PADI4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peptidyl arginine deiminase, type IV|This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 23569)
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Genes

358 genes differentially expressed following the PADI4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZACN zinc activated ligand-gated ion channel 3.40118
CASP5 caspase 5, apoptosis-related cysteine peptidase 3.40118
IL5RA interleukin 5 receptor, alpha 3.40118
CLEC19A C-type lectin domain family 19, member A 3.40118
ADTRP androgen-dependent TFPI-regulating protein 3.40118
CXORF65 chromosome X open reading frame 65 3.40118
GJB4 gap junction protein, beta 4, 30.3kDa 3.40118
TKTL1 transketolase-like 1 3.40118
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.40118
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.40118
HORMAD1 HORMA domain containing 1 3.40118
TM4SF1 transmembrane 4 L six family member 1 3.40118
CD160 CD160 molecule 3.40118
NKAPL NFKB activating protein-like 3.40118
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.40118
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.40118
LRRTM2 leucine rich repeat transmembrane neuronal 2 3.40118
IL22RA1 interleukin 22 receptor, alpha 1 3.40118
NANOS3 nanos homolog 3 (Drosophila) 3.40118
NXPH4 neurexophilin 4 3.40118
TRIM15 tripartite motif containing 15 3.40118
MUC6 mucin 6, oligomeric mucus/gel-forming 3.40118
OR52E8 olfactory receptor, family 52, subfamily E, member 8 3.40118
DEFB106B defensin, beta 106B 3.40118
CAPS calcyphosine 3.40118
BMP5 bone morphogenetic protein 5 3.40118
C2ORF78 chromosome 2 open reading frame 78 3.40118
STAP1 signal transducing adaptor family member 1 3.40118
FXYD3 FXYD domain containing ion transport regulator 3 3.40118
GALP galanin-like peptide 3.40118
TSSK1B testis-specific serine kinase 1B 3.40118
MAGEC3 melanoma antigen family C3 3.40118
C5ORF46 chromosome 5 open reading frame 46 3.40118
VSX1 visual system homeobox 1 3.40118
IL2RB interleukin 2 receptor, beta 3.40118
MMP20 matrix metallopeptidase 20 3.40118
BSX brain-specific homeobox 3.40118
C1ORF141 chromosome 1 open reading frame 141 3.40118
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.40118
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.40118
CD68 CD68 molecule 3.40118
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.40118
DLL4 delta-like 4 (Drosophila) 3.40118
HBZ hemoglobin, zeta 3.40118
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 3.40118
ANGPTL5 angiopoietin-like 5 3.40118
INHBC inhibin, beta C 3.40118
SPMIP9 sperm microtubule inner protein 9 3.40118
HTD2 hydroxyacyl-thioester dehydratase type 2 3.40118
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.40118
HBG1 hemoglobin, gamma A 3.40118
ALX4 ALX homeobox 4 3.40118
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.40118
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.40118
OTOR otoraplin 3.40118
SPATA31C1 SPATA31 subfamily C, member 1 3.40118
PDC phosducin 3.40118
CRACDL CRACD like 3.40118
RNF227 ring finger protein 227 3.40118
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.40118
TEX53 testis expressed 53 3.40118
RAB4A-AS1 RAB4A antisense RNA 1 3.40118
MDFIC2 MyoD family inhibitor domain containing 2 3.40118
H4C15 H4 clustered histone 15 3.40118
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.40118
LHFPL7 LHFPL tetraspan subfamily member 7 3.40118
PEAK3 PEAK family member 3 3.40118
ARMH2 armadillo like helical domain containing 2 3.40118
CCDC197 coiled-coil domain containing 197 3.40118
C20ORF202 chromosome 20 open reading frame 202 3.40118
TMPRSS3 transmembrane protease, serine 3 3.40118
PTGDR2 prostaglandin D2 receptor 2 3.40118
CFAP99 cilia and flagella associated protein 99 3.40118
PRB2 proline-rich protein BstNI subfamily 2 3.40118
CCIN calicin 3.40118
ACTL10 actin-like 10 3.40118
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.40118
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.40118
SYCP2 synaptonemal complex protein 2 3.40118
TPBGL trophoblast glycoprotein-like 3.40118
IL31RA interleukin 31 receptor A 3.40118
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.40118
RNF113B ring finger protein 113B 3.40118
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.40118
CFC1 cripto, FRL-1, cryptic family 1 3.40118
MAGIX MAGI family member, X-linked 3.40118
