PAFAH2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description platelet-activating factor acetylhydrolase 2, 40kDa|This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5051)
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Genes

313 genes differentially expressed following the PAFAH2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GSTM2 glutathione S-transferase mu 2 (muscle) 2.82456
BHLHE40 basic helix-loop-helix family, member e40 2.82456
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.82456
HCST hematopoietic cell signal transducer 2.82456
ZSCAN22 zinc finger and SCAN domain containing 22 2.82456
GLRA3 glycine receptor, alpha 3 2.82456
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.82456
C16ORF86 chromosome 16 open reading frame 86 2.82456
SYCE3 synaptonemal complex central element protein 3 2.82456
NPIPA7 nuclear pore complex interacting protein family, member A7 2.82456
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.82456
NCKAP1L NCK-associated protein 1-like 2.82456
GJB3 gap junction protein, beta 3, 31kDa 2.82456
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.82456
DSG3 desmoglein 3 2.82456
PDE7B phosphodiesterase 7B 2.82456
CEP295NL CEP295 N-terminal like 2.82456
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.82456
MYOM2 myomesin 2 2.82456
LYZL6 lysozyme-like 6 2.82456
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.82456
LRRC63 leucine rich repeat containing 63 2.82456
NT5E 5'-nucleotidase, ecto (CD73) 2.82456
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.82456
SNAI2 snail family zinc finger 2 2.82456
TPH1 tryptophan hydroxylase 1 2.82456
MEIG1 meiosis/spermiogenesis associated 1 2.82456
NFE2 nuclear factor, erythroid 2 2.82456
NLRP6 NLR family, pyrin domain containing 6 2.82456
KIF12 kinesin family member 12 2.82456
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.82456
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.82456
PRSS21 protease, serine, 21 (testisin) 2.82456
DGKK diacylglycerol kinase, kappa 2.82456
BMP5 bone morphogenetic protein 5 2.82456
GALR2 galanin receptor 2 2.82456
GALR3 galanin receptor 3 2.82456
OIT3 oncoprotein induced transcript 3 2.82456
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.82456
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.82456
PMCH pro-melanin-concentrating hormone 2.82456
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.82456
TLDC2 TBC/LysM-associated domain containing 2 2.82456
MMP12 matrix metallopeptidase 12 2.82456
SH2D7 SH2 domain containing 7 2.82456
REELD1 reeler domain containing 1 2.82456
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.82456
SPRR2F small proline-rich protein 2F 2.82456
C9ORF43 chromosome 9 open reading frame 43 2.82456
TMPRSS4 transmembrane protease, serine 4 2.82456
DOK2 docking protein 2, 56kDa 2.82456
TSPAN1 tetraspanin 1 2.82456
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.82456
CD70 CD70 molecule 2.82456
C15ORF62 chromosome 15 open reading frame 62 2.82456
MYH4 myosin, heavy chain 4, skeletal muscle 2.82456
YIPF7 Yip1 domain family, member 7 2.82456
C17ORF113 chromosome 17 open reading frame 113 2.82456
H3-7 H3.7 histone (putative) 2.82456
HOATZ HOATZ cilia and flagella associated protein 2.82456
CFAP299 cilia and flagella associated protein 299 2.82456
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.82456
PMIS2 PMIS2 transmembrane protein 2.82456
LOC112694756 uncharaterized LOC112694756 2.82456
SPATS1 spermatogenesis associated, serine-rich 1 2.82456
OTOF otoferlin 2.82456
CCDC42 coiled-coil domain containing 42 2.82456
CDKN2A cyclin-dependent kinase inhibitor 2A 2.82456
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.82456
SCG2 secretogranin II 2.82456
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.82456
STRIT1 small transmembrane regulator of ion transport 1 2.82456
ANKRD22 ankyrin repeat domain 22 2.82456
