PAK2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description p21 protein (Cdc42/Rac)-activated kinase 2|The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5062)
External Link http://www.ncbi.nlm.nih.gov/gene/5062
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Genes

185 interacting proteins for PAK2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI3 ABI family, member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACP1 acid phosphatase 1, soluble
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTBL2 actin, beta-like 2
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
AHCY adenosylhomocysteinase
AK2 adenylate kinase 2
ANXA2 annexin A2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APP amyloid beta (A4) precursor protein
ARHGAP10 Rho GTPase activating protein 10
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTF3 basic transcription factor 3
CALD1 caldesmon 1
CALR calreticulin
CAPNS1 calpain, small subunit 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CDH5 cadherin 5, type 2 (vascular endothelium)
CKB creatine kinase, brain
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CSDE1 cold shock domain containing E1, RNA-binding
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
DOCK2 dedicator of cytokinesis 2
DST dystonin
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EEF2 eukaryotic translation elongation factor 2
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EFNB3 ephrin-B3
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPHB6 EPH receptor B6
ERP44 endoplasmic reticulum protein 44
F2RL2 coagulation factor II (thrombin) receptor-like 2
FBXO28 F-box protein 28
FES FES proto-oncogene, tyrosine kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GANAB glucosidase, alpha; neutral AB
GDI2 GDP dissociation inhibitor 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GSTM3 glutathione S-transferase mu 3 (brain)
HCK HCK proto-oncogene, Src family tyrosine kinase
HIST1H4F histone cluster 1, H4f
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTT huntingtin
ISOC1 isochorismatase domain containing 1
JUN jun proto-oncogene
JUP junction plakoglobin
KDR kinase insert domain receptor
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LDHB lactate dehydrogenase B
LIMK1 LIM domain kinase 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAX MYC associated factor X
MCM3 minichromosome maintenance complex component 3
MKNK1 MAP kinase interacting serine/threonine kinase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYLK myosin light chain kinase
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NF2 neurofibromin 2 (merlin)
NPEPPS aminopeptidase puromycin sensitive
NPHP1 nephronophthisis 1 (juvenile)
NRP1 neuropilin 1
NUDC nudC nuclear distribution protein
P4HB prolyl 4-hydroxylase, beta polypeptide
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARD6A par-6 family cell polarity regulator alpha
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PEBP1 phosphatidylethanolamine binding protein 1
PFAS phosphoribosylformylglycinamidine synthase
PGRMC1 progesterone receptor membrane component 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
PLXNA1 plexin A1
PLXNA2 plexin A2
PLXNA3 plexin A3
PLXNA4 plexin A4
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCE protein kinase C, epsilon
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1B RAP1B, member of RAS oncogene family
RHOU ras homolog family member U
RIOK3 RIO kinase 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL23A ribosomal protein L23a
RPL24 ribosomal protein L24
RPL32 ribosomal protein L32
RPS6 ribosomal protein S6
SCLY selenocysteine lyase
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT2 septin 2
SFN stratifin
SH3GL2 SH3-domain GRB2-like 2
SH3KBP1 SH3-domain kinase binding protein 1
SH3PXD2A SH3 and PX domains 2A
SH3RF1 SH3 domain containing ring finger 1
SH3RF3 SH3 domain containing ring finger 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SNX33 sorting nexin 33
SNX9 sorting nexin 9
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STMN1 stathmin 1
STMN4 stathmin-like 4
SYN1 synapsin I
TGM2 transglutaminase 2
TNK2 tyrosine kinase, non-receptor, 2
TRIM28 tripartite motif containing 28
TRIO trio Rho guanine nucleotide exchange factor
UBC ubiquitin C
UBE2R2 ubiquitin-conjugating enzyme E2R 2
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBFD1 ubiquitin family domain containing 1
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VIM vimentin
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFYVE19 zinc finger, FYVE domain containing 19