PAFAH1B2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)|Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5049)
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Genes

312 genes differentially expressed following the PAFAH1B2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.82857
TM4SF1 transmembrane 4 L six family member 1 2.82857
GPR151 G protein-coupled receptor 151 2.82857
ADGRG4 adhesion G protein-coupled receptor G4 2.82857
KRT23 keratin 23, type I 2.82857
IL5RA interleukin 5 receptor, alpha 2.82857
SH2D6 SH2 domain containing 6 2.82857
TMEM191B transmembrane protein 191B 2.82857
TYRP1 tyrosinase-related protein 1 2.82857
PRODH2 proline dehydrogenase (oxidase) 2 2.82857
PDYN prodynorphin 2.82857
PON1 paraoxonase 1 2.82857
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.82857
CARD16 caspase recruitment domain family, member 16 2.82857
OR1I1 olfactory receptor, family 1, subfamily I, member 1 2.82857
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.82857
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.82857
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.82857
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.82857
GFRA4 GDNF family receptor alpha 4 2.82857
DMRTC1B DMRT-like family C1B 2.82857
CEP295NL CEP295 N-terminal like 2.82857
HES2 hes family bHLH transcription factor 2 2.82857
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.82857
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.82857
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 2.82857
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.82857
FAM81B family with sequence similarity 81, member B 2.82857
DCST1 DC-STAMP domain containing 1 2.82857
ASCL3 achaete-scute family bHLH transcription factor 3 2.82857
LVRN laeverin 2.82857
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.82857
RGPD3 RANBP2-like and GRIP domain containing 3 2.82857
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.82857
GPR26 G protein-coupled receptor 26 2.82857
ADAD2 adenosine deaminase domain containing 2 2.82857
GFI1 growth factor independent 1 transcription repressor 2.82857
THRSP thyroid hormone responsive 2.82857
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.82857
GADL1 glutamate decarboxylase-like 1 2.82857
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.82857
MROH2A maestro heat-like repeat family member 2A 2.82857
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.82857
LOC124905976 uncharacterized LOC124905976 2.82857
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.82857
GBP4 guanylate binding protein 4 2.82857
ZAR1 zygote arrest 1 2.82857
PROP1 PROP paired-like homeobox 1 2.82857
C10ORF53 chromosome 10 open reading frame 53 2.82857
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.82857
SPATA25 spermatogenesis associated 25 2.82857
ZNF705D zinc finger protein 705D 2.82857
CCN5 cellular communication network factor 5 2.82857
CCDC190 coiled-coil domain containing 190 2.82857
CFAP157 cilia and flagella associated protein 157 2.82857
LRTM3 leucine rich repeat transmembrane protein 3 2.82857
OR56B2 olfactory receptor family 56 subfamily B member 2 2.82857
FAM240C family with sequence similarity 240 member C 2.82857
H2BC12L H2B clustered histone 12 like 2.82857
GARIN4 golgi associated RAB2 interactor family member 4 2.82857
H1-8 H1.8 linker histone 2.82857
CATSPERZ catsper channel auxiliary subunit zeta 2.82857
VXN vexin 2.82857
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.82857
NDP Norrie disease (pseudoglioma) 2.82857
GDF10 growth differentiation factor 10 2.82857
IL4 interleukin 4 2.82857
SIM2 single-minded family bHLH transcription factor 2 2.82857
TMEM235 transmembrane protein 235 2.82857
PCDHA6 protocadherin alpha 6 2.82857
PCDHA3 protocadherin alpha 3 2.82857
RS1 retinoschisin 1 2.82857
TPBGL trophoblast glycoprotein-like 2.82857
PGC progastricsin (pepsinogen C) 2.82857
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.82857
ESR1 estrogen receptor 1 2.82857
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.82857
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.82857
ZAR1L zygote arrest 1-like 2.82857
SAMD11 sterile alpha motif domain containing 11 2.82857
PGA4 pepsinogen 4, group I (pepsinogen A) 2.82857
SBSN suprabasin 2.82857
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.82857
C1QL4 complement component 1, q subcomponent-like 4 2.82857
LAPTM5 lysosomal protein transmembrane 5 2.82857
PMP2 peripheral myelin protein 2 2.82857
CPA4 carboxypeptidase A4 2.82857
POU3F3 POU class 3 homeobox 3 2.82857
ADGRF5 adhesion G protein-coupled receptor F5 2.82857
DAND5 DAN domain family member 5, BMP antagonist 2.82857
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.82857
POTEJ POTE ankyrin domain family, member J 2.82857
PAGE3 P antigen family, member 3 (prostate associated) 2.82857
MT1A metallothionein 1A 2.82857
FGF18 fibroblast growth factor 18 2.82857
ERP27 endoplasmic reticulum protein 27 2.82857
GPBAR1 G protein-coupled bile acid receptor 1 2.82857
APOL6 apolipoprotein L, 6 2.82857
TECRL trans-2,3-enoyl-CoA reductase-like 2.82857
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.82857
