PAFAH1B1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)|This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq, Apr 2009] (NCBI Entrez Gene Database, 5048)
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Genes

360 genes differentially expressed following the PAFAH1B1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PNMA5 paraneoplastic Ma antigen family member 5 2.91114
CBLN3 cerebellin 3 precursor 2.91114
CD177 CD177 molecule 2.91114
COX7B2 cytochrome c oxidase subunit VIIb2 2.91114
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.91114
DNAAF1 dynein, axonemal, assembly factor 1 2.91114
NFAM1 NFAT activating protein with ITAM motif 1 2.91114
EFCAB3 EF-hand calcium binding domain 3 2.91114
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.91114
TMEM176A transmembrane protein 176A 2.91114
PRRT3 proline-rich transmembrane protein 3 2.91114
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.91114
CCNO cyclin O 2.91114
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.91114
SERINC4 serine incorporator 4 2.91114
ZAR1L zygote arrest 1-like 2.91114
CTSE cathepsin E 2.91114
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.91114
SLC22A31 solute carrier family 22, member 31 2.91114
PITX2 paired-like homeodomain 2 2.91114
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.91114
TMEM229A transmembrane protein 229A 2.91114
CRYGB crystallin, gamma B 2.91114
TMEM150B transmembrane protein 150B 2.91114
WEE2 WEE1 homolog 2 (S. pombe) 2.91114
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.91114
THPO thrombopoietin 2.91114
NLRP7 NLR family, pyrin domain containing 7 2.91114
IFI35 interferon-induced protein 35 2.91114
DMP1 dentin matrix acidic phosphoprotein 1 2.91114
STRN striatin, calmodulin binding protein 2.84945
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.79393
UPB1 ureidopropionase, beta 2.79393
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.79393
TMEM176B transmembrane protein 176B 2.79393
SCN2B sodium channel, voltage gated, type II beta subunit 2.79393
GIP gastric inhibitory polypeptide 2.79393
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.79393
HLF hepatic leukemia factor 2.79393
FAM187B family with sequence similarity 187, member B 2.79393
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.79393
HES5 hes family bHLH transcription factor 5 2.79393
SIRPB2 signal-regulatory protein beta 2 2.79393
IL5RA interleukin 5 receptor, alpha 2.79393
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.79393
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.79393
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.79393
KIF2B kinesin family member 2B 2.79393
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.79393
LRRC63 leucine rich repeat containing 63 2.79393
LGALS2 lectin, galactoside-binding, soluble, 2 2.79393
RTP4 receptor (chemosensory) transporter protein 4 2.79393
HIC1 hypermethylated in cancer 1 2.79393
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.79393
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.79393
IQCJ IQ motif containing J 2.79393
LRRC53 leucine rich repeat containing 53 2.79393
CEP295NL CEP295 N-terminal like 2.79393
GCKR glucokinase (hexokinase 4) regulator 2.79393
GPR26 G protein-coupled receptor 26 2.79393
TAL2 T-cell acute lymphocytic leukemia 2 2.79393
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.79393
SLC23A3 solute carrier family 23, member 3 2.79393
CA6 carbonic anhydrase VI 2.79393
TMEM132C transmembrane protein 132C 2.79393
SPMIP7 sperm microtubule inner protein 7 2.79393
H2BC1 H2B clustered histone 1 2.79393
SEPTIN14 septin 14 2.79393
CAPN9 calpain 9 2.79393
TCERG1L transcription elongation regulator 1-like 2.79393
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.79393
TMPRSS3 transmembrane protease, serine 3 2.79393
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.79393
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.79393
DYNLRB2 dynein, light chain, roadblock-type 2 2.79393
C15ORF62 chromosome 15 open reading frame 62 2.79393
H3-5 H3.5 histone 2.79393
GASK1B golgi associated kinase 1B 2.79393
CIMAP1A ciliary microtubule associated protein 1A 2.79393
SPATA31H1 SPATA31 subfamily H member 1 2.79393
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.79393
CPNE8-AS1 CPNE8 antisense RNA 1 2.79393
C1ORF232 chromosome 1 open reading frame 230 2.79393
