PAIP2B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description poly(A) binding protein interacting protein 2B|Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 400961)
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Genes

314 genes differentially expressed following the PAIP2B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
VIT vitrin 2.71823
CAMP cathelicidin antimicrobial peptide 2.71823
PCDHB1 protocadherin beta 1 2.71823
RIMBP2 RIMS binding protein 2 2.71823
SLC25A45 solute carrier family 25, member 45 2.71823
DUSP10 dual specificity phosphatase 10 2.71823
CCL5 chemokine (C-C motif) ligand 5 2.71823
HBA1 hemoglobin, alpha 1 2.71823
FETUB fetuin B 2.71823
OLIG3 oligodendrocyte transcription factor 3 2.71823
SCGN secretagogin, EF-hand calcium binding protein 2.71823
USP26 ubiquitin specific peptidase 26 2.71823
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.71823
GGT5 gamma-glutamyltransferase 5 2.71823
ACTL10 actin-like 10 2.71823
HBA2 hemoglobin, alpha 2 2.71823
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.71823
CFHR3 complement factor H-related 3 2.71823
HLX H2.0-like homeobox 2.71823
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.71823
ZNF282 zinc finger protein 282 2.71823
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.71823
ASB10 ankyrin repeat and SOCS box containing 10 2.71823
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.71823
UPB1 ureidopropionase, beta 2.71823
R3HDML R3H domain containing-like 2.71823
GLB1L galactosidase, beta 1-like 2.71823
AOC1 amine oxidase, copper containing 1 2.71823
RAB7B RAB7B, member RAS oncogene family 2.71823
TAS2R43 taste receptor, type 2, member 43 2.71823
PADI1 peptidyl arginine deiminase, type I 2.71823
THEM6 thioesterase superfamily member 6 2.71823
OR51Q1 olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene) 2.71823
STEAP4 STEAP family member 4 2.71823
RNF39 ring finger protein 39 2.71823
FAM181B family with sequence similarity 181, member B 2.71823
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.71823
CD68 CD68 molecule 2.71823
TTLL8 tubulin tyrosine ligase-like family member 8 2.71823
CRIPT cysteine-rich PDZ-binding protein 2.71823
OC90 otoconin 90 2.71823
HBZ hemoglobin, zeta 2.71823
ATOH8 atonal homolog 8 (Drosophila) 2.71823
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.71823
MPL MPL proto-oncogene, thrombopoietin receptor 2.71823
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.71823
DNAAF19 dynein axonemal assembly factor 19 2.71823
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.71823
C6ORF47 chromosome 6 open reading frame 47 2.71823
HBG2 hemoglobin, gamma G 2.71823
ACER1 alkaline ceramidase 1 2.71823
ELOVL3 ELOVL fatty acid elongase 3 2.71823
FOXN4 forkhead box N4 2.71823
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.71823
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.71823
F5 coagulation factor V (proaccelerin, labile factor) 2.71823
NECTIN1 nectin cell adhesion molecule 1 2.71823
VSIR V-set immunoregulatory receptor 2.71823
NSG2 neuronal vesicle trafficking associated 2 2.71823
LOC122526780 uncharacterized LOC122526780 2.71823
SMIM45 small integral membrane protein 45 2.71823
EZHIP EZH inhibitory protein 2.71823
MUCL3 mucin like 3 2.71823
H1-8 H1.8 linker histone 2.71823
FLACC1 flagellum associated containing coiled-coil domains 1 2.71823
JAML junction adhesion molecule like 2.71823
AJM1 apical junction component 1 homolog 2.71823
CCN6 cellular communication network factor 6 2.71823
GATA2 GATA binding protein 2 2.71823
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.71823
GJD2 gap junction protein, delta 2, 36kDa 2.71823
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.71823
GLP2R glucagon-like peptide 2 receptor 2.71823
