P53_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/P53_DN.V1_UP
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Genes

386 genes differentially expressed following the P53_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AIM1 absent in melanoma 1
AMPH amphiphysin
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANXA1 annexin A1
ANXA2P1 annexin A2 pseudogene 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ARL4A ADP-ribosylation factor-like 4A
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAR3 breast cancer anti-estrogen resistance 3
BCL10 B-cell CLL/lymphoma 10
BIRC2 baculoviral IAP repeat containing 2
BMP4 bone morphogenetic protein 4
C4BPB complement component 4 binding protein, beta
CA6 carbonic anhydrase VI
CALB1 calbindin 1, 28kDa
CAMK1 calcium/calmodulin-dependent protein kinase I
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CAT catalase
CD24 CD24 molecule
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH13 cadherin 13
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHKA choline kinase alpha
CLDN3 claudin 3
CLIP3 CAP-GLY domain containing linker protein 3
CLTCL1 clathrin, heavy chain-like 1
CNN3 calponin 3, acidic
CNR1 cannabinoid receptor 1 (brain)
COL13A1 collagen, type XIII, alpha 1
COL17A1 collagen, type XVII, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CORO2A coronin, actin binding protein, 2A
CPE carboxypeptidase E
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CST6 cystatin E/M
CTAG2 cancer/testis antigen 2
CTNNBIP1 catenin, beta interacting protein 1
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DAAM1 dishevelled associated activator of morphogenesis 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DSC2 desmocollin 2
DSP desmoplakin
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
ELF4 E74-like factor 4 (ets domain transcription factor)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPCAM epithelial cell adhesion molecule
EXPH5 exophilin 5
F3 coagulation factor III (thromboplastin, tissue factor)
FBLN2 fibulin 2
FHL2 four and a half LIM domains 2
FOXN3 forkhead box N3
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GLUL glutamate-ammonia ligase
GP1BB glycoprotein Ib (platelet), beta polypeptide
GPSM2 G-protein signaling modulator 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GSTT1 glutathione S-transferase theta 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HDAC9 histone deacetylase 9
HIST1H2AE histone cluster 1, H2ae
IFI27 interferon, alpha-inducible protein 27
IGFBP6 insulin-like growth factor binding protein 6
IL18 interleukin 18
INHBB inhibin, beta B
INPP1 inositol polyphosphate-1-phosphatase
IRF1 interferon regulatory factor 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB4 integrin, beta 4
KAT5 K(lysine) acetyltransferase 5
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF5 Kruppel-like factor 5 (intestinal)
KLK1 kallikrein 1
KLK10 kallikrein-related peptidase 10
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMB2 laminin, beta 2 (laminin S)
LAMP3 lysosomal-associated membrane protein 3
LHFPL2 lipoma HMGIC fusion partner-like 2
LOXL1 lysyl oxidase-like 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC42 leucine rich repeat containing 42
LSR lipolysis stimulated lipoprotein receptor
LTBP1 latent transforming growth factor beta binding protein 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MARK2 MAP/microtubule affinity-regulating kinase 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MISP mitotic spindle positioning
MMP1 matrix metallopeptidase 1
MSLN mesothelin
MTAP methylthioadenosine phosphorylase
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYOF myoferlin
NDC80 NDC80 kinetochore complex component
NEBL nebulette
NKX2-1 NK2 homeobox 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OIP5 Opa interacting protein 5
OLFML2A olfactomedin-like 2A
PITX1 paired-like homeodomain 1
PLAU plasminogen activator, urokinase
PLCE1 phospholipase C, epsilon 1
PODXL podocalyxin-like
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPL periplakin
PRDX2 peroxiredoxin 2
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTK7 protein tyrosine kinase 7 (inactive)
PTN pleiotrophin
PTPRH protein tyrosine phosphatase, receptor type, H
RABGAP1L RAB GTPase activating protein 1-like
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
REEP2 receptor accessory protein 2
RNASE4 ribonuclease, RNase A family, 4
RNF11 ring finger protein 11
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRN1 secernin 1
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLIT2 slit homolog 2 (Drosophila)
SMAD6 SMAD family member 6
SMAGP small cell adhesion glycoprotein
SNHG3 small nucleolar RNA host gene 3
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRY2 sprouty homolog 2 (Drosophila)
SULF1 sulfatase 1
SUN1 Sad1 and UNC84 domain containing 1
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TGFBI transforming growth factor, beta-induced, 68kDa
THOC1 THO complex 1
TJP2 tight junction protein 2
TMEM30B transmembrane protein 30B
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TPTEP1 transmembrane phosphatase with tensin homology pseudogene 1
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT8 UDP glycosyltransferase 8
UNC13B unc-13 homolog B (C. elegans)
UQCRH ubiquinol-cytochrome c reductase hinge protein
USP1 ubiquitin specific peptidase 1
VASP vasodilator-stimulated phosphoprotein
VIPR1 vasoactive intestinal peptide receptor 1
YAP1 Yes-associated protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZNF160 zinc finger protein 160
ZNF165 zinc finger protein 165
ZNF185 zinc finger protein 185 (LIM domain)
ZNF415 zinc finger protein 415
ZNF44 zinc finger protein 44
ZNF799 zinc finger protein 799

