PAC-1 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/135421197
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Genes

198 proteins with high or low expression in PAC-1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
RTN1 reticulon 1 1.29
NRP1 neuropilin 1 1.26
ANGPTL4 angiopoietin-like 4 1.19
PDK1 pyruvate dehydrogenase kinase, isozyme 1 1.12
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.12
GGACT gamma-glutamylamine cyclotransferase 1.12
KDM3A lysine (K)-specific demethylase 3A 1.09
LAMB3 laminin, beta 3 1.06
DAP death-associated protein 1.03
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.03
COL12A1 collagen, type XII, alpha 1 1.02
JUN jun proto-oncogene 0.99
NDRG1 N-myc downstream regulated 1 0.98
DOHH deoxyhypusine hydroxylase/monooxygenase 0.97
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.96
FXN frataxin 0.87
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 0.87
NLRC3 NLR family, CARD domain containing 3 0.86
LAMC2 laminin, gamma 2 0.85
ALDOC aldolase C, fructose-bisphosphate 0.85
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.82
COL18A1 collagen, type XVIII, alpha 1 0.8
LMOD1 leiomodin 1 (smooth muscle) 0.78
VIM vimentin 0.73
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.73
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.72
TRIB3 tribbles pseudokinase 3 0.72
TACSTD2 tumor-associated calcium signal transducer 2 0.69
HBA1 hemoglobin, alpha 1 0.69
MXRA7 matrix-remodelling associated 7 0.69
JAG1 jagged 1 0.66
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.66
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.66
ENO2 enolase 2 (gamma, neuronal) 0.65
GDF15 growth differentiation factor 15 0.65
TSPAN3 tetraspanin 3 0.64
SPAG17 sperm associated antigen 17 0.64
CSRNP1 cysteine-serine-rich nuclear protein 1 0.62
LMAN1 lectin, mannose-binding, 1 0.62
CPA4 carboxypeptidase A4 0.6
MYH15 myosin, heavy chain 15 0.59
HK2 hexokinase 2 0.58
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.58
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.57
STMN1 stathmin 1 0.54
RPE ribulose-5-phosphate-3-epimerase 0.53
NUCB2 nucleobindin 2 0.53
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.53
LDLR low density lipoprotein receptor 0.52
TPM1 tropomyosin 1 (alpha) 0.52
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.52
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.52
PLAUR plasminogen activator, urokinase receptor 0.51
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.51
SIX5 SIX homeobox 5 0.5
FOSL2 FOS-like antigen 2 0.5
CD58 CD58 molecule 0.5
PRG4 proteoglycan 4 0.49
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.49
ERRFI1 ERBB receptor feedback inhibitor 1 0.49
CNPY3 canopy FGF signaling regulator 3 0.49
MFAP3L microfibrillar-associated protein 3-like 0.49
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.49
DEGS1 delta(4)-desaturase, sphingolipid 1 0.49
RARA retinoic acid receptor, alpha 0.48
LGALS1 lectin, galactoside-binding, soluble, 1 0.48
EFNB2 ephrin-B2 0.48
KDM4B lysine (K)-specific demethylase 4B 0.48
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.48
CCN2 cellular communication network factor 2 0.48
NENF neudesin neurotrophic factor 0.47
WWC2 WW and C2 domain containing 2 0.47
PLAU plasminogen activator, urokinase 0.47
CCN1 cellular communication network factor 1 0.47
TMEM109 transmembrane protein 109 0.47
SCARB2 scavenger receptor class B, member 2 0.47
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.47
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.47
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 0.46
WNT16 wingless-type MMTV integration site family, member 16 0.46
CHRD chordin 0.45
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.45
PEX19 peroxisomal biogenesis factor 19 0.45
NUCB1 nucleobindin 1 0.45
HELB helicase (DNA) B 0.45
MTG2 mitochondrial ribosome-associated GTPase 2 0.45
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.45
UPP1 uridine phosphorylase 1 0.44
LRP1 low density lipoprotein receptor-related protein 1 0.44
LGALS8 lectin, galactoside-binding, soluble, 8 0.44
DPYSL2 dihydropyrimidinase-like 2 0.44
AK4 adenylate kinase 4 0.44
SDHAF4 succinate dehydrogenase complex assembly factor 4 0.44
CCDC158 coiled-coil domain containing 158 0.44
IREB2 iron-responsive element binding protein 2 0.43
ABLIM3 actin binding LIM protein family, member 3 0.43
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.43
FAM162A family with sequence similarity 162, member A 0.43
GPI glucose-6-phosphate isomerase 0.43