CARD9 caspase recruitment domain family, member 9 2.82857
APOB apolipoprotein B 2.82857
NIM1K NIM1 serine/threonine protein kinase 2.82857
CLIC5 chloride intracellular channel 5 2.82857
CT55 cancer/testis antigen 55 2.82857
KIF4B kinesin family member 4B 2.82857
DMBT1 deleted in malignant brain tumors 1 2.82857
FZD1 frizzled class receptor 1 2.82857
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.82857
FZD6 frizzled class receptor 6 2.82857
SPATA3 spermatogenesis associated 3 2.82857
WDFY4 WDFY family member 4 2.82857
C9ORF57 chromosome 9 open reading frame 57 2.82857
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.82857
PPY pancreatic polypeptide 2.82857
THEM5 thioesterase superfamily member 5 2.82857
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.82857
LRRC25 leucine rich repeat containing 25 2.82857
MYLK2 myosin light chain kinase 2 2.82857
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.82857
IFNE interferon, epsilon 2.82857
TGM1 transglutaminase 1 2.82857
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.82857
ESPNL espin-like 2.82857
WNT10B wingless-type MMTV integration site family, member 10B 2.82857
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.82857
STOML3 stomatin (EPB72)-like 3 2.82857
CXORF58 chromosome X open reading frame 58 2.82857
CSF1R colony stimulating factor 1 receptor 2.82857
RGS4 regulator of G-protein signaling 4 2.82857
TUBAL3 tubulin, alpha-like 3 2.82857
TG thyroglobulin 2.82857
SNTN sentan, cilia apical structure protein 2.82857
TH tyrosine hydroxylase 2.82857
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.82857
LRRC38 leucine rich repeat containing 38 2.82857
FCAR Fc fragment of IgA receptor 2.82857
SYNGR4 synaptogyrin 4 2.82857
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.82857
BCL2L15 BCL2-like 15 2.82857
CD28 CD28 molecule 2.82857
RPL6 ribosomal protein L6 2.82857
GOLGA8O golgin A8 family, member O 2.82857
GSS glutathione synthetase 2.80665
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.7954
C7ORF25 chromosome 7 open reading frame 25 2.7954
GSE1 Gse1 coiled-coil protein 2.78717
TDRD1 tudor domain containing 1 2.77545
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 2.77545
RBSN rabenosyn, RAB effector 2.75278
PEX12 peroxisomal biogenesis factor 12 2.61626
MARCHF4 membrane associated ring-CH-type finger 4 2.61626
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.61083
PTPRG protein tyrosine phosphatase, receptor type, G 2.58317
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.56517
GJA4 gap junction protein, alpha 4, 37kDa 2.56517
GCOM1 GRINL1A complex locus 1 2.56517
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 2.54023
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 2.54023
TUBD1 tubulin, delta 1 2.53425
METTL15 methyltransferase like 15 2.53155
LINGO2 leucine rich repeat and Ig domain containing 2 2.46752
BABAM2 BRISC and BRCA1 A complex member 2 2.44657
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 2.4187
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.41307
CHPT1 choline phosphotransferase 1 2.41051
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.3937
OPRM1 opioid receptor, mu 1 2.38784
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.38784
CARD19 caspase recruitment domain family member 19 2.37678
PHETA1 PH domain containing endocytic trafficking adaptor 1 2.37175
FOXO6 forkhead box O6 2.34462
MASTL microtubule associated serine/threonine kinase-like 2.32702
POM121C POM121 transmembrane nucleoporin C 2.32277
MAN2B2 mannosidase, alpha, class 2B, member 2 2.32277
ZNF490 zinc finger protein 490 2.32175
LARS1 leucyl-tRNA synthetase 1 2.31918
SCCPDH saccharopine dehydrogenase (putative) 2.30635
NPAP1 nuclear pore associated protein 1 2.30599
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.25184
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 2.23423
CSNK1G1 casein kinase 1, gamma 1 2.22537
PGBD4 piggyBac transposable element derived 4 2.22537
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.22289
MBD4 methyl-CpG binding domain protein 4 2.21784
ZNF646 zinc finger protein 646 2.21626
RPL15 ribosomal protein L15 2.20341
SRXN1 sulfiredoxin 1 2.20021
TCEA1 transcription elongation factor A (SII), 1 2.19778
CDK6 cyclin-dependent kinase 6 2.17168
EMP2 epithelial membrane protein 2 2.14698
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.13621
TMEM132B transmembrane protein 132B 2.12905
ZNF878 zinc finger protein 878 2.12187
MTCL1 microtubule crosslinking factor 1 2.12048
TSPAN10 tetraspanin 10 2.11622
SOWAHC sosondowah ankyrin repeat domain family member C 2.09475
JUND jun D proto-oncogene 2.09475
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 2.09475
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 2.09392
ZNF891 zinc finger protein 891 2.07163
PLXNA2 plexin A2 2.06873
FGFR4 fibroblast growth factor receptor 4 2.06873
PPIG peptidylprolyl isomerase G (cyclophilin G) 2.06873
THAP1 THAP domain containing, apoptosis associated protein 1 2.06739
TMEM269 transmembrane protein 269 2.04998
RPL13A ribosomal protein L13a 2.04998
LRP1B low density lipoprotein receptor-related protein 1B 2.04998
DPP8 dipeptidyl-peptidase 8 2.04769
SRRD SRR1 domain containing 2.02387