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.71823
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.71823
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.71823
MYH13 myosin, heavy chain 13, skeletal muscle 2.71823
ZIC4 Zic family member 4 2.71823
ULBP2 UL16 binding protein 2 2.71823
EXOC3L1 exocyst complex component 3-like 1 2.71823
CCR9 chemokine (C-C motif) receptor 9 2.71823
CLDN22 claudin 22 2.71823
PXDC1 PX domain containing 1 2.71823
GDF6 growth differentiation factor 6 2.71823
GDF9 growth differentiation factor 9 2.71823
FRK fyn-related Src family tyrosine kinase 2.71823
TAS1R1 taste receptor, type 1, member 1 2.71823
ABHD15 abhydrolase domain containing 15 2.71823
PLB1 phospholipase B1 2.71823
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.71823
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.71823
SCN10A sodium channel, voltage gated, type X alpha subunit 2.71823
KLK14 kallikrein-related peptidase 14 2.71823
UTS2R urotensin 2 receptor 2.71823
UTS2B urotensin 2B 2.71823
CPSF4L cleavage and polyadenylation specific factor 4-like 2.71823
CTAGE9 CTAGE family, member 9 2.71823
S100Z S100 calcium binding protein Z 2.71823
BSPH1 binder of sperm protein homolog 1 2.71823
POF1B premature ovarian failure, 1B 2.71823
CLEC9A C-type lectin domain family 9, member A 2.71823
MAGED4B melanoma antigen family D4B 2.71823
GPR150 G protein-coupled receptor 150 2.71823
MRLN myoregulin 2.71823
PRSS38 protease, serine, 38 2.71823
CLIC3 chloride intracellular channel 3 2.71823
LYZ lysozyme 2.71823
ARHGAP25 Rho GTPase activating protein 25 2.71823
FNDC1 fibronectin type III domain containing 1 2.71823
TPSG1 tryptase gamma 1 2.71823
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.71823
CHI3L2 chitinase 3-like 2 2.71823
TEKT2 tektin 2 (testicular) 2.71823
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.71823
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 2.71823
COX7B2 cytochrome c oxidase subunit VIIb2 2.71823
LMOD3 leiomodin 3 (fetal) 2.71823
TBXA2R thromboxane A2 receptor 2.71823
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.71823
IL36R interleukin 36 receptor 2.71823
FAM177B family with sequence similarity 177, member B 2.71823
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.71823
TEX11 testis expressed 11 2.71823
SST somatostatin 2.71823
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.71823
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.71823
PRPH peripherin 2.71823
FANCB Fanconi anemia, complementation group B 2.71823
LAMP5 lysosomal-associated membrane protein family, member 5 2.71823
ACKR3 atypical chemokine receptor 3 2.71823
LMX1B LIM homeobox transcription factor 1, beta 2.71823
PRRX1 paired related homeobox 1 2.71823
CARD6 caspase recruitment domain family, member 6 2.71823
FKBP1C FK506 binding protein 1C 2.71823
GOLGA8J golgin A8 family, member J 2.71823
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.71823
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.71823
CARNS1 carnosine synthase 1 2.71823
ADGRF4 adhesion G protein-coupled receptor F4 2.71823
ROM1 retinal outer segment membrane protein 1 2.71823
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.71823
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.71823
MMP3 matrix metallopeptidase 3 2.71823
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.71823
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.71823
DBX2 developing brain homeobox 2 2.71823
MEPE matrix extracellular phosphoglycoprotein 2.71823
ARHGAP40 Rho GTPase activating protein 40 2.71823
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.71823
PRR33 proline rich 33 2.71823
GPR146 G protein-coupled receptor 146 2.71823
ZNF366 zinc finger protein 366 2.71823
ENDOU endonuclease, polyU-specific 2.71823
