| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | p21 protein (Cdc42/Rac)-activated kinase 3|PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5063) |
| External Link | https://ncbi.nlm.nih.gov/gene/5063 |
| Similar Terms | |
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498 genes differentially expressed following the PAK3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA1A | heat shock 70kDa protein 1A | 0.0152957 |
| RGCC | regulator of cell cycle | 0.0123132 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0119673 |
| KRT15 | keratin 15, type I | 0.0110091 |
| TSPAN7 | tetraspanin 7 | 0.0107839 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0105827 |
| MAGEA3 | melanoma antigen family A3 | 0.0101409 |
| XIC | X chromosome inactivation center | 0.0100833 |
| MEF2C | myocyte enhancer factor 2C | 0.0100587 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00992943 |
| CAV2 | caveolin 2 | 0.00917759 |
| KYNU | kynureninase | 0.00911185 |
| CD200 | CD200 molecule | 0.00893054 |
| EMP1 | epithelial membrane protein 1 | 0.00890323 |
| EGR2 | early growth response 2 | 0.00888359 |
| CANX | calnexin | 0.00886587 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.00844917 |
| SPRR3 | small proline-rich protein 3 | 0.00833839 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00832206 |
| HHEX | hematopoietically expressed homeobox | 0.00827008 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | 0.00821423 |
| AHSG | alpha-2-HS-glycoprotein | 0.00816744 |
| FGB | fibrinogen beta chain | 0.00812768 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00801954 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00800673 |
| EGR1 | early growth response 1 | 0.00792238 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.00785297 |
| FGG | fibrinogen gamma chain | 0.0077078 |
| PCNA | proliferating cell nuclear antigen | 0.00768788 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00762083 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.00750497 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00748875 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00747083 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00741145 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 0.00733747 |
| PRDX1 | peroxiredoxin 1 | 0.00729795 |
| FGA | fibrinogen alpha chain | 0.0072812 |
| F2R | coagulation factor II (thrombin) receptor | 0.0072694 |
| PRSS21 | protease, serine, 21 (testisin) | 0.0072516 |
| APOA2 | apolipoprotein A-II | 0.00721819 |
| RGS10 | regulator of G-protein signaling 10 | 0.00720528 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.0071919 |
| ADM | adrenomedullin | 0.00713731 |
| NRCAM | neuronal cell adhesion molecule | 0.00712261 |
| DMD | dystrophin | 0.00712021 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | 0.00711173 |
| CAPRIN1 | cell cycle associated protein 1 | 0.00710806 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.00703696 |
| ORM1 | orosomucoid 1 | 0.00703044 |
| MED6 | mediator complex subunit 6 | 0.00701595 |
| MAGEA12 | melanoma antigen family A12 | 0.00698612 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.006956 |
| PDE8B | phosphodiesterase 8B | 0.00673438 |
| VNN1 | vanin 1 | 0.00673306 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.00667485 |
| ZNF665 | zinc finger protein 665 | 0.00667357 |
| PRAME | preferentially expressed antigen in melanoma | 0.00658361 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.0065677 |
| NELL1 | NEL-like 1 (chicken) | 0.00654571 |
| XPO7 | exportin 7 | 0.0065448 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.00653584 |
| GIMAP4 | GTPase, IMAP family member 4 | 0.00651922 |
| AFP | alpha-fetoprotein | 0.00651774 |
| CHP1 | calcineurin-like EF-hand protein 1 | 0.00647747 |
| TSPAN5 | tetraspanin 5 | 0.00647516 |
| APOB | apolipoprotein B | 0.00646543 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.00645279 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00640435 |
| CD14 | CD14 molecule | 0.00640322 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 0.00640082 |
| CTSS | cathepsin S | 0.00637923 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.00636929 |
| PODXL | podocalyxin-like | 0.00633846 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00632943 |
| COL15A1 | collagen, type XV, alpha 1 | 0.00631276 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 0.00631228 |
| CPD | carboxypeptidase D | 0.00628909 |
| MYOF | myoferlin | 0.00628846 |
| DUSP1 | dual specificity phosphatase 1 | 0.00628267 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.00626142 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.00625564 |
| NCOA3 | nuclear receptor coactivator 3 | 0.00624979 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.00623971 |