NPIPB8 nuclear pore complex interacting protein family, member B8 3.40118
GPR83 G protein-coupled receptor 83 3.40118
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.40118
OPN4 opsin 4 3.40118
IL1RN interleukin 1 receptor antagonist 3.40118
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.40118
FOXQ1 forkhead box Q1 3.40118
SYNGR4 synaptogyrin 4 3.40118
DCT dopachrome tautomerase 3.40118
S100A14 S100 calcium binding protein A14 3.40118
CYSLTR1 cysteinyl leukotriene receptor 1 3.40118
NOX1 NADPH oxidase 1 3.40118
LHX5 LIM homeobox 5 3.40118
CPA3 carboxypeptidase A3 (mast cell) 3.40118
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.40118
PAGE4 P antigen family, member 4 (prostate associated) 3.40118
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.40118
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.40118
BARHL2 BarH-like homeobox 2 3.40118
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.40118
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.40118
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.40118
SMYD1 SET and MYND domain containing 1 3.40118
CPZ carboxypeptidase Z 3.40118
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.40118
FBXO39 F-box protein 39 3.40118
NCR3 natural cytotoxicity triggering receptor 3 3.40118
IRGM immunity-related GTPase family, M 3.40118
SVOP SV2 related protein homolog (rat) 3.40118
TAAR2 trace amine associated receptor 2 3.40118
CTSF cathepsin F 3.40118
LY96 lymphocyte antigen 96 3.40118
ITGB7 integrin, beta 7 3.40118
ZC3H12D zinc finger CCCH-type containing 12D 3.40118
CTSS cathepsin S 3.40118
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.40118
PRTN3 proteinase 3 3.40118
KLK11 kallikrein-related peptidase 11 3.40118
F13B coagulation factor XIII, B polypeptide 3.40118
POU2AF1 POU class 2 associating factor 1 3.40118
C22ORF42 chromosome 22 open reading frame 42 3.40118
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.40118
LMOD3 leiomodin 3 (fetal) 3.40118
DNTT DNA nucleotidylexotransferase 3.40118
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.40118
EMILIN1 elastin microfibril interfacer 1 3.40118
CLUL1 clusterin-like 1 (retinal) 3.40118
FOXF2 forkhead box F2 3.40118
ANXA8 annexin A8 3.40118
CFB complement factor B 3.40118
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.40118
SHOX short stature homeobox 3.40118
GOLGA8J golgin A8 family, member J 3.40118
CLCA1 chloride channel accessory 1 3.40118
PTGDR prostaglandin D2 receptor (DP) 3.40118
TEX26 testis expressed 26 3.40118
ECM1 extracellular matrix protein 1 3.40118
ANKRD33 ankyrin repeat domain 33 3.40118
NUTM2B NUT family member 2B 3.40118
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.40118
TTC34 tetratricopeptide repeat domain 34 3.40118
GOLGA6A golgin A6 family, member A 3.40118
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 3.40118
IHH indian hedgehog 3.40118
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 3.40118
ANXA1 annexin A1 3.40118
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.40118
A3GALT2 alpha 1,3-galactosyltransferase 2 3.40118
PADI6 peptidyl arginine deiminase, type VI 3.40118
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.40118
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.40118
CIB3 calcium and integrin binding family member 3 3.40118
SCN3B sodium channel, voltage gated, type III beta subunit 3.35247
FLACC1 flagellum associated containing coiled-coil domains 1 3.35247
NCKAP5L NCK-associated protein 5-like 3.20511
STK26 serine/threonine protein kinase 26 3.11774
RNF152 ring finger protein 152 3.08876
PLAC8L1 PLAC8-like 1 3.08348
JPH4 junctophilin 4 2.98688
SLC25A34 solute carrier family 25, member 34 2.98441
SP140 SP140 nuclear body protein 2.97303
FAM53A family with sequence similarity 53, member A 2.94297
PI4K2B phosphatidylinositol 4-kinase type 2 beta 2.93844
RAB5B RAB5B, member RAS oncogene family 2.84517
GLRX3 glutaredoxin 3 2.81348
ZNF440 zinc finger protein 440 2.7219
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.67409
PDAP1 PDGFA associated protein 1 2.67409
UBXN8 UBX domain protein 8 2.64567
INTS9 integrator complex subunit 9 2.60491
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 2.54388
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 2.52945
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.52063
OVOL1 ovo-like zinc finger 1 2.47163
MINAR1 membrane integral NOTCH2 associated receptor 1 2.47163