AKR1C2 aldo-keto reductase family 1, member C2 2.82456
FGL2 fibrinogen-like 2 2.82456
HGD homogentisate 1,2-dioxygenase 2.82456
NOD2 nucleotide-binding oligomerization domain containing 2 2.82456
RNF17 ring finger protein 17 2.82456
FOXL2 forkhead box L2 2.82456
CREB3L3 cAMP responsive element binding protein 3-like 3 2.82456
CATSPER1 cation channel, sperm associated 1 2.82456
LDHAL6A lactate dehydrogenase A-like 6A 2.82456
IRF4 interferon regulatory factor 4 2.82456
TMIE transmembrane inner ear 2.82456
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.82456
PCDHB12 protocadherin beta 12 2.82456
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.82456
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.82456
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.82456
A1CF APOBEC1 complementation factor 2.82456
OPRK1 opioid receptor, kappa 1 2.82456
CPA2 carboxypeptidase A2 (pancreatic) 2.82456
PSKH2 protein serine kinase H2 2.82456
CYS1 cystin 1 2.82456
CER1 cerberus 1, DAN family BMP antagonist 2.82456
THBD thrombomodulin 2.82456
KLK5 kallikrein-related peptidase 5 2.82456
LY96 lymphocyte antigen 96 2.82456
TG thyroglobulin 2.82456
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 2.82456
PLET1 placenta expressed transcript 1 2.82456
SCT secretin 2.82456
GP5 glycoprotein V (platelet) 2.82456
UBQLNL ubiquilin-like 2.82456
KLHL1 kelch-like family member 1 2.82456
BTNL8 butyrophilin-like 8 2.82456
CXCR4 chemokine (C-X-C motif) receptor 4 2.82456
CTAGE4 CTAGE family, member 4 2.82456
CPSF4L cleavage and polyadenylation specific factor 4-like 2.82456
TIGD3 tigger transposable element derived 3 2.82456
SMIM17 small integral membrane protein 17 2.82456
MYL10 myosin, light chain 10, regulatory 2.82456
RIN1 Ras and Rab interactor 1 2.82456
HLA-G major histocompatibility complex, class I, G 2.82456
GPR149 G protein-coupled receptor 149 2.82456
PLA2G2C phospholipase A2, group IIC 2.82456
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.82456
NPY2R neuropeptide Y receptor Y2 2.82456
GOLGA8H golgin A8 family, member H 2.82456
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.82456
ABLIM3 actin binding LIM protein family, member 3 2.82456
NOTCH4 notch 4 2.82456
NMBR neuromedin B receptor 2.82456
TP63 tumor protein p63 2.82456
GPR62 G protein-coupled receptor 62 2.82456
ZIM2 zinc finger, imprinted 2 2.82456
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.82456
LYPD3 LY6/PLAUR domain containing 3 2.82456
LYPD5 LY6/PLAUR domain containing 5 2.82456
CLEC1A C-type lectin domain family 1, member A 2.82456
NKX6-1 NK6 homeobox 1 2.82456
THTPA thiamine triphosphatase 2.82456
CCNO cyclin O 2.82456
EPX eosinophil peroxidase 2.82456
TECRL trans-2,3-enoyl-CoA reductase-like 2.82456
AZIN2 antizyme inhibitor 2 2.82456
FAM47C family with sequence similarity 47, member C 2.82456
CARNS1 carnosine synthase 1 2.82456
DMTN dematin actin binding protein 2.82456
CSPG4 chondroitin sulfate proteoglycan 4 2.82456
SPRN shadow of prion protein homolog (zebrafish) 2.82456
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.82456
ROM1 retinal outer segment membrane protein 1 2.82456
POTEF POTE ankyrin domain family, member F 2.82456
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.82456
AGBL1 ATP/GTP binding protein-like 1 2.82456
C10ORF90 chromosome 10 open reading frame 90 2.82456
SYTL4 synaptotagmin-like 4 2.82456
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.82456
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.82456
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.82456
RNF222 ring finger protein 222 2.82456
PXT1 peroxisomal, testis specific 1 2.82456
OR8H1 olfactory receptor, family 8, subfamily H, member 1 2.82456
CABP7 calcium binding protein 7 2.82456
APOD apolipoprotein D 2.82456
PRF1 perforin 1 (pore forming protein) 2.82456
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.82456