IHO1 interactor of HORMAD1 1 2.79393
DNAAF6 dynein axonemal assembly factor 6 2.79393
CBY2 chibby family member 2 2.79393
TAFA3 TAFA chemokine like family member 3 2.79393
CALHM5 calcium homeostasis modulator family member 5 2.79393
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.79393
CLEC6A C-type lectin domain family 6, member A 2.79393
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.79393
TLR6 toll-like receptor 6 2.79393
SCYL1 SCY1-like 1 (S. cerevisiae) 2.79393
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.79393
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.79393
LIX1 Lix1 homolog (chicken) 2.79393
ITK IL2-inducible T-cell kinase 2.79393
TUBA3E tubulin, alpha 3e 2.79393
C5ORF52 chromosome 5 open reading frame 52 2.79393
LBHD1 LBH domain containing 1 2.79393
RNF113B ring finger protein 113B 2.79393
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.79393
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.79393
CCDC42 coiled-coil domain containing 42 2.79393
UBE2E1 ubiquitin-conjugating enzyme E2E 1 2.79393
BEST3 bestrophin 3 2.79393
LRRC73 leucine rich repeat containing 73 2.79393
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.79393
IL1R2 interleukin 1 receptor, type II 2.79393
CELA2A chymotrypsin-like elastase family, member 2A 2.79393
CLDN22 claudin 22 2.79393
CCR7 chemokine (C-C motif) receptor 7 2.79393
ACR acrosin 2.79393
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 2.79393
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.79393
NPBWR1 neuropeptides B/W receptor 1 2.79393
BTNL8 butyrophilin-like 8 2.79393
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.79393
AGR3 anterior gradient 3 2.79393
PSKH2 protein serine kinase H2 2.79393
MAB21L2 mab-21-like 2 (C. elegans) 2.79393
TBC1D28 TBC1 domain family, member 28 2.79393
PRR15L proline rich 15-like 2.79393
LPAR5 lysophosphatidic acid receptor 5 2.79393
CFB complement factor B 2.79393
STMND1 stathmin domain containing 1 2.79393
ZNF534 zinc finger protein 534 2.79393
DRD2 dopamine receptor D2 2.79393
GPBAR1 G protein-coupled bile acid receptor 1 2.79393
LMOD3 leiomodin 3 (fetal) 2.79393
NPFFR1 neuropeptide FF receptor 1 2.79393
PRSS55 protease, serine, 55 2.79393
ADAM7 ADAM metallopeptidase domain 7 2.79393
HCRT hypocretin (orexin) neuropeptide precursor 2.79393
AHDC1 AT hook, DNA binding motif, containing 1 2.79393
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.79393
FATE1 fetal and adult testis expressed 1 2.79393
LRRC46 leucine rich repeat containing 46 2.79393
VAX2 ventral anterior homeobox 2 2.79393
CABP5 calcium binding protein 5 2.79393
FBXO39 F-box protein 39 2.79393
KRT222 keratin 222, type II 2.79393
ANKRD63 ankyrin repeat domain 63 2.79393
AURKC aurora kinase C 2.79393
TBK1 TANK-binding kinase 1 2.79393
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.79393
TBC1D10C TBC1 domain family, member 10C 2.79393
RORC RAR-related orphan receptor C 2.79393
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.79393
TMEM86B transmembrane protein 86B 2.79393
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.79393
FOXG1 forkhead box G1 2.79393
QRFP pyroglutamylated RFamide peptide 2.79393
SLC25A34 solute carrier family 25, member 34 2.79393
MSMP microseminoprotein, prostate associated 2.79393
ZNF648 zinc finger protein 648 2.79393
POU4F3 POU class 4 homeobox 3 2.79393
GLB1L galactosidase, beta 1-like 2.79393
LAMB4 laminin, beta 4 2.79393
IRX1 iroquois homeobox 1 2.79393
GHRH growth hormone releasing hormone 2.79393
GBX2 gastrulation brain homeobox 2 2.79393
CD34 CD34 molecule 2.79393
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.79393
EVI2A ecotropic viral integration site 2A 2.79393
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.79393
FGF9 fibroblast growth factor 9 2.79393
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.79393
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.79393
GCSAML germinal center-associated, signaling and motility-like 2.79393
CETP cholesteryl ester transfer protein, plasma 2.79393
BSPH1 binder of sperm protein homolog 1 2.79393
PDZRN4 PDZ domain containing ring finger 4 2.79393
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.79393
LYZL1 lysozyme-like 1 2.79393
MMP10 matrix metallopeptidase 10 2.79393
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.79393
