PAK1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description p21 protein (Cdc42/Rac)-activated kinase 1|This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 5058)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase PAK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MAP3K2 mitogen-activated protein kinase kinase kinase 2
TTN titin
LMO7 LIM domain 7
ZBTB44 zinc finger and BTB domain containing 44
PPP1R10 protein phosphatase 1, regulatory subunit 10
MAP7D3 MAP7 domain containing 3
TTC39B tetratricopeptide repeat domain 39B
RPTOR regulatory associated protein of MTOR, complex 1
IER2 immediate early response 2
PRICKLE3 prickle homolog 3 (Drosophila)
TOR4A torsin family 4, member A
SCAF1 SR-related CTD-associated factor 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE3A phosphodiesterase 3A, cGMP-inhibited
SETD2 SET domain containing 2
NUMA1 nuclear mitotic apparatus protein 1
BIVM basic, immunoglobulin-like variable motif containing
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
UBE2O ubiquitin-conjugating enzyme E2O
KIF23 kinesin family member 23
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
HEPH hephaestin
KAT5 K(lysine) acetyltransferase 5
TRA2A transformer 2 alpha homolog (Drosophila)
WDR81 WD repeat domain 81
SEPT1 septin 1
ESR1 estrogen receptor 1
CCDC120 coiled-coil domain containing 120
CASKIN2 CASK interacting protein 2
PBRM1 polybromo 1
LTF lactotransferrin
FRMD4B FERM domain containing 4B
PRPF38B pre-mRNA processing factor 38B
PELI1 pellino E3 ubiquitin protein ligase 1
RPS6 ribosomal protein S6
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
DMXL1 Dmx-like 1
CENPA centromere protein A
DEPDC5 DEP domain containing 5
TRPS1 trichorhinophalangeal syndrome I
MYO7B myosin VIIB
MVD mevalonate (diphospho) decarboxylase
SOX9 SRY (sex determining region Y)-box 9
KDM3B lysine (K)-specific demethylase 3B
SRSF2 serine/arginine-rich splicing factor 2
PCLO piccolo presynaptic cytomatrix protein
ATR ATR serine/threonine kinase
MLPH melanophilin
GAS7 growth arrest-specific 7
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
KCTD15 potassium channel tetramerization domain containing 15
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LIMCH1 LIM and calponin homology domains 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
HBP1 HMG-box transcription factor 1
TP53BP1 tumor protein p53 binding protein 1
GRK7 G protein-coupled receptor kinase 7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
VANGL1 VANGL planar cell polarity protein 1
AEBP2 AE binding protein 2
CHERP calcium homeostasis endoplasmic reticulum protein
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NCOA6 nuclear receptor coactivator 6
FRYL FRY-like
PYGO2 pygopus family PHD finger 2
PPHLN1 periphilin 1
ILDR1 immunoglobulin-like domain containing receptor 1
CDCA2 cell division cycle associated 2
ZFP91 ZFP91 zinc finger protein
KIAA1211 KIAA1211
CHKB choline kinase beta
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
RNF111 ring finger protein 111
SECISBP2L SECIS binding protein 2-like
CDC25A cell division cycle 25A
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
RBM8A RNA binding motif protein 8A
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R12C protein phosphatase 1, regulatory subunit 12C
SETD1A SET domain containing 1A
EI24 etoposide induced 2.4
RBM15B RNA binding motif protein 15B
ZFC3H1 zinc finger, C3H1-type containing
CDC25B cell division cycle 25B
NCAPH non-SMC condensin I complex, subunit H
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
C6ORF25 chromosome 6 open reading frame 25
FAM214B family with sequence similarity 214, member B
SRRM2 serine/arginine repetitive matrix 2
RSBN1 round spermatid basic protein 1
ARHGAP21 Rho GTPase activating protein 21
MEPCE methylphosphate capping enzyme
CLK3 CDC-like kinase 3
BAG6 BCL2-associated athanogene 6
ZNF212 zinc finger protein 212
IRF2BP2 interferon regulatory factor 2 binding protein 2
TWIST1 twist family bHLH transcription factor 1