decreased expression

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACP5 acid phosphatase 5, tartrate resistant
ACTA2 actin, alpha 2, smooth muscle, aorta
ADA adenosine deaminase
ADAM23 ADAM metallopeptidase domain 23
ADCY1 adenylate cyclase 1 (brain)
ADRA2C adrenoceptor alpha 2C
AJAP1 adherens junctions associated protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARMC2 armadillo repeat containing 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
BCHE butyrylcholinesterase
BCL2A1 BCL2-related protein A1
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAPN3 calpain 3, (p94)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CD1D CD1d molecule
CD247 CD247 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH19 cadherin 19, type 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGA chromogranin A
CHL1 cell adhesion molecule L1-like
COLEC10 collectin sub-family member 10 (C-type lectin)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CRYAB crystallin, alpha B
CTSK cathepsin K
CTSL cathepsin L
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DCT dopachrome tautomerase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DFNA5 deafness, autosomal dominant 5
DOCK2 dedicator of cytokinesis 2
ECM1 extracellular matrix protein 1
ELOVL2 ELOVL fatty acid elongase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESM1 endothelial cell-specific molecule 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM155B family with sequence similarity 155, member B
FAM50B family with sequence similarity 50, member B
FAS Fas cell surface death receptor
FBLN5 fibulin 5
FDXR ferredoxin reductase
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FRMD4B FERM domain containing 4B
FXYD2 FXYD domain containing ion transport regulator 2
GAL3ST1 galactose-3-O-sulfotransferase 1
GAMT guanidinoacetate N-methyltransferase
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GAS7 growth arrest-specific 7
GBA glucosidase, beta, acid
GFRA1 GDNF family receptor alpha 1
GLDC glycine dehydrogenase (decarboxylating)
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPR143 G protein-coupled receptor 143
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRAMD1B GRAM domain containing 1B
GREB1 growth regulation by estrogen in breast cancer 1
HGD homogentisate 1,2-dioxygenase
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HOXD8 homeobox D8
HSPA12A heat shock 70kDa protein 12A
HSPA2 heat shock 70kDa protein 2
IFFO1 intermediate filament family orphan 1
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IL2RB interleukin 2 receptor, beta
IRF4 interferon regulatory factor 4
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITK IL2-inducible T-cell kinase
KANK1 KN motif and ankyrin repeat domains 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
L1CAM L1 cell adhesion molecule
LAMA1 laminin, alpha 1
LAT linker for activation of T cells
LY96 lymphocyte antigen 96
LYRM9 LYR motif containing 9
MAL mal, T-cell differentiation protein
MATK megakaryocyte-associated tyrosine kinase
MGLL monoglyceride lipase
MIA melanoma inhibitory activity
MITF microphthalmia-associated transcription factor
MLANA melan-A
MMP7 matrix metallopeptidase 7
MTUS1 microtubule associated tumor suppressor 1
MYO5A myosin VA (heavy chain 12, myoxin)
MYOM2 myomesin 2
NAMPT nicotinamide phosphoribosyltransferase
NAV3 neuron navigator 3
NCALD neurocalcin delta
NDN necdin, melanoma antigen (MAGE) family member
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NID1 nidogen 1
NINJ1 ninjurin 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NRP2 neuropilin 2
NSG1 neuron specific gene family member 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OCA2 oculocutaneous albinism II
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE4B phosphodiesterase 4B, cAMP-specific
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
PLXNC1 plexin C1
PMEL premelanosome protein
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRAME preferentially expressed antigen in melanoma
PRG1 p53-responsive gene 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRM protein tyrosine phosphatase, receptor type, M
QPCT glutaminyl-peptide cyclotransferase
RAD51C RAD51 paralog C
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RENBP renin binding protein
RGS20 regulator of G-protein signaling 20
RHOQ ras homolog family member Q
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX3 runt-related transcription factor 3
S100A1 S100 calcium binding protein A1
S100B S100 calcium binding protein B
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A4 solute carrier family 16, member 4
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SOCS3 suppressor of cytokine signaling 3
SOX10 SRY (sex determining region Y)-box 10
SOX4 SRY (sex determining region Y)-box 4
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STOM stomatin
TAGLN3 transgelin 3
TDRD3 tudor domain containing 3
TFPI2 tissue factor pathway inhibitor 2
THBD thrombomodulin
TM4SF4 transmembrane 4 L six family member 4
TMEM5 transmembrane protein 5
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS2 tensin 2
TP53TG1 TP53 target 1 (non-protein coding)
TRAF4 TNF receptor-associated factor 4
TRIM22 tripartite motif containing 22
TRIM38 tripartite motif containing 38
TSPAN7 tetraspanin 7
TYR tyrosinase
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VCAN versican
VGF VGF nerve growth factor inducible
VIM vimentin
VLDLR very low density lipoprotein receptor
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF516 zinc finger protein 516