P70S6K Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description ribosomal protein S6 kinase, 70kDa, polypeptide 1|This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013] (NCBI Entrez Gene Database, 6198)
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100 substrates of the kinase P70S6K from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
SCAF1 SR-related CTD-associated factor 1
PLXNB1 plexin B1
ARHGAP11A Rho GTPase activating protein 11A
APTX aprataxin
KSR2 kinase suppressor of ras 2
ARHGAP39 Rho GTPase activating protein 39
TTN titin
OSBPL5 oxysterol binding protein-like 5
PPP1R8 protein phosphatase 1, regulatory subunit 8
MKI67 marker of proliferation Ki-67
TNS3 tensin 3
SETD2 SET domain containing 2
LARP4B La ribonucleoprotein domain family, member 4B
TBC1D4 TBC1 domain family, member 4
UBE2O ubiquitin-conjugating enzyme E2O
WWC3 WWC family member 3
BRCA1 breast cancer 1, early onset
KIF27 kinesin family member 27
KIF23 kinesin family member 23
EHBP1L1 EH domain binding protein 1-like 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CASP9 caspase 9, apoptosis-related cysteine peptidase
IER2 immediate early response 2
DEPDC5 DEP domain containing 5
S1PR1 sphingosine-1-phosphate receptor 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
HDGFRP2 hepatoma-derived growth factor-related protein 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
IWS1 IWS1 homolog (S. cerevisiae)
TCF20 transcription factor 20 (AR1)
RPS6 ribosomal protein S6
LDB1 LIM domain binding 1
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
RBM34 RNA binding motif protein 34
SRSF2 serine/arginine-rich splicing factor 2
GOLGA3 golgin A3
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
TP53RK TP53 regulating kinase
TRIM17 tripartite motif containing 17
HEATR3 HEAT repeat containing 3
CTR9 CTR9, Paf1/RNA polymerase II complex component
WDR81 WD repeat domain 81
SEPT1 septin 1
BAHD1 bromo adjacent homology domain containing 1
TRPS1 trichorhinophalangeal syndrome I
MVD mevalonate (diphospho) decarboxylase
FAM13A family with sequence similarity 13, member A
LYAR Ly1 antibody reactive
URI1 URI1, prefoldin-like chaperone
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRKD3 protein kinase D3
RARA retinoic acid receptor, alpha
EPRS glutamyl-prolyl-tRNA synthetase
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
HBP1 HMG-box transcription factor 1
POM121 POM121 transmembrane nucleoporin
GPR15 G protein-coupled receptor 15
ATAD2 ATPase family, AAA domain containing 2
ANKRD33B ankyrin repeat domain 33B
ATRX alpha thalassemia/mental retardation syndrome X-linked
SORBS2 sorbin and SH3 domain containing 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
EDC3 enhancer of mRNA decapping 3
CEP128 centrosomal protein 128kDa
PHF20 PHD finger protein 20
ILDR1 immunoglobulin-like domain containing receptor 1
CDCA2 cell division cycle associated 2
PHF3 PHD finger protein 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
SP100 SP100 nuclear antigen
KAZN kazrin, periplakin interacting protein
BLVRA biliverdin reductase A
NOS3 nitric oxide synthase 3 (endothelial cell)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
PPP1R12A protein phosphatase 1, regulatory subunit 12A
EI24 etoposide induced 2.4
ZFC3H1 zinc finger, C3H1-type containing
CLASP1 cytoplasmic linker associated protein 1
WNK4 WNK lysine deficient protein kinase 4
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
KANK1 KN motif and ankyrin repeat domains 1
RAP1GAP2 RAP1 GTPase activating protein 2
RARG retinoic acid receptor, gamma
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
RGS18 regulator of G-protein signaling 18
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SECISBP2L SECIS binding protein 2-like
BRD1 bromodomain containing 1
FAM214B family with sequence similarity 214, member B
ALPK3 alpha-kinase 3
LLGL2 lethal giant larvae homolog 2 (Drosophila)
HMHA1 histocompatibility (minor) HA-1
TWIST1 twist family bHLH transcription factor 1