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.82456
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.82456
ECE2 endothelin converting enzyme 2 2.82456
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.82456
MORC1 MORC family CW-type zinc finger 1 2.82456
TBPL2 TATA box binding protein like 2 2.82456
TDGF1 teratocarcinoma-derived growth factor 1 2.66524
MIX23 mitochondrial matrix import factor 23 2.65375
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.62025
ZNF646 zinc finger protein 646 2.60605
UNC13A unc-13 homolog A (C. elegans) 2.60605
VWA1 von Willebrand factor A domain containing 1 2.60605
BDH2 3-hydroxybutyrate dehydrogenase, type 2 2.60449
ITPRID1 ITPR interacting domain containing 1 2.54896
YJU2 YJU2 splicing factor homolog 2.51868
NUDCD3 NudC domain containing 3 2.50981
HNMT histamine N-methyltransferase 2.45192
TCEAL8 transcription elongation factor A (SII)-like 8 2.43886
TSPAN16 tetraspanin 16 2.39511
C6ORF52 chromosome 6 open reading frame 52 2.39511
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.39511
MRPL41 mitochondrial ribosomal protein L41 2.39511
PHACTR2 phosphatase and actin regulator 2 2.3901
PAWR PRKC, apoptosis, WT1, regulator 2.35854
MRPS16 mitochondrial ribosomal protein S16 2.3463
APOO apolipoprotein O 2.3463
SGPL1 sphingosine-1-phosphate lyase 1 2.30001
LYPLAL1 lysophospholipase-like 1 2.28401
SCRIB scribbled planar cell polarity protein 2.27847
METTL18 methyltransferase like 18 2.27785
SF3A2 splicing factor 3a, subunit 2, 66kDa 2.25105
FBXO2 F-box protein 2 2.19618
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.18585
FBXO32 F-box protein 32 2.15604
RLN2 relaxin 2 2.1419
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.112
SLTM SAFB-like, transcription modulator 2.08393
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 2.07885
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 2.04307
UBL4A ubiquitin-like 4A 2.02609
ADIPOR1 adiponectin receptor 1 2.01845

decreased expression

Symbol Name Standardized Value
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa -2.82456
GTF2IRD2B GTF2I repeat domain containing 2B -2.82456
SMAD6 SMAD family member 6 -2.82456
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.82456
ELAC1 elaC ribonuclease Z 1 -2.82456
MRPS24 mitochondrial ribosomal protein S24 -2.82456
SBK2 SH3 domain binding kinase family, member 2 -2.82456
FER1L5 fer-1-like family member 5 -2.82456
PRSS27 protease, serine 27 -2.82456
LRTM1 leucine-rich repeats and transmembrane domains 1 -2.82456
PRR15 proline rich 15 -2.82456
FAM156A family with sequence similarity 156, member A -2.82456
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -2.82456
CMKLR2 chemerin chemokine-like receptor 2 -2.82456
ADPRHL1 ADP-ribosylhydrolase like 1 -2.82456
GARIN2 golgi associated RAB2 interactor family member 2 -2.82456
TMEM114 transmembrane protein 114 -2.82456
STARD8 StAR-related lipid transfer (START) domain containing 8 -2.82456
BRICD5 BRICHOS domain containing 5 -2.82456
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -2.77711
ADAR adenosine deaminase, RNA-specific -2.74908
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.69348
SIRT2 sirtuin 2 -2.64895
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.64895
TCF24 transcription factor 24 -2.6341
TWIST2 twist family bHLH transcription factor 2 -2.6341
RHCE Rh blood group, CcEe antigens -2.60605
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.60605
THRSP thyroid hormone responsive -2.60605
SFTPD surfactant protein D -2.60605
SLC23A3 solute carrier family 23, member 3 -2.60605
MROH6 maestro heat-like repeat family member 6 -2.60605
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.60605
NEU4 sialidase 4 -2.60605
GJB5 gap junction protein, beta 5, 31.1kDa -2.60605
SLC67A1 solute carrier family 67 member 1 -2.60605
MON1A MON1 secretory trafficking family member A -2.60605
