PAK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description p21 protein (Cdc42/Rac)-activated kinase 2|The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5062)
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100 substrates of the kinase PAK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MAST1 microtubule associated serine/threonine kinase 1
TRA2B transformer 2 beta homolog (Drosophila)
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
MYD88 myeloid differentiation primary response 88
SCAF1 SR-related CTD-associated factor 1
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
ARHGAP11A Rho GTPase activating protein 11A
OSBPL5 oxysterol binding protein-like 5
FAM65B family with sequence similarity 65, member B
ZBTB44 zinc finger and BTB domain containing 44
TRA2A transformer 2 alpha homolog (Drosophila)
HEPH hephaestin
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
NUMA1 nuclear mitotic apparatus protein 1
MYO9B myosin IXB
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
DENND4C DENN/MADD domain containing 4C
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
UBE2O ubiquitin-conjugating enzyme E2O
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
KIF23 kinesin family member 23
PPP1R10 protein phosphatase 1, regulatory subunit 10
CASP9 caspase 9, apoptosis-related cysteine peptidase
PLEKHA6 pleckstrin homology domain containing, family A member 6
DMXL1 Dmx-like 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
PPAPDC3 phosphatidic acid phosphatase type 2 domain containing 3
PBRM1 polybromo 1
LTF lactotransferrin
PRPF38B pre-mRNA processing factor 38B
PELI1 pellino E3 ubiquitin protein ligase 1
RPS6 ribosomal protein S6
ZC3HAV1 zinc finger CCCH-type, antiviral 1
DEPDC5 DEP domain containing 5
GPR161 G protein-coupled receptor 161
ATR ATR serine/threonine kinase
RPTOR regulatory associated protein of MTOR, complex 1
IER2 immediate early response 2
TOR4A torsin family 4, member A
WDR81 WD repeat domain 81
TERF2IP telomeric repeat binding factor 2, interacting protein
BAHD1 bromo adjacent homology domain containing 1
TRPS1 trichorhinophalangeal syndrome I
MYO7B myosin VIIB
SRSF2 serine/arginine-rich splicing factor 2
PCLO piccolo presynaptic cytomatrix protein
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRKD3 protein kinase D3
RARA retinoic acid receptor, alpha
CASC5 cancer susceptibility candidate 5
GRK7 G protein-coupled receptor kinase 7
RARG retinoic acid receptor, gamma
CDR2L cerebellar degeneration-related protein 2-like
C6ORF25 chromosome 6 open reading frame 25
FAM214B family with sequence similarity 214, member B
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
IL1A interleukin 1, alpha
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
DDA1 DET1 and DDB1 associated 1
FCHSD2 FCH and double SH3 domains 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
PPHLN1 periphilin 1
CDCA2 cell division cycle associated 2
INF2 inverted formin, FH2 and WH2 domain containing
PHF3 PHD finger protein 3
CHKB choline kinase beta
CHERP calcium homeostasis endoplasmic reticulum protein
SRRM2 serine/arginine repetitive matrix 2
MORC3 MORC family CW-type zinc finger 3
PPP1R12C protein phosphatase 1, regulatory subunit 12C
LAG3 lymphocyte-activation gene 3
SETD1A SET domain containing 1A
EI24 etoposide induced 2.4
FAM207A family with sequence similarity 207, member A
RBM15B RNA binding motif protein 15B
ZFC3H1 zinc finger, C3H1-type containing
TWIST1 twist family bHLH transcription factor 1
SHKBP1 SH3KBP1 binding protein 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PYGL phosphorylase, glycogen, liver
SP100 SP100 nuclear antigen
ZNF212 zinc finger protein 212
IRF2BP2 interferon regulatory factor 2 binding protein 2
IRF2BPL interferon regulatory factor 2 binding protein-like
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
NCAPH non-SMC condensin I complex, subunit H
CCNY cyclin Y
CDC25B cell division cycle 25B
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
PYGB phosphorylase, glycogen; brain
SETD2 SET domain containing 2