PACS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphofurin acidic cluster sorting protein 1|This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 55690)
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Genes

339 genes differentially expressed following the PACS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OOSP1 oocyte secreted protein 1, pseudogene 2.48774
CFHR3 complement factor H-related 3 2.48774
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.48774
ARSF arylsulfatase F 2.48774
LY96 lymphocyte antigen 96 2.48774
BOLL boule-like RNA-binding protein 2.48774
ACTL10 actin-like 10 2.48774
TRIM55 tripartite motif containing 55 2.48774
ARHGAP30 Rho GTPase activating protein 30 2.48774
IL10RA interleukin 10 receptor, alpha 2.48774
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.48774
C1ORF141 chromosome 1 open reading frame 141 2.48774
S100Z S100 calcium binding protein Z 2.48774
PDF peptide deformylase (mitochondrial) 2.48774
BDKRB2 bradykinin receptor B2 2.48774
AKR1C2 aldo-keto reductase family 1, member C2 2.48774
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.48774
SNAI2 snail family zinc finger 2 2.48774
BMP8A bone morphogenetic protein 8a 2.48774
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 2.46651
UPK3B uroplakin 3B 2.40676
IL4I1 interleukin 4 induced 1 2.40676
SELPLG selectin P ligand 2.40676
LAPTM5 lysosomal protein transmembrane 5 2.40676
TMPRSS11A transmembrane protease, serine 11A 2.40676
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 2.40676
CD300LG CD300 molecule-like family member g 2.40676
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.40676
LOC390937 Ets2 repressor factor-like 2.40676
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.40676
PRLHR prolactin releasing hormone receptor 2.40676
TSSK4 testis-specific serine kinase 4 2.40676
IL31RA interleukin 31 receptor A 2.40676
UQCRC2 ubiquinol-cytochrome c reductase core protein II 2.40676
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.40676
UCN urocortin 2.40676
SCG2 secretogranin II 2.40676
SAV1 salvador family WW domain containing protein 1 2.40676
LCN12 lipocalin 12 2.40676
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.40676
LGI1 leucine-rich, glioma inactivated 1 2.40676
COPZ2 coatomer protein complex, subunit zeta 2 2.40676
SLC44A2 solute carrier family 44 (choline transporter), member 2 2.40676
ERVK3-1 endogenous retrovirus group K3, member 1 2.40676
ATOH1 atonal homolog 1 (Drosophila) 2.40676
ACOT12 acyl-CoA thioesterase 12 2.40676
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.40676
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.40676
SACK1A scaffolding CK1 anchoring protein A 2.40676
CELA3B chymotrypsin-like elastase family, member 3B 2.40676
GJB4 gap junction protein, beta 4, 30.3kDa 2.40676
CSTL1 cystatin-like 1 2.40676
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.40676
PRL prolactin 2.40676
OLIG1 oligodendrocyte transcription factor 1 2.40676
C19ORF67 chromosome 19 open reading frame 67 2.40676
GPR22 G protein-coupled receptor 22 2.40676
BMP5 bone morphogenetic protein 5 2.40676
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.40676
SMIM39 small integral membrane protein 39 2.40676
CCDC190 coiled-coil domain containing 190 2.40676
KASH5 KASH domain containing 5 2.40676
PLPP4 phospholipid phosphatase 4 2.40676
ABHD18 abhydrolase domain containing 18 2.40676
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.40676
GOLGA6L7 golgin A6 family like 7 2.40676
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.40676
SPATS1 spermatogenesis associated, serine-rich 1 2.40676
SRGN serglycin 2.40676
FOXN4 forkhead box N4 2.40676
H3-4 H3.4 histone, cluster member 2.40676
GARIN6 golgi associated RAB2 interactor family member 6 2.40676
OR1R1 olfactory receptor family 1 subfamily R member 1 2.40676
SPMIP10 sperm microtubule inner protein 10 2.40676
LOC114841035 uncharacterized LOC114841035 2.40676
LRRC8C-DT LRRC8C divergent transcript 2.40676
PRRT1B proline rich transmembrane protein 1B 2.40676
SPAAR small regulatory polypeptide of amino acid response 2.40676
SMIM31 small integral membrane protein 31 2.40676
MYMK myomaker, myoblast fusion factor 2.40676
H3C12 H3 clustered histone 12 2.40676
