| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/P53_DN.V1_UP |
| Similar Terms | |
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386 genes differentially expressed following the P53_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| ADM | adrenomedullin |
| ADORA2B | adenosine A2b receptor |
| AGR2 | anterior gradient 2 |
| AHR | aryl hydrocarbon receptor |
| AIM1 | absent in melanoma 1 |
| AMPH | amphiphysin |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) |
| ANXA1 | annexin A1 |
| ANXA2P1 | annexin A2 pseudogene 1 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 |
| AREG | amphiregulin |
| ARL4A | ADP-ribosylation factor-like 4A |
| ASS1 | argininosuccinate synthase 1 |
| AUTS2 | autism susceptibility candidate 2 |
| AXL | AXL receptor tyrosine kinase |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding |
| BCAR3 | breast cancer anti-estrogen resistance 3 |
| BCL10 | B-cell CLL/lymphoma 10 |
| BIRC2 | baculoviral IAP repeat containing 2 |
| BMP4 | bone morphogenetic protein 4 |
| C4BPB | complement component 4 binding protein, beta |
| CA6 | carbonic anhydrase VI |
| CALB1 | calbindin 1, 28kDa |
| CAMK1 | calcium/calmodulin-dependent protein kinase I |
| CAND2 | cullin-associated and neddylation-dissociated 2 (putative) |
| CAT | catalase |
| CD24 | CD24 molecule |
| CD9 | CD9 molecule |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) |
| CDH13 | cadherin 13 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A |
| CDKN2D | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
| CEMIP | cell migration inducing protein, hyaluronan binding |
| CFB | complement factor B |
| CHKA | choline kinase alpha |
| CLDN3 | claudin 3 |
| CLIP3 | CAP-GLY domain containing linker protein 3 |
| CLTCL1 | clathrin, heavy chain-like 1 |
| CNN3 | calponin 3, acidic |
| CNR1 | cannabinoid receptor 1 (brain) |
| COL13A1 | collagen, type XIII, alpha 1 |
| COL17A1 | collagen, type XVII, alpha 1 |
| COL1A2 | collagen, type I, alpha 2 |
| COL3A1 | collagen, type III, alpha 1 |
| CORO2A | coronin, actin binding protein, 2A |
| CPE | carboxypeptidase E |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) |
| CST6 | cystatin E/M |
| CTAG2 | cancer/testis antigen 2 |
| CTNNBIP1 | catenin, beta interacting protein 1 |
| CXADR | coxsackie virus and adenovirus receptor |
| CYR61 | cysteine-rich, angiogenic inducer, 61 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| DMD | dystrophin |
| DSC2 | desmocollin 2 |
| DSP | desmoplakin |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| EFNB2 | ephrin-B2 |
| EGFR | epidermal growth factor receptor |
| ELF4 | E74-like factor 4 (ets domain transcription factor) |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) |
| EPCAM | epithelial cell adhesion molecule |
| EXPH5 | exophilin 5 |
| F3 | coagulation factor III (thromboplastin, tissue factor) |
| FBLN2 | fibulin 2 |
| FHL2 | four and a half LIM domains 2 |
| FOXN3 | forkhead box N3 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| G0S2 | G0/G1 switch 2 |
| GLUL | glutamate-ammonia ligase |
| GP1BB | glycoprotein Ib (platelet), beta polypeptide |
| GPSM2 | G-protein signaling modulator 2 |
| GRIK2 | glutamate receptor, ionotropic, kainate 2 |
| GSTT1 | glutathione S-transferase theta 1 |
| HAPLN1 | hyaluronan and proteoglycan link protein 1 |
| HDAC9 | histone deacetylase 9 |
| HIST1H2AE | histone cluster 1, H2ae |
| IFI27 | interferon, alpha-inducible protein 27 |
| IGFBP6 | insulin-like growth factor binding protein 6 |
| IL18 | interleukin 18 |
| INHBB | inhibin, beta B |
| INPP1 | inositol polyphosphate-1-phosphatase |
| IRF1 | interferon regulatory factor 1 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
| ITGB4 | integrin, beta 4 |
| KAT5 | K(lysine) acetyltransferase 5 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 |
| KLF5 | Kruppel-like factor 5 (intestinal) |
| KLK1 | kallikrein 1 |
| KLK10 | kallikrein-related peptidase 10 |
| KRT15 | keratin 15, type I |