SLC38A8 solute carrier family 38, member 8 2.71823
IL17REL interleukin 17 receptor E-like 2.71823
DES desmin 2.71823
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.71823
PDCD1 programmed cell death 1 2.71823
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.71823
BARHL2 BarH-like homeobox 2 2.71823
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.71823
KMT2D lysine (K)-specific methyltransferase 2D 2.68245
SPMIP2 sperm microtubule inner protein 2 2.66351
ZNF853 zinc finger protein 853 2.66351
BCAS1 breast carcinoma amplified sequence 1 2.66351
CEP112 centrosomal protein 112kDa 2.61713
CNN2 calponin 2 2.5782
MALSU1 mitochondrial assembly of ribosomal large subunit 1 2.57076
FBXO45 F-box protein 45 2.54878
ZNHIT6 zinc finger, HIT-type containing 6 2.54878
CCDC78 coiled-coil domain containing 78 2.50414
ZNF513 zinc finger protein 513 2.49097
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.46787
MEP1B meprin A, beta 2.40598
WFDC8 WAP four-disulfide core domain 8 2.40598
PCDHAC1 protocadherin alpha subfamily C, 1 2.40598
SDSL serine dehydratase-like 2.39378
TPH1 tryptophan hydroxylase 1 2.39378
SPON2 spondin 2, extracellular matrix protein 2.39378
SHLD2 shieldin complex subunit 2 2.38821
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 2.32869
LIFR leukemia inhibitory factor receptor alpha 2.29175
C19ORF25 chromosome 19 open reading frame 25 2.29171
NKIRAS2 NFKB inhibitor interacting Ras-like 2 2.28677
AGO1 argonaute RISC catalytic component 1 2.26853
JADE1 jade family PHD finger 1 2.26506
BGN biglycan 2.2369
USP3 ubiquitin specific peptidase 3 2.21555
KLF3 Kruppel-like factor 3 (basic) 2.1961
TOP2A topoisomerase (DNA) II alpha 170kDa 2.16467
NTM neurotrimin 2.16467
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 2.16438
CHERP calcium homeostasis endoplasmic reticulum protein 2.15636
EID2 EP300 interacting inhibitor of differentiation 2 2.15392
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 2.15392
MREG melanoregulin 2.13293
USP9X ubiquitin specific peptidase 9, X-linked 2.12434
H2BC14 H2B clustered histone 14 2.11211
BMF Bcl2 modifying factor 2.10943
IQCB1 IQ motif containing B1 2.08539
GLOD4 glyoxalase domain containing 4 2.0825
KIAA0513 KIAA0513 2.0825
TP53BP1 tumor protein p53 binding protein 1 2.07083
TENM4 teneurin transmembrane protein 4 2.06328
FBXO34 F-box protein 34 2.05261
DPY19L2 dpy-19-like 2 (C. elegans) 2.04872
ZMIZ2 zinc finger, MIZ-type containing 2 2.04837
DPH2 DPH2 homolog (S. cerevisiae) 2.04665
ZNF579 zinc finger protein 579 2.04665
EDNRA endothelin receptor type A 2.04618
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.04105
TAC4 tachykinin 4 (hemokinin) 2.03358
NANP N-acetylneuraminic acid phosphatase 2.01328
HLA-DMA major histocompatibility complex, class II, DM alpha 2.00845

decreased expression

Symbol Name Standardized Value
CPHXL2 cytoplasmic polyadenylated homeobox like 2 -2.71823
HAS1 hyaluronan synthase 1 -2.71823
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -2.71823
PLA2G10 phospholipase A2, group X -2.71823
CEP44 centrosomal protein 44kDa -2.71823
TMEM184A transmembrane protein 184A -2.71823
PITX2 paired-like homeodomain 2 -2.71823
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 -2.71823
CDC40 cell division cycle 40 -2.71823
PXT1 peroxisomal, testis specific 1 -2.71823
SUN3 Sad1 and UNC84 domain containing 3 -2.71823
HSPB2 heat shock 27kDa protein 2 -2.71823
FNDC7 fibronectin type III domain containing 7 -2.71823
ASB18 ankyrin repeat and SOCS box containing 18 -2.71823
HYAL3 hyaluronoglucosaminidase 3 -2.71823
HARS1 histidyl-tRNA synthetase 1 -2.71823
OPRM1 opioid receptor, mu 1 -2.71823
FMOD fibromodulin -2.71823
TBX10 T-box 10 -2.71823
NCAN neurocan -2.71823
NFILZ NFIL3 like basic leucine zipper -2.71823