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.79393
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.79393
C10ORF90 chromosome 10 open reading frame 90 2.79393
GPR62 G protein-coupled receptor 62 2.79393
SNTN sentan, cilia apical structure protein 2.79393
IFNE interferon, epsilon 2.79393
KCTD2 potassium channel tetramerization domain containing 2 2.74808
RBM20 RNA binding motif protein 20 2.71516
RTBDN retbindin 2.71516
ONECUT1 one cut homeobox 1 2.71516
ZBTB6 zinc finger and BTB domain containing 6 2.71516
TEDC1 tubulin epsilon and delta complex 1 2.71516
DSN1 DSN1, MIS12 kinetochore complex component 2.66638
SRP54 signal recognition particle 54kDa 2.63743
NBPF10 neuroblastoma breakpoint family, member 10 2.62542
NCKAP1 NCK-associated protein 1 2.62153
GOLGA2 golgin A2 2.62027
UTRN utrophin 2.61706
WIPF3 WAS/WASL interacting protein family, member 3 2.61114
EMC3 ER membrane protein complex subunit 3 2.59885
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.56966
DNAAF3 dynein, axonemal, assembly factor 3 2.56675
ZNF668 zinc finger protein 668 2.5603
HAUS8 HAUS augmin-like complex, subunit 8 2.55714
NT5DC3 5'-nucleotidase domain containing 3 2.48687
MCTP1 multiple C2 domains, transmembrane 1 2.48196
C17ORF78 chromosome 17 open reading frame 78 2.48009
MINAR1 membrane integral NOTCH2 associated receptor 1 2.46219
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.44934
COPS7B COP9 signalosome subunit 7B 2.44778
ABLIM1 actin binding LIM protein 1 2.44778
STRBP spermatid perinuclear RNA binding protein 2.41386
NFE2L2 nuclear factor, erythroid 2-like 2 2.41139
RNF181 ring finger protein 181 2.40616
LMBRD1 LMBR1 domain containing 1 2.3902
POMP proteasome maturation protein 2.34821
RSPO2 R-spondin 2 2.32367
SARS1 seryl-tRNA synthetase 1 2.30191
WDR26 WD repeat domain 26 2.29296
WDR77 WD repeat domain 77 2.28229
PAH phenylalanine hydroxylase 2.27514
CDA cytidine deaminase 2.26526
FIG4 FIG4 phosphoinositide 5-phosphatase 2.24419
ETFB electron-transfer-flavoprotein, beta polypeptide 2.24399
PRR12 proline rich 12 2.23891
TERF2IP telomeric repeat binding factor 2, interacting protein 2.23717
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.22634
NXN nucleoredoxin 2.20583
WIF1 WNT inhibitory factor 1 2.19972
PNMA2 paraneoplastic Ma antigen 2 2.18559
MTRF1 mitochondrial translational release factor 1 2.1826
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 2.14015
SMAP1 small ArfGAP 1 2.13846
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.12323
FAM81A family with sequence similarity 81, member A 2.12323
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.10982
SLC30A7 solute carrier family 30 (zinc transporter), member 7 2.08202
ZNF814 zinc finger protein 814 2.08044
SORT1 sortilin 1 2.07397
ARF3 ADP-ribosylation factor 3 2.06544
SETDB2 SET domain, bifurcated 2 2.06491
SH3RF2 SH3 domain containing ring finger 2 2.06264
NAV3 neuron navigator 3 2.06073
ACBD7 acyl-CoA binding domain containing 7 2.05141
CBX3 chromobox homolog 3 2.04175
MAPK12 mitogen-activated protein kinase 12 2.04162
STAMBP STAM binding protein 2.03948
CAPRIN2 caprin family member 2 2.0172
TBRG1 transforming growth factor beta regulator 1 2.01184
TMEM209 transmembrane protein 209 2.00079

decreased expression

Symbol Name Standardized Value
PTPRK protein tyrosine phosphatase, receptor type, K -2.91114
ZNF225 zinc finger protein 225 -2.91114
TBX6 T-box 6 -2.84945
IL18R1 interleukin 18 receptor 1 -2.84945
APOB apolipoprotein B -2.84945
MYOCOS myocilin opposite strand -2.84945
NOTO notochord homeobox -2.84945
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.84945
PVALEF parvalbumin like EF-hand containing -2.84945
TMEM171 transmembrane protein 171 -2.84945
TBC1D15 TBC1 domain family, member 15 -2.79393
HFE hemochromatosis -2.79393
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -2.79393
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -2.79393
KCNIP2 Kv channel interacting protein 2 -2.79393
TDRD12 tudor domain containing 12 -2.79393
RFLNB refilin B -2.79393
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -2.78652
ACVR1C activin A receptor, type IC -2.72981
IL4I1 interleukin 4 induced 1 -2.71516
GADL1 glutamate decarboxylase-like 1 -2.71516
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.71516
ZNF324B zinc finger protein 324B -2.71516
LDHC lactate dehydrogenase C -2.71516