| KRT18 | keratin 18, type I |
| KRT19 | keratin 19, type I |
| LAMB2 | laminin, beta 2 (laminin S) |
| LAMP3 | lysosomal-associated membrane protein 3 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 |
| LOXL1 | lysyl oxidase-like 1 |
| LPCAT4 | lysophosphatidylcholine acyltransferase 4 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
| LRRC42 | leucine rich repeat containing 42 |
| LSR | lipolysis stimulated lipoprotein receptor |
| LTBP1 | latent transforming growth factor beta binding protein 1 |
| LZTS3 | leucine zipper, putative tumor suppressor family member 3 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 |
| ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial |
| MEIS2 | Meis homeobox 2 |
| MEST | mesoderm specific transcript |
| MISP | mitotic spindle positioning |
| MMP1 | matrix metallopeptidase 1 |
| MSLN | mesothelin |
| MTAP | methylthioadenosine phosphorylase |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
| MYOF | myoferlin |
| NDC80 | NDC80 kinetochore complex component |
| NEBL | nebulette |
| NKX2-1 | NK2 homeobox 1 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 |
| NMU | neuromedin U |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 |
| OIP5 | Opa interacting protein 5 |
| OLFML2A | olfactomedin-like 2A |
| PITX1 | paired-like homeodomain 1 |
| PLAU | plasminogen activator, urokinase |
| PLCE1 | phospholipase C, epsilon 1 |
| PODXL | podocalyxin-like |
| PPARD | peroxisome proliferator-activated receptor delta |
| PPARG | peroxisome proliferator-activated receptor gamma |
| PPL | periplakin |
| PRDX2 | peroxiredoxin 2 |
| PRSS2 | protease, serine, 2 (trypsin 2) |
| PRSS3 | protease, serine, 3 |
| PTK7 | protein tyrosine kinase 7 (inactive) |
| PTN | pleiotrophin |
| PTPRH | protein tyrosine phosphatase, receptor type, H |
| RABGAP1L | RAB GTPase activating protein 1-like |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 |
| RBP1 | retinol binding protein 1, cellular |
| REEP2 | receptor accessory protein 2 |
| RNASE4 | ribonuclease, RNase A family, 4 |
| RNF11 | ring finger protein 11 |
| RP2 | retinitis pigmentosa 2 (X-linked recessive) |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 |
| S100P | S100 calcium binding protein P |
| SAP30 | Sin3A-associated protein, 30kDa |
| SCG2 | secretogranin II |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SCRN1 | secernin 1 |
| SDC4 | syndecan 4 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 |
| SLC16A2 | solute carrier family 16, member 2 (thyroid hormone transporter) |
| SLIT2 | slit homolog 2 (Drosophila) |
| SMAD6 | SMAD family member 6 |
| SMAGP | small cell adhesion glycoprotein |
| SNHG3 | small nucleolar RNA host gene 3 |
| SOX9 | SRY (sex determining region Y)-box 9 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| SULF1 | sulfatase 1 |
| SUN1 | Sad1 and UNC84 domain containing 1 |
| SYNJ2 | synaptojanin 2 |
| TACSTD2 | tumor-associated calcium signal transducer 2 |
| TGFBI | transforming growth factor, beta-induced, 68kDa |
| THOC1 | THO complex 1 |
| TJP2 | tight junction protein 2 |
| TMEM30B | transmembrane protein 30B |
| TOX3 | TOX high mobility group box family member 3 |
| TPBG | trophoblast glycoprotein |
| TPTEP1 | transmembrane phosphatase with tensin homology pseudogene 1 |
| TSPAN8 | tetraspanin 8 |
| TUBA4A | tubulin, alpha 4a |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| UGT8 | UDP glycosyltransferase 8 |
| UNC13B | unc-13 homolog B (C. elegans) |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein |
| USP1 | ubiquitin specific peptidase 1 |
| VASP | vasodilator-stimulated phosphoprotein |
| VIPR1 | vasoactive intestinal peptide receptor 1 |
| YAP1 | Yes-associated protein 1 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase |
| ZNF160 | zinc finger protein 160 |
| ZNF165 | zinc finger protein 165 |
| ZNF185 | zinc finger protein 185 (LIM domain) |
| ZNF415 | zinc finger protein 415 |
| ZNF44 | zinc finger protein 44 |
| ZNF799 | zinc finger protein 799 |