SLC22A14 solute carrier family 22, member 14 -2.71823
SYCP1 synaptonemal complex protein 1 -2.71823
LRRD1 leucine-rich repeats and death domain containing 1 -2.71823
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -2.71823
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.71823
ZMYND10 zinc finger, MYND-type containing 10 -2.71823
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -2.71823
PCDH12 protocadherin 12 -2.71823
MUC19 mucin 19, oligomeric -2.71823
KLK6 kallikrein-related peptidase 6 -2.71823
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.71823
EDN1 endothelin 1 -2.71823
ARFRP1 ADP-ribosylation factor related protein 1 -2.71823
CD53 CD53 molecule -2.71823
CALR3 calreticulin 3 -2.71823
TP63 tumor protein p63 -2.71823
GSDMD gasdermin D -2.71823
KLHL10 kelch-like family member 10 -2.71823
COX19 COX19 cytochrome c oxidase assembly factor -2.71823
PRDM10 PR domain containing 10 -2.67301
CHMP4A charged multivesicular body protein 4A -2.65686
MAP3K11 mitogen-activated protein kinase kinase kinase 11 -2.61713
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.6065
MXD3 MAX dimerization protein 3 -2.56197
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa -2.55769
EIF4E eukaryotic translation initiation factor 4E -2.55222
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) -2.47731
NDRG3 NDRG family member 3 -2.46787
CASS4 Cas scaffolding protein family member 4 -2.44372
TFEB transcription factor EB -2.44372
SSC5D scavenger receptor cysteine rich family, 5 domains -2.44372
CFAP74 cilia and flagella associated protein 74 -2.44372
MARCHF10 membrane associated ring-CH-type finger 10 -2.40466
PGM5 phosphoglucomutase 5 -2.40466
SPATA20 spermatogenesis associated 20 -2.40466
DMKN dermokine -2.39378
SNX15 sorting nexin 15 -2.3435
HOMEZ homeobox and leucine zipper encoding -2.33557
TMOD3 tropomodulin 3 (ubiquitous) -2.33461
GRAMD2A GRAM domain containing 2A -2.3315
ADCK2 aarF domain containing kinase 2 -2.31188
TXN2 thioredoxin 2 -2.31009
RBFA ribosome binding factor A (putative) -2.25575
MAPK15 mitogen-activated protein kinase 15 -2.24746
PPP4C protein phosphatase 4, catalytic subunit -2.2154
SPEF2 sperm flagellar 2 -2.21504
ATAD3B ATPase family, AAA domain containing 3B -2.19363
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.18192
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -2.17012
LCA5L Leber congenital amaurosis 5-like -2.16344
ZNF517 zinc finger protein 517 -2.15392
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.15392
CFAP44 cilia and flagella associated protein 44 -2.15392
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -2.13894
RECQL4 RecQ protein-like 4 -2.11973
ANXA4 annexin A4 -2.10599
ZNF836 zinc finger protein 836 -2.08539
TRAPPC2L trafficking protein particle complex 2-like -2.08539
ZNF860 zinc finger protein 860 -2.08539
PIBF1 progesterone immunomodulatory binding factor 1 -2.08539
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.0825
SURF1 surfeit 1 -2.0825
TBC1D16 TBC1 domain family, member 16 -2.08121
SCLY selenocysteine lyase -2.07325
BEST4 bestrophin 4 -2.07083
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.07083
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.07083
RHOV ras homolog family member V -2.07083
PLEKHN1 pleckstrin homology domain containing, family N member 1 -2.07083
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -2.06311
NOX4 NADPH oxidase 4 -2.04872
NTNG2 netrin G2 -2.04872
FAM131A family with sequence similarity 131, member A -2.04872
GRB2 growth factor receptor-bound protein 2 -2.04665
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.03154
LTO1 LTO1 maturation factor of ABCE1 -2.02801
MLEC malectin -2.02334
NOP58 NOP58 ribonucleoprotein -2.01328
GCK glucokinase (hexokinase 4) -2.01328