FAM186A family with sequence similarity 186, member A -2.60605
PRB2 proline-rich protein BstNI subfamily 2 -2.60605
ZMAT2 zinc finger, matrin-type 2 -2.60605
FAM86B2 family with sequence similarity 86, member B2 -2.60605
INHBC inhibin, beta C -2.60605
SLC46A2 solute carrier family 46, member 2 -2.60605
CCDC68 coiled-coil domain containing 68 -2.60605
VSTM2A V-set and transmembrane domain containing 2A -2.60605
NSG2 neuronal vesicle trafficking associated 2 -2.60605
CRIP1 cysteine-rich protein 1 (intestinal) -2.60605
GREM2 gremlin 2, DAN family BMP antagonist -2.60605
BOLL boule-like RNA-binding protein -2.60605
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.60605
IL17C interleukin 17C -2.60605
SGMS2 sphingomyelin synthase 2 -2.60605
NIM1K NIM1 serine/threonine protein kinase -2.60605
DRD3 dopamine receptor D3 -2.60605
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.60605
GARNL3 GTPase activating Rap/RanGAP domain-like 3 -2.60605
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -2.60605
RELN reelin -2.60605
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.60605
CCDC78 coiled-coil domain containing 78 -2.60605
MAPK15 mitogen-activated protein kinase 15 -2.60605
ATL1 atlastin GTPase 1 -2.60449
KCTD12 potassium channel tetramerization domain containing 12 -2.59997
DGLUCY D-glutamate cyclase -2.57347
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.52735
NYNRIN NYN domain and retroviral integrase containing -2.50779
E2F2 E2F transcription factor 2 -2.49775
IL13RA1 interleukin 13 receptor, alpha 1 -2.48948
PRX periaxin -2.48461
IRF7 interferon regulatory factor 7 -2.48461
SLC66A3 solute carrier family 66 member 3 -2.45389
SCARA3 scavenger receptor class A, member 3 -2.43886
SEC14L5 SEC14-like 5 (S. cerevisiae) -2.43664
APCDD1 adenomatosis polyposis coli down-regulated 1 -2.41176
C1QTNF6 C1q and tumor necrosis factor related protein 6 -2.41176
FOSL2 FOS-like antigen 2 -2.41176
GRID1 glutamate receptor, ionotropic, delta 1 -2.41176
QRFPR pyroglutamylated RFamide peptide receptor -2.39889
TMED3 transmembrane emp24 protein transport domain containing 3 -2.37732
ACAD9 acyl-CoA dehydrogenase family, member 9 -2.37628
MIPEP mitochondrial intermediate peptidase -2.35854
SORBS3 sorbin and SH3 domain containing 3 -2.30802
MAIP1 matrix AAA peptidase interacting protein 1 -2.28474
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.28401
HASPIN histone H3 associated protein kinase -2.27797
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.26088
KIF4A kinesin family member 4A -2.24019
ERCC6L excision repair cross-complementation group 6-like -2.23975
EXOG endo/exonuclease (5'-3'), endonuclease G-like -2.23841
GPR180 G protein-coupled receptor 180 -2.22816
TJP1 tight junction protein 1 -2.21463
ZNG1F Zn regulated GTPase metalloprotein activator 1F -2.17344
GAS2L3 growth arrest-specific 2 like 3 -2.17344
CPEB2 cytoplasmic polyadenylation element binding protein 2 -2.17344
ADGRF3 adhesion G protein-coupled receptor F3 -2.17008
PTGR3 prostaglandin reductase 3 -2.17008
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -2.17007
TPRN taperin -2.15799
MORC2 MORC family CW-type zinc finger 2 -2.15452
MDH1B malate dehydrogenase 1B, NAD (soluble) -2.13328
RANBP1 RAN binding protein 1 -2.12927
ADAT2 adenosine deaminase, tRNA-specific 2 -2.11472
SUCLG1 succinate-CoA ligase, alpha subunit -2.112
MKX mohawk homeobox -2.07885
FRS3 fibroblast growth factor receptor substrate 3 -2.07885
CIDEB cell death-inducing DFFA-like effector b -2.07885
GLIS1 GLIS family zinc finger 1 -2.07885
SHISA6 shisa family member 6 -2.07777
ZBTB10 zinc finger and BTB domain containing 10 -2.06665
NREP neuronal regeneration related protein -2.04668
SLC44A3 solute carrier family 44, member 3 -2.04307
TNRC6B trinucleotide repeat containing 6B -2.04038
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.0339
TSPAN6 tetraspanin 6 -2.0339