low expression

Symbol Name Standardized Value
KIAA0825 KIAA0825 -1.73
NTHL1 nth endonuclease III-like 1 (E. coli) -1.63
MUTYH mutY homolog -1.42
LIAS lipoic acid synthetase -1.31
FTH1 ferritin, heavy polypeptide 1 -1.24
FECH ferrochelatase -1.17
ADCY10 adenylate cyclase 10 (soluble) -1.11
MYH2 myosin, heavy chain 2, skeletal muscle, adult -1.1
PSRC1 proline/serine-rich coiled-coil 1 -1.08
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.07
METTL17 methyltransferase like 17 -1.06
C1ORF43 chromosome 1 open reading frame 43 -1.06
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -1.01
FDX1 ferredoxin 1 -1.0
FAT4 FAT atypical cadherin 4 -1.0
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -0.99
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -0.97
ODC1 ornithine decarboxylase 1 -0.92
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -0.92
MIEF2 mitochondrial elongation factor 2 -0.92
CCNF cyclin F -0.91
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.89
CDC25B cell division cycle 25B -0.88
RNF4 ring finger protein 4 -0.87
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.86
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -0.85
SLC25A38 solute carrier family 25, member 38 -0.84
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.84
BCOR BCL6 corepressor -0.83
ELP3 elongator acetyltransferase complex subunit 3 -0.83
CIAO3 cytosolic iron-sulfur assembly component 3 -0.83
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -0.82
DUSP7 dual specificity phosphatase 7 -0.81
SLF1 SMC5-SMC6 complex localization factor 1 -0.81
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene -0.8
ZNF580 zinc finger protein 580 -0.8
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -0.8
POLE polymerase (DNA directed), epsilon, catalytic subunit -0.79
GIN1 gypsy retrotransposon integrase 1 -0.79
ZRANB1 zinc finger, RAN-binding domain containing 1 -0.78
ZXDC ZXD family zinc finger C -0.78
PPAT phosphoribosyl pyrophosphate amidotransferase -0.78
RBIS ribosomal biogenesis factor -0.77
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -0.76
ZIC2 Zic family member 2 -0.76
SYTL3 synaptotagmin-like 3 -0.76
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -0.75
CISD3 CDGSH iron sulfur domain 3 -0.74
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 -0.73
PRELID1 PRELI domain containing 1 -0.73
ZNF354B zinc finger protein 354B -0.73
ETFDH electron-transferring-flavoprotein dehydrogenase -0.72
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -0.72
SERF2 small EDRK-rich factor 2 -0.71
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -0.71
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -0.71
POLD2 polymerase (DNA directed), delta 2, accessory subunit -0.7
TBC1D31 TBC1 domain family, member 31 -0.7
CCND1 cyclin D1 -0.69
EVI5L ecotropic viral integration site 5-like -0.69
MT2A metallothionein 2A -0.68
MRPL16 mitochondrial ribosomal protein L16 -0.68
MAK16 MAK16 homolog (S. cerevisiae) -0.68
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 -0.68
SDE2 SDE2 telomere maintenance homolog (S. pombe) -0.67
RTL6 retrotransposon Gag like 6 -0.67
RTEL1 regulator of telomere elongation helicase 1 -0.66
KMT2B lysine (K)-specific methyltransferase 2B -0.66
ATF6B activating transcription factor 6 beta -0.66
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae) -0.66
DPH1 diphthamide biosynthesis 1 -0.64
IGFBP6 insulin-like growth factor binding protein 6 -0.64
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -0.63
MRPS21 mitochondrial ribosomal protein S21 -0.63
COA5 cytochrome c oxidase assembly factor 5 -0.63
PRICKLE3 prickle homolog 3 (Drosophila) -0.63
ZNF584 zinc finger protein 584 -0.63
CCN3 cellular communication network factor 3 -0.63
ZUP1 zinc finger containing ubiquitin peptidase 1 -0.63
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -0.63
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -0.62
CDK18 cyclin-dependent kinase 18 -0.62
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa -0.62
SOCS7 suppressor of cytokine signaling 7 -0.61
BTBD11 BTB (POZ) domain containing 11 -0.61
SNX17 sorting nexin 17 -0.61
N4BP2L2 NEDD4 binding protein 2-like 2 -0.61
SOX4 SRY (sex determining region Y)-box 4 -0.61
CEP70 centrosomal protein 70kDa -0.6
CCDC170 coiled-coil domain containing 170 -0.6
LRRC58 leucine rich repeat containing 58 -0.6
CISD1 CDGSH iron sulfur domain 1 -0.6
RLIM ring finger protein, LIM domain interacting -0.59
MAGEF1 melanoma antigen family F1 -0.59
MKS1 Meckel syndrome, type 1 -0.59
ARID5B AT rich interactive domain 5B (MRF1-like) -0.58
MARK2 MAP/microtubule affinity-regulating kinase 2 -0.58
MRPS18C mitochondrial ribosomal protein S18C -0.58
GLT8D1 glycosyltransferase 8 domain containing 1 -0.58