GLYATL1B glycine-N-acyltransferase like 1B 2.40676
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.40676
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.40676
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.40676
COX8C cytochrome c oxidase subunit VIIIC 2.40676
ZAR1L zygote arrest 1-like 2.40676
IL1R1 interleukin 1 receptor, type I 2.40676
SBSN suprabasin 2.40676
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.40676
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.40676
IL4 interleukin 4 2.40676
ANXA10 annexin A10 2.40676
DUSP29 dual specificity phosphatase 29 2.40676
CCR6 chemokine (C-C motif) receptor 6 2.40676
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.40676
VSIG8 V-set and immunoglobulin domain containing 8 2.40676
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.40676
TMPRSS5 transmembrane protease, serine 5 2.40676
WDR64 WD repeat domain 64 2.40676
UXS1 UDP-glucuronate decarboxylase 1 2.40676
MIOX myo-inositol oxygenase 2.40676
MYPN myopalladin 2.40676
GC group-specific component (vitamin D binding protein) 2.40676
WNT16 wingless-type MMTV integration site family, member 16 2.40676
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.40676
ZNF441 zinc finger protein 441 2.40676
CLDN9 claudin 9 2.40676
ZNF679 zinc finger protein 679 2.40676
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.40676
TEKT1 tektin 1 2.40676
CHI3L2 chitinase 3-like 2 2.40676
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.40676
SIRPG signal-regulatory protein gamma 2.40676
LENEP lens epithelial protein 2.40676
CCDC107 coiled-coil domain containing 107 2.40676
SAMD7 sterile alpha motif domain containing 7 2.40676
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.40676
TBXA2R thromboxane A2 receptor 2.40676
FAM209A family with sequence similarity 209, member A 2.40676
GOLGA6B golgin A6 family, member B 2.40676
TBPL2 TATA box binding protein like 2 2.40676
TFAP2D transcription factor AP-2 delta (activating enhancer binding protein 2 delta) 2.40676
FNDC9 fibronectin type III domain containing 9 2.40676
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.40676
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.40676
LCNL1 lipocalin-like 1 2.40676
CERS3 ceramide synthase 3 2.40676
CXCR4 chemokine (C-X-C motif) receptor 4 2.40676
IL21R interleukin 21 receptor 2.40676
HLA-DOB major histocompatibility complex, class II, DO beta 2.40676
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.40676
GPR150 G protein-coupled receptor 150 2.40676
PCDHAC2 protocadherin alpha subfamily C, 2 2.40676
CNR2 cannabinoid receptor 2 (macrophage) 2.40676
C10ORF105 chromosome 10 open reading frame 105 2.40676
TEX26 testis expressed 26 2.40676
MB myoglobin 2.40676
KDM1B lysine (K)-specific demethylase 1B 2.40676
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.40676
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.40676
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.40676
CD28 CD28 molecule 2.40676
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.40676
VSTM1 V-set and transmembrane domain containing 1 2.40676
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.40676
FAM91A1 family with sequence similarity 91, member A1 2.40676
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.40676
PDCD1LG2 programmed cell death 1 ligand 2 2.40676
SIGLEC15 sialic acid binding Ig-like lectin 15 2.40676
SYNGR4 synaptogyrin 4 2.40676
TAGAP T-cell activation RhoGTPase activating protein 2.40676
DAW1 dynein assembly factor with WDR repeat domains 1 2.40676
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 2.40676
MAPK11 mitogen-activated protein kinase 11 2.40676
SNTN sentan, cilia apical structure protein 2.40676
NRSN1 neurensin 1 2.40676
SORD sorbitol dehydrogenase 2.40676
AQP10 aquaporin 10 2.40676
MROH2A maestro heat-like repeat family member 2A 2.40676
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.40676
ADAM29 ADAM metallopeptidase domain 29 2.40676
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.40676
PADI4 peptidyl arginine deiminase, type IV 2.40676
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.40676
TMPRSS13 transmembrane protease, serine 13 2.40676
AGBL1 ATP/GTP binding protein-like 1 2.40676