| MED1 | mediator complex subunit 1 | 0.00618149 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.00616535 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.00616519 |
| BCL2A1 | BCL2-related protein A1 | 0.00616034 |
| ALB | albumin | 0.00612777 |
| EXOC5 | exocyst complex component 5 | 0.00611688 |
| MBD2 | methyl-CpG binding domain protein 2 | 0.00610513 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0060889 |
| MCL1 | myeloid cell leukemia 1 | 0.00608524 |
| MYO1B | myosin IB | 0.00606696 |
| KRT13 | keratin 13, type I | 0.00605652 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.00603903 |
| MRTFB | myocardin related transcription factor B | 0.00602845 |
| TBC1D1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 | 0.006017 |
| TYMS | thymidylate synthetase | 0.00601361 |
| FAM198B | family with sequence similarity 198, member B | 0.0059986 |
| IGSF3 | immunoglobulin superfamily, member 3 | 0.00599789 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.00599214 |
| CD93 | CD93 molecule | 0.00598678 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.00598164 |
| RAB3GAP2 | RAB3 GTPase activating protein subunit 2 (non-catalytic) | 0.00597037 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00595011 |
| OSMR | oncostatin M receptor | 0.00594212 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.005939 |
| APOBEC3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | 0.00593462 |
| RIOK3 | RIO kinase 3 | 0.00592784 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.00592462 |
| IL27RA | interleukin 27 receptor, alpha | 0.00591161 |
| PCLAF | PCNA clamp associated factor | 0.00590779 |
| USP6NL | USP6 N-terminal like | 0.00589577 |
| UBXN7 | UBX domain protein 7 | 0.00589298 |
| SCARB2 | scavenger receptor class B, member 2 | 0.00587053 |
| AGPS | alkylglycerone phosphate synthase | 0.00585992 |
| TGFA | transforming growth factor, alpha | 0.00582169 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.00580147 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.00578937 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00577349 |
| FLT1 | fms-related tyrosine kinase 1 | 0.00577072 |
| PLS3 | plastin 3 | 0.00575919 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.00573946 |
| SYNM | synemin, intermediate filament protein | 0.00573543 |
| ABLIM1 | actin binding LIM protein 1 | 0.00570721 |
| TPD52L1 | tumor protein D52-like 1 | 0.00570596 |
| AZIN1 | antizyme inhibitor 1 | 0.00570543 |
| AIM2 | absent in melanoma 2 | 0.00570317 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00569808 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0056711 |
| RASGRP3 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | 0.00566184 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.00564039 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00562934 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.00560503 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.00560448 |
| MEF2A | myocyte enhancer factor 2A | 0.00559741 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.00559531 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00558666 |
| NOTCH2 | notch 2 | 0.00557485 |
| PAM | peptidylglycine alpha-amidating monooxygenase | 0.00557319 |
| CALCRL | calcitonin receptor-like | 0.00555394 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.00554963 |
| IPO7 | importin 7 | 0.00553999 |
| FHOD3 | formin homology 2 domain containing 3 | 0.0055375 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.00553731 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.00553509 |
| ZNF654 | zinc finger protein 654 | 0.0055119 |
| ACOT9 | acyl-CoA thioesterase 9 | 0.0055069 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00548925 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.00548078 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0054723 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.00545592 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.00545327 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.00544025 |
| GOLGA8A | golgin A8 family, member A | 0.00543611 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.00543446 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.00542332 |
| KIF14 | kinesin family member 14 | 0.0054217 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00541439 |
| VWF | von Willebrand factor | 0.00540589 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0054053 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.00540438 |
| UNC45A | unc-45 homolog A (C. elegans) | 0.00539014 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.0053723 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.00537229 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00535405 |
| ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial | 0.00535302 |
| GLUL | glutamate-ammonia ligase | 0.00533279 |
| C5AR1 | complement component 5a receptor 1 | 0.00531584 |
| FABP7 | fatty acid binding protein 7, brain | 0.00530659 |
| KRT23 | keratin 23, type I | 0.00530361 |
| UIMC1 | ubiquitin interaction motif containing 1 | 0.00530134 |
| ITM2A | integral membrane protein 2A | 0.00529017 |
| EMC2 | ER membrane protein complex subunit 2 | 0.005286 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.00527722 |
| CCL14 | chemokine (C-C motif) ligand 14 | 0.00527059 |
| IRS1 | insulin receptor substrate 1 | 0.00525821 |
| GUCY2C | guanylate cyclase 2C | 0.0052539 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 0.00523932 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | 0.00522854 |
| PRNP | prion protein | 0.00522666 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00522366 |
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | 0.00520831 |
| ZWINT | ZW10 interacting kinetochore protein | 0.00520763 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | 0.00520761 |
| EFNA1 | ephrin-A1 | 0.00520395 |
| BAG3 | BCL2-associated athanogene 3 | 0.00520267 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.00519069 |
| EMCN | endomucin | 0.00519017 |
| TBXA2R | thromboxane A2 receptor | 0.00518827 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.00518811 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.00518627 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0051742 |
| SYT17 | synaptotagmin XVII | 0.0051506 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00514276 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.00513136 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00513113 |
| RAB1A | RAB1A, member RAS oncogene family | 0.00513013 |
| AREG | amphiregulin | 0.00512998 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | 0.00512747 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00511147 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0051099 |
| IER5 | immediate early response 5 | 0.00510113 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | 0.00509379 |
| AEBP1 | AE binding protein 1 | 0.00508984 |
| CPOX | coproporphyrinogen oxidase | 0.00507901 |
| CHMP4A | charged multivesicular body protein 4A | 0.00506867 |
| PHF21A | PHD finger protein 21A | 0.00506288 |
| RAP1A | RAP1A, member of RAS oncogene family | 0.00505562 |
| POSTN | periostin, osteoblast specific factor | 0.0050511 |
| VCAN | versican | 0.00504904 |
| ATP6V0A4 | ATPase, H+ transporting, lysosomal V0 subunit a4 | 0.00504329 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00504255 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.00503838 |
| EREG | epiregulin | 0.00503354 |
| CRP | C-reactive protein, pentraxin-related | 0.00503293 |
| PFKP | phosphofructokinase, platelet | 0.00502458 |
| WDR26 | WD repeat domain 26 | 0.00500331 |
| CHI3L2 | chitinase 3-like 2 | 0.00500069 |
| ZNF589 | zinc finger protein 589 | 0.0050002 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.0049876 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.00497952 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0049776 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.00496917 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.00496906 |
| CDC42SE1 | CDC42 small effector 1 | 0.00495255 |
| RAN | RAN, member RAS oncogene family | 0.0049499 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.00494139 |
| SCD5 | stearoyl-CoA desaturase 5 | 0.00493326 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.00493092 |
| RHCG | Rh family, C glycoprotein | 0.00492115 |
| RREB1 | ras responsive element binding protein 1 | 0.00492025 |
| INHBB | inhibin, beta B | 0.00491528 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00491178 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0049117 |
| RDX | radixin | 0.00490757 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.00488952 |
| PNN | pinin, desmosome associated protein | 0.0048894 |
| MECOM | MDS1 and EVI1 complex locus | 0.00487826 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00486923 |
| CD163 | CD163 molecule | 0.00486545 |
| CFI | complement factor I | 0.00485034 |
| IL6ST | interleukin 6 signal transducer | 0.00484955 |
| YIPF5 | Yip1 domain family, member 5 | 0.00484855 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.00483646 |
| HAL | histidine ammonia-lyase | 0.00483178 |
| ATF6 | activating transcription factor 6 | 0.00481264 |
| SPRR1B | small proline-rich protein 1B | 0.00480957 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.00480841 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.0149933 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.013452 |
