAL1 serum amyloid A-like 1 -2.0726
LZTS2 leucine zipper, putative tumor suppressor 2 -2.07084
FHOD1 formin homology 2 domain containing 1 -2.0687
OXCT2 3-oxoacid CoA transferase 2 -2.02049
STPG2 sperm-tail PG-rich repeat containing 2 -2.02049
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.01618
MKRN2OS MKRN2 opposite strand -2.0075