SYTL4 synaptotagmin-like 4 2.40676
CD8B CD8b molecule 2.40676
TWIST1 twist family bHLH transcription factor 1 2.40676
POTEE POTE ankyrin domain family, member E 2.40676
PRAP1 proline-rich acidic protein 1 2.40676
ACKR2 atypical chemokine receptor 2 2.40676
MYO1G myosin IG 2.40676
GYS2 glycogen synthase 2 (liver) 2.40676
EPO erythropoietin 2.40676
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.40676
GH2 growth hormone 2 2.40676
STEAP4 STEAP family member 4 2.40676
PRSS21 protease, serine, 21 (testisin) 2.40676
CCDC83 coiled-coil domain containing 83 2.40676
LEP leptin 2.40676
FAM9C family with sequence similarity 9, member C 2.40676
NWD2 NACHT and WD repeat domain containing 2 2.40676
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.39588
SMYD2 SET and MYND domain containing 2 2.37815
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.36864
IGFBP7 insulin-like growth factor binding protein 7 2.36864
ZNF319 zinc finger protein 319 2.33004
LGALSL lectin, galactoside-binding-like 2.32547
MFSD6L major facilitator superfamily domain containing 6-like 2.31136
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.31136
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.25396
GRAMD2A GRAM domain containing 2A 2.2357
VSTM2B V-set and transmembrane domain containing 2B 2.2357
TRHR thyrotropin-releasing hormone receptor 2.2357
SOX7 SRY (sex determining region Y)-box 7 2.2357
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.23546
EIF5 eukaryotic translation initiation factor 5 2.2132
ARMH1 armadillo like helical domain containing 1 2.20942
MAT2B methionine adenosyltransferase II, beta 2.17481
NFYB nuclear transcription factor Y, beta 2.16959
PRKD1 protein kinase D1 2.16436
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.15761
SCFD2 sec1 family domain containing 2 2.14864
LARP4 La ribonucleoprotein domain family, member 4 2.13901
NCAPG2 non-SMC condensin II complex, subunit G2 2.1354
RND3 Rho family GTPase 3 2.12573
ARPC5L actin related protein 2/3 complex, subunit 5-like 2.11483
ATAT1 alpha tubulin acetyltransferase 1 2.0921
MED12 mediator complex subunit 12 2.09054
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus) 2.0765
SMAD5 SMAD family member 5 2.07603
TOP1 topoisomerase (DNA) I 2.07603
SKIL SKI-like proto-oncogene 2.06224
EAF2 ELL associated factor 2 2.05866
ZNF525 zinc finger protein 525 2.05866
ECD ecdysoneless homolog (Drosophila) 2.05866
NPIPB4 nuclear pore complex interacting protein family, member B4 2.04625
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.03707
DUSP16 dual specificity phosphatase 16 2.01357
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 2.01357
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.01249
GOSR1 golgi SNAP receptor complex member 1 2.00939
DLAT dihydrolipoamide S-acetyltransferase 2.00939

decreased expression

Symbol Name Standardized Value
PACS1 phosphofurin acidic cluster sorting protein 1 -2.48774
RGS20 regulator of G-protein signaling 20 -2.48774
APC2 adenomatosis polyposis coli 2 -2.48774
PCDHA4 protocadherin alpha 4 -2.48774
CLIC2 chloride intracellular channel 2 -2.48774
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -2.48774
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -2.48774
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.48774
TTLL9 tubulin tyrosine ligase-like family member 9 -2.48774
NLRP2 NLR family, pyrin domain containing 2 -2.48774
LDHD lactate dehydrogenase D -2.48774
EVI2B ecotropic viral integration site 2B -2.48774
NOD2 nucleotide-binding oligomerization domain containing 2 -2.40676
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -2.40676
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.40676
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -2.40676
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.40676
COL8A1 collagen, type VIII, alpha 1 -2.40676
DENND4C DENN/MADD domain containing 4C -2.40676
S100A2 S100 calcium binding protein A2 -2.40676
SYNE4 spectrin repeat containing, nuclear envelope family member 4 -2.40676
GLIS1 GLIS family zinc finger 1 -2.40676
TNS4 tensin 4 -2.40676
CXCL2 chemokine (C-X-C motif) ligand 2 -2.40676
UNC45B unc-45 homolog B (C. elegans) -2.40676
CA1 carbonic anhydrase I -2.40676