| CFB | complement factor B | -0.0123655 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.01235 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.0116699 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.011264 |
| ASS1 | argininosuccinate synthase 1 | -0.0111727 |
| CD320 | CD320 molecule | -0.0109179 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0105158 |
| TRIB2 | tribbles pseudokinase 2 | -0.010132 |
| GPX1 | glutathione peroxidase 1 | -0.010121 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -0.010036 |
| RNF167 | ring finger protein 167 | -0.00990358 |
| FKBP11 | FK506 binding protein 11, 19 kDa | -0.00968026 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00918218 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00911944 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.00906456 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00897042 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.008931 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00885507 |
| TSPAN8 | tetraspanin 8 | -0.00881734 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.00879863 |
| OLFM4 | olfactomedin 4 | -0.00879252 |
| SDC1 | syndecan 1 | -0.00877344 |
| REG3A | regenerating islet-derived 3 alpha | -0.00863511 |
| PRDX2 | peroxiredoxin 2 | -0.00857679 |
| ADIRF | adipogenesis regulatory factor | -0.00828761 |
| NKG7 | natural killer cell granule protein 7 | -0.00826869 |
| CD8A | CD8a molecule | -0.00821177 |
| ADI1 | acireductone dioxygenase 1 | -0.00811492 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | -0.00802745 |
| KAZN | kazrin, periplakin interacting protein | -0.00797399 |
| S100P | S100 calcium binding protein P | -0.0078397 |
| PYCARD | PYD and CARD domain containing | -0.00781075 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | -0.00774891 |
| TARP | TCR gamma alternate reading frame protein | -0.00765806 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00760413 |
| CLU | clusterin | -0.00759909 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00759124 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | -0.00755278 |
| AOC1 | amine oxidase, copper containing 1 | -0.00753968 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.00753246 |
| NXN | nucleoredoxin | -0.00749125 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00748864 |
| MLPH | melanophilin | -0.00737313 |
| HSPA2 | heat shock 70kDa protein 2 | -0.0073723 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.0073528 |
| CLCA1 | chloride channel accessory 1 | -0.0073379 |
| SLC44A4 | solute carrier family 44, member 4 | -0.0073344 |
| REG1B | regenerating islet-derived 1 beta | -0.00729843 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00728653 |
| DMBT1 | deleted in malignant brain tumors 1 | -0.0072777 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -0.0072403 |
| TST | thiosulfate sulfurtransferase (rhodanese) | -0.00723993 |
| QDPR | quinoid dihydropteridine reductase | -0.0072243 |
| IL7R | interleukin 7 receptor | -0.00709694 |
| CTSW | cathepsin W | -0.00702851 |
| REG1A | regenerating islet-derived 1 alpha | -0.00702365 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | -0.00702024 |
| ACP5 | acid phosphatase 5, tartrate resistant | -0.00699632 |
| ACE2 | angiotensin I converting enzyme 2 | -0.00692501 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.00689101 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00688858 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00687229 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | -0.00686616 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -0.00680737 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00680257 |
| TBX3 | T-box 3 | -0.00677421 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.00676717 |
| PRKCZ | protein kinase C, zeta | -0.00675786 |
| CLDN3 | claudin 3 | -0.00675064 |
| CST7 | cystatin F (leukocystatin) | -0.00673566 |
| GAS1 | growth arrest-specific 1 | -0.00671027 |
| COPS7A | COP9 signalosome subunit 7A | -0.00669065 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | -0.00668492 |
| GSTT1 | glutathione S-transferase theta 1 | -0.00666561 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | -0.00664662 |
| KRT20 | keratin 20, type I | -0.00662888 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.00662411 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | -0.00661452 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00658737 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00657099 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00656765 |
| NNMT | nicotinamide N-methyltransferase | -0.00656044 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | -0.00655946 |