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.71516
GUCY2F guanylate cyclase 2F, retinal -2.71516
PEAK3 PEAK family member 3 -2.71516
STAP1 signal transducing adaptor family member 1 -2.71516
PCDHGA11 protocadherin gamma subfamily A, 11 -2.71516
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.71516
DUSP9 dual specificity phosphatase 9 -2.71516
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 -2.71516
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.71516
FGF20 fibroblast growth factor 20 -2.71516
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.71516
AKR1C2 aldo-keto reductase family 1, member C2 -2.71516
TBX20 T-box 20 -2.71516
C3ORF80 chromosome 3 open reading frame 80 -2.71516
CLEC19A C-type lectin domain family 19, member A -2.71516
MAP3K4-AS1 MAP3K4 antisense RNA 1 -2.71516
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.71516
MUC5B mucin 5B, oligomeric mucus/gel-forming -2.71516
SFXN3 sideroflexin 3 -2.71516
NRSN1 neurensin 1 -2.71516
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.71516
NLRC3 NLR family, CARD domain containing 3 -2.71516
C6ORF163 chromosome 6 open reading frame 163 -2.71516
BTNL9 butyrophilin-like 9 -2.71516
OLFML1 olfactomedin-like 1 -2.71516
C9ORF43 chromosome 9 open reading frame 43 -2.71516
KLK14 kallikrein-related peptidase 14 -2.71516
RELN reelin -2.71516
ITGA11 integrin, alpha 11 -2.71516
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.71516
TTC29 tetratricopeptide repeat domain 29 -2.71516
WFDC13 WAP four-disulfide core domain 13 -2.71516
GOLGA8K golgin A8 family, member K -2.71516
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.68557
LOC124902436 talanin -2.68557
ZSCAN22 zinc finger and SCAN domain containing 22 -2.68557
DPP8 dipeptidyl-peptidase 8 -2.68214
TSC22D3 TSC22 domain family, member 3 -2.6519
GPER1 G protein-coupled estrogen receptor 1 -2.64165
NKD2 naked cuticle homolog 2 (Drosophila) -2.64165
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -2.6341
ZNF592 zinc finger protein 592 -2.56966
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha -2.56412
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 -2.55714
MXD4 MAX dimerization protein 4 -2.52856
EID2B EP300 interacting inhibitor of differentiation 2B -2.52354
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.52126
RMC1 regulator of MON1-CCZ1 -2.50214
UNC13D unc-13 homolog D (C. elegans) -2.47796
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.46688
CYB5R1 cytochrome b5 reductase 1 -2.45426
VLDLR very low density lipoprotein receptor -2.42436
ZNF384 zinc finger protein 384 -2.41386
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 -2.41386
IQCH IQ motif containing H -2.3978
MPND MPN domain containing -2.38685
TLL2 tolloid-like 2 -2.37326
DPH6 diphthamine biosynthesis 6 -2.36771
SNX9 sorting nexin 9 -2.36321
HSPA12A heat shock 70kDa protein 12A -2.36152
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -2.26285
ELMOD2 ELMO/CED-12 domain containing 2 -2.25546
NPIPB15 nuclear pore complex interacting protein family, member B15 -2.24394
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -2.24394
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.24394
PIERCE2 piercer of microtubule wall 2 -2.24394
INSL6 insulin-like 6 -2.24394
CPN1 carboxypeptidase N, polypeptide 1 -2.21938
TNC tenascin C -2.21938
CGGBP1 CGG triplet repeat binding protein 1 -2.19194
ELP3 elongator acetyltransferase complex subunit 3 -2.1826
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -2.1674
ZNF407 zinc finger protein 407 -2.1603
GPA33 glycoprotein A33 (transmembrane) -2.15886
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -2.15791
DNAI4 dynein axonemal intermediate chain 4 -2.1417
ADGRL1 adhesion G protein-coupled receptor L1 -2.14015
LATS1 large tumor suppressor kinase 1 -2.12055
MANEAL mannosidase, endo-alpha-like -2.10693
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.07453
GSK3B glycogen synthase kinase 3 beta -2.0725
MTUS1 microtubule associated tumor suppressor 1 -2.05227
SYNJ1 synaptojanin 1 -2.05141
PIBF1 progesterone immunomodulatory binding factor 1 -2.05141
STX10 syntaxin 10 -2.05141
MSRB1 methionine sulfoxide reductase B1 -2.05121
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.01994
ITGB5 integrin, beta 5 -2.01226
MAST2 microtubule associated serine/threonine kinase 2 -2.00441