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.47163
FAM177B family with sequence similarity 177, member B 2.47163
ACKR3 atypical chemokine receptor 3 2.47163
ALKAL1 ALK and LTK ligand 1 2.47163
DNAI2 dynein, axonemal, intermediate chain 2 2.47163
DGLUCY D-glutamate cyclase 2.47163
ADIRF adipogenesis regulatory factor 2.42906
STUM stum, mechanosensory transduction mediator homolog 2.40992
SPDYE1 speedy/RINGO cell cycle regulator family member E1 2.40992
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 2.40402
ACADL acyl-CoA dehydrogenase, long chain 2.39176
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.39089
THAP2 THAP domain containing, apoptosis associated protein 2 2.38481
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 2.35242
HEPHL1 hephaestin-like 1 2.34721
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.33019
NOCT nocturnin 2.32744
PCGF1 polycomb group ring finger 1 2.32709
TLR2 toll-like receptor 2 2.3124
TCOF1 Treacher Collins-Franceschetti syndrome 1 2.29059
EMID1 EMI domain containing 1 2.28416
MBIP MAP3K12 binding inhibitory protein 1 2.26076
GALC galactosylceramidase 2.26076
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.2475
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 2.24302
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 2.22866
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.12493
ACVR1 activin A receptor, type I 2.12046
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.11152
ATG5 autophagy related 5 2.11124
PKN2 protein kinase N2 2.10701
ASRGL1 asparaginase like 1 2.10316
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 2.09865
CEP295NL CEP295 N-terminal like 2.09865
SNPH syntaphilin 2.09865
INVS inversin 2.09574
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.08643
KTN1 kinectin 1 (kinesin receptor) 2.07814
VSTM2B V-set and transmembrane domain containing 2B 2.07734
NCEH1 neutral cholesterol ester hydrolase 1 2.0732
NR6A1 nuclear receptor subfamily 6, group A, member 1 2.07041
EPHA2 EPH receptor A2 2.05566
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.05263
AQR aquarius intron-binding spliceosomal factor 2.05171
LMNA lamin A/C 2.04139
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.04139
MDP1 magnesium-dependent phosphatase 1 2.03349
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.03349
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2.02362
MARCHF7 membrane associated ring-CH-type finger 7 2.02288
KANSL1 KAT8 regulatory NSL complex subunit 1 2.01458
FRS3 fibroblast growth factor receptor substrate 3 2.00246
NALCN sodium leak channel, non selective 2.00106
SOS2 son of sevenless homolog 2 (Drosophila) 2.00106
METAP1D methionyl aminopeptidase type 1D (mitochondrial) 2.00106

decreased expression

Symbol Name Standardized Value
SNCG synuclein, gamma (breast cancer-specific protein 1) -3.40118
PCDHB14 protocadherin beta 14 -3.40118
RAB11FIP3 RAB11 family interacting protein 3 (class II) -3.40118
FAM229A family with sequence similarity 229, member A -3.40118
BTBD18 BTB (POZ) domain containing 18 -3.40118
DRC3 dynein regulatory complex subunit 3 -3.40118
SLC22A25 solute carrier family 22, member 25 -3.20511
CRYBB3 crystallin, beta B3 -3.20511
IRF7 interferon regulatory factor 7 -3.20511
STRIT1 small transmembrane regulator of ion transport 1 -3.20511
IL12A interleukin 12A -3.20511
NKX3-1 NK3 homeobox 1 -3.20511
TMEM150B transmembrane protein 150B -3.20511
DPF3 D4, zinc and double PHD fingers, family 3 -3.20511
GJA5 gap junction protein, alpha 5, 40kDa -3.20511
PLGLB2 plasminogen-like B2 -3.20511
KCTD4 potassium channel tetramerization domain containing 4 -3.20511
VWC2L von Willebrand factor C domain containing protein 2-like -3.20511
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -3.20511
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 -3.20511
CXCR2 chemokine (C-X-C motif) receptor 2 -3.20511
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -3.20511
SPMIP3 sperm microtubule inner protein 3 -3.20511
AMH anti-Mullerian hormone -3.20511
GDF6 growth differentiation factor 6 -3.20511
PDF peptide deformylase (mitochondrial) -3.20511
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 -3.20511
GPR78 G protein-coupled receptor 78 -3.20511
C1QL3 complement component 1, q subcomponent-like 3 -3.20511
LMOD2 leiomodin 2 (cardiac) -3.20511