TM9SF4 transmembrane 9 superfamily protein member 4 2.02156
AMACR alpha-methylacyl-CoA racemase 2.01886
CDKN3 cyclin-dependent kinase inhibitor 3 2.0159
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 2.01037
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase 2.00939
ZFP36L2 ZFP36 ring finger protein-like 2 2.00592

decreased expression

Symbol Name Standardized Value
CRHR1 corticotropin releasing hormone receptor 1 -2.82857
ZNF221 zinc finger protein 221 -2.82857
LRRC66 leucine rich repeat containing 66 -2.82857
PBK PDZ binding kinase -2.82857
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.82857
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 -2.82857
LEP leptin -2.82857
H2BC12 H2B clustered histone 12 -2.82857
CIBAR1 CBY1 interacting BAR domain containing 1 -2.82857
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.82857
SH2D7 SH2 domain containing 7 -2.82857
ACP4 acid phosphatase 4 -2.82857
ZBTB7B zinc finger and BTB domain containing 7B -2.82857
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.82857
TMT1B thiol methyltransferase 1B -2.82857
PTPRO protein tyrosine phosphatase, receptor type, O -2.82857
IGFL4 IGF-like family member 4 -2.82857
FBXO32 F-box protein 32 -2.75342
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.73274
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.72197
CIITA class II, major histocompatibility complex, transactivator -2.72197
RCSD1 RCSD domain containing 1 -2.72197
AOC1 amine oxidase, copper containing 1 -2.72197
IRX5 iroquois homeobox 5 -2.72197
MEIG1 meiosis/spermiogenesis associated 1 -2.72197
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -2.72197
SOX18 SRY (sex determining region Y)-box 18 -2.72197
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -2.72197
RSPO3 R-spondin 3 -2.72197
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.72197
COL17A1 collagen, type XVII, alpha 1 -2.72197
SVOP SV2 related protein homolog (rat) -2.72197
UTS2B urotensin 2B -2.72197
CFAP61 cilia and flagella associated protein 61 -2.72197
GPR150 G protein-coupled receptor 150 -2.72197
GRAP GRB2-related adaptor protein -2.72197
TMEM132E transmembrane protein 132E -2.72197
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.72197
MTMR11 myotubularin related protein 11 -2.72197
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -2.72197
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.72197
HMOX1 heme oxygenase 1 -2.68672
HYDIN HYDIN, axonemal central pair apparatus protein -2.64389
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.57499
SMAD4 SMAD family member 4 -2.57499
PABIR2 PABIR family member 2 -2.55584
SUZ12 SUZ12 polycomb repressive complex 2 subunit -2.51837
RAP1B RAP1B, member of RAS oncogene family -2.51837
CCNL1 cyclin L1 -2.51035
ZNF70 zinc finger protein 70 -2.48538
FKBP11 FK506 binding protein 11, 19 kDa -2.4187
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.41051
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 -2.4027
ZC3H11C zinc finger CCCH-type containing 11C -2.4027
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -2.35291
PROCR protein C receptor, endothelial -2.3486
HP1BP3 heterochromatin protein 1, binding protein 3 -2.30635
BAIAP3 BAI1-associated protein 3 -2.30635
OSBPL6 oxysterol binding protein-like 6 -2.30408
ARSJ arylsulfatase family, member J -2.2965
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.28509
STEAP1 six transmembrane epithelial antigen of the prostate 1 -2.25844
POMK protein-O-mannose kinase -2.25024
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.24515
CYBRD1 cytochrome b reductase 1 -2.24079
SRSF8 serine/arginine-rich splicing factor 8 -2.23719
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 -2.23472
FEM1A fem-1 homolog a (C. elegans) -2.21784
PON3 paraoxonase 3 -2.20342
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.20341
PMPCA peptidase (mitochondrial processing) alpha -2.19778
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -2.17628
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 -2.16253
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.13739
ARSL arylsulfatase L -2.13586
CD70 CD70 molecule -2.13181
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.13181
ARID5A AT rich interactive domain 5A (MRF1-like) -2.10845
CACNB1 calcium channel, voltage-dependent, beta 1 subunit -2.10435
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.10016
ILDR2 immunoglobulin-like domain containing receptor 2 -2.09475
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.09392
C11ORF42 chromosome 11 open reading frame 42 -2.08288
TGFB3 transforming growth factor, beta 3 -2.08288
SHBG sex hormone-binding globulin -2.08288
RNF11 ring finger protein 11 -2.0769
ENOSF1 enolase superfamily member 1 -2.07058
NFIA nuclear factor I/A -2.06667
KIF3A kinesin family member 3A -2.04416
THADA thyroid adenoma associated -2.04045
SH2B1 SH2B adaptor protein 1 -2.03686
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 -2.02387
TLE4 transducin-like enhancer of split 4 -2.00774
BCL10 B-cell CLL/lymphoma 10 -2.00624
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.00457
MCM7 minichromosome maintenance complex component 7 -2.00041