PAK3 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description p21 protein (Cdc42/Rac)-activated kinase 3|PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5063)
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Genes

100 substrates of the kinase PAK3 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
TWIST1 twist family bHLH transcription factor 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
MYD88 myeloid differentiation primary response 88
SCAF1 SR-related CTD-associated factor 1
FAM65B family with sequence similarity 65, member B
ZBTB44 zinc finger and BTB domain containing 44
PPP1R10 protein phosphatase 1, regulatory subunit 10
FAM129A family with sequence similarity 129, member A
MAP7D3 MAP7 domain containing 3
TTC39B tetratricopeptide repeat domain 39B
RPTOR regulatory associated protein of MTOR, complex 1
PDE3A phosphodiesterase 3A, cGMP-inhibited
RGL2 ral guanine nucleotide dissociation stimulator-like 2
TRA2B transformer 2 beta homolog (Drosophila)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
SETD2 SET domain containing 2
DGKZ diacylglycerol kinase, zeta
GRN granulin
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
CDK13 cyclin-dependent kinase 13
UBE2O ubiquitin-conjugating enzyme E2O
KIF23 kinesin family member 23
TRA2A transformer 2 alpha homolog (Drosophila)
IER2 immediate early response 2
PRICKLE3 prickle homolog 3 (Drosophila)
MRVI1 murine retrovirus integration site 1 homolog
CCDC120 coiled-coil domain containing 120
CASKIN2 CASK interacting protein 2
PBRM1 polybromo 1
LTF lactotransferrin
FRMD4B FERM domain containing 4B
PRPF38B pre-mRNA processing factor 38B
PELI1 pellino E3 ubiquitin protein ligase 1
RPS6 ribosomal protein S6
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
DMXL1 Dmx-like 1
GPATCH8 G patch domain containing 8
DEPDC5 DEP domain containing 5
TOR4A torsin family 4, member A
WDR81 WD repeat domain 81
SEPT1 septin 1
TRPS1 trichorhinophalangeal syndrome I
MYO7B myosin VIIB
KDM3B lysine (K)-specific demethylase 3B
SRSF2 serine/arginine-rich splicing factor 2
PCLO piccolo presynaptic cytomatrix protein
ATR ATR serine/threonine kinase
GAS7 growth arrest-specific 7
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
IL1A interleukin 1, alpha
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LIMCH1 LIM and calponin homology domains 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
ANKRD33B ankyrin repeat domain 33B
PRKD1 protein kinase D1
PRKD2 protein kinase D2
HBP1 HMG-box transcription factor 1
CASC5 cancer susceptibility candidate 5
TP53BP1 tumor protein p53 binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
RGCC regulator of cell cycle
CHKB choline kinase beta
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
FAM122A family with sequence similarity 122A
PYGO2 pygopus family PHD finger 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
SRSF12 serine/arginine-rich splicing factor 12
PPHLN1 periphilin 1
ILDR1 immunoglobulin-like domain containing receptor 1
CDCA2 cell division cycle associated 2
ZFP91 ZFP91 zinc finger protein
PHF3 PHD finger protein 3
GRK7 G protein-coupled receptor kinase 7
RNF111 ring finger protein 111
CDC25A cell division cycle 25A
PQLC1 PQ loop repeat containing 1
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
RBM8A RNA binding motif protein 8A
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R12C protein phosphatase 1, regulatory subunit 12C
EI24 etoposide induced 2.4
RBM15B RNA binding motif protein 15B
EPSTI1 epithelial stromal interaction 1 (breast)
CDC25B cell division cycle 25B
UBR5 ubiquitin protein ligase E3 component n-recognin 5
NCAPH non-SMC condensin I complex, subunit H
SECISBP2L SECIS binding protein 2-like
C6ORF25 chromosome 6 open reading frame 25
FAM214B family with sequence similarity 214, member B
SRRM2 serine/arginine repetitive matrix 2
ARHGAP23 Rho GTPase activating protein 23
ARHGAP21 Rho GTPase activating protein 21
ZNF212 zinc finger protein 212
IRF2BP2 interferon regulatory factor 2 binding protein 2
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
ZFC3H1 zinc finger, C3H1-type containing