NR4A3 nuclear receptor subfamily 4, group A, member 3 -2.40676
MAGEA2 melanoma antigen family A2 -2.40676
SLC26A9 solute carrier family 26 (anion exchanger), member 9 -2.40676
PNMA8C PNMA family member 8C -2.40676
H3C4 H3 clustered histone 4 -2.40676
TERB1 telomere repeat binding bouquet formation protein 1 -2.40676
POU2AF3 POU class 2 homeobox associating factor 3 -2.40676
TMEM276 transmembrane protein 276 -2.40676
ANO3 anoctamin 3 -2.40676
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.40676
TMEM190 transmembrane protein 190 -2.40676
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.40676
PGA5 pepsinogen 5, group I (pepsinogen A) -2.40676
COG7 component of oligomeric golgi complex 7 -2.40676
CAPRIN2 caprin family member 2 -2.40676
SCRG1 stimulator of chondrogenesis 1 -2.40676
TAS2R31 taste receptor, type 2, member 31 -2.40676
ZNF583 zinc finger protein 583 -2.40676
FER1L6 fer-1-like family member 6 -2.40676
CD96 CD96 molecule -2.40676
PNMA6F PNMA family member 6F -2.40676
PPP1R3C protein phosphatase 1, regulatory subunit 3C -2.40676
TTC36 tetratricopeptide repeat domain 36 -2.40676
ANKRD61 ankyrin repeat domain 61 -2.40676
CERKL ceramide kinase-like -2.40676
GSTO2 glutathione S-transferase omega 2 -2.40676
ZNF296 zinc finger protein 296 -2.40676
DNAH12 dynein, axonemal, heavy chain 12 -2.40676
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.40676
ACKR3 atypical chemokine receptor 3 -2.40676
PRAM1 PML-RARA regulated adaptor molecule 1 -2.40676
TBC1D28 TBC1 domain family, member 28 -2.40676
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin -2.40676
IL12A interleukin 12A -2.40676
UPK1A uroplakin 1A -2.40676
SHISA3 shisa family member 3 -2.40676
SOGA1 suppressor of glucose, autophagy associated 1 -2.40676
TRIB1 tribbles pseudokinase 1 -2.40676
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -2.40676
SVOPL SVOP-like -2.40676
ARL9 ADP-ribosylation factor-like 9 -2.40676
APOA1 apolipoprotein A-I -2.40676
OSBP2 oxysterol binding protein 2 -2.40676
IL32 interleukin 32 -2.40676
COPS8 COP9 signalosome subunit 8 -2.40676
CPA6 carboxypeptidase A6 -2.40676
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.40417
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.38599
GUCA1B guanylate cyclase activator 1B (retina) -2.36691
JAKMIP1 janus kinase and microtubule interacting protein 1 -2.34967
UBE2K ubiquitin-conjugating enzyme E2K -2.25034
ASGR1 asialoglycoprotein receptor 1 -2.22808
FABP3 fatty acid binding protein 3, muscle and heart -2.21909
SUMF1 sulfatase modifying factor 1 -2.21784
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.2132
PFDN2 prefoldin subunit 2 -2.19599
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.16739
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.15761
PDE4B phosphodiesterase 4B, cAMP-specific -2.15761
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.14634
FBXO34 F-box protein 34 -2.14444
FAM111B family with sequence similarity 111, member B -2.14172
ZNF644 zinc finger protein 644 -2.1354
NPDC1 neural proliferation, differentiation and control, 1 -2.13441
PGRMC2 progesterone receptor membrane component 2 -2.11021
TINAGL1 tubulointerstitial nephritis antigen-like 1 -2.11021
KIZ kizuna centrosomal protein -2.10404
GLDC glycine dehydrogenase (decarboxylating) -2.1028
MASTL microtubule associated serine/threonine kinase-like -2.0921
OOEP oocyte expressed protein -2.08409
CDC73 cell division cycle 73 -2.08102
CSNK1E casein kinase 1, epsilon -2.07603
H2BC5 H2B clustered histone 5 -2.05274
RAVER1 ribonucleoprotein, PTB-binding 1 -2.04625
TARS1 threonyl-tRNA synthetase 1 -2.03017
ZNF214 zinc finger protein 214 -2.02985
EPS15 epidermal growth factor receptor pathway substrate 15 -2.02141
AARS1 alanyl-tRNA synthetase 1 -2.01357
MTFR1 mitochondrial fission regulator 1 -2.01249
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.01112
CFAP221 cilia and flagella associated protein 221 -2.00939
TMEM187 transmembrane protein 187 -2.00939
MAT1A methionine adenosyltransferase I, alpha -2.00939
DNAH6 dynein, axonemal, heavy chain 6 -2.00939
PAX5 paired box 5 -2.00939
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.00939
CNGA4 cyclic nucleotide gated channel alpha 4 -2.00939
C7ORF25 chromosome 7 open reading frame 25 -2.00854