| RPL36 | ribosomal protein L36 | -0.00654383 |
| SEPTIN10 | septin 10 | -0.00647617 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00647218 |
| STK10 | serine/threonine kinase 10 | -0.00646045 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00642375 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | -0.00639261 |
| TTC38 | tetratricopeptide repeat domain 38 | -0.00635948 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.0063471 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.006338 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | -0.00627636 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | -0.0062549 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00623628 |
| OTULINL | OTU deubiquitinase with linear linkage specificity like | -0.00620382 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | -0.0062035 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | -0.00620066 |
| LSM4 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00619585 |
| LST1 | leukocyte specific transcript 1 | -0.00619258 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00616856 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00616849 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | -0.00616673 |
| EPHB2 | EPH receptor B2 | -0.00612149 |
| TECR | trans-2,3-enoyl-CoA reductase | -0.00611927 |
| FBLN2 | fibulin 2 | -0.00610569 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00610417 |
| REX1BD | required for excision 1-B domain containing | -0.0061038 |
| RAPSN | receptor-associated protein of the synapse | -0.00609753 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | -0.00609634 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00608783 |
| TMC5 | transmembrane channel-like 5 | -0.00605423 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00604724 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00604249 |
| GMPR | guanosine monophosphate reductase | -0.0060242 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | -0.00601689 |
| CTBP2 | C-terminal binding protein 2 | -0.00598853 |
| NTS | neurotensin | -0.00598748 |
| BIN1 | bridging integrator 1 | -0.00598471 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.00598219 |
| TFF1 | trefoil factor 1 | -0.00597596 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | -0.00590776 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | -0.00590725 |
| RTN1 | reticulon 1 | -0.00588627 |
| TOX3 | TOX high mobility group box family member 3 | -0.00586757 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00585389 |
| S100A6 | S100 calcium binding protein A6 | -0.00583981 |
| MYO1D | myosin ID | -0.00583493 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.00582941 |
| TSPAN1 | tetraspanin 1 | -0.00581706 |
| RUNX3 | runt-related transcription factor 3 | -0.00580062 |
| HMG20B | high mobility group 20B | -0.0057941 |
| WDTC1 | WD and tetratricopeptide repeats 1 | -0.00578626 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.00578161 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | -0.0057797 |
| INSM1 | insulinoma-associated 1 | -0.00576841 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.0057538 |
| SST | somatostatin | -0.0057401 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00572913 |
| JUND | jun D proto-oncogene | -0.0057054 |
| FASN | fatty acid synthase | -0.00570333 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.0056917 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | -0.0056876 |
| AMDHD2 | amidohydrolase domain containing 2 | -0.00566634 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.00564787 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | -0.00562377 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00562371 |
| PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | -0.00562252 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.00561828 |
| GAL | galanin/GMAP prepropeptide | -0.0056175 |
| MT1E | metallothionein 1E | -0.00561175 |
| CCP110 | centriolar coiled coil protein 110kDa | -0.00559706 |
| CCNF | cyclin F | -0.0055947 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | -0.00559095 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | -0.00555888 |
| NVL | nuclear VCP-like | -0.00555794 |
| LCN2 | lipocalin 2 | -0.00555585 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -0.0055532 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -0.00555225 |
| DPEP1 | dipeptidase 1 (renal) | -0.00554286 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00552821 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.00552475 |
| ZG16 | zymogen granule protein 16 | -0.00551659 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | -0.00550677 |