| Symbol | Name |
|---|---|
| ABCA4 | ATP-binding cassette, sub-family A (ABC1), member 4 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
| ACADS | acyl-CoA dehydrogenase, C-2 to C-3 short chain |
| ACP5 | acid phosphatase 5, tartrate resistant |
| ACTA2 | actin, alpha 2, smooth muscle, aorta |
| ADA | adenosine deaminase |
| ADAM23 | ADAM metallopeptidase domain 23 |
| ADCY1 | adenylate cyclase 1 (brain) |
| ADRA2C | adrenoceptor alpha 2C |
| AJAP1 | adherens junctions associated protein 1 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 |
| APOC1 | apolipoprotein C-I |
| APOC2 | apolipoprotein C-II |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 |
| ARMC2 | armadillo repeat containing 2 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 |
| BASP1 | brain abundant, membrane attached signal protein 1 |
| BAX | BCL2-associated X protein |
| BCHE | butyrylcholinesterase |
| BCL2A1 | BCL2-related protein A1 |
| BEX4 | brain expressed, X-linked 4 |
| BTG2 | BTG family, member 2 |
| CA12 | carbonic anhydrase XII |
| CA2 | carbonic anhydrase II |
| CAPN3 | calpain 3, (p94) |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase |
| CBX4 | chromobox homolog 4 |
| CD1D | CD1d molecule |
| CD247 | CD247 molecule |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
| CDH19 | cadherin 19, type 2 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CHGA | chromogranin A |
| CHL1 | cell adhesion molecule L1-like |
| COLEC10 | collectin sub-family member 10 (C-type lectin) |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial |
| CPVL | carboxypeptidase, vitellogenic-like |
| CRYAB | crystallin, alpha B |
| CTSK | cathepsin K |
| CTSL | cathepsin L |
| CTSZ | cathepsin Z |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 |
| DCT | dopachrome tautomerase |
| DDB2 | damage-specific DNA binding protein 2, 48kDa |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| DFNA5 | deafness, autosomal dominant 5 |
| DOCK2 | dedicator of cytokinesis 2 |
| ECM1 | extracellular matrix protein 1 |
| ELOVL2 | ELOVL fatty acid elongase 2 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 |
| ESM1 | endothelial cell-specific molecule 1 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FAM155B | family with sequence similarity 155, member B |
| FAM50B | family with sequence similarity 50, member B |
| FAS | Fas cell surface death receptor |
| FBLN5 | fibulin 5 |
| FDXR | ferredoxin reductase |
| FGB | fibrinogen beta chain |
| FGG | fibrinogen gamma chain |
| FRMD4B | FERM domain containing 4B |
| FXYD2 | FXYD domain containing ion transport regulator 2 |
| GAL3ST1 | galactose-3-O-sulfotransferase 1 |
| GAMT | guanidinoacetate N-methyltransferase |
| GAPDHS | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
| GAS7 | growth arrest-specific 7 |
| GBA | glucosidase, beta, acid |
| GFRA1 | GDNF family receptor alpha 1 |
| GLDC | glycine dehydrogenase (decarboxylating) |
| GLS | glutaminase |
| GPNMB | glycoprotein (transmembrane) nmb |
| GPR137B | G protein-coupled receptor 137B |
| GPR143 | G protein-coupled receptor 143 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B |
| GRAMD1B | GRAM domain containing 1B |
| GREB1 | growth regulation by estrogen in breast cancer 1 |
| HGD | homogentisate 1,2-dioxygenase |
| HMOX1 | heme oxygenase 1 |
| HOXB2 | homeobox B2 |
| HOXD8 | homeobox D8 |
| HSPA12A | heat shock 70kDa protein 12A |
| HSPA2 | heat shock 70kDa protein 2 |
| IFFO1 | intermediate filament family orphan 1 |
| IFI16 | interferon, gamma-inducible protein 16 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| IGFBP7 | insulin-like growth factor binding protein 7 |
| IL1R1 | interleukin 1 receptor, type I |
| IL2RB | interleukin 2 receptor, beta |
| IRF4 | interferon regulatory factor 4 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
| ITK | IL2-inducible T-cell kinase |
| KANK1 | KN motif and ankyrin repeat domains 1 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 |