CFAP299 cilia and flagella associated protein 299 -3.20511
LTF lactotransferrin -3.20511
ZNF638 zinc finger protein 638 -3.06415
RTP1 receptor (chemosensory) transporter protein 1 -3.04779
RPRML reprimo-like -3.02764
ECT2 epithelial cell transforming 2 -3.02604
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.91757
KIAA1549 KIAA1549 -2.88074
DOCK8 dedicator of cytokinesis 8 -2.81348
FOS FBJ murine osteosarcoma viral oncogene homolog -2.80553
WDR1 WD repeat domain 1 -2.78645
SCAMP1 secretory carrier membrane protein 1 -2.74207
CKAP2L cytoskeleton associated protein 2-like -2.67901
BTBD17 BTB (POZ) domain containing 17 -2.66853
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -2.62628
RPS12 ribosomal protein S12 -2.60645
FZD7 frizzled class receptor 7 -2.5517
ISCA1 iron-sulfur cluster assembly 1 -2.50217
ARHGAP32 Rho GTPase activating protein 32 -2.47208
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.47208
ZBTB49 zinc finger and BTB domain containing 49 -2.47163
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -2.47163
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.42096
SPN sialophorin -2.40992
DUSP26 dual specificity phosphatase 26 (putative) -2.40992
SCGB3A2 secretoglobin, family 3A, member 2 -2.40078
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.39606
ACAN aggrecan -2.39089
ZNF446 zinc finger protein 446 -2.39089
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.35992
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.3563
SPRYD7 SPRY domain containing 7 -2.3563
RPL5 ribosomal protein L5 -2.3563
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -2.35175
NUP153 nucleoporin 153kDa -2.32743
KLC4 kinesin light chain 4 -2.32653
NUP205 nucleoporin 205kDa -2.32134
ACY1 aminoacylase 1 -2.29899
MGST2 microsomal glutathione S-transferase 2 -2.28806
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -2.28416
RPL27 ribosomal protein L27 -2.24517
DNAH14 dynein, axonemal, heavy chain 14 -2.20789
ANKRD52 ankyrin repeat domain 52 -2.20789
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.20639
FIP1L1 factor interacting with PAPOLA and CPSF1 -2.19002
CORO1A coronin, actin binding protein, 1A -2.18085
DCHS2 dachsous cadherin-related 2 -2.17793
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -2.15731
JUND jun D proto-oncogene -2.15731
USP54 ubiquitin specific peptidase 54 -2.15731
SZRD1 SUZ RNA binding domain containing 1 -2.14806
AQP4 aquaporin 4 -2.14806
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -2.14806
CXCL17 chemokine (C-X-C motif) ligand 17 -2.14639
ZNF275 zinc finger protein 275 -2.14639
CCDC159 coiled-coil domain containing 159 -2.14639
CORIN corin, serine peptidase -2.14639
SMIM41 small integral membrane protein 41 -2.14639
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.14639
MMRN2 multimerin 2 -2.14639
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.14639
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.14427
EFHC2 EF-hand domain (C-terminal) containing 2 -2.14295
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.13647
KARS1 lysyl-tRNA synthetase 1 -2.13619
MIGA2 mitoguardin 2 -2.12493
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -2.12493
RPS18 ribosomal protein S18 -2.12493
SLC22A31 solute carrier family 22, member 31 -2.10644
DNM1 dynamin 1 -2.09865
ZBTB1 zinc finger and BTB domain containing 1 -2.09109
NT5C3B 5'-nucleotidase, cytosolic IIIB -2.0886
SRSF6 serine/arginine-rich splicing factor 6 -2.08175
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.08175
VEGFD vascular endothelial growth factor D -2.08175
TAS2R31 taste receptor, type 2, member 31 -2.08175
ZNF404 zinc finger protein 404 -2.08175
BAX BCL2-associated X protein -2.08175
ACRBP acrosin binding protein -2.08175
UBQLN4 ubiquilin 4 -2.0796
KLF13 Kruppel-like factor 13 -2.07505
MAPT microtubule-associated protein tau -2.05171
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.03801
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.03801
KLHL9 kelch-like family member 9 -2.03349
ZNF774 zinc finger protein 774 -2.03316
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.02778
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.02288
CYB5R3 cytochrome b5 reductase 3 -2.02288
NBPF15 neuroblastoma breakpoint family, member 15 -2.02024
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -2.01719
KDM8 lysine (K)-specific demethylase 8 -2.00563