| MSMO1 | methylsterol monooxygenase 1 | -0.00550568 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0054952 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00547425 |
| CHN2 | chimerin 2 | -0.00546581 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00544348 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | -0.00544023 |
| CDC20 | cell division cycle 20 | -0.00543726 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00543265 |
| CAPG | capping protein (actin filament), gelsolin-like | -0.00542928 |
| FBN2 | fibrillin 2 | -0.00542679 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | -0.00540264 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.00539925 |
| ACSF2 | acyl-CoA synthetase family member 2 | -0.00539147 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | -0.00538859 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -0.00536645 |
| COLEC12 | collectin sub-family member 12 | -0.00535737 |
| ILVBL | ilvB (bacterial acetolactate synthase)-like | -0.00534874 |
| MICU2 | mitochondrial calcium uptake 2 | -0.00534551 |
| GPX4 | glutathione peroxidase 4 | -0.00534545 |
| GNLY | granulysin | -0.00532765 |
| DCXR | dicarbonyl/L-xylulose reductase | -0.00532661 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) | -0.00530546 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.00528674 |
| DAXX | death-domain associated protein | -0.00528605 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00528378 |
| BABAM1 | BRISC and BRCA1 A complex member 1 | -0.00528016 |
| ATP5ME | ATP synthase membrane subunit e | -0.00527718 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | -0.0052561 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -0.0052533 |
| FSTL1 | follistatin-like 1 | -0.00525269 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00524932 |
| TUBA4A | tubulin, alpha 4a | -0.00524737 |
| QPRT | quinolinate phosphoribosyltransferase | -0.00522413 |
| WBP5 | WW domain binding protein 5 | -0.0052056 |
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | -0.00520292 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00519561 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0051923 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00517163 |
| NEFH | neurofilament, heavy polypeptide | -0.00516395 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.00516175 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.00516037 |
| KIAA0930 | KIAA0930 | -0.00515382 |
| RNASE6 | ribonuclease, RNase A family, k6 | -0.00515027 |
| CD1C | CD1c molecule | -0.00514747 |
| GDF15 | growth differentiation factor 15 | -0.00514628 |
| GCG | glucagon | -0.00513983 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.00513867 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.00513775 |
| SPCS3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | -0.00513289 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00512209 |
| LYZ | lysozyme | -0.00509447 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -0.00509055 |
| SELENBP1 | selenium binding protein 1 | -0.00508332 |
| DVL1 | dishevelled segment polarity protein 1 | -0.00506475 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | -0.00506204 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | -0.0050463 |
| BAG1 | BCL2-associated athanogene | -0.00503579 |
| TRPA1 | transient receptor potential cation channel, subfamily A, member 1 | -0.00502753 |
| GPC4 | glypican 4 | -0.00502258 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.00500738 |
| TRIP10 | thyroid hormone receptor interactor 10 | -0.00499805 |
| GCAT | glycine C-acetyltransferase | -0.0049976 |
| IL2RB | interleukin 2 receptor, beta | -0.00499584 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -0.00499518 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.00499189 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00498792 |
| PNKP | polynucleotide kinase 3'-phosphatase | -0.00497866 |
| NUP107 | nucleoporin 107kDa | -0.00496974 |
| FAM53B | family with sequence similarity 53, member B | -0.0049668 |
| YEATS4 | YEATS domain containing 4 | -0.00494635 |
| ATP5F1D | ATP synthase F1 subunit delta | -0.00494526 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.00493497 |
| SCAND1 | SCAN domain containing 1 | -0.00492363 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.00491638 |
| SCG5 | secretogranin V | -0.00491585 |
| MPST | mercaptopyruvate sulfurtransferase | -0.00491196 |
| CD48 | CD48 molecule | -0.00490668 |
| VARS | valyl-tRNA synthetase | -0.00490644 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.00490221 |
| SMYD3 | SET and MYND domain containing 3 | -0.00489195 |
| BCL7C | B-cell CLL/lymphoma 7C | -0.00487758 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00487319 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00486797 |
