PAK1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description p21 protein (Cdc42/Rac)-activated kinase 1|This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 5058)
External Link http://www.ncbi.nlm.nih.gov/gene/5058
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Genes

44 substrates of the kinase PAK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AJUBA ajuba LIM protein
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
BRAF B-Raf proto-oncogene, serine/threonine kinase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DYNLL1 dynein, light chain, LC8-type 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ESR1 estrogen receptor 1
FLNA filamin A, alpha
FXR1 fragile X mental retardation, autosomal homolog 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
HIST1H3A histone cluster 1, H3a
ILK integrin-linked kinase
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF2C kinesin family member 2C
LIMK1 LIM domain kinase 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MORC2 MORC family CW-type zinc finger 2
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NET1 neuroepithelial cell transforming 1
NF2 neurofibromin 2 (merlin)
PA2G4 proliferation-associated 2G4, 38kDa
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCBP1 poly(rC) binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PLK1 polo-like kinase 1
PXN paxillin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SNAI1 snail family zinc finger 1
SPEN spen family transcriptional repressor
STAT5A signal transducer and activator of transcription 5A
STMN1 stathmin 1
TBCB tubulin folding cofactor B
VIM vimentin