| KCNJ8 | potassium channel, inwardly rectifying subfamily J, member 8 |
| L1CAM | L1 cell adhesion molecule |
| LAMA1 | laminin, alpha 1 |
| LAT | linker for activation of T cells |
| LY96 | lymphocyte antigen 96 |
| LYRM9 | LYR motif containing 9 |
| MAL | mal, T-cell differentiation protein |
| MATK | megakaryocyte-associated tyrosine kinase |
| MGLL | monoglyceride lipase |
| MIA | melanoma inhibitory activity |
| MITF | microphthalmia-associated transcription factor |
| MLANA | melan-A |
| MMP7 | matrix metallopeptidase 7 |
| MTUS1 | microtubule associated tumor suppressor 1 |
| MYO5A | myosin VA (heavy chain 12, myoxin) |
| MYOM2 | myomesin 2 |
| NAMPT | nicotinamide phosphoribosyltransferase |
| NAV3 | neuron navigator 3 |
| NCALD | neurocalcin delta |
| NDN | necdin, melanoma antigen (MAGE) family member |
| NEFL | neurofilament, light polypeptide |
| NEFM | neurofilament, medium polypeptide |
| NID1 | nidogen 1 |
| NINJ1 | ninjurin 1 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 |
| NRCAM | neuronal cell adhesion molecule |
| NRP2 | neuropilin 2 |
| NSG1 | neuron specific gene family member 1 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| OCA2 | oculocutaneous albinism II |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent |
| PDE4B | phosphodiesterase 4B, cAMP-specific |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
| PLCB4 | phospholipase C, beta 4 |
| PLIN2 | perilipin 2 |
| PLXNC1 | plexin C1 |
| PMEL | premelanosome protein |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
| PRAME | preferentially expressed antigen in melanoma |
| PRG1 | p53-responsive gene 1 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) |
| PTPRM | protein tyrosine phosphatase, receptor type, M |
| QPCT | glutaminyl-peptide cyclotransferase |
| RAD51C | RAD51 paralog C |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 |
| RENBP | renin binding protein |
| RGS20 | regulator of G-protein signaling 20 |
| RHOQ | ras homolog family member Q |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| RUNX3 | runt-related transcription factor 3 |
| S100A1 | S100 calcium binding protein A1 |
| S100B | S100 calcium binding protein B |
| SGK1 | serum/glucocorticoid regulated kinase 1 |
| SLC16A4 | solute carrier family 16, member 4 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 |
| SLC24A5 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 |
| SLC26A4 | solute carrier family 26 (anion exchanger), member 4 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 |
| SLC6A15 | solute carrier family 6 (neutral amino acid transporter), member 15 |
| SOCS3 | suppressor of cytokine signaling 3 |
| SOX10 | SRY (sex determining region Y)-box 10 |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SPG20 | spastic paraplegia 20 (Troyer syndrome) |
| SPP1 | secreted phosphoprotein 1 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
| ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 |
| STAT4 | signal transducer and activator of transcription 4 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced |
| STOM | stomatin |
| TAGLN3 | transgelin 3 |
| TDRD3 | tudor domain containing 3 |
| TFPI2 | tissue factor pathway inhibitor 2 |
| THBD | thrombomodulin |
| TM4SF4 | transmembrane 4 L six family member 4 |
| TMEM5 | transmembrane protein 5 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 |
| TNS2 | tensin 2 |
| TP53TG1 | TP53 target 1 (non-protein coding) |
| TRAF4 | TNF receptor-associated factor 4 |
| TRIM22 | tripartite motif containing 22 |
| TRIM38 | tripartite motif containing 38 |
| TSPAN7 | tetraspanin 7 |
| TYR | tyrosinase |
| UGT2B7 | UDP glucuronosyltransferase 2 family, polypeptide B7 |
| VCAN | versican |
| VGF | VGF nerve growth factor inducible |
| VIM | vimentin |
| VLDLR | very low density lipoprotein receptor |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) |
| ZFYVE16 | zinc finger, FYVE domain containing 16 |
| ZNF516 | zinc finger protein 516 |
